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AsyCo: an asymmetric dual-task co-training model for partial-label learning

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Science China(Information Sciences) 2025年

作者： Beibei LI Yiyuan ZHENG Beihong jin Tao XIANG Haobo WANG Lei feng College of Computer Science Chongqing University State Key Laboratory of Computer Science Institute of Software Chinese Academy of Sciences University of Chinese Academy of Sciences School of Software Technology Zhejiang University School of Computer Science and Engineering Nanyang Technological University

Partial-label learning (PLL) is a typical problem of weakly supervised learning, where each training instance is annotated with a set of candidate labels. Self-training PLL models achieve state-of-the-art performance but suffer from error accumulation problems caused by mistakenly disambiguated instances. Although co-training can alleviate this issue by training two networks simultaneously and allowing them to interact with each other, most existing co-training methods train two structurally identical networks with the same task, i.e., are symmetric, rendering it insufficient for them to correct each other due to their similar limitations. Therefore, in this paper, we propose an asymmetric dual-task co-training PLL model called AsyCo,which forces its two networks, i.e., a disambiguation network and an auxiliary network, to learn from different views explicitly by optimizing distinct tasks. Specifically, the disambiguation network is trained with a self-training PLL task to learn label confidence, while the auxiliary network is trained in a supervised learning paradigm to learn from the noisy pairwise similarity labels that are constructed according to the learned label confidence. Finally, the error accumulation problem is mitigated via information distillation and confidence refinement. Extensive experiments on both uniform and instance-dependent partially labeled datasets demonstrate the effectiveness of AsyCo.

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Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu feng Yuan Shi Xin-lin Li Zheng-Rong Shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

肉豆蔻薄层色谱用对照提取物的制备与应用研究

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药物分析杂志 2015年第7期35卷 1283-1286页

作者：杨志业李曼莎林锦锋魏锋广东省食品药品检验所广州510180 广州泽力医药科技有限公司广州510663 中国食品药品检定研究院北京100050

目的:研究制备肉豆蔻薄层色谱用对照提取物,探讨对照提取物替代对照药材在肉豆蔻药材及其制剂质量控制中的应用。方法:通过药材筛选、制备工艺摸索、稳定性影响因素考察等,研制肉豆蔻薄层用对照提取物,并应用于肉豆蔻药材、二十五味松... 详细信息

目的:研究制备肉豆蔻薄层色谱用对照提取物,探讨对照提取物替代对照药材在肉豆蔻药材及其制剂质量控制中的应用。方法:通过药材筛选、制备工艺摸索、稳定性影响因素考察等,研制肉豆蔻薄层用对照提取物,并应用于肉豆蔻药材、二十五味松石丸、四神丸等中国药典2010年版一部药品标准中的薄层色谱鉴别项。结果:肉豆蔻薄层用对照提取物与肉豆蔻对照药材薄层色谱效果一致,等量同质。结论:研制了定性用的肉豆蔻薄层色谱用对照提取物标准物质,并用于肉豆蔻药材及肉豆蔻类制剂的质量控制分析,为中药对照提取物的进一步发展提供研究基础。

关键词：肉豆蔻对照提取物薄层色谱制备中药材标准

Constructing quasi-2D perovskite to collect hot carriers to reduce open-circuit voltage loss for efficient inverted perovskite solar cells

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Science China Chemistry 2025年

作者： Lei Gu Xing Li Chao Wu Yang feng Chunming Yang lin Song Frontiers Science Center for Flexible Electronics Institute of Flexible Electronics Northwestern Polytechnical University Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences

Inverted perovskite solar cells （PSCs） have received great attention owing to the high certificated power conversion efficiency（PCE） reaching 26.7%. However, interfacial charge recombination is far superior to perovskite bulk charge recombination due to the use of fullerenes and their derivatives in inverted perovskite solar cells, which induces devastating open circuit voltage（VOC） losses. For this reason the present work attempts to use 4-chloropiperidine hydrochloride for the upper surface modification of perovskite to construct a quasi-two-dimensional （2D） structure with suitable 2D layer widths （n=2, 3 dominant）,which has a smaller electron carrier transport barrier without sacrificing short-circuit current （JSC） in the device. This strategy effectively passivates the interfacial defect states while promoting energy level alignment to achieve carrier dissociation and equilibrium transport at the interface, which in turn resulted in improved fill factor （FF）. In addition, additional energy levels are provided by 2D perovskites to collect hot carriers, resulting in improved device open circuit voltage （VOC）. As a result, the device PCE increases from 22.37%to 24.11%after the 4CPD treatment. In addition, the 4CPD-treated PSCs maintain 90%of the initial PCE after storage in an N2atmosphere at 50°C for 1,080 h, whereas the control devices show a 15%PCE loss under the same aging conditions. This work provides new opportunities to suppress interfacial charge recombination in inverted devices.

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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun lin Hou Huang jin-Jie Yu feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Fine mapping and identification of CaTTG1,a candidate gene that regulates the hypocotyl anthocyanin accumulation in Capsicum annuum

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Horticultural Plant Journal 2025年第1期11卷 264-274页

作者： jin Wang Yao Dai Luzhao Pan Ying Chen Li Dai Yanqing Ma Xiaoxun Zhou Wu Miao Muhammad Rizwan Hamid Xuexiao Zou feng Liu Cheng Xiong Engineering Research Center for Germplasm Innovation and New Varieties Breeding of Horticultural Crops Key Laboratory for Vegetable Biology of Hunan ProvinceCollege of HorticultureHunan Agricultural UniversityChangshaHunan 410000China Hunan Xiangyan Seed Industry Co. LTDChangshaHunan 410000China

Pepper(Capsicum annuum L.)is a typical self-pollinating crop with obvious heterosis in ***,the use of morphological markers during the pepper seedling stage is crucial for pepper *** color of hypocotyl is widely used as a phenotypic marker in crossing studies of *** accessions generally have purple hypocotyls,which are mainly due to the anthocyanin accumulation in seedlings,and green hypocotyls are rarely observed in *** we reported the characterization of a green hypocotyl mutant of pepper,Cha1,which was identified from a pepper ethyl methanesulfonate(EMS)mutant *** mapping revealed that the causal gene,CaTTG1,belonging to the WD40 repeat family,controlled the green hypocotyl phenotype of the ***-induced gene silencing(VIGS)confirmed that CaTTG1 regulated anthocyanin ***-seq data showed that expression of structural genes CaDFR,CaANS,and CaUF3GT in the anthocyanin biosynthetic pathway was significantly decreased in Cha1 compared to the wild *** two-hybrid(Y2H)experiments also confirmed that CaTTG1 activated the synthesis of anthocyanin structural genes by forming a MBW complex with CaAN1 and *** summary,this study provided a green hypocotyl mutant of pepper,and the Kompetitive Allele Specific PCR(KASP)marker developed based on the mutation site of the underlying gene would be helpful for pepper breeding.

关键词： Pepper CaTTG1 Anthocyanin Hypocotyl color Fine-mapping

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie jin Huajing Zhang Qianying Lu linqiang Tian Sanqiao Yao feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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一种适合于深空星际互联网的传输控制协议

计算机科学 2013年第1期40卷 37-40,80页

作者：金凤林刘炯崔玉萍南京大学计算机科学与技术系南京210093 解放军理工大学指挥自动化学院南京210007 解放军西安通信学院西安710106

目前国内外已经开展了大量针对同步卫星互联网的传输控制技术研究,提出了很多传输控制协议方案。然而,这些协议方案在信道条件更加恶劣的行星际互联网中的性能表现并不理想。针对深空通信信道特点,在TP-Sa-tellite协议的基础上提出了TP-... 详细信息

目前国内外已经开展了大量针对同步卫星互联网的传输控制技术研究,提出了很多传输控制协议方案。然而,这些协议方案在信道条件更加恶劣的行星际互联网中的性能表现并不理想。针对深空通信信道特点,在TP-Sa-tellite协议的基础上提出了TP-Satellite+协议。仿真表明,TP-Satellite+协议在月球与地球之间的行星际互联网中,不仅能够有效对抗信道误码,节省反向链路资源占用,而且能缩短连接建立时间,提高行星际互联网的网络性能。

关键词：深空通信行星际互联网传输控制协议 TP-Satellite+

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation