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The Mine Geostress Testing Methods and Design

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Open Journal of Geology 2014年第12期4卷 622-626页

作者： jin-long su Ping-Song Zhang Rong-Xin Wu School of Earth and Environment Anhui University of Science and Technology Huainan China

The?mine geostress measurement is the indispensable key to safe and efficient production of the mine. Currently, stress relief method, hydraulic fracturing method and acoustic emission method are widely used in mine geostress test fields. As deficiencies of the above several methods, the author designed a detailed borehole acoustic program for the tectonic fault conditions of a mine in Huainan, and got geostress parameter values according to the combination of site measured velocity values and laboratory tests.

关键词： Mine Geostress Borehole Acoustic Method Test Program

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猕猴额叶神经元视辨别机能可塑性的研究

生理学报 1989年第5期41卷 504-511页

作者：刘觐龙宿双宁航天医学工程研究所

我们曾经提出,额叶神经元的反应,主要不是取决于刺激物的物理属性,而是与信号意义有密切的关系。为了验证这一看法,设计了两套作业,即视延缓辨别作业(作业Ⅰ)和视辨别反应作业(作业Ⅰ),对4只成年猕猴进行实验。两套作业都由1—4期组成,... 详细信息

我们曾经提出,额叶神经元的反应,主要不是取决于刺激物的物理属性,而是与信号意义有密切的关系。为了验证这一看法,设计了两套作业,即视延缓辨别作业(作业Ⅰ)和视辨别反应作业(作业Ⅰ),对4只成年猕猴进行实验。两套作业都由1—4期组成,在第2期都有伪随机出现的红绿灯光信号,在第3期都要求动物密切注意随后的灯光信号变化。但是,作业Ⅰ要求动物对第2期出现的红绿灯光进行辨别,作业Ⅰ则要求对第4期的红绿灯光进行辨别。待动物学会作业,正确率达90％以上,在动物进行作业的同时引导额叶神经元放电。共记录作业相关神经元163个。其中作业Ⅰ98个,作业Ⅱ 65个。在作业Ⅰ中,神经元的反应多数出现在第2、3期,占该作业反应总数的70％。而在作业Ⅱ中,反应多数出现在第3、4期,也占该作业反应总数的70％。其次,作业Ⅰ第2期的神经元反应绝大多数对红、绿灯光有明显的特异性,而作业Ⅱ第2期的则没有,只有第4期的反应才有明显的特异性。本实验结果进一步支持了我们的上述看法,并且表明,额叶神经元对信号的反应主要是在学习中逐渐形成的,有很大的可塑性。

关键词：额叶皮层单神经元活动视辨别作业

Modeling and Capacity Configuration Optimization of CRH5 EMU On-Board Energy Storage System

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Energy Engineering 2025年第1期122卷 307-329页

作者： Mingxing Tian Weiyuan Zhang Zhaoxu su School of Automation and Electrical Engineering Lanzhou Jiaotong UniversityLanzhou730070China

In the context of the“dual carbon”goals,to address issues such as high energy consumption,high costs,and low power quality in the rapid development of electrified railways,this study focused on the China Railways High-Speed 5 Electric Multiple Unit and proposed a mathematical model and capacity optimization method for an onboard energy storage system using lithium batteries and supercapacitors as storage ***,considering the electrical characteristics,weight,and volume of the storage media,a mathematical model of the energy storage system was ***,to tackle problems related to energy consumption and power quality,an energy management strategy was proposed that comprehensively considers peak shaving and valley filling and power quality by controlling the charge/discharge thresholds of the storage *** optimization adopted a bilevel programming model,with the series/parallel number of storage modules as variables,considering constraints imposed by the Direct Current to Direct Current converter,train load,and *** improved Particle Swarm Optimization algorithm and linear programming solver were used to solve specific *** results show that the proposed onboard energy storage system can effectively achieve energy savings,reduce consumption,and improve power qualitywhile meeting the load and space limitations of the train.

关键词： Electrified railway regenerative braking bi-level programming on-board energy storage power quality capacity configuration

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Effect of Progressive substitution of Cement and Lime by Powdered Shells Used as a Curing Agent for Dredged Soil in a Port Area

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 88-102页

作者： suN Yang WANG Faxin su Yaying LI Yiwei HE Feng College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Huai'an Research Institute Hohai UniversityHuai'an 223025China Jiangsu Fangyang Industrial Investment Corp.Ltd. Lianyungang 210098China

This study aimed to address the challenges of solid waste utilization,cost reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in Lianyungang city of *** research in this area was ***,a curing agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physical and mechanical properties of the powdered shell-based curing *** was collected by conducting experiments to assess the role of powdered shells in the curing process and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenced by the substitution rate of powdered shells and their interaction with *** cement content had a positive effect on *** high-strength solidified soil,the recommended ratio of wet soil:cement:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the recommended ratio was 100:5.4:2.4:***,under appropriate conditions,improved short-term strength by promoting the formation of expansive ettringite minerals that contributed to cementation and *** findings suggest that the combination of cement and powdered shells is synergistic,positively affecting the strength of solidified *** recommended ratios provide practical guidance for achieving desired strength levels while considering factors such as cost and carbon *** role of seawater in enhancing short-term strength through crystal formation is noteworthy and can be advantageous for certain *** conclusion,this research demonstrates the potential of using a powdered shell-based curing agent for solidifying dredged soil in an environmentally friendly and cost-effective *** recommended ratios for different str

关键词： carbon reduction and solidification dredged soil abandoned shells orthogonal test chemical additives(lime and cement) unconfined compressive strength(UCS)

Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang su Ian N.Levasseur Kimberly M.Alonge Department of Medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Boosting aqueous nickel-zinc battery stability with bimetallic ion-integrated 1D metal-organic nanowires

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Science China Chemistry 2025年

作者： Yihao Chen jin Liang Yichun su Guoyin Zhu Hengyue Xu Hongye Ding Guangxun Zhang Dianheng Yu Zizhou Shen Yizhou Zhang Wei Huang Huan Pang School of Chemistry and Chemical Engineering Yangzhou University Key Laboratory of Flexible Electronics (KLoFE) & Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies) Nanjing Tech University (NanjingTech) Institute of Advanced Materials and Flexible Electronics (IAMFE) School of Chemistry and Materials Science Nanjing University of Information Science & Technology Department of Chemistry Tsinghua University State Key Laboratory of Coordination Chemistry Nanjing University

Limited by low conductivity,designing cathode materials with excellent electron transfer efficiency for high-performance nickel-zinc batteries （NZBs） remains *** this study,a series of bimetallic metal-organic nanowires were fabricated by doping M ions in NiNTA,resulting in NiMNTA (M=Mg2+,Mn2+,Co2+,Zn2+,Ag+),and NixCo6-xNTA （x=1,2,3,4,5）.The proportions and types of metal ions can be modified without altering the initial coordination structure.X-ray absorption fine structure spectroscopy （XAFS） revealed that only M–O bonds,not metal bonds,were present in the *** performance of Ni2Co4NTA as the cathode for aqueous NZBs was significantly improved,achieving the maximum energy density of 279.17Wh kg-1with the high cycle stability （retention rate of 72.0%after 1,000 cycles）.The flexible Ni2Co4NTA//Zn@carbon cloth battery employing gel electrolyte also exhibits the excellent Coulombic efficiency of 96%after 350 *** approach shows considerable potential for designing one-dimensional materials with bimetallic modifications,providing new strategies for developing cathode materials for NZBs with high specific capacity and cycle stability.

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Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng su Yanfang Huang Bingbing Liu Hu sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress