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Liver abnormalities following SARS-CoV 2 infection in children 1 to 10 years of age

Family Medicine and Community Health 2024年第1期12卷 28-35页

作者： Pauline Terebuh Veronica R Olaker Ellen K Kendall David C Kaelber Rong xu Pamela B Davis Center for Artificial Intelligence in Drug Discovery Case Western Reserve UniversityClevelandOHUSA The Center for Clinical Informatics Research and Education The MetroHealth SystemClevelandOHUSA Department of Medicine PediatricsDepartment of Population and Quantitative Health SciencesCase Western Reserve UniversityClevelandOHUSA Center for Community Health Integration Case Western Reserve UniversityClevelandOHUSA

Objective Beginning in October 2021 in the USA and elsewhere,cases of severe paediatric hepatitis of unknown aetiology were identified in young *** the adenovirus and adenovirus-associated virus have emerged as leading aetiological suspects,we attempted to investigate a potential role for SARS-CoV 2 in the development of subsequent liver *** We conducted a study using retrospective cohorts of deidentified,aggregated data from the electronic health records of over 100 million patients contributed by US healthcare *** Compared with propensity score matched children with other respiratory infections,children aged 1-10 years with COVID-19 had a higher risk of elevated transaminases(HR(95%CI)2.16(1.74 to 2.69))or total bilirubin(HR(95%CI)3.02(1.91 to 4.78)),or new diagnoses of liver diseases(HR(95%CI)1.67(1.21 to 2.30))from 1 to 6 months after *** with pre-existing liver abnormalities,liver abnormalities surrounding acute infection,younger age(1-4 years)or illness requiring hospitalisation all had similarly elevated *** who developed liver abnormalities following COVID-19 had more pre-existing conditions than those who developed abnormalities following other *** These results indicate that SARS-CoV 2 may prime the patient for subsequent development of liver infections or non-infectious liver *** rare(~1 in 1000),SARS-CoV 2 is a risk for subsequent abnormalities in liver function or the diagnosis of diseases of the liver.

关键词： elevated diagnosis subsequent

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Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis

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Bone Research 2024年第1期12卷 215-226页

作者： Yuhang Liu Ruihan Hao Jia Lv Jie Yuan xuelei Wang Churong xu Ding Ma Zhouyi Duan Bingjun Zhang Liming Dai Yiyun Cheng Wei Lu Xiaoling Zhang Department of Orthopedic Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200092China National Facility for Translational Medicine Shanghai 200240China Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Orthopaedic Surgery The Second Hospital of Shanxi Medical UniversityTaiyuan 030001China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China School of Medicine Shanghai UniversityShanghai 200444China

Osteoarthritis(OA)is a common degenerative disease worldwide and new therapeutics that target inflammation and the crosstalk between immunocytes and chondrocytes are being developed to prevent and treat *** attempts involve repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype in *** this study,we found that phosphoglycerate mutase 5(PGAM5)significantly increased in macrophages in OA synovium compared to controls based on histology of human samples and single-cell RNA sequencing results of mice *** address the role of PGAM5 in macrophages in OA,we found conditional knockout of PGAM5 in macrophages greatly alleviated OA symptoms and promoted anabolic metabolism of chondrocytes in vitro and in ***,we found that PGAM5 enhanced M1 polarization via AKT-mTOR/p38/ERK pathways,whereas inhibited M2 polarization via STAT6-PPARγpathway in murine bone marrow-derived ***,we found that PGAM5 directly dephosphorylated Dishevelled Segment Polarity Protein 2(DVL2)which resulted in the inhibition ofβ-catenin and repolarization of M2 macrophages into M1 *** knockout of both PGAM5 andβ-catenin in macrophages significantly exacerbated osteoarthritis compared to PGAM5-deficient *** by these findings,we successfully designed mannose modified fluoropolymers combined with siPGAM5 to inhibit PGAM5 specifically in synovial macrophages via intra-articular injection,which possessed desired targeting abilities of synovial macrophages and greatly attenuated murine ***,these findings defined a key role for PGAM5 in orchestrating macrophage polarization and provides insights into novel macrophage-targeted strategy for treating OA.

关键词： osteoarthritis metabolism inhibited

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Improving color rendering index of Mn-doped ZnO nanorods on silicon-based substrate

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Rare Metals 2017年第9期36卷 711-717页

作者： Zheng-long Wu Bin Tian Hai-Jun xu Analytical and Testing Center Beijing Normal University State Key Laboratory of Chemical Resource Engineering and School of Science Beijing University of Chemical Technology

Porous silicon pillar array（PSPA） samples which are ideal substantial materials with dominant electronic and luminescence properties were prepared by surface etching method. ZnO nanorods with or without Mn doping grown uniformly and aligned onto PSPA regardless of lattice matching show various photoluminescence（PL）properties. The doped Mn ions in ZnO nanorods were directly observed by X-ray photoelectron spectroscopy（XPS）,and ZnO structures were detected by X-ray diffraction（XRD）. As the doping concentration increases,XRD peaks of ZnO nanorods shift to low angle. The influences of doping Mn ions on luminescence properties of ZnO nanorods were investigated. Except for the ultraviolet（UV） PL band, the broad PL band is observed at visible region. The band could be divided into three separate bands（orange, green and red） by Lorentzian deconvolution. The intensity of orange PL band firstly increases then decreases, and then gets the maximum at the doping Mn-to-Zn molar ratio of 2.0：100.0 which is the most effective doping concentration. The green PL band is attributed to zinc vacancy of ZnO, the orange PL band to Mn ions recombination of itself, and the red PL band to oxygen vacancy of ZnO, respectively. As the Mn-doped ZnO nanorods could emit yellow green luminescence excited by UV radiation, and doped Mn ions could improve the color rendering index of the luminescence, the nanorods could be used as promising white-light emitters in the future.

关键词： ZnO/Mn nanorod arrays Photoluminescence White light Hydrothermal synthesis

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膜分离与变压吸附耦合工艺提氦试验研究

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膜科学与技术 2024年第2期44卷 150-156页

作者：邹彦荣张瑾孙启邦罗宗敏徐徜徉中石化绿源地热能开发有限公司雄安071800 中国石化华北油气分公司采气二厂咸阳712000 西安石油大学地球科学与工程学院西安710065 西安石油大学陕西省油气成藏地质学重点实验室西安710065 天邦膜技术国家工程研究中心有限责任公司大连116000

我国氦气资源贫乏,主要依靠进口.近年来,已在多个盆地发现2种不同类型的氦气资源,其中含氦天然气资源丰富但品位低,地热水溶性伴生氦气品位高,但受限于地热水的开采,可采资源量较小,还未到工业化利用阶段.目前国内外氦气提取主要采用深... 详细信息

我国氦气资源贫乏,主要依靠进口.近年来,已在多个盆地发现2种不同类型的氦气资源,其中含氦天然气资源丰富但品位低,地热水溶性伴生氦气品位高,但受限于地热水的开采,可采资源量较小,还未到工业化利用阶段.目前国内外氦气提取主要采用深冷法技术,应用在我国存在能耗高、经济性差的问题.在三普2号地热井开展地热水溶氦气的常温膜分离与变压吸附耦合工艺提取试验,将体积分数为3%左右的氦气利用膜分离工艺提浓至50%左右,提浓后的气体再利用变压吸附工艺提纯至99%以上,通过2种技术的联合运用,在国内首次完成了常温膜分离与变压吸附技术耦合工艺提氦试验.该技术也即将成果转化,应用到我国的天然气田提氦,对解决我国氦气供需矛盾、降低对外依存度具有重要的作用.

关键词：膜分离变压吸附耦合工艺氦气提纯

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Serological Investigation into the Infected Genotypes of Patients with Japanese Encephalitis in the Coastal Provinces of China

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Biomedical and Environmental Sciences 2024年第7期37卷 716-725页

作者： Weijia Zhang Jierong Zhao Qikai Yin Shenghui Liu Ruichen Wang Shihong Fu Fan Li Ying He Kai Nie Guodong Liang Songtao xu Guang Yang Huanyu Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Basic Medicine and Public Health Jinan UniversityGuangzhou 510000GuangdongChina

Objective Genotypes(G)1,3,and 5 of the Japanese encephalitis virus(JEV)have been isolated in China,but the dominant genotype circulating in Chinese coastal areas remains *** searched for G5 JEV-infected cases and attempted to elucidate which JEV genotype was most closely related to human Japanese encephalitis(JE)in the coastal provinces of *** In this study,we collected serum specimens from patients with JE in three coastal provinces of China(Guangdong,Zhejiang,and Shandong)from 2018 to 2020 and conducted JEV cross-neutralization tests against G1,G3,and *** Acute serum specimens from clinically reported JE cases were obtained for laboratory confirmation from hospitals in Shandong(92 patients),Zhejiang(192 patients),and Guangdong(77 patients),China,from 2018 to *** of the 361 serum specimens were laboratory-confirmed to be infected with *** cases were confirmed to be infected with G1 JEV,32 with G3 JEV,and two with G5 *** G3 was the primary infection genotype among JE cases with a definite infection genotype,and the infection caused by G5 JEV was confirmed serologically in China.

关键词： Japanese encephalitis virus Serological investigation Plaque reduction neutralization test Cross-neutralization test Genotype

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Neosophoflavonoids A–C, A class of highly oxidized hybrid flavonoids from Sophora flavescens with antidiabetic effects

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Chinese Chemical Letters 2024年第10期35卷 295-298页

作者： xu Zhang Jiang Li Kai-Zhou Lu Ya-Nan Yang Jian-Shuang Jiang Xiang Yuan Zi-Ming Feng Fei Ye Pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and PekingUnionMedical CollegeBeijing100050China

Three highly oxidized hybrid flavonoids neosophoflavonoids A–C(1,2a,and 2b)were isolated from the roots of Sophora *** A possesses a unique highly oxidized heptacyclic6/6/6/6/6/6/5 *** B and C are isomers and share the same highly oxidized hexacyclic 6/6/6/6/6/6 *** planar structures were elucidated from 1D/2D nuclear magnetic resonance(NMR),ultraviolet spectroscopy(UV),infrared spectroscopy(IR),and high resolution electrospray ionization mass spectroscopy(HRESIMS)*** absolute configurations were determined by thorough GIAO13C NMR(DP4+)calculation protocol and electronic circular dichroism(ECD)calculation *** plausible biosynthetic routes for the compounds were also *** compounds exhibited significant protein tyrosine phosphatase-1B(PTP1B)inhibitory activity with half maximal inhibitory concentration(IC_(5)0)values 3.94±0.01,0.38±0.13,and 0.70±0.01μmol/L,*** addition,compared to a positive control fenofibrate(Feno)at 20μmol/L,compounds 2a and 2b exhibited stronger inhibitory effects on lipid accumulation in the oleic acid(OA)-induced cell model at 5 and 10μmol/L.

关键词： Sophora flavescens Highly oxidized hybrid flavonoids Neosophoflavonoids A-C PTP1B inhibition Lipid accumulation inhibition

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ECC壳-RC组合墩柱抗震性能及塑性铰形成机制

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复合材料学报 2024年第7期41卷 3689-3703页

作者：王瑾许维炳杜修力丁梦佳陈彦江方荣闫晓宇华北电力大学水利与水电工程学院北京102206 北京工业大学城市建设学部北京100124 国家开放大学理工教学部北京100039

为提升钢筋混凝土(RC)墩柱的抗震性能并充分利用工程水泥基复合材料(ECC)的力学性能,提出了ECC壳-RC组合墩柱的构造;基于ABAQUS有限元软件建立了现浇ECC壳-RC组合墩柱数值分析模型,并基于既有试验结果验证;进而探究了ECC节段高度、ECC... 详细信息

为提升钢筋混凝土(RC)墩柱的抗震性能并充分利用工程水泥基复合材料(ECC)的力学性能,提出了ECC壳-RC组合墩柱的构造;基于ABAQUS有限元软件建立了现浇ECC壳-RC组合墩柱数值分析模型,并基于既有试验结果验证;进而探究了ECC节段高度、ECC壳厚度、纵筋配筋率、体积配箍率、轴压比等参数对组合墩柱抗震性能的影响规律。在此基础上,探讨了该型组合墩柱塑性铰形成机制。结果表明:相较于RC墩柱,ECC壳-RC组合墩柱的承载能力、延性和耗能能力均有所提高。增加ECC节段高度,组合墩柱的峰值荷载有所增加,ECC节段高度达到1.4h(h为截面高度)后组合墩柱的抗震性能接近全高度ECC墩柱的抗震性能;增加ECC壳厚度及纵筋配筋率可同时提高组合墩柱的峰值荷载及延性,ECC壳厚度达到1/5h后继续增加ECC壳厚度对提升组合墩柱抗震性能效果不明显;增加轴压比可使试件初始刚度和峰值荷载增加,但对延性产生不利影响;减小塑性铰区域的体积配箍率试件延性明显降低,而承载力变化不明显;组合墩柱的塑性铰形成机制受ECC壳-RC组合节段高度影响显著,存在一个组合节段临界高度使该组合柱的塑性铰区不发生转移。

关键词：抗震性能数值模拟 ECC壳 ECC壳-RC组合墩柱塑性铰

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Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes

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Chinese Chemical Letters 2024年第10期35卷 404-407页

作者： Hao Wang Meng-Qi Pan Ya-Fei Wang Chao Chen Jian xu Yuan-Yuan Gao Chuan-Song Qi Wei Li Xian-He Bu College of New Materials and Chemical Engineering Beijing Key Lab of Special Elastomeric Composite MaterialsBeijing Institute of Petrochemical TechnologyBeijing 102617China School of Materials Science and Engineering National Institute for Advanced MaterialsTKL of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin300350China College of Chemical Engineering Inner Mongolia University of TechnologyHohhot 010051China

Post-synthetic modifications(PSM)have drawn great attention as a vigoroso tool to tune or enhance the performance of metal-organic frameworks(MOFs).However,the current PSM method usually have to sacrifice the porosity of MOFs to enrich their functionality,such as pore space partition(PSP)and postsynthetic elimination and insertion(PSE&I),causing a trade-off in this *** address this issue,we herein propose a new PSM strategy of using the size-matching ligands as the bolts to lock MOFs'pores,which could be anchored onto open metal sites(OMSs)after guest loading through a stepwise *** a result,the loaded cargoes undergo a controlled releasing process with respect to different bolt *** proposed strategy provides a promising way to balance the functionality and porosity of MOFs.

关键词： Post-synthetic modifications Metal-organic frameworks Bolting ligand Control release Cargo

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Innovative integration of lung ultrasound and wearable monitoring for predicting pulmonary complications in colorectal surgery:A prospective study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2649-2661页

作者： Chen Lin Pei-Pei Wang Zi-Yan Wang Guo-Ru Lan Kai-Wen xu Chun-Hua Yu Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China School of Medicine Tsinghua UniversityBeijing 100084China Department of Anesthesiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Clinical Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Postoperative pulmonary complications(PPCs)are common in patients who undergo colorectal *** have focused on how to accurately diagnose and reduce the incidence of *** ultrasound has been proven to be useful in preoperative monitoring and postoperative care after cardiopulmonary ***,lung ultrasound has not been studied in abdominal surgeries and has not been used with wearable devices to evaluate the influence of postoperative ambulation on the incidence of *** To investigate the relationship between lung ultrasound scores,PPCs,and postoperative physical activity levels in patients who underwent colorectal *** In this prospective observational study conducted from November 1,2019 to August 1,2020,patients who underwent colorectal surgery underwent daily bedside ultrasonography from the day before surgery to postoperative day(POD)*** ultrasound scores and PPCs were recorded and analyzed to investigate their *** bracelets measured the daily movement distance for 5 days post-surgery,and the correlation between postoperative activity levels and lung ultrasound scores was *** Thirteen cases of PPCs was observed in the cohort of 101 *** mean(standard deviation)peak lung ultrasound score was 5.32(2.52).Patients with a lung ultrasound score of≥6 constituted the high-risk ***-risk lung ultrasound scores were associated with an increased incidence of PPCs after colorectal surgery(logistic regression coefficient,1.715;odds ratio,5.556).Postoperative movement distance was negatively associated with the lung ultrasound scores[Spearman’s rank correlation coefficient(r),-0.356,P<0.05].CONCLUSION Lung ultrasound effectively evaluates pulmonary condition post-colorectal *** ambulation and respiratory exercises in the initial two PODs will reduce PPCs and optimize postoperative care in patients undergoing colorectal surgery.

关键词： Colorectal cancer Pulmonary complications Lung ultrasound Wearable devices Respiratory exercises

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家庭医生签约服务质量评价指标体系的构建研究

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卫生软科学 2024年第4期38卷 71-73,92页

作者：许忠琴龙江程春梅许红重庆医科大学公共卫生学院重庆400016 重庆市疾病预防控制中心重庆400016

参照服务质量(Service Quality,SERVQUAL)量表模型,应用文献分析法和专家咨询法,构建了家庭医生签约服务质量评价指标体系。该指标体系包含有形性、可靠性、响应性、保证性与移情性5个一级指标和24个二级指标,为科学评价家庭医生签约服... 详细信息

参照服务质量(Service Quality,SERVQUAL)量表模型,应用文献分析法和专家咨询法,构建了家庭医生签约服务质量评价指标体系。该指标体系包含有形性、可靠性、响应性、保证性与移情性5个一级指标和24个二级指标,为科学评价家庭医生签约服务质量提供了有效的测评工具。

关键词：家庭医生签约服务质量评价指标体系

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