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基于实体退化虚拟层合单元预制桥墩承载力分析

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公路交通科技 2016年第3期33卷 71-75页

作者：景强港珠澳大桥管理局广东珠海519015

以某跨海桥梁工程中采用的埋床法施工的预制墩台为研究对象,该预制墩台的承载能力是设计的重点,设计阶段需对不同荷载工况下的墩台承载能力进行精细分析。墩台承载能力分析需要考虑混凝土和钢筋两种不同材料的非线性,并考虑预应力筋的... 详细信息

以某跨海桥梁工程中采用的埋床法施工的预制墩台为研究对象,该预制墩台的承载能力是设计的重点,设计阶段需对不同荷载工况下的墩台承载能力进行精细分析。墩台承载能力分析需要考虑混凝土和钢筋两种不同材料的非线性,并考虑预应力筋的作用。一般的有限元程序在处理材料非线性问题时往往存在计算效率低、计算成本高、计算不收敛等问题。实体退化序列单元,该单元基于经典的三维实体等参元和梁、板壳理论简化假定得出,在保证计算精度的前提下,该单元更为简单、高效。采用该单元对施工过程中桥墩墩身进行了承载力分析,并对其安全性进行了评估。分析结果表明,桥墩在关键荷载工况下,其正常使用状态的钢筋应力处于较低水平,关键部位混凝土未出现裂缝,对结构安全、耐久性无影响,结构承载力满足要求。

关键词：桥梁工程预制墩台埋置施工极限承载力实体退化单元

Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid

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Acta Pharmacologica Sinica 2006年第8期27卷 1078-1084页

作者： jing-jing LI~2 qiang TANG~2 Yuan LI Ben-rong HU Zhang-yin MING Qin FU~3 Jia-qing QIAN Ji-zhou XIANG~3 Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:The present study was designed to determine the possible pathway under-lying the enhancement of apoptosis induced by the combined use of arsenictrioxide(As2O3)and ascorbic acid(AA).Methods:The level of intracellular reac-tive oxygen species(ROS)was detected by means of flow cytometry analysis withan oxidation-sensitive fuorescent probe(6-carboxy-2′,7′dichlorodihydrofluoresceindiacetate)*** activity of glutathione(GSH),glutathione peroxidase(GPx),and superoxide dismutase(SOD)were detected by biochemical *** mitochondrial membrane potential was measured by flow cytometry analysiswith rhodamine 123 ***-2,Bax,and p17 subunit of caspase-3 were ana-lyzed using the Western blot *** apoptosis rate was determined by flowcytometry with annexin-V/propidium iodide ***:Compared withAs2O3(2.0 μmol/L)treated alone,As2O3(2.0 μmol/L)in combination with AA(100μmol/L)decreased intracellular GSH content from 101.30+5.76 to 81.91+3.12 mg/gprotein,and increased ROS level from 127.61+5.12 to 152.60+5.88,which was rep-resented by the 2,7-dichlorofluorescein *** loss of mitochondria mem-brane potential was increased from 1269.97±36.11 to 1540.52+52.63,which waspresented by fluorescence *** p17 subunit of caspase-3 expressionwas increased approximately ***,SOD and GPx depletion and theratio of Bcl-2 to Bax were equal to that of As2O3treated alone(P>0.05).When theROS scavenger,N-acetyl-L-cysteine,was added to As2O3and AA combined treat-ment group,the apoptosis rate decreased from 15.60%±1.14% to 9.48%±0.67%,and the ROS level decreased from 152.60±5.88 to 102.77±***:AApotentiated As2O3-induced apoptosis through the oxidative pathway by increas-ing the ROS *** may be the result of depleting intracellular *** mayinfluence the downstream cascade following ROS,including mitochondria depo-larization and caspase-3 ***,SOD and GPx depletion and theratio of Bcl-2 to Bax influenced by

关键词： arsenic trioxide ascorbic acid hepatocellular carcinoma apoptosis glutathione reactive oxygen species

Studies of tris[(phenyldimethyisilyl)methylene]-tin carboxylates

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Chinese Journal of Chemistry 1991年第4期9卷 327-334页

作者： XIE,Qing-Lan LI,jing YANG,Zhi-qiang ZHANG,Dian-Kun WANG,Ji-Tao Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 Institute of Elemento‐Organic Chemistry Nankai University Tianjin 300071

Twenty-six derivatives of tris[(phenyldimethylsilyl)methyleneltin carboxylates have been pre- *** compounds are new and characterized through elemental analysis IR spectra,and ~1H,^(13)C, ^(119)Sn NMR spectral *** spectral results showed that all compounds are four coordinated organotin *** Δv(=v(?)-v(?))of them are over 300 cm^(-1).The chemical shifts(δ)of ^(119)Sn of ArCO_2Sn(CH_2SiMe_2Ph)_3 and ArOCH_2CO_2Sn(CH_2SiMe_2Ph)_3 give good straight-line correlation with para-substituent *** compounds have good acaricide activity,but their action on the mite are slower than that of Torque.

关键词： phenyldimethyisilyl)methylene OCH Sn tin carboxylates Studies of tris

One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM) in Water

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Chinese Journal of Polymer Science 2024年第1期42卷 1-6,I0004页

作者： Zi-Shan Li jing Lyu Bei Qiu Ying-Hao Li Ruth Foley Ri-Jian Song Melissa Johnson qiang Geng Wen-Xin Wang Institute of Precision Medicine(AUST-IPM) Anhui University of Science and TechnologyHuainan 232001China Charles Institute of Dermatology School of MedicineUniversity College DublinDublin D04 V1W8Ireland

Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP) of the water-soluble monomer Nisopropylacrylamide(NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights(MWs) or complex or multi reaction steps, etc. In this work, we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu~I at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator(i.e., Cu~II) to the system. Moreover, a low reaction temperature(4 ℃) is necessary in the controlled synthesis of higher MW poly(Nisopropylacrylamide)(PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions(MWDs) and varied MWs were successfully achieved.

关键词： Cu(0)-mediated RDRP N-isopropylacrylamide Propagation Deactivation Reaction parameters

Single transition-metal atoms anchored on a novel Diracdispersiveπ-πconjugated holey graphitic carbon nitride substrate:computational screening toward efficient bifunctional OER/ORR electrocatalysts

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Rare Metals 2024年第8期43卷 3819-3832页

作者： Chun-Yao Fang Xi-Hang Zhang qiang Zhang Di Liu Xiao-Meng Cui jing-Cheng Xu Cheng-Long Shi Meng-Yu Yang College of Science University of Shanghai for Science and TechnologyShanghai 200093China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China

Nonprecious-metal-group single-metal-atom catalysts with bifunctional catalytic capabilities toward the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)are highly sought after in energy-conversion and storage ***,producing renewable and sustainable energy sources remains ***,single-transition metal atoms anchored onπ-πconjugated two-dimensional(2D)graphitic carbon nitride substrates formπ-d conjugated conductive channels that enhance the overall electrocatalytic ***,firstprinciples calculations were carried out to design and demonstrate a novel macropore graphitic carbon nitride(gC_(10)N_(3))as a promising 2D electrocatalyst substrate to support single-transition metal(TM,from Sc to Au).The"donation-acceptance"charge interaction in the TM-N_(2)moiety effectively balances the adsorption strength of oxygenated intermediates in Ni@g-C_(10)N_(3)and Rh@gC_(10)N_3,making them effective bifunctional OER/ORR electrocatalysts with IrO_(2)/Pt-beyond overpotentials being as low as 0.39/0.38 V and 0.54/0.44 V,***,they possess high stability and conductivity and are less susceptible to oxidation and corrosion under working *** guarantees high activity under ambient ***,the origin of the OER/ORR activity of TM@g-C_(10)N_(3) is explained using multilevel descriptors:intrinsic(p,Bader charge,integral crystal orbital Hamilton population(ICOHP),bond length,and d-band center(εd).In particular,for optimal Ni@g-C_(10)N_(3),the clear hybridization between the Ni-d orbital and surface O-p orbital causes the paired electrons to occupy the bonding *** enables OH~*to be adsorbed on the Ni@g-C_(10)N_(3),thereby achieving the highest catalytic performance.

关键词： First-principles calculation Oxygen evolution reaction Oxygen reduction reaction Bifunctional electrocatalysts Single-metal-atom electrocatalysts

Insights into layered-tunnel dynamic structural evolution based on local coordination chemistry regulation for high-energy-density and long-cycle-life sodium-ion oxide cathodes

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InfoMat 2023年第10期5卷 32-42页

作者： Yao Xiao Yi-Feng Liu Hong-Wei Li Jia-Yang Li jing-qiang Wang Hai-Yan Hu Yu Su Zhuang-Chun Jian Hu-Rong Yao Shuang-qiang Chen Xian-Xiang Zeng Xiong-Wei Wu Jia-Zhao Wang Yan-Fang Zhu Shi-Xue Dou Shu-Lei Chou Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouthe People's Republic of China Wenzhou Key Laboratory of Sodium-Ion Batteries Wenzhou University Technology Innovation Institute for Carbon NeutralizationWenzhouthe People's Republic of China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong UniversityXi'anthe People'sRepublic of China School of Chemistry and Materials Science Hunan Agricultural UniversityChangshathe People's Republic of China Institute for Superconducting and Electronic Materials Australian Institute for Innovative Materials University of Wollongong Innovation CampusNorth WollongongNew South WalesAustralia Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials College of Physics and EnergyFujian Normal UniversityFuzhouthe People's Republic of China

The pursuit of high energy density while achieving long cycle life remains a challenge in developing transition metal(TM)oxide cathode materials for sodium-ion batteries(SIBs).Here,we present a concept of precisely manipulating structural evolution via local coordination chemistry regulation to design high-performance composite cathode *** controllable structural evolution process is realized by tuning magnesium content in Na0.6Mn1-xMgxO2,which is elucidated by a combination of experimental analysis and theoretical *** substitution of Mg into Mn sites not only induces a unique structural evolu-tion from layered–tunnel structure to layered structure but also mitigates the Jahn–Teller distortion of Mn3+.Meanwhile,benefiting from the strong ionic inter-action between Mg2+and O2-,local environments around O2-coordinated with electrochemically inactive Mg2+are anchored in the TM layer,providing a pinning effect to stabilize crystal structure and smooth electrochemical *** layered–tunnel Na0.6Mn0.95Mg0.05O2 cathode material delivers 188.9 mAh g-1 of specific capacity,equivalent to 508.0 Wh kg-1 of energy density at 0.5C,and exhibits 71.3%of capacity retention after 1000 cycles at 5C as well as excellent compatibility with hard carbon *** work may provide new insights of manipulating structural evolution in composite cathode materials via local coordi-nation chemistry regulation and inspire more novel design of high-performance SIB cathode materials.

关键词： dynamic structural evolution high-energy-density layered-tunnel structure local coordination chemistry sodium-ion oxide cathodes

The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes

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Virologica Sinica 2024年第2期39卷 228-234页

作者： Ru-Yi Chen Teng Zhao jing-jing Guo Feng Zhu Na-Na Zhang Xiao-Feng Li Hai-Tao Liu Fei Wang Yong-qiang Deng Cheng-Feng Qin College of Bioscience and Bioengineering Jiangxi Agricultural UniversityNanchang330045China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing100071China School of Life Sciences Southwest Forestry UniversityKunming650224China

Guaico Culex virus(GCXV)is a newly identified segmented jingmenvirus from Culex *** in Central and South *** genome of GCXV is composed of four or five single-stranded positive RNA ***,the infection kinetics and transmission capability of GCXV in mosquitoes remain *** this study,we used reverse genetics to rescue two GCXVs(4S and 5S)that contained four and five RNA segments,respectively,in C6/36 *** in vitro characterization revealed that the two GCXVs exhibited comparable replication kinetics,protein expression and viral ***,GCXV RNAs were detected in the bodies,salivary glands,midguts and ovaries of Culex quinquefasciatus at 4–10 days after oral *** addition,two GCXVs can colonize *** eggs,resulting in positive rates of 15%–35%for the second gonotrophic *** conclusion,our results demonstrated that GCXVs with four or five RNA segments can be detected in *** eggs during the first and second gonotrophic cycles after oral infection.

关键词： Guaico Culex virus(GCXV) jingmenvirus Culex quinquefasciatus Vertical transmission

Synergistic coupling among Mg_(2)B_(2)O_(5),polycarbonate and N,Ndimethylformamide enhances the electrochemical performance of PVDF-HFP-based solid electrolyte

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Journal of Energy Chemistry 2024年第7期94卷 158-168页

作者： Yutong jing qiang Lv Yujia Chen Bo Wang Bochen Wu Cheng Li Shengbo Yang Zhipeng He Dianlong Wang Huakun Liu Shixue Dou MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Institute of Energy Material Science University of Shanghai for Science and TechnologyShanghai 200093China Institute for Superconducting&Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNSW 2500Australia

Polymer solid electrolytes(SPEs)based on the[solvate-Li+]complex structure have promising prospects in lithium metal batteries(LMBs)due to their unique ion transport ***,the solvation structure may compromise the mechanical performance and safety,hindering practical application of *** this work,a composite solid electrolyte(CSE)is designed through the organic-inorganic syner-gistic interaction among N,N-dimethylformamide(DMF),polycarbonate(PC),and Mg_(2)B_(2)O_(5) in poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP).Flame-retardant Mg_(2)B_(2)O_(5) nanowires provide non-flammability to the prepared CSEs,and the addition of PC improves the dispersion of Mg_(2)B_(2)O_(5) ***,the organic-inorganic synergistic action of PC plasticizer and Mg_(2)B_(2)O_(5) nanowires pro-motes the dissociation degree of LiTFSI and reduces the crystallinity of PVDF-HFP,enabling rapid Li ion ***,Raman spectroscopy and DFT calculations confirm the coordination between Mg atoms in Mg_(2)B_(2)O_(5) and N atoms in DMF,which exhibits Lewis base-like behavior attacking adjacent C-F and C-H bonds in PVDF-HFP while inducing dehydrofluorination of *** on the syner-gistic coupling of Mg_(2)B_(2)O_(5),PC,and DMF in the PVDF-HFP matrix,the prepared CSE exhibits superior ion conductivity(9.78×10^(-4) s cm^(-1)).The assembled Li symmetric cells cycle stably for 3900 h at a current density of 0.1 mA cm^(-2) without short *** LFP||Li cells assembled with PDL-Mg_(2)B_(2)O_(5)/PC CSEs show excellent rate capability and cycling performance,with a capacity retention of 83.3%after 1000 cycles at 0.5 *** work provides a novel approach for the practical application of organic-inorganic Synergistic CSEs in LMBs.

关键词： Composite solid electrolytes Safe Li metal batteries Synergistic coupling effect Poly(vinylidene fluoride-co-hexafluoropro pylene)

Biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration

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Neural Regeneration Research 2024年第10期19卷 2157-2174页

作者： Shihong Zhu Xiaoyin Liu Xiyue Lu qiang Liao Huiyang Luo Yuan Tian Xu Cheng Yaxin Jiang Guangdi Liu jing Chen Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Pharmacy West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Out-patient Department West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Respiratory and Critical Care Medicine West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina

Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties

关键词： bioactive materials biomaterials exosomes neural regeneration scaffolds stem cells tissue engineering traumatic brain injury