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互通式立体交叉与土地综合开发融合方案研究

公路 2024年第7期69卷 252-255页

作者：李锋利唐登科中交第二公路勘察设计研究院有限公司武汉市430056

广深高速沿线互通密集,大部分互通占地面积大,深挖潜力巨大。以道滘互通为例,通过方案研究,实施交通优化、改善提升出行条件、提高土地使用效率,实现集约节约用地和综合开发。

关键词：高速公路改扩建项目互通立交土地释放综合开发

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

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Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue li Yang DI Lei CHENG Ranran liU lijuan li Hongmei li Yi TANG Zhangrui YAN Yongming LU Tao FU Rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ22,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***22’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 *** interaction disrupted the MDM2-p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***,LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ22 administration in tumor-bearing mice did not manifest notable side *** findings position LZ22 as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ22 Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

重庆市输入性卵形疟原虫curtisi和wallikeri亚种分子特征分析

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中国人兽共患病学报 2024年第9期40卷 814-822页

作者：谭妍罗飞李志峰向尧许静茹蔡娇娇李迎丽重庆医科大学公共卫生学院重庆市高致病性微生物重点实验室重庆市疾病预防控制中心

目的为了解重庆市输入性卵形疟原虫curtisi和wallikeri亚种的分子特征，对卵形疟病例的卵形疟原虫Cox1、Cytb、Tra、Dhfr、K13基因位点多态性进行分析。方法回顾性分析2013-2023年确诊的卵形疟原虫感染患者血样，PCR扩增卵形疟原虫Cox... 详细信息

目的为了解重庆市输入性卵形疟原虫curtisi和wallikeri亚种的分子特征，对卵形疟病例的卵形疟原虫Cox1、Cytb、Tra、Dhfr、K13基因位点多态性进行分析。方法回顾性分析2013-2023年确诊的卵形疟原虫感染患者血样，PCR扩增卵形疟原虫Cox1、Cytb、Tra、Dhfr、K13基因的部分片段，利用测序技术及生物信息学方法区分2个亚种，分析卵形疟curtisi和wallikeri亚种核苷酸多态性位点以及氨基酸突变位点等多态性。结果以ssrRNA区分26例卵形疟(curtisi亚种14例；wallikeri亚种12例)与Cox1、Cytb、Tra基因分类结果一致。Cox1基因在145、153等13个位点呈现二态性，仅在528、862位点氨基酸M176I、I288V变异，单例N337H变异。Cytb基因亚种间发现12个位点发生碱基置换，仅248号氨基酸M248I突变。Tra基因发现49个核苷酸二态性位点，致18个氨基酸突变，curtisi型样本中poc1型比poc2型多PINTINPINTIN和TITPIS氨基酸单元。Dhfr基因突变率较高，25%样本出现S58R突变。K13基因亚种内不呈单态，1例样本为杂合。结论确认了重庆市输入性卵形疟在Cox1、Cytb、Tra、Dhfr、K13基因片段中curtisi和wallikeri亚种间的二态性位点、突变位点，丰富了输入性卵形疟原虫两个亚种基因多态性信息。

关键词：输入性卵形疟 curtisi亚种 wallikeri亚种 Cox1 Cytb Tra Dhfr K13

Electron delocalization-enhanced sulfur reduction kinetics on an MXene-derived heterostructured electrocatalyst

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Nano Research 2024年第8期17卷 7153-7162页

作者： Yunmeng li Yinze Zuo Xiang li Yongzheng Zhang Cheng Ma Xiaomin Cheng Jian Wang Jitong Wang Hongzhen lin licheng ling State Key Laboratory of Chemical Engineering Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education)East China University of Science and TechnologyShanghai 200237China Institute of New Energy Materials and Engineering College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education) School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China i-Lab&CAS Key Laboratory of Nanophotonic Materials and Device Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China Helmholtz Institute Ulm(HIU) D89081 UlmGermany

lithium-sulfur(li-S)batteries mainly rely on the reversible electrochemical reaction of between lithium ions(li^(+))and sulfur species to achieve energy storage and conversion,therefore,increasing the number of free li^(+)and improving the li^(+)diffusion kinetics will effectively enhance the cell ***,Mo-based MXene heterostructure(MoS_(2)@Mo_(2)C)was developed by partial vulcanization of Mo_(2)C MXene,in which the introduction of similar valence S into Mo-based MXene(Mo_(2)C)can create an electron delocalization *** theoretical simulations and electrochemical characterisation,it is demonstrated that the MoS_(2)@Mo_(2)C heterojunction can effectively promote ion desolvation,increase the amount of free li^(+),and accelerate li^(+)transport for more efficient polysulfide *** addition,the MoS_(2)@Mo_(2)C material is also capable of accelerating the oxidation and reduction of polysulfides through its sufficient defects and vacancies to further enhance the catalytic ***,the li-S battery with the designed MoS_(2)@Mo_(2)C electrocatalyst performed for 500 cycles at 1 C and still maintained the ideal capacity(664.7 mAh·g^(−1)),and excellent rate performance(567.6 mAh·g^(−1)at 5 C).Under the extreme conditions of high loading,the cell maintained an excellent capacity of 775.6 mAh·g^(−1)after 100 *** also retained 838.4 mAh·g^(−1)for 70 cycles at a low temperature of 0℃,and demonstrated a low decay rate(0.063%).These results indicate that the delocalized electrons effectively accelerate the catalytic conversion of lithium polysulfide,which is more practical for enhancing the behaviour of li-S batteries.

关键词： delocalized electron lithium sulfur batteries MXene-based heterostructures catalytic desolvation multi-catalytic sites

外部力量何以“激活”乡村治理共同体的内生动力——基于E市K村志愿服务的案例考察

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中央民族大学学报（哲学社会科学版） 2024年第4期51卷 100-113页

作者：潘博王立峰华中科技大学马克思主义学院湖北武汉430074 吉林大学行政学院吉林长春130012

外部力量进入村落场域中,何以“激活”乡村治理共同体的内生动力?基于“网络-角色”分析视角的个案研究发现,在外部力量介入后,可以通过前期准备、融入村庄、聚合主体和长效发展四个阶段,形成“志愿者-支持者”的庞大队伍,以此不断促进... 详细信息

外部力量进入村落场域中,何以“激活”乡村治理共同体的内生动力?基于“网络-角色”分析视角的个案研究发现,在外部力量介入后,可以通过前期准备、融入村庄、聚合主体和长效发展四个阶段,形成“志愿者-支持者”的庞大队伍,以此不断促进村民身份认知转换,为乡村治理共同体提供内生动力。研究提炼阐释了在乡村治理共同体“激活”过程中所依循“外部力量作用-行动者网络发展-角色认知转换-内生动力增强”的内在逻辑,明确推动行动者网络框架下村民的角色认知从“原子化个体”向“共同体成员”转换,是“激活”乡村治理共同体内生动力的关键。这有助于破解乡村治理所普遍存在的“外部力量两难”困境,并为更好地在治理共同体中发挥“民心政治”的作用优势提供了可行路径。

关键词：乡村治理共同体网络-角色内生动力激活

Preparation and Performance of Organically Modified Montmorillonite Composite Separation Membrane

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1100-1107页

作者： liU Peng BI Yuanyuan CHEN Shaowei WAN Ye YU Yunwu FANG Yanfeng GU Yaxin li Feihong TANG Ning li Xiangyu School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new composite separation membrane was developed by using organically modified montmorillonite(OMMT)as an *** effects of OMMT on the modification and properties of PVDF composite membranes were *** is found that different kinds and amounts of OMMT into the casting solution can obviously change the pure water flux,separation performance and hydrophilicity of composite membrane in varying *** the TA/PDA-MMT was 0.5 wt%,the pure water flux of the membrane reached the maximum,which was 584.7 L/(m^(2)·h),about 6 times that of the original *** OMMT/PVDF composite membrane had good hydrophilicity and stability in the treatment of oily *** development of novel OMMT/PVDF composite membrane will provide a new idea for solving the problem of oily wastewater treatment.

关键词： membrane montmorillonite composite wastewater

Phase reconfiguration of heterogeneous CoFeS/CoNiS nanoparticles for superior battery-type supercapacitors

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Journal of Energy Chemistry 2024年第9期96卷 217-225页

作者： lina Ma Fan li Min Zhou Jidong Dong Hao Luo Wei Zhang Wenchao Zhao Xinliang li Zaixing Jiang Yudong Huang College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071ShandongChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037JiangusChina Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Material Science and Engineering College Northeast Forestry UniversityHarbin 150040HeilongjiangChina

Developing advanced battery-type materials with abundant active sites,high conductivity,versatile morphologies,and hierarchically porous structures is crucial for realizing high-quality hybrid ***,heterogeneous FeS@NiS is synthesized by cationic Co doping via surface-structure *** density functional theory(DFT)theoretical calculations are firstly performed to predict the advantages of Co dopant by improving the OH^(−)adsorption properties and adjusting electronic structure,benefiting ions/electron *** dynamic surface evolution is further explored which demonstrates that CoFeS@CoNiS could be quickly reconstructed to Ni(Co)Fe_(2)O_(4)during the charging process,while the unstable structure of the amorphous Ni(Co)Fe_(2)O_(4)results in partial conversion to Ni/Co/FeOOH at high potentials,which contributes to the more reactive active site and good structural ***,the free-standing electrode reveals excellent electrochemical performance with a superior capacity(335.6 mA h g^(−1),2684 F g^(−1))at 3 A g^(−1).Furthermore,the as-fabricated device shows a quality energy density of 78.1 W h kg^(−1)at a power density of 750 W kg^(−1)and excellent cycle life of 92.1%capacitance retention after 5000 *** work offers a facile strategy to construct versatile morphological structures using electrochemical activation and holds promising applications in energy-related fields.

关键词： In-situ reconfiguration Heterogeneous design Battery-type supercapacitors Superior performance Sulphide

Enhancing hydrogen sorption in MgH_(2) by controlling particle size and contact of Ni catalysts

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Rare Metals 2021年第4期40卷 995-1002页

作者： Ting-Zhi Si Xue-Yang Zhang jing-jing feng Xiao-li Ding Yong-Tao li School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China

A comparative study based on MgH2 ball-milled with altered Ni particle sizes under different conditions was conducted to reveal the effect of close contact between hydrides and metal catalysts on their hydrogen sorption *** is found that the Mg+nano-Ni(5 at%)composites not only exhibit a substantial decreased onset desorption temperature by approximately 180℃ but also dramatically enhance the absorption kinetics by sixteen times in comparison with those of pure MgH_(2).This remarkable kinetics enhancement can be explained by the superior catalytic effect of Ni present in composites that highly depends on its particle size and its close contact with MgH2.

关键词： Hydrogen storage Magnesium hydride Nickel Sorption properties Catalytic effect

Spatiotemporal mapping of(ultra‐)mafic magmatic mine areas:Implications of economic and political realities in China

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Deep Underground Science and Engineering 2024年第1期3卷 91-102页

作者： Heling li liang Tang Tim T.Werner Zhengmeng Hou Fan Meng jingjing li College of Earth Sciences Chengdu University of TechnologyChengduChina Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal ZellerfeldGermany School of Geography Earth and Atmospheric SciencesFaculty of ScienceThe University of MelbourneMelbourneVictoriaAustralia

The spatiotemporal extension/expansion of mine areas is affected by multiple *** far,very little has been done to examine the interaction between mine areas and political or economic ***(ultra‐)mafic magmatic mines in China played a specific role in supporting national development and providing an ideal research subject for monitoring their *** this study,remote sensing and mining‐related GIS data were used to identify and analyze 1233(ultra‐)mafic magmatic mine area polygons in China,which covered approximately 322.96 km2 of land and included a V–Ti–Fe mine,a copper–nickel mine,a chromite mine,an asbestos mine,and a diamond *** was found that(1)the areal expansion of mines is significantly related to the mine types,perimeter,topography,and population density.(2)The mine area variation also reflects market and policy *** temporal expansion of the mine area from 2010 to 2020 followed an S‐shaped pattern(with the turning point occurring in 2014),closely related to iron overcapacity and tightened mining policies.(3)The complexity(D)of the mine area may reflect mine design and excavation *** be specific,lower D indicates early‐stage or artisanal/small‐scale mining,whereas higher D represents large‐scale *** study demonstrates that the detailed mapping of mine land can serve as an indicator to implement miningrelated market and policy ***(ultra‐)mafic mines area data set can be accessed at https://***/record/7636616#.Y-p0uXaZOa0.

关键词： complexity mine area mining and socioeconomic interaction spatiotemporal distribution (ultra‐)mafic magmatic mine