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Compression and stretching of ring vortex in a bulk nonlinear medium

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Chinese Physics B 2024年第2期33卷 264-270页

作者：来娴静蔡晓鸥邵雅斌王悦悦 Department of Basic Science Zhejiang Shuren UniversityHangzhou 310015China School of Sciences Zhejiang A&F UniversityHangzhou 311300China

We explore the nonlinear gain coupled Schrödinger system through the utilization of the variables separation method and ansatz *** employing these approaches,we generate hierarchies of explicit dissipative vector vortices(DVVs)that possess diverse vorticity *** fundamental characteristics of the DVVs are examined,encompassing amplitude profiles,energy fluxes,parameter effects,as well as linear and dynamic stability.

关键词： vector optical vortices dissipative nonlinear gain

High percentage of bone marrow CD8^(+)tissue-resident-like memory T cells predicts inferior survival in patients with acute myeloid leukemia

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Blood Science 2024年第3期6卷 23-32页

作者： Letong Cai Wenpu lai Danlin Yao Yinfeng Gu Chaofeng Liang Lian Liu jing lai Zhi Yu Xianfeng Zha Xibao Yu Xiuli Wu Shaohua Chen Oscar Junhong Luo Yangqiu Li Chunyan Wang Pengfei Qin Xin Huang Ling Xu Key Laboratory for Regenerative Medicine of Ministry of Education Institute of HematologySchool of MedicineDepartment of HematologyThe First Affiliated Hospital Jinan UniversityGuangzhou 510632China b Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China Department of Clinical Laboratory First Affiliated HospitalJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China Department of Hematology First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Hematology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina

Tissue-resident memory T(TRM)cells infiltrating solid tumors could influence tumor progression and the response to immune ***,the proportion and prognostic value of TRM cells in the bone marrow(BM)of patients with acute myeloid leukemia(AML)are *** this study,we used flow cytometry to assay the phenotype of 49 BM samples from patients newly diagnosed with AML(ND-AML).We found that the BM CD8^(+)effector memory(TEM)cells highly expressed CD69(CD8^(+)TRM-like T cells),and their percentage was significantly increased in patients with ND-AML compared with that in healthy individuals(HI).The high percentage of CD8^(+)TRM-like subset was associated with poor overall survival in our ND-AML *** Kaplan–Meier Plotter database verified a significantly reduced survival rate among patients with high expression of CD8^(+)TRM-like T cell characteristic genes(CD8A,CD69,and TOX),especially the M4 and M5 *** analysis revealed that the BM CD8^(+)TRM-like subpopulation exhibited exhausted T cell characteristics,but its high expression of CD27 and CD28 and low expression of CD57 suggested its high proliferative *** single-cell proteogenomic dataset confirmed the existence of TRM-like CD8^(+)T cells in the BM of patients with AML and verified the high expression of immune checkpoints and costimulatory *** conclusion,we found that the accumulation of BM CD8^(+)TRM-like cells could be an immune-related survival prediction marker for patients with AML.

关键词： Acute myeloid leukemia Bone marrow CD69 Tissue-resident-like memory T cells

Synergistic rare-earth yttrium single atoms and copper phosphide nanoparticles for high-selectivity ammonia electrosynthesis

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Rare Metals 2024年第11期 5792-5801页

作者： Yi-Meng Cai Yang-Hua Li Yi Xiao Quentin Meyer Qian Sun Wan-jing lai Shu-Wen Zhao Jun Li Lin-Jie Zhang Han Wang Zhang Lin Jun Luo Li-Li Han School of Materials Science and Engineering Institute for New Energy Materials and Low-Carbon TechnologiesTianjin University of Technology State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences School of Chemistry The University of New South Wales School of Metallurgy and Environment Central South University Chinese National Engineering Research Center for Control & Treatment of Heavy Metal Pollution ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of China

Electrochemical nitrate reduction to NH3holds a great promise for N-upcycling in nature,while its sluggish reaction kinetics involved in both the stepwise deoxygenation and hydrogenation processes necessitates the development of bespoke catalysts with multi-site ***,we report a hybrid catalyst composed of rare-earth（RE） yttrium（Y） single atoms and copper phosphide（Cu3P） nanoparticles loaded on N,P-doped carbon(YSA-Cu3P/CNP) through a chelating and pyrolysis *** to a synergistic contribution of Y single atoms and Cu3P nanoparticles,YSA-Cu3P/CNP achieves an impressive NH3Faradaic efficiency（FE） of 92% at-0.5V（***） and the highest NH3yield rate of11.4 mg·h-1·cm-2at-0.6 V（***） in an alkaline media,which surpass most of the reported *** intricate reaction pathway has been explored by online differential electrochemical mass spectrometry（DEMS）,and the synergistic effect between Y single atoms and Cu3P nanoparticles has been studied by in situ synchrotron X-ray absorption ***,density-functional theory（DFT） calculations unveil that the high-efficiency nitrate reduction on YSA-Cu3P/CNP is attributed to a reduced energy barrier of the rate-determining deoxygenation step coupled with the enhanced stabilization of active hydrogen favorable for the hydrogenation steps,thereby boosting the overall reaction *** addition,a prototype Zn-nitrate battery utilizing YSA-Cu3P/CNP as the cathode is *** work not only elucidates the mechanism behind the enhanced catalytic performance but also paves the way for the future development of highefficiency electrocatalysts through dual-site engineering.

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基于YOLOv5的轻量级雾天目标检测方法

计算机工程与应用 2024年第6期60卷 78-88页

作者：赖镜安陈紫强孙宗威裴庆祺桂林电子科技大学信息与通信学院广西桂林541000 西安电子科技大学通信工程学院西安710126

针对雾天场景下目标检测算法精度较低、模型复杂度较高,提出一种基于YOLOv5的轻量级雾天目标检测方法。采用感受野注意力模块(RFAblock)通过交互感受野特征信息,对感受野添加注意力机制,提高特征提取能力;采用轻量化网络Slimneck作为颈... 详细信息

针对雾天场景下目标检测算法精度较低、模型复杂度较高,提出一种基于YOLOv5的轻量级雾天目标检测方法。采用感受野注意力模块(RFAblock)通过交互感受野特征信息,对感受野添加注意力机制,提高特征提取能力;采用轻量化网络Slimneck作为颈部结构,在保持精度的同时降低模型参数和复杂度;在损失函数中引入真实框与预测框之间的角度向量,提高训练速度和推理的准确性;采用PNMS(precise non-maximum suppression)改进候选框选择机制,降低车辆遮挡情况下的漏检率。在真实雾天数据集RTTS和合成雾天数据集Foggy Cityscapes上进行测试,实验结果表明,与YOLOv5l相比mAP50分别提高了4.9和3.5个百分点,模型参数量仅为YOLOv5l的54.6%。

关键词：目标检测深度学习雾天场景轻量化注意力机制

伏美替尼联合特瑞普利单抗治疗EGFR基因突变阳性晚期非小细胞肺癌的临床研究

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国际医药卫生导报 2024年第20期30卷 3387-3392页

作者：李超来静杨俊安康市中心医院呼吸与危重症医学科安康725000

目的探讨伏美替尼联合特瑞普利单抗治疗表皮生长因子受体(EGFR)基因突变阳性晚期非小细胞肺癌(NSCLC)的疗效及安全性。方法本研究为随机对照试验。选取2019年2月至2021年2月安康市中心医院收治的164例EGFR基因突变阳性晚期NSCLC为研究... 详细信息

目的探讨伏美替尼联合特瑞普利单抗治疗表皮生长因子受体(EGFR)基因突变阳性晚期非小细胞肺癌(NSCLC)的疗效及安全性。方法本研究为随机对照试验。选取2019年2月至2021年2月安康市中心医院收治的164例EGFR基因突变阳性晚期NSCLC为研究对象。采用随机数字表法将其分为试验组和对照组,每组82例。试验组男45例,女37例;年龄(63.28±6.75)岁。对照组男45例,女37例;年龄(65.02±7.19)岁。基础治疗:静脉滴注培美曲塞500 mg·m^(-2),间隔21 d治疗1次,21 d为1个治疗周期。对照组口服甲磺酸伏美替尼片40 mg·次-1,2次·d-1。试验组在对照组基础上,静脉滴注特瑞普利单抗注射液3 mg·kg^(-1),间隔21 d治疗1次,21 d为1个治疗周期。治疗3个周期后,比较两组的疗效、不良反应、细胞角质蛋白19片段抗原21-1(CYFRA21-1)、糖类抗原-199(CA-199)、CD4^(+)、CD4^(+)/CD8^(+)。随访2年比较两组的生存预后。采用χ^(2)检验、t检验。结果治疗期间试验组失访5例,收集试验数据77例;对照组失访8例,收集试验数据74例。治疗3个周期后,试验组和对照组的CYFRA21-1分别为(5.18±1.62)μg·L^(-1)和(7.03±1.89)μg·L^(-1),CA-199分别为(36.71±6.93)U·ml^(-1)和(49.46±8.02)U·ml^(-1),CD4^(+)分别为(39.06±5.32)%和(31.92±4.15)%,CD4^(+)/CD8^(+)分别为(1.48±0.53)和(1.05±0.48),两组比较差异均有统计学意义(t=6.467、10.465、9.171、5.219,均P<0.05)。试验组和对照组的疾病控制率分别为88.31%(68/77)、75.68%(56/74),两组比较差异有统计学意义(χ^(2)=4.103,P=0.043)。截至随访结束,试验组死亡30例,中位无进展生存期(PFS)19个月,未达到中位总生存期(OS);对照组死亡35例,中位PFS 15个月,未达到中位OS;两组PFS比较,差异有统计学意义(Log-rankχ^(2)=2.608,P=0.031)。结论伏美替尼联合特瑞普利单抗治疗EGFR基因突变阳性晚期NSCLC,能够提高疾病控制率,降低肿瘤标志物CYFRA21-1、CA-199水平,延长PFS,未明显增加药物不良反应发生率,安全性良好。

关键词：非小细胞肺癌晚期表皮生长因子受体-酪氨酸激酶抑制剂伏美替尼特瑞普利单抗

异基因造血干细胞移植后患者口腔及肠道菌群与早期胃肠道急性移植物抗宿主病的关系

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陆军军医大学学报 2024年第4期46卷 331-339页

作者：赖静傅鑫李成龙杨曦周杨黄晓兵四川省医学科学院·四川省人民医院(电子科技大学医学院)血液内科成都610072 浙江省立同德医院检验科杭州310012

目的初步探讨异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation, allo-HSCT)患者肠道菌群及口腔菌群的变化与早期胃肠道急性移植物抗宿主病(acute graft versus host disease, aGVHD)之间的关联,寻找可能有... 详细信息

目的初步探讨异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation, allo-HSCT)患者肠道菌群及口腔菌群的变化与早期胃肠道急性移植物抗宿主病(acute graft versus host disease, aGVHD)之间的关联,寻找可能有效的生物学标志物。方法选取2021年9月至2023年6月在四川省人民医院血液内科接受allo-HSCT后1个月内发生胃肠道aGVHD的10例急性白血病患者,收集其aGVHD前后粪便样本与唾液样本,采用16S rRNA测序分析方法,研究早期胃肠道aGVHD发生前后肠道菌群、口腔菌群的差异性改变。结果 (1)肠道菌群中拟杆菌属减少、肠球菌属及肠杆菌科增加与早期上消化道aGVHD发生呈正相关(P0.05)。(2)胃肠道aGVHD前后肠道菌群LEfSe分析发现克雷伯杆菌属、肠球菌属增加,大肠埃希菌减少;口腔菌群LEfSe分析发现存在差异显著10个微生物标志物,其中γ-变形菌纲的差异较为显著。(3)肠道菌群β多样性差异显著(P=0.03),而口腔菌群α、β多样性无显著差异。结论 Allo-HSCT患者发生早期胃肠道aGVHD前后肠道菌群存在显著差异,可能与口腔菌群变化有关。

关键词：异基因造血干细胞移植急性移植物抗宿主病肠道菌群口腔菌群

Effects of PEG Molecular Weight on Its Interaction with Albumin

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Chinese Journal of Polymer Science 2015年第10期33卷 1373-1379页

作者： jing-jing lai Huai-yu Yan Yan Liu 黄延宾 Key Laboratory of Advanced Materials(MOE) Department of Chemical Engineering Tsinghua University

The fluorescence property of bovine serum albumin was investigated in the presence of PEGs of different molecular weights. Based on our results, we propose that PEGs of different molecular weights bind to albumin in the pH 7.4 aqueous solution, but only when the polymer size is larger than the protein size, one polymer chain may bind to multiple proteins and cause the proteins to aggregate.

关键词： Polyethylene glycol Bovine serum albumin Protein-polymer interactions Fluorescence analysis

国土空间规划背景下湿地生态保护现状及生态修复模式研究

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环境科学与管理 2024年第10期49卷 164-168页

作者：吴书娟来晶陕西地矿区研院有限公司陕西咸阳712000 咸阳市规划设计研究院陕西咸阳712000

由于湿地的生态效益与环境调节服务功能巨大,是城市绿色可持续发展的重要支持。为此,提出国土空间规划背景下湿地生态保护现状及生态修复模式研究。首先,根据所选研究区域内湿地生态保护现状的分析结果,从生态敏感性切入,规划目标地区... 详细信息

由于湿地的生态效益与环境调节服务功能巨大,是城市绿色可持续发展的重要支持。为此,提出国土空间规划背景下湿地生态保护现状及生态修复模式研究。首先,根据所选研究区域内湿地生态保护现状的分析结果,从生态敏感性切入,规划目标地区的湿地生态空间。其次,基于不同空间的生态敏感度,从自然与人工两方面设计湿地生态修复模式,并提出因地制宜策略。最后,经土地盐碱度、大气温度等生态评估指标与生态环境质量等级的对比验证,所提模式能够有效改善湿地生态系统结构,加强系统服务功能,提高生态环境水平,保证湿地的可持续发展。

关键词：国土空间规划层次分析法湿地生态保护现状生态敏感性湿地生态修复模式

Defocus Hyperspectral Image Deblurring with Adaptive Reference Image and Scale Map

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Journal of Computer Science & Technology 2019年第3期34卷 569-580页

作者： De-Wang Li Lin-jing lai Hua Huang School of Computer Science and Technology Beijing Institute of TechnologyBeijing 100081China

Defocus blur is one of the primary problems among hyperspectral imaging systems equipped with simple lenses. Most of the previous deblurring methods focus on how to utilize structure information of a single channel, while ignoring the characteristics of hyperspectral images. In this work, we analyze the correlations and differences among spectral channels, and propose a deblurring framework for defocus hyperspectral images. First, we divide the hyperspectral image channels into two sets, and the set with less blur is treated as a group of spectral bases. Then, according to the inherent correlations of spectral channels, a reference image can be derived from the spectral bases to guide the restoration of blurry channels. Finally, considering the disagreement between the reference image and the ground truth, a scale map based on gradient similarity is introduced as a prior in the deblurring framework. The experimental results on public dataset demonstrate that the proposed method outperforms several image deblurring methods in both visual effect and quality metrics.

关键词： hyperspectral image defocus blur deblurring reference image scale map