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悬停旋翼地面效应研究

飞行力学 1988年第3期 20-26页

作者：高正戴世增杨金川南京航空学院南京航空学院

本文给出了确定悬停旋翼在地面效应中的诱速分布和升力增益的一种计算方法,并经实验验证.与前人的结论不同,本研究证明地面效应随参数（CT）1/2/σ（而不是 CT/σ）的增大而减小.同时,对于流行的关于地效的物理解释,本文指出了其力学概... 详细信息

本文给出了确定悬停旋翼在地面效应中的诱速分布和升力增益的一种计算方法,并经实验验证.与前人的结论不同,本研究证明地面效应随参数（CT）1/2/σ（而不是 CT/σ）的增大而减小.同时,对于流行的关于地效的物理解释,本文指出了其力学概念上的错误并予以纠正.

关键词：地面效应旋翼诱导速度环量物理解释地效桨叶诱导阻力力学概念迎角

儿童肝移植术后药物代谢差异相关mRNA及lncRNA的高通量测序分析

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中华器官移植杂志 2019年第4期40卷 219-225页

作者：秦天顾向前郑建新刘金川唐元家薛峰夏强上海交通大学医学院附属仁济医院肝脏外科 200127

目的用高通量二代测序(nextgenerationsequencing, NGS)分析儿童肝移植供肝标本的长链非编码RNA(lncRNAs)及mRNA的表达情况,寻找差异表达的lncRNA以及药物代谢基因mRNA,为儿童肝移植免疫抑制剂个体化指导提供依据。方法收集2016年10月至... 详细信息

目的用高通量二代测序(nextgenerationsequencing, NGS)分析儿童肝移植供肝标本的长链非编码RNA(lncRNAs)及mRNA的表达情况,寻找差异表达的lncRNA以及药物代谢基因mRNA,为儿童肝移植免疫抑制剂个体化指导提供依据。方法收集2016年10月至2017年12月亲属活体肝移植的供肝组织标本10例,根据术后药物代谢情况分为快代谢和慢代谢两组(各5例),进行mRNA和lncRNA高通量测序。对差异基因进行功能通路分析,并通过靶基因预测筛选关键基因。结果慢代谢组与快代谢组中有908个mRNA和1 228个lncRNA的表达差异有统计学意义(P<0.05),其中表达丰度高且差异显著的药物代谢相关mRNA有40个,22个上调,18个下调;lncRNA 有37个,13个上调,24个下调。除经典药物代谢相关基因CYP3A5之外,我们还发现CYP2C19、CYP1A2、UGT1A1可能对他克莫司的代谢产生影响作用。同时lncRNA中NONH-SAT108 617. 2可能靶向调节CYP3A5基因的表达。结论本研究全面分析了儿童亲属活体肝移植供肝标本中lncRNA及mRNA的表达特征,其中一些差异的药物代谢相关基因可能共同作用影响他克莫司体内代谢,进而对术后免疫抑制剂用药产生影响。

关键词：肝移植长链非编码RNA 药物代谢

Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers

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Biomedical and Environmental Sciences 2015年第9期28卷 679-682页

作者： WU Shan BAI Ya Na PU Hong Quan HE Jie zheng Tong Zhang LI Hai Yan DAI Min CHENG Ning Institute of Epidemiology and Statistics Center for Cancer Prevention and Treatment School of Public HealthLanzhou University Workers’ Hospital of jinchuan Company Jinchuan Group Co. Ltd. Cancer Institute and Hospital Chinese Academy of Medical Sciences School of Public Health Brown University College of Basic Medicine Lanzhou University

Our study explored the dynamic changes in andthe relationship between the DNA damage marker8-hydroxy-2＇-deoxyguanosine （8-OHdG） and theDNA repair marker 8-hydroxyguanine DNAglycosidase 1 （hOGG1） according to the length ofoccupational employment in nickel smeltingworkers. One hundred forty nickel-exposedsmelting workers and 140 age-matched unexposedoffice workers were selected from the Jinchangcohort. The 8-OHdG levels in smelting workers wassignificantly higher than in office workers （Z=-8.688,P〈0.05） and the 8-OHdG levels among nickelsmelting workers in the 10-14 y employment lengthcategory was significantly higher than among allpeers. The hOGG1 levels among smelting workerswere significantly lower than those of non-exposedworkers （Z=-8.948, P〈0.05）. There were significantdifferences between employment length andhOGG1 levels, with subjects employed in nickelsmelting for 10-14 y showing the highest levels ofhOGG1. Correlation analysis showed positivecorrelations between 8-OHdG and hOGG1 levels（r=0.413; P〈0.01）. DNA damage was increased withemployment length among nickel smelting workersand was related to the inhibition of hOGG1 repaircapacity.

关键词： DNA Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers length

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市政道路白改黑工程施工及病害处理方案分析

江西建材 2022年第12期 324-325,329页

作者：郑武链宁德东侨城市建设发展有限公司福建宁德352100

市政道路是影响城市交通运营质量的主要因素,也是城市交通建设的主要部分。文中以宁德市区金川路改建工程为例,分析了白改黑的基本思路与原则,设计了路基轻度病害处理方案,总结了白改黑工程中的防治措施,以提高路面的使用性能。

关键词：市政道路白改黑沥青加铺层病害处理

Effects of Outdoor Temperature on Blood Pressure in a Prospective Cohort of Northwest China

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Biomedical and Environmental Sciences 2021年第2期34卷 89-100页

作者： zheng Shan WANG Min Zhen CHENG Zhi Yuan KANG Feng NIE Yong Hong MI Xiu Ying LI Hai Yan JIN Lan ZHANG Ya Wei BAI Ya Na Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 73000GansuChina Department of Epidemiology School of Public HealthBrown UniversityProvidenceRhode Island 02903USA Workers'Hospital of jinchuan Group Co. Ltd.Jinchang 737103GansuChina Jinchang Center for Disease Prevention and Control Jinchang 737100GansuChina Jinchang Meteorological Service Jinchang737100GansuChina Department of Surgery Yale School of MedicineNew Haven 06511USA Department of Environmental Health Sciences Yale School of Public HealthNew Haven 06511US

Objective The relationship between outdoor temperature and blood pressure(BP) has been inconclusive. We analyzed data from a prospective cohort study in northwestern China to investigate the effect of outdoor temperature on BP and effect modification by *** A total of 32,710 individuals who participated in both the baseline survey and the first follow-up in 2011–2015 were included in the study. A linear mixed-effect model and generalized additive mixed model(GAMM) were applied to estimate the association between outdoor temperature and BP after adjusting for confounding *** The mean differences in systolic blood pressure(SBP) and diastolic blood pressure(DBP)between summer and winter were 3.5 mm Hg and 2.75 mm Hg, respectively. After adjusting for individual characteristics, meteorological factors and air pollutants, a significant increase in SBP and DBP was observed for lag 06 day and lag 04 day, a 0.28 mm Hg(95% CI: 0.27–0.30) per 1 °C decrease in average temperature for SBP and a 0.16 mm Hg(95% CI: 0.15–0.17) per 1 °C decrease in average temperature for DBP, respectively. The effects of the average temperature on both SBP and DBP were stronger in summer than in other seasons. The effects of the average temperature on BP were also greater if individuals were older, male, overweight or obese, a smoker or drinker, or had cardiovascular diseases(CVDs), hypertension, and *** This study demonstrated a significant negative association between outdoor temperature and BP in a high-altitude environment of northwest China. Moreover, BP showed a significant seasonal variation. The association between BP and temperature differed by season and individuals' demographic characteristics(age, gender, BMI), unhealthy behaviors(smoking and alcohol consumption), and chronic disease status(CVDs, hypertension, and diabetes).

关键词： Outdoor temperature Season Blood pressure Jinchang cohort

不同浇注工艺对真空感应熔炼铸棒冶金质量的影响研究

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金川科技 2024年第1期 47-50页

作者：陈韩锋张东王江王雪连周文政镍钻共伴生资源开发及综合利用全国重点实验室金川镍钻研究设计院

本文以VIM工艺制备的K418合金为试验原料,研究了氩气保护浇注和真空浇注不同条件下铸棒在表面质量、化学成分、中心缩孔、微观组织等方面的差异。研究结果表明:真空浇注条件下,铸棒表面质量、中心缩孔明显好于氩气保护浇注条件;真空浇... 详细信息

本文以VIM工艺制备的K418合金为试验原料,研究了氩气保护浇注和真空浇注不同条件下铸棒在表面质量、化学成分、中心缩孔、微观组织等方面的差异。研究结果表明:真空浇注条件下,铸棒表面质量、中心缩孔明显好于氩气保护浇注条件;真空浇注与氩气保护浇注条件下产品化学成分无明显差异;真空浇注条件下产品中析出相的数量、尺寸以及分布明显好于氩气保护浇注条件。

关键词： K418合金氩气保护浇注真空浇注

黔北正安区块牛栏组基于叠后地震属性的多尺度裂缝预测

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特种油气藏 2020年第5期27卷 81-87页

作者：蓝宝锋黄艺张福李刚权刘婷张金川贵州页岩气勘探开发有限责任公司贵州贵阳550008 贵州省土地矿产资源储备局贵州贵阳550008 贵州乌江能源集团有限责任公司贵州贵阳550008 中国地质大学(北京) 北京100083

黔北正安地区安场向斜石牛栏组为一套深水陆棚沉积的泥灰岩地层,前期钻探显示,石牛栏组气藏分布与裂缝发育程度密切相关,为典型的裂缝型气藏。为进一步对安场向斜石牛栏组储层的裂缝平面展布规律进行研究,该文通过岩心、成像测井等资料... 详细信息

黔北正安地区安场向斜石牛栏组为一套深水陆棚沉积的泥灰岩地层,前期钻探显示,石牛栏组气藏分布与裂缝发育程度密切相关,为典型的裂缝型气藏。为进一步对安场向斜石牛栏组储层的裂缝平面展布规律进行研究,该文通过岩心、成像测井等资料分析目的层的裂缝发育特征,优选裂缝预测敏感地震属性,基于地震像素处理的裂缝增强属性对石牛栏组裂缝分布进行了预测。研究结果表明:利用常规的地震曲率属性预测裂缝识别能力有限,而基于地震像素处理的地震数据能够有效改善小断层及构造形变特征成像,在此基础上开展的裂缝增强属性可大大提高裂缝的识别能力,经实钻井验证,基于叠后地震属性裂缝分布预测方法的结果与钻井泥浆漏失点综合吻合率达83.3%以上,预测结果较为可靠,该研究为石牛栏组区带优选及钻井风险预警提供了技术支撑。

关键词：泥灰岩地震优化裂缝气藏增强属性正安地区石牛栏组

The Combined Effect of Dyslipidemia on the Incidence of Type 2 Diabetes:A Prospective Cohort Study in Northwest of China

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Biomedical and Environmental Sciences 2021年第10期34卷 814-818页

作者： WANG Min Zhen DAI Tian zheng Shan YU Cheng XIA Miao YANG Hong Yan ZHANG De Sheng YIN Chun JIN Ya Fei CHENG Ning BAI Ya Na Department of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 730000GansuChina Workers'Hospital of jinchuan Group Co. Ltd.Jinchang 737100GansuChina Centre of Medical Laboratory School of Basic Medical ScienceLanzhou UniversityLanzhou 730000GansuChina

Type 2 diabetes mellitus(T2DM)is a major noncommunicable chronic disease in the population and is a major threat to global public *** to the International Diabetes Federation[1],there were at least 463 million patients with diabetes between the ages of 20 and 79 in 2019,and this number will rise to 700 million by *** is the most important factor that influences *** present,cross-sectional studies are mainly used to determine the correlation between single lipid index,lipid ratio,and T2DM and its complications[2].Few studies have focused on dyslipidemia and its aggregation patterns in relation to T2DM.

关键词： T2DM Diabetes Dyslipidemia

A Retrospective Cohort Mortality Study in Jinchang,the Largest Nickel Production Enterprise in China

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Biomedical and Environmental Sciences 2014年第7期27卷 567-571页

作者： MA Li BAI Ya Na PU Hong Quan HE Jie Bryan A.Bassig DAI Min ZHANG Ya Wei zheng Tong Zhang CHENG Ning Center for Cancer prevent and treatment School of Public Health of Lanzhou University Workers'Hospital of jinchuan Company Jinchuan Group CO.LTD Cancer Institute and Hospital Chinese Academy of Medical Sciences School of Public Health Yale University College of Basic Medicine Lanzhou University

Nickel is an essential trace metal used in the occupational setting, resulting in both occupational and nonoccupational exposures to individuals at varying levels. Exposure to nickel has been associated with several toxicities and the International Agency for Research on Cancer has concluded that there is sufficient evidence in humans associating exposure to nickel compounds with risk of lung cancer and sinonasal cancer. This study confirmed a significant excess of mortality from diseases of the lung including silicosis, lung cancer, and cor pulmonale among workers involved in nickel mining or smelting in China.

关键词： SMR A Retrospective Cohort Mortality Study in Jinchang,the Largest Nickel Production Enterprise in China