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慢性髓系白血病慢性期TKI治疗未达最佳反应或不耐受患者转换氟马替尼的有效性和安全性临床观察

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陆军军医大学学报 2024年第4期46卷 340-346页

作者：杨松凡文钦张颖吕敬龙舒华娥颜红菊张诚魏锦张曦川北医学院附属医院血液科南充637002 陆军军医大学(第三军医大学)第二附属医院血液病医学中心全军临床重点专科创伤与化学中毒全国重点实验室重庆市临床重点专科血液病与微环境重庆市重点实验室重庆400037 重庆医科大学第二附属医院血液科重庆401336 重庆大学附属三峡医院血液科重庆404100 开州区人民医院血液科重庆405400 金凤实验室重庆401329

目的观察TKI未达最佳反应或不耐受的慢性髓系白血病-慢性期(chronic myelogenous leukemia-chronicphase, CML-CP)患者转换氟马替尼治疗的效果及安全性。方法从重庆市医院及川北医学院附属医院共5家医院收集2020年2月至2022年8月对一... 详细信息

目的观察TKI未达最佳反应或不耐受的慢性髓系白血病-慢性期(chronic myelogenous leukemia-chronicphase, CML-CP)患者转换氟马替尼治疗的效果及安全性。方法从重庆市医院及川北医学院附属医院共5家医院收集2020年2月至2022年8月对一线伊马替尼、达沙替尼、尼洛替尼未达最佳反应或不耐受,转换氟马替尼(600 mg/d)治疗的患者,观察氟马替尼的疗效及安全。统计患者治疗3、6、12个月时最佳反应率及主要分子学反应(major molecular response, MMR)率、累积完全细胞遗传学反应(complete cytogenetic response, CCyR)率、累积MMR率、累积深度分子学反应(deep molecular response, DMR)率、无进展生存(progression-free survival, PFS)、无事件生存(event-free survival, EFS)情况及不良反应情况。结果共纳入100例CML-CP患者,中位随访时间为18(3~36)个月,3、6、12个月最佳反应率分别为92.6%(88/95)、94.4%(85/90)和92.9%(79/85),随访截止至2023年8月20日,累积CCyR、MMR率分别为98.0%(98/100)、81.9%(77/94),达CCyR和MMR的中位时间均为3个月,累积DMR率为51.0%(51/100)。随访时间内,PFS率为100.0%(100/100),1年EFS率为85.6%(75/90)。氟马替尼最常见非血液学不良反应为腹泻腹痛(7.0%),其次为肾功能损害(6.0%)、肌肉骨骼疼痛(2.0%);血液学不良反应主要有血小板减少(12.0%)、贫血(6.0%)和白细胞减少(2.0%)。结论氟马替尼治疗TKI未达最佳反应或不耐受的CML-CP患者有较好的MMR和DMR,耐受性及安全性良好。

关键词：慢性髓系白血病 BCR-ABL阳性 TKI 氟马替尼

不规则区域溶质迁移问题的局部径向基函数算法研究

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地下水 2024年第4期46卷 1-5页

作者：凌美慧危嵩夏源王琪桂林理工大学广西环境污染控制理论与技术重点实验室广西桂林541006 桂林理工大学岩溶地区水污染控制与用水安全保障协同创新中心广西桂林541006

地下水污染物迁移的数值模拟能为地下水体污染防治提供科学依据,具有重要的意义。结合局部径向基函数法与有限差分法求解不规则区域中溶质迁移问题。局部径向基函数法不同于传统的全局径向基函数法,仅需通过位于配置点周围子域内的邻近... 详细信息

地下水污染物迁移的数值模拟能为地下水体污染防治提供科学依据,具有重要的意义。结合局部径向基函数法与有限差分法求解不规则区域中溶质迁移问题。局部径向基函数法不同于传统的全局径向基函数法,仅需通过位于配置点周围子域内的邻近节点来构造插值矩阵,可以有效避免全局径向基函数法计算大规模矩阵时矩阵病态及对形状参数敏感的问题,提高了数值解的精确性和稳定性。通过数值算例验证了算法在处理不规则区域问题上的有效性,并分析了形状参数、总节点数、子域节点数、布点方式和边界形状等因素对算法精确性和鲁棒性的影响。

关键词：局部径向基函数不规则区域形状参数对流扩散方程

Pore structure evolution of lacustrine organic-rich shale from the second member of the Kongdian formation in the Cangdong Sag,Bohai Bay Basin,China

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Petroleum Science 2022年第2期19卷 459-471页

作者： Xiao-Ping Liu Ming Guan Zhi-Jun jin Zhe Cao jin Lai Lun-Ju Zheng Wen-qi Li Biao Sun Shan-Yong Chen State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing100083China Institute of Energy Peking UniversityBeijing100871China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing100083China Sinopec Petroleum Exploration and Production Research Institute Beijing102206China Wuxi Petroleum Geology Institute Research Institute of Petroleum Exploration and DevelopmentSinopecWuxiJiangsu 214126China Petro China Dagang Oil Field Company Tianjin300280China

Pyrolysis experiments were conducted on lacustrine organic-rich shale from Cangdong Sag in Bohai Bay Basin,China,to investigate the impact of hydrocarbon generation on shale pore structure *** evolution is found to control the transformation of organic matter,hydrocarbon products characteristics,and pore structure ***,pore volume and specific surface area increase with increasing *** low-mature stage,the retained oil content begins to increase,pore volumes show slight changes,and primary pores are occluded by the generated crude oil of high molecular weight and *** the oil-window stage,the retained oil content rapidly increases and reaches maximum,and pore volumes gradually increase with increasing thermal *** high mature stage,the retained oil content begins to decrease,and the pore volume increases considerably owing to the expulsion of liquid *** over mature stage,natural gas content significantly increases and kerogen transforms to *** organic pores are formed and the pore size gradually increases,resulting from the connection of organic pores caused the increasing thermal *** study lays a foundation for understanding variation of hydrocarbon products during the thermal evolution of lacustrine shales and its relationship with the evolution of shale reservoirs.

关键词： Lacustrine shale Pyrolysis Thermal maturity Pore structure evolution Hydrocarbon generation evolution

基于绝经后女性股骨样本的骨髓造血干细胞自噬与骨质疏松相关性研究

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中华骨质疏松和骨矿盐疾病杂志 2024年第3期17卷 221-229页

作者：袁晔王晓娟朱柯雨魏祺郑苗邢丹徐又佳林剑浩北京大学人民医院骨关节科北京100044 西安交通大学第一附属医院血液内科西安710075 苏州大学附属第二医院骨质疏松症临床中心江苏苏州215004 苏州大学附属第二医院骨科江苏苏州215004

目的通过绝经后女性髋部骨折手术抽取分离获得骨髓造血干细胞,研究造血干细胞自噬与骨质疏松相关性。方法19例绝经后女性患者于髋部骨折手术中抽取骨髓,根据股骨颈、腰椎骨密度将患者分为骨质疏松组(n=13)和非骨质疏松组(n=6)。流式细... 详细信息

目的通过绝经后女性髋部骨折手术抽取分离获得骨髓造血干细胞,研究造血干细胞自噬与骨质疏松相关性。方法19例绝经后女性患者于髋部骨折手术中抽取骨髓,根据股骨颈、腰椎骨密度将患者分为骨质疏松组(n=13)和非骨质疏松组(n=6)。流式细胞术分选获得造血干细胞。成像流式细胞术检测两组造血干细胞自噬功能。反转录PCR(reverse transcription PCR,RT-PCR)检测两组骨髓造血干细胞自噬相关基因Atg7、LC3b、LAMP2a、P62、Atg5、Atg12表达。使用卵巢去势骨质疏松小鼠模型骨髓分选获得造血干细胞,RT-PCR检测造血干细胞自噬相关基因Atg7、LC3b、LAMP2a、P62、Atg5、Atg12表达。通过Western blot检测小鼠自噬相关蛋白表达。探究细胞自噬异常后血管内皮生长因子A(vascular endothelial growth factor A,VEGF-A)表达。结果骨质疏松患者骨髓造血干细胞自噬受抑制,自噬相关基因Atg7、LC3b、LAMP2a、P62、Atg5、Atg12表达下调(P<0.05)。小鼠骨质疏松组ATG7、BECLIN1、LC3-Ⅰ/LC3-Ⅱ蛋白表达受抑制。卵巢去势骨质疏松小鼠模型骨髓造血干细胞自噬相关基因Atg7、LC3b、LAMP2a、P62、Atg5、Atg12表达受抑制(P<0.05),细胞自噬被抑制后VEGF-A表达下降。结论骨髓造血干细胞自噬受抑制与骨质疏松有相关性。

关键词：髋部骨折造血干细胞骨质疏松自噬

Classifying Single-Trial Event-Related Potentials using xDAWN and Denoising Auto-Encoder

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Classifying Single-Trial Event-Related Potentials using xDAW...

Unfolded protein response activation compensates endoplasmic reticulum-associated degradation deficiency in Arabidopsis

第36届中国控制会议

作者： Shuai Cao wei Wu FeiFei qi School of Automation Science and Engineering South China University of Technology

ISBN: (纸本)9781538629185

Event-Related Potentials（ERPs） is a regular electrophysiological response which is evoked by outer world events or stimuli from brain,and an important approach to explore the human cognitive function.A variety of methods have been proposed for an attempt to analyze it,with varying degrees of *** this paper,we have proposed a novel method for learning the ERPs,which bases on the effective spatial filtering implementation-xDAWN for maximizing the signal-noise ratio and initializes the parameters by capturing the temporal filters using Denoising Auto-Encoder（DAE）.DAE is a three layers neural network which compels the hidden layer to learn the intrinsic features by corrupting the clean ***,our result have manifested that a superiority comparing to some advanced method listed.

关键词： Brain-Computer Interfaces ERPs Spatial Filtering Temporal Filtering

来源： cnki会议评论

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Journal of Integrative Plant Biology 2017年第7期59卷 506-521页

作者： qingliang Li Hai wei Lijing Liu Xiaoyuan Yang Xiansheng Zhang qi Xie State Key Laboratory of Plant Genomics National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology College of Life Sciences Shandong Agricultural University

Abiotic stresses often disrupt protein folding and induce endoplasmic reticulum （ER） stress. There is a sophisticated ER quality control （ERQC） system to mitigate the effects of malfunctioning proteins and maintain ER homeostasis. The accumulation of misfolded proteins in the ER activates the unfolded protein response （UPR） to enhance ER protein folding and the degradation of misfolded proteins mediate by ER- associated degradation （ERAD）. That ERQC reduces abiotic stress damage has been well studied in mammals and yeast. However, in plants, both ERAD and UPR have been studied separately and found to be critical for plant abiotic stress tolerance. In this study, we discovered that UPR-associated transcription factors AtbZlP17, AtbZIP28 and AtbZIP60 responded to tunicamycin （TM） and NaCl induced ER stress and subsequently enhanced Arabidopsis thaliana abiotic stress tolerance. They regulated the expression level of ER chaperones and the HRD1-complex components. Moreover, overexpression of AtbZIP17, AtbZIP28 and AtbZIP60 could restore stress tolerance via ERAD in the HRD1-complex mutant hrd3a-2, which suggested that UPR and ERAD have an interactive mechanism in Arabidopsts.

关键词： ZIP ERAD HRD in of UPR

Water-induced reversible dissolution/reorganization transformations of Cu(Ⅱ)-K(I) heterometallic coordination polymers

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Science China Chemistry 2014年第9期57卷 1225-1234页

作者： ZHANG Sheng wei qing LIU XiangYu YANG qi XIE Gang CHEN SanPing Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials ScienceNorthwest University

Three new heterometallic coordination compounds, namely, [KCu（I3）（L）2（H2O）2]n （1）, [KCu（I3）（L）2（H20）]n （2） and [CIIK4（I3）z（L＇）4]n （3）, were prepared and characterized （HL=5-methylpyrazine-2-carboxylic acid, HL＇=p-tolylacetic acid）. Structural studies revealed that 1 and 2 exhibit 3D frameworks with rectangular channels occupied by triiodide ions. Both compounds can be symbolized as a 5-connected net with pcu topology. In compound 3, a one-dimensional polyhedral chain is connected by hexanuclear mask like clusters [Cu2K408]. These chains are further linked each other via rare （1,1,3,3）-triiodide ion-bridging units to generate a 3D （4,5,6）-connected net with the point symbol of { 12}2{4·12^2}4{4^6}{4^8·62}4{49.66}4. It is noteworthy that water-induced reversible dissolution/reorganization processes occur between 1/2 and [Cu（L）2（HzO）],＇3nH20. The thermal and photoluminescence properties of compounds 1, 2, and 3 were investigated as well.

关键词： heterometallic compound reversible structural transformation dissolution/reorganization triiodide

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冲反结合型汽轮机推力平衡系统优化研究

电站系统工程 2024年第4期40卷 48-50页

作者：张启林高天任伟刘家根哈尔滨汽轮机厂有限责任公司

电站汽轮机有冲动式和反动式两种形式,其中绝大部分中小型汽轮机因带有复杂抽汽功能采用冲动式,而反动式汽轮机以其高效、高可靠性等优势占据了几乎所有大容量电力市场。冲反结合是近年提出的新概念,既要满足机组抽汽需求,还要保证高效... 详细信息

电站汽轮机有冲动式和反动式两种形式,其中绝大部分中小型汽轮机因带有复杂抽汽功能采用冲动式,而反动式汽轮机以其高效、高可靠性等优势占据了几乎所有大容量电力市场。冲反结合是近年提出的新概念,既要满足机组抽汽需求,还要保证高效率,这会带来机组轴向推力过大和变工况峰谷推力偏差大等问题,给设计汽轮机推力平衡系统带来困难。通过对汽封系统平衡鼓结构、冲反结合冲动段通流等进行优化设计,提出一种全新的推力平衡系统优化模式,为今后电站汽轮机设计提供指导性帮助。

关键词：推力平衡系统冲反结合反动度平衡鼓

A robust deformed convolutional neural network(CNN)for image denoising

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CAAI Transactions on Intelligence Technology 2023年第2期8卷 331-342页

作者： qi Zhang jingyu Xiao Chunwei Tian Jerry Chun‐wei Lin Shichao Zhang School of Economics and Management Harbin Institute of Technology at WeihaiWeihaiChina School of Computer Science Central South UniversityChangshaChina School of Software Northwestern Polytechnical UniversityXi'anShaanxiChina Research&Development Institute Northwestern Polytechnical UniversityShenzhenChina Yangtze River Delta Research Institute Northwestern Polytechnical UniversityTaicangChina Department of Computer Science Electrical Engineering and Mathematical SciencesWestern Norway University of Applied SciencesBergenNorway

Due to strong learning ability,convolutional neural networks(CNNs)have been developed in image ***,convolutional operations may change original distributions of noise in corrupted images,which may increase training difficulty in image *** relations of surrounding pixels can effectively resolve this *** by that,we propose a robust deformed denoising CNN(RDDCNN)in this *** proposed RDDCNN contains three blocks:a deformable block(DB),an enhanced block(EB)and a residual block(RB).The DB can extract more representative noise features via a deformable learnable kernel and stacked convolutional architecture,according to relations of surrounding *** EB can facilitate contextual interaction through a dilated convolution and a novel combination of convolutional layers,batch normalisation(BN)and ReLU,which can enhance the learning ability of the proposed *** address long-term dependency problem,the RB is used to enhance the memory ability of shallow layer on deep layers and construct a clean ***,we implement a blind denoising *** results demonstrate that our denoising model outperforms popular denoising methods in terms of qualitative and quantitative *** can be obtained at https://***/hellloxiaotian/RDDCNN.

关键词： blind denoising CNN deformed block enhanced block