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Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat

Science China Life Sciences 2024年第10期67卷 2251-2266页

作者： Xuemei Liu Min Deng Bingxin Shi Kehui Zhu jinchao chen Shujuan Xu Xiaomin Bie Xiansheng Zhang Xuelei Lin Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of Sciences University of Chinese Academy of Sciences Institute of Science and Technology Austria (ISTA) National Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural University Centre of Excellence for Plant and Microbial Science (CEPAMS) JIC-CAS

Winter plants rely on vernalization, a crucial process for adapting to cold conditions and ensuring successful reproduction. However,understanding the role of histone modifications in guiding the vernalization process in winter wheat remains limited. In this study, we investigated the transcriptome and chromatin dynamics in the shoot apex throughout the life cycle of winter wheat in the field. Two core histone modifications, H3K27me3 and H3K36me3, exhibited opposite patterns on the key vernalization gene VERNALIZATION1(VRN1),correlating with its induction during cold exposure. Moreover, the H3K36me3 level remained high at VRN1 after cold exposure, which may maintain its active state. Mutations in FERTILIZATION-INDEPENDENT ENDOSPERM(TaFIE) and SET DOMAIN GROUP 8/EARLY FLOWERING IN SHORT DAYS(TaSDG8/TaEFS), components of the writer complex for H3K27me3 and H3K36me3, respectively, affected flowering time. Intriguingly, VRN1 lost its high expression after the cold exposure memory in the absence of H3K36me3. During embryo development,VRN1 was silenced with the removal of active histone modifications in both winter and spring wheat, with selective restoration of H3K27me3 in winter wheat. The mutant of Tafie-cr-87, a component of H3K27me3 “writer” complex, did not influence the silence of VRN1during embryo development, but rather attenuated the cold exposure requirement of winter wheat. Integrating gene expression with H3K27me3 and H3K36me3 patterns identified potential regulators of flowering. This study unveils distinct roles of H3K27me3 and H3K36me3 in controlling vernalization response, maintenance, and resetting in winter wheat.

关键词： vernalization H3K27me3 H3K36me3 winter wheat resetting maintenance

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±550 kV直流GIS多柱并联避雷器螺旋结构自生电感均流特性研究

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电瓷避雷器 2024年第4期 1-9页

作者：刘思远王柳丹陈金超陈奕帆西安交通大学西安710049

为解决±550 kV直流GIS避雷器多柱并联吸能时的电流分流不均难题,提出一种氧化锌电阻片螺旋排布结构的多柱并联避雷器。螺旋排布的氧化锌电阻片不仅能有效缩短避雷器长度,从而降低海上平台振动对直流GIS避雷器的应力冲击;同时螺旋结构... 详细信息

为解决±550 kV直流GIS避雷器多柱并联吸能时的电流分流不均难题,提出一种氧化锌电阻片螺旋排布结构的多柱并联避雷器。螺旋排布的氧化锌电阻片不仅能有效缩短避雷器长度,从而降低海上平台振动对直流GIS避雷器的应力冲击;同时螺旋结构电阻片自生电感可以在多柱并联吸能时降低各柱电流分布的不均匀性。本研究首先设计了±550 kV直流GIS多柱并联避雷器螺旋结构参数,并建立避雷器多物理场仿真模型,计算了氧化锌电阻片螺旋排布结构下的自生电感。进一步研究了自生电感对多柱并联避雷器吸收能量时电流分布的影响规律。研究结果表明,±550 kV直流GIS避雷器单柱芯体螺旋结构自生电感为4.6μH,可以将避雷器多柱并联吸能时各柱电流的偏差系数降低20%~65%,验证了多柱并联避雷器螺旋结构电阻片自生电感均流的有效性。

关键词：直流GIS避雷器螺旋结构并联均流多物理场仿真

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基于软探针的NFV虚拟网络时延计算方法研究

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移动信息 2024年第7期46卷 260-262页

作者：陈锦潮关伟杰贾国祖中国移动通信集团广东有限公司广州510623

随着电信传统网络向NFV虚拟化网络的转型和全面演进,虚拟化网络性能分析和优化成为网络运维的重大任务和挑战之一。鉴于ping、iperf等传统的IP网络性能检测工具以及华为公司的IP染色技术存在的缺点和问题,本文提出一种基于软探针的NFV... 详细信息

随着电信传统网络向NFV虚拟化网络的转型和全面演进,虚拟化网络性能分析和优化成为网络运维的重大任务和挑战之一。鉴于ping、iperf等传统的IP网络性能检测工具以及华为公司的IP染色技术存在的缺点和问题,本文提出一种基于软探针的NFV虚拟网络时延计算方法,通过构建两个虚拟机之间完整的端到端的IP路径,选择在4个关键节点放置软探针获取和汇总目标业务流量,通过哈希算法识别、统计流经4个关键节点的IP报文,根据各节点的计数及时间戳在沿途各节点的变化情况,计算出网络时延。

关键词： NFV 虚拟网络软探针时延计算

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Salt-Gathering and Potassium Formation of Potassium-Rich Brine during the Triassic in the Sichuan Basin, China

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Acta Geologica Sinica(English Edition) 2018年第6期92卷 2233-2250页

作者： ZHANG Bing YANG Kai WANG Xuben XU Zhengqi YANG Hongyu ZHANG Saimin chen jinchao ZHANG Mingming LIU Wei State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology Earth Exploration and Information Technology Key Laboratory of Ministry of Education Chengdu University of Technology

Potassium-rich brine in the Sichuan Basin has been much studied in recent years, but few studies have focused on the distribution and migration of salt basin and the differences of potassium formation mechanisms. This work examined the salt-gathering and potassium formation of potassiumrich brine during the Triassic in the Sichuan Basin using lithofacies palaeogeographic depiction and geochemical analyses.(1) The favorable sedimentary facies controlling the formation of potassium-rich brine during the Triassic in the Sichuan Basin are evaporation platform and restricted platform, whereas the salt basin is one of the main factors controlling the poly-salt center.(2) The distribution and migration of this salt basin were affected by certain factors. The salt basin of the Jialingjiang Formation was mainly distributed in the east and central Sichuan Basin, whereas that of the Leikoupo Formation was mainly distributed in the central and west Sichuan Basin. The sedimentary centers have gradually moved westward and become smaller.(3) Three main formation mechanisms were identified for the potassium-rich brine during the Triassic in the Sichuan Basin, i.e., evaporation and concentration of seawater, surface fresh water leaching, and deep water-rock reaction. Fresh water leaching was characterized by low anomaly δ18 O and δ13 C values. Water-rock reaction was mainly related to temperature, and high temperature environment(caused by burial depth, overthrust and deep hydrothermal fluids) was beneficial to water-rock reaction. The characteristics of water-rock reaction do not correspond to the increase ratio of K·103/Cl and Br·103/Cl in brine, and the Rb+ content of the brine was high.(4) The formation mechanisms of potassium-rich brine differed between different areas of the Sichuan Basin. In east Sichuan, the evaporation and concentration of seawater, together with meteoric fresh water leaching, was the main formation factor, whereas the evaporation and concentration of seawa

关键词： potassium-rich brine sedimentary environment formation mechanism evolution model Sichuan Basin

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The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells

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Science China(Life Sciences) 2024年第9期67卷 1867-1880页

作者： Weixiao Yan Xiaotong Wang Wenjing Wang Qi Guo Na Huang Hao chen Xing-Jie Liang Yu Han Dandan Liu jinchao Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients/Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education/College of Chemistry and Materials Science Chemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding 071002China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

Cancer stem cells(CSCs)play an important role in metastasis development,tumor recurrence,and treatment resistance,and are essential for the eradication of ***,therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape,which leads to enhanced aggressive behaviors compared with CSCs that have never been ***,the underlying mechanisms regulating the therapeutic escape remain *** this end,we established a model to isolate the therapeutic escaped CSCs(TSCSCs)from breast CSCs and performed the transcription profile to reveal the ***,we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway,resulting in TSCSCs exhibiting enhanced motility and ***,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo,which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and *** obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy.

关键词： therapeutic escape breast cancer stem cells motility p38/MAPK signaling pathway molecular mechanism

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Preparation of Sn-doped CsPbBr3 for photodegradation of antibiotics in organic solvent

Preparation of Sn-doped CsPbBr3 for photodegradation of anti...

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第八届新型太阳能材料科学与技术学术研讨会

作者： Chunxi Liu Wan Zhao Wenya Chang Xiangyu chen Weiwei Wang jinchao chen Zhi chen College of Materials and Chemistry China Jiliang University

In this study, Sn doped CsPbSnBr(CPSB) perovskite has been successfully synthesized by the anti-solvent precipitation method and applied in visible-light photodegradation of antibiotic residue in ethanol. The synthesized CsPbSnBr perovskite is well characterized by XRD, XPS, SEM, TEM, and other methods, which confirms the successfully partially isomorphous substitution of Pb with Sn. Enhanced photocatalytic efficiency is observed in the CsPbSnBr which is also closely related to the doping quantity. The active species are uncovered through capture experiments and a reaction mechanism is proposed. This work shows that Sn substitution can reduce the toxicity of Pb-based perovskite quantum dots with improved photocatalytic property for degrading tetracycline hydrochloride in organic system selectively, which reduces the toxicity of Pb-based perovskite and broadens its application.

关键词： CsPbBr3 perovskite Sn substitution Anti-solvent precipitation method Tetracycline hydrochloride disposal Photocatalytic degradation

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无铅卤化物钙钛矿可见光催化研究进展

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稀有金属 2022年第1期46卷 96-108页

作者：吴健豪赵婉陈默刘纯希陈金超陈智中国计量大学材料与化学学院浙江杭州310018

在光催化剂上以太阳光为驱动的催化反应是目前太阳能转化和利用的一个有效途径,对解决当前日益严重的环境和能源问题具有重要作用。光催化技术的核心是开发新型光催化剂材料以实现对太阳能的高效利用。卤化铅钙钛矿材料作为一种光电性... 详细信息

在光催化剂上以太阳光为驱动的催化反应是目前太阳能转化和利用的一个有效途径,对解决当前日益严重的环境和能源问题具有重要作用。光催化技术的核心是开发新型光催化剂材料以实现对太阳能的高效利用。卤化铅钙钛矿材料作为一种光电性能优异的半导体材料已经被开创性地应用于光催化领域中,但其差的环境稳定性和元素毒性限制了其未来的发展。以Sn基、Ge基、Bi基和部分过渡金属为主的无铅卤化物钙钛矿有着无毒、带隙可调等优势,有望成为替代铅基卤化物钙钛矿的候选材料。本综述在介绍无铅卤化物钙钛矿结构性质的基础上,总结了不同种类无铅卤化物钙钛矿在光催化领域的应用及性能特性与制备方法,重点阐述了其光催化性能优化策略及环境稳定性的改性方案,最后对无铅卤化物钙钛矿在光催化水解制氢、CO_(2)还原与有机污染物降解等方面的应用进行了展望,并提出了其光催化应用方面的前景与挑战。

关键词：无铅卤化物钙钛矿光催化光催化制氢光催化CO_(2)还原有机物污染物光催化降解

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4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI

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Chinese Chemical Letters 2024年第6期35卷 486-490页

作者： Hualei Xu Manman Han Haiqiang Liu Liang Qin Lulu chen Hao Hu Ran Wu chenyu Yang Hua Guo Jinrong Li Jinxiang Fu Qichen Hao Yijun Zhou jinchao Feng Xiaodong Wang Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) State Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Centre for Imaging&Systems BiologyMinzu University of ChinaBeijing 100081China

Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological *** direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)could provide a more comprehensive understanding of their essential ***,we evaluated 4-nitrocatechol(4-NC)as a novel positive-ion matrix for enhancing in situ detection and imaging of LMW compounds from the rat liver,brain,and germinating Chinese-yew seed by *** results showed that the 4-NC possessed remarkable features,including strong ultraviolet absorption,uniform matrix crystal,excellent chemical stability,and fewer matrix-related background *** use of 4-NC led to the successful detection of 232,218,and193 LMW compounds from the three abovementioned tissue sections,***,the use of 4-NC improved the imaging quality of LMW compounds in tissue sections through MALDI-MSI and has the potential as a matrix for MALDI tissue imaging of LMW compounds.

关键词： MALDI-MSI 4-Nitrocatechol LMW compounds In situ detection Tissue imaging

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单处理器平台下的严格周期任务可调度性判定

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计算机工程 2016年第5期42卷 288-291页

作者：陈进朝杜承烈西北工业大学计算机学院西安710129

针对系统调度理论研究中的严格周期任务可调度性判定问题,从研究实时系统中严格周期任务之间的相互干涉关系出发,提出一种基于特征任务的可调度性判定方法。分析严格周期任务在单一处理器平台下无冲突运行的时间约束,计算任务所能使用... 详细信息

针对系统调度理论研究中的严格周期任务可调度性判定问题,从研究实时系统中严格周期任务之间的相互干涉关系出发,提出一种基于特征任务的可调度性判定方法。分析严格周期任务在单一处理器平台下无冲突运行的时间约束,计算任务所能使用的全部空余时间,进而界定连续空余时间是否满足任务执行的需要,得到一个可调度性判定的充要条件。实验结果表明,与特征映射任务分配方法相比,该方法能够减少判定时间,提高判定成功率,具有更优的可调度判定性能。

关键词：严格周期任务可调度性判定单处理器特征任务实时系统空余时间

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地西他滨诱导miR-200c/141表达抑制肾癌细胞侵袭迁移

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中国现代应用药学 2019年第13期36卷 1601-1607页

作者：陈梦娇王华陈锦超赵安胡海红曾苏浙江大学药学院浙江省抗肿瘤药物临床前研究重点实验室杭州310058 浙江省肿瘤医院杭州310022

目的探讨DNA甲基转移酶抑制剂地西他滨对人肾细胞癌786-O和769-P细胞侵袭迁移能力的影响,并进行相关机制的研究。方法实时荧光定量PCR法检测肾癌及其癌旁组织中miR-200c/141的表达量及2.5μmol·L^-1地西他滨对肾癌细胞系miR-200c/141... 详细信息

目的探讨DNA甲基转移酶抑制剂地西他滨对人肾细胞癌786-O和769-P细胞侵袭迁移能力的影响,并进行相关机制的研究。方法实时荧光定量PCR法检测肾癌及其癌旁组织中miR-200c/141的表达量及2.5μmol·L^-1地西他滨对肾癌细胞系miR-200c/141的诱导作用;Transwell试验、划痕试验分别检测地西他滨、miR-200c/141对细胞侵袭迁移的影响;实时荧光定量PCR法、蛋白印迹法检测786-O和769-P细胞系钙黏蛋白表达量。结果与正常肾癌旁组织相比,miR-200c/141在肾癌组织中的表达量显著下调。2.5μmol·L^-1地西他滨能诱导786-O和769-P细胞系中miR-200c/141的表达增加。地西他滨、miR-200c/141均能抑制细胞的侵袭迁移能力。786-O和769-P细胞经地西他滨处理后,与上皮间充质转化相关的钙黏蛋白表达水平显著上调。结论地西他滨可以通过上调miR-200c/141的表达水平减弱肾癌细胞系的侵袭迁移能力。

关键词：地西他滨 miR-200c miR-141 肾细胞癌侵袭迁移

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