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Growth regulation of luminescent gold nanoparticles directed from amphiphilic block copolymers:highly-controlled nanoassemblies toward tailored in-vivo transport

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Science China Chemistry 2021年第1期64卷 157-164页

作者： Liting Nong Tingyao Zhou Huarui Chen Bing Tang jinbin liu Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

The understanding of amphiphilic block copolymers(ABC)in encapsulation and transport of inorganic nanomedicines is highly ***,it remains limited due to the challenges in the fabrication of nanoassemblies(NAs)with highly-controlled shape and loading of ***,through growth regulation of luminescent gold nanoparticles(Au NPs)by different reductants with ABC pluronic F127 as a template,a straightforward strategy is reported for in-situ fabrication of three wellcontrolled gold NAs(Au NAs)that display tunable shapes from spherical to elongated nanostructures and controllable surface chemistry and loading of Au NPs with distinct emissions but identical individual Au NP *** three Au NAs exhibit tailored invivo transport behaviours:those with spherical shape and more hydrophilic surface show longer blood retention with higher tumor-targeting efficiency(~25.3%injection dose/g)and excellent long-term near-infrared tumor imaging even after 96 h *** findings provide a useful guidance in designing specific nanostructures for future nanomedicine transport.

关键词： luminescence gold nanoparticle self-assembly in-vivo transport imaging

Magnetospheric Physics in China During the Period of 2004 - 2006

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空间科学学报 2006年第Z1期26卷 97-111页

作者： CAO jinbin liu Zhenxing State Key Laboratory for Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China State Key Laboratory for Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China

Their brief report presents the advances of the magnetospheric physics researches in China during the period of 2004-2006. During the past two years, China-ESA cooperation DSP (Double Star Program) satellites were successively launched. In addition, China also participated in the scientific research of ESA's Cluster mission. The DSP and Cluster missions provide Chinese space physicists high quality data to study multiscale physical process in the magnetosphere. The work made based on the data of DSP is presented in the paper of "Progress of Double Star Program" of this issue.

关键词： Magnetosphere physics

Multi-Scale Physical Process in the Magnetosphere

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空间科学学报 2008年第5期28卷 454-467页

作者： CAO jinbin liu Zhenxing State Key Laboratory for Space Weather Center for Space Sciences and Applied Research Chinese Academy of Sciences Beijing 100190

The brief report presents a part of the research results of the magnetospheric physics researches in China during the period of 2006—*** the past two years,China-ESA co-operation DSP(Double Star Program) satellites were basically operating normally in its extended *** DSP and Cluster missions provide Chinese space physicists high quality data to study multi-scale physical process in the *** work made based on the data of DSP is presented in the paper of "Progress of Double Star Program" of this issue.

关键词：双星探测计划多尺度物理过程磁气圈空间研究

MAGNETOSPHERIC PHYSICS IN CHINA:2000-2002

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空间科学学报 2002年第Z1期22卷 81-98页

作者： CAO jinbin liu Zhenxing PU Zhuyin Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied ResearchThe Chinese Academy of Sciences Beijing 100080 P.R. China School of Earth and Space Sciences Peking University P. R. China

This brief report presents the latest advances of the magnetospheric physics researches in China during the period of 2000-2002, made independently by Chinese space physicists and through international cooperation. Th... 详细信息

关键词： Magnetospheric physics

In situ self-assembly of near-infrared-emitting gold nanoparticles into body-clearable ID nanostructures with rapid lysosome escape and fast cellular excretion

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Nano Research 2021年第4期14卷 1087-1094页

作者： Kui He Jiayi Zhu Lingshan Gong Yue Tan Huarui Chen Huarun Liang Baihao Huang jinbin liu Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

The integration of strong near-infrared(NIR)emission,rapid lysosome escape,fast cellular excretion,and efficient total body clearance is highly desired for nanoparticles(NPs)to achieve synergistic functions in both molecular imaging and ***,using a well-designed cyclopeptide(CP)that can spontaneously assem ble into controllable nanofibers a s template,a facile strategy is reported for in situ self-assembly of NIR-emitting gold NPs(AuNPs)into ordered and well-controlled one-dimensional(1D)nanostructures(AuNPs@CP)with greatly enhanced NIR emission(〜6 fold).Comparing with the unassem bled AuNPs,the AuNPs@CP are observed to enter living cells through endocytosis,escap e from lysosome rapidly,and excrete the cell fast,which shows high gene transfection efficiencies in construction of cell line with-7.5-fold overexpression of p53 ***,the AuNPs@CP exhibit high in vivo diffusibility and total body clearance efficiency with minimized healthy organ retention,which are also demonstrated to be good nanovectors for plasmid complementary deoxyribonucleic acid 3.1(pcDNA3.1)(+)-internal ribosome entry site(IRES)-green fluorescent protein(GFP)-p53 plasmid with efficient p53 gene over-expression in tumor *** facile in situ strategy in fabricating highly luminescent 1D nanostructures provides a promising approach toward future translatable multifunctional nanostructures for delivering,tracking,and therapy.

关键词： luminescent gold nanoparticle self-assembly intracellular imaging body clearance gene delivery

Magnetospheric Physics in China: 2002-2004

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空间科学学报 2004年第Z1期24卷 116-127页

作者： CAO jinbin liu Zhenxing LI Lei PU Zhuying Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 China School of Earth and Space Sciences Peking University Beijing 100871 China

This brief report presents the latest advances of the magnetospheric physics researches in China during the period of 2002-2004. The progress of the magnetospheric space mission DSP is given in another dedicated paper... 详细信息

关键词： Magnetospheric physics, Geospace storm, Progress

Special Issue of ＂Bioimaging＂

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Chinese Journal of Chemistry 2016年第6期34卷 539-539页

作者： liu, jinbin South China Univ Technol Sch Chem & Chem Engn Guangzhou Guangdong Peoples R China

Bioimaging has become an indispensable tool in disease early diagnose, prevention and, particularly ac- complishment of precision medicine. In the past few decades, huge advances have been achieved in the number of imaging technologies including optical im- aging, ultrasonography, magnetic resonance imaging, positron emission tomography and X-ray computed tomography. Meanwhile, the range of small molecules and nanoscale materials （nanoprobes） used as targeting or contrast agents has been considerably diversified. More specially, the nanoprobes that allow the combination of multiple imaging techniques into one nanoscale platform together with the therapeutic capabilities such as drug delivery and photothermal therapy can poten- tially serve as a new generation of nanomedicines.

关键词： NANOSTRUCTURED materials IMAGING systems in biology

A dual-RPA based lateral flow strip for sensitive,on-site detection of CP4-EPSPS and Cry1Ab/Ac genes in genetically modified crops

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Food Science and Human Wellness 2024年第1期13卷 183-190页

作者： jinbin Wang Yu Wang Xiuwen Hu Yifan Chen Wei Jiang Xiaofeng liu Juan liu Lemei Zhu Haijuan Zeng Hua liu Key Laboratory of Agricultural Genetics and Breeding Institute of Biotechnology ResearchShanghai Academy of Agricultural SciencesShanghai 201106China Crops Ecological Environment Security Inspection and Supervision Center(Shanghai) Ministry of Agriculture and Rural AffairsShanghai 201106China School of Life Science and Engineering Lanzhou University of TechnologyLanzhou 730050China School of Public Health Changsha Medical UniversityChangsha 410219China Academician Workstation Changsha Medical UniversityChangsha 410219China

Traditional transgenic detection methods require high test conditions and struggle to be both sensitive and *** this study,a one-tube dual recombinase polymerase amplification(RPA)reaction system for CP4-EPSPS and Cry1Ab/Ac was proposed and combined with a lateral flow immunochromatographic assay,named“Dual-RPA-LFD”,to visualize the dual detection of genetically modified(GM)*** which,the herbicide tolerance gene CP4-EPSPS and the insect resistance gene Cry1Ab/Ac were selected as targets taking into account the current status of the most widespread application of insect resistance and herbicide tolerance traits and their stacked *** diluted plasmids,transgenic standards,and actual samples were used as templates to conduct sensitivity,specificity,and practicality assays,*** constructed method achieved the visual detection of plasmid at levels as low as 100 copies,demonstrating its high *** addition,good applicability to transgenic samples was observed,with no cross-interference between two test lines and no influence from other *** conclusion,this strategy achieved the expected purpose of simultaneous detection of the two popular targets in GM crops within 20 min at 37°C in a rapid,equipmentfree field manner,providing a new alternative for rapid screening for transgenic assays in the field.

关键词： Genetically modifi ed crops On-site detection Lateral fl ow test strips Dual recombinase polymerase amplification (RPA)

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学前识字量与小学语文成绩的相关性研究

上海教育科研 2007年第3期 62-63页

作者：刘晋斌肖晶浙江省杭州市江干区春劳实验学校 310020 湖北省武昌水果湖第二小学 430077

学前教育越来越受到家长和社会的重视,而名目繁多的学前教育行为在一定程度上迎合了家长对孩子进行“超前教育”的需求。一些家长(甚至一些教育机构和非教育机构)认为孩子认字越多越聪明,越有利于他们将来的语文学习。本文对学生学前识... 详细信息

学前教育越来越受到家长和社会的重视,而名目繁多的学前教育行为在一定程度上迎合了家长对孩子进行“超前教育”的需求。一些家长(甚至一些教育机构和非教育机构)认为孩子认字越多越聪明,越有利于他们将来的语文学习。本文对学生学前识字量与其四年级上学期的语文成绩进行了相关性研究。研究显示,学前识字量对语文成绩有影响但也是有限的;学前识字量的多少不能完全反映儿童心智水平;识字量只是促进语文成绩提高的一个方面。

关键词：语文成绩识字量小学教育机构学前教育超前教育教育行为语文学习