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Chinese Chemical Letters 2017年第5期28卷 981-985页

作者： jin-wei yuan Ling-Bo Qu School of Chemistry & Chemical Engineering Henan University of TechnologyAcademician Workstation for Natural Medicinal Chemistry of Henan Province

Direct C—H functionalization of quinoline N-oxides with arylboronic acids is achieved using KMnOas the sole and efficient oxidative *** method provides an efficient protocol to construct regioselectively 2-arylquinol... 详细信息

关键词： Quinoline N-oxide Arylboronic acid KMnO_4-mediated Radical reaction Arylation

A copper- and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand

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Chinese Chemical Letters 2012年第2期23卷 185-188页

作者： Wen Peng Mai jin wei yuan Zhi Cheng Li Gang Chun Sun Chemistry and Chemical Engineering School Henan University of TechnologyZhengzhou 450001China

An efficient palladium-catalyzed copper- and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new *** use of 2 mol%Pd（OAc）_2 i... 详细信息

关键词： Palladium Copper-free Coupling Sonogashira reaction Chlorophosphine

Palladium-catalyzed Suzuki couplings using a novel diaminophosphine oxide as ligand

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Chinese Chemical Letters 2012年第5期23卷 521-524页

作者： Wen Peng Mai Hui Hui Wang jin wei yuan Liang Ru Yang Zhi Cheng Li Chemistry and Chemical Engineering School Henan University of TechnologyZhengzhou 450001China

A novel diaminophosphine oxide was synthesized and applied as ligand in palladium-catalyzed Suzuki couplings reaction of aryl bromides and *** coupling reaction proceeded smoothly at mild conditions using 2 mol%Pd_2（... 详细信息

关键词： Palladium Suzuki reaction Coupling Diaminophosphine oxide

A novel and facile synthesis of 4-arylquinolin-2(1H)-ones under metal-free conditions

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Chinese Chemical Letters 2015年第8期26卷 977-979页

作者： Bin Sun Wen-Peng Mai Liang-Ru Yang Pu Mao jin-wei yuan Yong-Mei Xiao School of Chemistry and Chemical Engineering Henan University of Technology

A novel and facile synthesis of 4-arylquinolin-2（1H）-ones without metal catalysis has been *** reaction involved cyclization/elimination steps and was performed under metal-free conditions using inexpensive reagents... 详细信息

关键词： facile inexpensive steps catalysis cyclization elimination spectrometer silver catalyzed silica

On the regulation of PP2A and its role in controlling sister chromatid cohesion and microtubule-kinetochore attachment

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TMR Cancer 2020年第3期3卷 127-136页

作者： jin-wei yuan Tianjin Medical University Tianjin300070China

Protein phosphatase 2A(PP2A)plays a critical multi-faceted role in the regulation of the cell ***2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes,which are regulated spatially and temporally by specific *** requires the correct arrangement of sister chromatids so that replicated chromosomes can bind correctly to microtubules and segregate towards opposite poles.A large number of studies have shown that PP2A is mainly involved in a series of phosphorylation processes during the G2/M phase transition and the termination of M ***,PP2A shows a more substantial contribution to sister chromatid cohesion and microtubule-kinetochore *** processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases.

关键词： PP2A Cell cycle Sister chromatid cohesion Microtubule-kinetochore attachment

Network pharmacology： an important breakthrough in traditional Chinese medicine research

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TMR Integrative Medicine 2018年第3期2卷 92-98页

作者： jin-wei yuan Jian Hao Dan Chen School of Basic Medical Sciences Tianjin Medical University Tianjin China Tianjin Medical University Cancer Institute and Hospital Tianjin China.

Objective： To study the relationship between traditional Chinese medicine （TCM） research and network pharmacology. Methods： Discuss the common features of TCM and network pharmacology through the analysis of the characteristics of TCM, the background of network pharmacology, so as better interpretation of TCM and in-depth understanding of TCM research and network pharmacology. Results： Multicomponent and multitarget characteristics of TCM as same as the study thought of network pharmacology. Network pharmacology breaks through the research model of linear and coincides with the complexity of TCM, provides technical support for rational design of TCM formulae, both and a new way in the research of TCM. It becomes a new strategy for modern TCM research. Conclusion： Network pharmacology is an important breakthrough in TCM research, its research promote modernization and internationalization process of TCM conduce to the research and development of TCM and have important significance for the integration of Chinese and Western medicine.

关键词： Traditional Chinese medicine Network pharmacology Multicomponent Multitarget

Nephrotoxicity and carcinogenesis of aristolochic acids and their derivates

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Traditional Medicine Research 2018年第1期3卷 1-9页

作者： Zi-Qi jin jin-wei yuan Jian Hao Xiong-Zhi Wu Tianjin Medical University School of Basic Medical Sciences Department of Pharmacology Tianjin China TianjinMedical University Cancer Institute and Hospital Tianjin China

Aristolochic acids （AAs）, a natural mixture of 8-methoxy-6-nitro-phenanthro-（3,4-d）-1,3-dioxolo-5-carboxylic acid （AAI）and 6-nitro-phenanthro-（3,4-d）-1,3-dioxolo-5-carboxylic acid （AAII）, derived from aristolochiaceae species, has beenreported to cause AAS-induced nephropathy and upper urothelial cancer. In this review, we summarize the informationon the nephrotoxicity and carcinogenesis of AAs and their derivatives. AAs nephrotoxicity can lead to apoptosis andoxidative stress of renal tubular cells, and inhibition of the expression of aquaporins. AAs can also reduce the capabilityfor renal tubular epithelial cell repair after acute injury and further produce renal fibrosis by activating TGF-β-Smadsignaling and promoting the migration of macrophages. Moreover, AAs-induced carcinogenesis may be due to theformation of covalent adducts with DNA which can lead to the mutation in certain tumor suppressor genes orproto-oncogenes and the different catalyzing capacity of the microsomal cytochrome P450 of individuals in AAImetabolism.

关键词： Aristolochic acids Aristolochic acids nephropathy Nephrotoxicity Carcinogenesis

Th(Ⅳ) and U(Ⅵ) removal by TODGA in ionic liquids:extraction behavior and mechanism,and radiation effect

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Nuclear Science and Techniques 2017年第5期28卷 28-34页

作者： Zhen Dong wei-jin yuan Chao Liu Long Zhao Chao Zhao Fang-Dong Tang Lin-Feng He Non-power Nuclear Technology Collaborative Innovation Center School of Nuclear Technology and Chemistry & Biology Hubei University of Science and TechnologyXianning 437100 China School of Nuclear Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Division of Chemistry and Ionizing Radiation Measurement Technology Shanghai Institute of Measurement and Testing Technology Shanghai 201203 China

Extraction behavior of thorium(Ⅳ) and uranium(Ⅵ) from nitric acid(HNO_3) was studied using N,N,N',N'-tetraoctyldiglycolamide(TODGA) as extractant in different ionic liquids, and isooctane as *** analyses with varying HNO_3 concentrations and diluents revealed the extraction mechanism. With increasing length of alkyl chain and HNO_3 concentration, the extraction mechanism of TODGA/IL system changed from cation exchange to neutral complex and/or anion exchange,and the molar ratio between TODGA and metal ions varied gradually from 2:1 to 1:1 for Th(Ⅳ) and 3:1 to 1:1 for U(Ⅵ). The kinetics and thermodynamic studies of Th(Ⅳ)and U(Ⅵ) by the best TODGA/[C_2mim][NTf_2] system showed that the extraction equilibrium was reached within 2 h and extraction reactions were endothermic. Compared to TODGA/isooctane system, TODGA/[C_2mim][NTf_2]system presented higher radiation stability under c-irradiation. Therefore, it would have a promising application in spent fuel reprocessing.

关键词： Extraction TODGA Ionic liquids Thorium(IV) and uranium(VI) Radiation effect

Melting Evaluation of Phase Change Materials Impregnated into Cascaded Metal Foams with Regionalized Enhancement

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Journal of Thermal Science 2025年第1期34卷 223-241页

作者： wei Xinyi ZHANG Nan ZHANG Zhaoli CAO Xiaoling yuan Yanping School of Mechanical Engineering Southwest Jiaotong University

Metal foam promotes the heat transfer of phase change materials(PCMs) in the penalty of reducing the energy storage density of the composite *** this work,the effects of constant porosity(0.96,0.94,0.92,or 0.90) and pore density(PPI) of metal foam on heat transfer of composite PCMs are *** rate could be enhanced by employing with low porosity copper ***,aiming to the right bottom phase changing "dead region",a regionalized enhancement strategy of cascaded metal foams is *** dynamic melting performances of all the composite PCMs are comprehensively *** results reveal that the cascaded configuration is beneficial for *** show that the horizontal strategy enhances melting performance:a maximum of 17.98% reduction in total melting time could be reached when the rear part porosity is 90%.The energy storage density rate could be raised by 5.48%.Besides,the vertical strategy performs with a better average temperature uniformity of 0.441 and brings a lower temperature in the heated *** sum up,the regionalized enhancement of copper foam provides better performance in the phase change *** shows significant potential for solar heat storage and thermal protection.

关键词： copper metal foam heat transfer enhancement phase change materials regionalized enhancement

Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： LI Shuiping CHENG Jian wei Chao yuan Bin YU Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss