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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu jing liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Multiphase flow physics of room temperature liquid metals and its applications

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Science China(Technological Sciences) 2023年第6期66卷 1483-1510页

作者： QIAO MengWen XING ZeRong fu Jun-Heng liu jing CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryBeijing 100190China School of future Technology University of Chinese Academy of SciencesBeijing 100049China Beijing Key Laboratory of Cryo-Biomedical Engineering Beijing 100190China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYa’an 625014China Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China

Multiphase flow existing everywhere in the motion evolution of nature,industrial processes,and daily life,has been an interdisciplinary cutting-edge frontier covering rather diverse *** multiphase flow of high melting metals typically involves gas/vapor-liquid two-phase fluidics which usually requests intense energy processes and therefore limits their applications to a large *** from this,the newly emerging room-temperature liquid metals(RTLMs)with fascinating metallic fluidic properties and multifunctional behaviors,not only well resolve the existing challenges facing conventional technologies,but also open up a series of new scientific and engineering *** the conceptual introduction of multiphase composites endows liquid metal with many unconventional fluidic *** further push forward the advancement of this new area,the present article is dedicated to systematically outlining the scientific category of RTLMs multiphase flow physics and interpreting its fundamental and practical *** vision is to provide insights into promising developmental directions of RTLMs multiphase flow and thus facilitate synergetic research and progress among different ***,the traditional metal multiphase flow was briefly ***,we summarized the physics of RTLMs multiphase flow,the common types of liquid metals,the basic physical and chemical properties of their multiphase flow and governing equations,*** that,various typical driving modalities and manipulation methods of RTLMs were ***,important implementations of RTLMs multiphase flow into thermal management,energy harvesting,catalysis,soft machines,biomedicine,and printed electronics were ***,the multiphase flow physics of RTLMs is currently still in its incubation stage and there exist tremendous opportunities and challenges which are worth further pursuing in the coming time.

关键词： room-temperature liquid metals multiphase flow physics composite solution nanofluids fluid mechanics micro-/nanodroplets

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Nanoscale zero-valent iron integrated with bioreactor for recalcitrant antimony-Congo red dyeing wastewater treatment

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Progress in Natural Science:Materials International 2023年第5期33卷 569-574页

作者： jing liu Airong liu Yi Wei Jiahui fu Wei-xian Zhang College of Environmental Science and Engineering Tongji University State Key Laboratory for Pollution Control and Resource Reuse

Antimony(Sb) and recalcitrant organic dyes often coexist in dyeing wastewater, and the simultaneous removal of Sb and dyes has been a challenge for traditional biological method in the treatment of Sb-dyeing *** zero-valent iron(n ZVI) is particularly suitable for separating heavy metals and enhancing the biodegradability of recalcitrant organic compounds. Herein, n ZVI is integrated with bioreactors(n ZVI-bio system) to achieve enhanced removal of Sb and degradation of Congo red(CR) in wastewater. The n ZVI-bio system achieves a reduction in Sb levels from 2.5 g L-1to 0.064 mg L-1, with a color removal efficiency of up to 98.60 % and a reduction in COD from 167 mg L-1to 55 mg L-1. The excellent performance is mainly attributed to n ZVI pretreatment, which removes Sb and degrades CR into smaller and more biodegradable organic compounds,providing favorable environmental conditions for the subsequent biotreatment system. This suggests that integrated n ZVI-bio system has potential for the treatment of complex wastewater containing heavy metals and recalcitrant organic dyes.

关键词： Nanoscale zero-valent iron Biotreatment Antimony Congo red nZVI-bio system

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin liu Lu Xu Lin fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Microstructure and properties of aging Cu–Cr–Zr alloy

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Rare Metals 2014年第2期33卷 134-138页

作者： Kun Wang Ke-fu liu jing-Bo Zhang Institute of Electric Lighting Source Fudan University No.23 Research Institute China Electronics Technology Group Corporation No. 23 Research Institute China Electronics Technology Group Corporation

The crystallography and morphology of precipitate particles in a Cu matrix were studied using an aged Cu–Cr–Zr alloy by transmission electron microscopy（TEM） and high-resolution transmission electron microscopy（HRTEM）. The tensile strength and electrical conductivity of this alloy after various aging processes were tested. The results show that two kinds of crystallographic structure associated with chromium-rich phases, fcc and bcc structure, exist in the peak-aging of the alloy. The orientation relationship between bcc Cr precipitate and the matrix exhibits Nishiyama–Wasserman orientation relationship. Two kinds of Zr-rich phases（Cu4Zr and Cu5Zr）can be identified and the habit plane is parallel to {111}Cu plane during the aging. The increase in strength is ascribed to the precipitation of Cr- and Zr-rich phase.

关键词： Cu–Cr–Zr alloy Aging process Crystallography Morphology Strengthening mechanism

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Nanoencapsulation of arsenate with nanoscale zero-valent iron(nZVI):A 3D perspective

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Science Bulletin 2018年第24期63卷 1641-1648页

作者： Airong liu Wei Wang jing liu Rongbing fu Wei-xian Zhang State Key Laboratory for Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongii UniversityShanghai 200092China School of Chemical Sdence and Engineering Tongji UniversztyShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

The principal forces driving the efficient enrichment and encapsulation of arsenic(As) into nanoscale zero-valent iron(nZVI) are the disordered arrangement of the atoms and the gradient chemical potentials within the core-shell interface. The chemical compositions and the fine structure of nZVI are characterized with a combination of spherical aberration corrected scanning transmission electron microscopy(Cs-STEM), X-ray energy-dispersive spectroscopy(XEDS), electron energy loss spectroscopy(EELS), and high-resolution X-ray photoelectron spectroscopy(HR-XPS). Atomically resolved EELS at the oxygen K-edge unfolds that the Fe species in nZVI are well stratified from Fe(Ⅲ) oxides in the outermost periphery to a mixed Fe(Ⅲ)/Fe(Ⅱ) interlayer, then Fe(Ⅱ) oxide and the pure Fe(0) phase. Reactions between As(Ⅴ)and nZVI suggest that a well-structured local redox gradient exists within the shell layer, which serves as a thermodynamically favorable conduit for electron transfer from the iron core to the surface-bound As(Ⅴ). HR-XPS with ion sputtering shows that arsenic species shift from As(Ⅴ), As(Ⅲ)/As(Ⅴ) to As(Ⅴ)/As(Ⅲ)/As(0) from the iron oxide shell–water interface to the Fe(0) core. Results reinforce previous work on the efficacy of nZVI for removing and remediating arsenic while the analytical TEM methods are also applicable to the study of environmental interfaces and surface chemistry.

关键词： Arsenate Nanoscale zero-valent iron Spherical aberration corrected scanning transmission electron microscopy X-ray energy-dispersive spectroscopy Electron energy-loss spectroscopy X-ray photoelectron spectroscopy

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Empirical Likelihood Based Diagnostics for Heteroscedasticity in Semiparametric Varying-Coefficient Partially Linear Models with Missing Responses

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Journal of Systems Science & Complexity 2021年第3期34卷 1175-1188页

作者： liu Feng GAO Weiqing HE jing fu Xinwei KANG Xinmei School of Science Chongqing University of TechnologyChongqing 401331China

This paper proposes an empirical likelihood based diagnostic technique for heteroscedasticity for semiparametric varying-coefficient partially linear models with missing responses. Firstly, the authors complement the missing response variables by regression method. Then, the empirical likelihood method is introduced to study the heteroscedasticity of the semiparametric varying-coefficient partially linear models with complete-case data. Finally, the authors obtain the finite sample property by numerical simulation.

关键词： Empirical likelihood ratio heteroscedasticity response missing with MAR semiparametric varying-coefficient partially linear models

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting fu jing liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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Identification of Colour Reconnection using Factorial Correlator

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Chinese Physics Letters 2000年第5期17卷 338-339页

作者： fu jing-Hua liu Lian-Shou Institute of Particle Physics Huazhong Normal UniversityWuhan 430079

A new signal is proposed for the colour reconnection in the hadronic decay of W^(+) W^(-) in e^(+)e^(-) *** Pythia Monte Carlo it is shown that factorial correlators for W^(+) and W^(-) without colour reconnection are almost identical to unity,while those for the cases with colour reconnection fall down approximately linearly in the loglog plot-This signal,being based on the tactorial correlator,is more sensitive than the ones using only averaged quantities.

关键词： quantities identical approximate

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[Construction of a 17 β-estradiol sensor based on a magnetic graphene oxide/aptamer separating material]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 87-95页

作者： Xin-Yu Jin Le-Yuan Chen Ya-Nna liu Wen-jing Xie Han-Yong Peng State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. University of Chinese Academy of Sciences Beijing 100049 China. School of Environment Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Hangzhou 310024 China.

17-Estradiol (E2) is a natural steroidal estrogen essential for a variety of physiological functions in organisms. However, external E2, which is renowned for its potent biological effects, is also considered to be an endocrine-disrupting compound (EDC) capable of disturbing the normal operation of the endocrine system, even at nanogram-per-liter (ng/L) concentrations. Studies have revealed that medical and livestock wastewater can be contaminated with E2, which poses potential risks to human health. Currently, the primary method for detecting E2 relies on liquid chromatography-mass spectrometry, which is limited with regard to on-site or large-scale sample testing due to instrumental constraints. Herein, we developed a magnetic graphene oxide (MGO)/aptamer separating material. The MGO was synthesized by creating a water-in-oil microemulsion at 90 ℃, an agarose hydrogel to load the FeO nanoparticles, and layered graphene oxide (GO). In contrast to conventional methods, such as chemical co-precipitation and solvothermal approaches, this method is more time-efficient and does not require high temperature or pressure. Moreover, the use of a physical encapsulation technique for enwrapping the FeO nanoparticles and layered GO eliminates the need for chemical modification. This approach reduces the use of harmful chemicals, ensures complete loading, and results in highly efficient encapsulation. The MGO was characterized using Fourier-transform infrared (FT-IR) spectroscopy and transmission electron microscopy (TEM), as well as dynamic light scattering (DLS) and Zeta potential analyses, which revealed that the FeO nanoparticles had been successfully loaded onto the GO to produce MGO particles mainly around 5 μm in size. Additionally, this study demonstrated that the aqueous MGO dispersion is highly stable. This substance was used to develop a fluorescent biosensor that uses a "turn-on" mechanism to rapidly and highly sensitively detect E2. MGO is capable of adsorbing a fl

关键词： 17-estradiol (E2) fluorescence biosensor magnetic graphene oxide (MGO) magnetic solid phase separation

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