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Degradable and Tunable Keratin-fibrinogen Hydrogel as Controlled Release System for Skin Tissue Regeneration

Journal of Bionic Engineering 2023年第3期20卷 1049-1059页

作者： Sung Jun Min Jae Seo Lee Haram Nah Ho-jin Moon Sang jin Lee Hyeon jeong Kang Yu-Shik Hwang Il Keun Kwon Dong Nyoung Heo Department of Dentistry Graduate SchoolKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Biofriends Inc 26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Dental Materials School of DentistryKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology School of DentistryKyung Hee UniversitySeoul02447Korea Kyung Hee University Medical Science Research Institute Kyung Hee University23 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea

Biodegradable hydrogels are promising biomaterials for use in controlled-release systems for skin tissue regeneration. Controlled delivery systems constitute an important aspect of tissue engineering because they can modulate various physiological responses, including early immune response, tissue remodeling, and cell proliferation and maturation in the wound-healing process. Hydrogels composed of various biomaterials have been developed to overcome the limitations of conventional drug- or protein-delivery systems, such as limited targeting ability, low stability, and the induction of drug resistance. Hydrogels based on keratin, a natural polymer extracted from human hair, can provide adequate cell support and control homeostasis. Consequently, they can be applied for skin tissue engineering. In this study, we prepared degradable, tunable, and biocompatible hydrogels for controllable protein delivery. We synthesized keratin-fibrinogen (KER-FBG) by the chemical coupling reaction and prepared hydrogels through polymerization with thrombin. The structures and morphologies of the KER-FBG hydrogels were confirmed. Furthermore, the mechanical properties, swelling ratio, degradation, release behavior, and biocompatibility were investigated. The KER-FBG hydrogels presented promising biological performance, indicating that the material is suitable as a controlled protein delivery carrier.

关键词： Keratin Fibrinogen Hydrogel Drug delivery Degradable

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Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes

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Acta Pharmacologica Sinica 2007年第4期28卷 503-510页

作者： Cuk-seong KIM Nam LEE sook-jin SON Kyu-seung LEE Hyo-shin KIM Yong-geun KWAK Soo-wan CHAE Sang-do LEE Byeong-hwa JEON jin-bong PARK Department of Physiology College of MedicineChungnam National UniversityDaejeon 301131Korea Department of Pharmacology Chonbuk National UniversityMedical SchoolChonju 561-180Korea

Aim:To characterize the effects of papaverine on HERG channels expressed inXenopus oocytes as well as cardiac action potential in rabbit ventricular ***:Conventional microelectrodes were used to record action potential inrabbit ventricular *** currents were recorded by 2-electrode voltageclamp technique in Xenopus oocytes injected with HERG ***:Papa-verine increased the cardiac action potential duration in rabbit ventricular *** blocked heterologously-expressed HERG currents in a concentration-depen-dent manner (IC5071.03±4.75 μmol/L,NH 0.80,n=6),whereas another phosphodi-esterase inhibitor,theophylline （500 μmol/L）,did *** blockade of papaverineon HERG currents was not *** slope conductance measuredas a slope of the fully activated HERG current-voltage curves decreased from78.03±4.25 μS of the control to 56.84±5.33,36.06±6.53,and 27.09±5.50 μS （n=4） by30,100,and 300 μmol/L of papaverine,*** （100 μmol/L）caused a 9 mV hyperpolarizing shift in the voltage-dependence of steady-stateinactivation,but there were no changes in the voltage-dependence of HERG cur-rent *** blocked HERG channels in the closed,open,andinactivated ***:These results showed that papaverine blockedHERG channels in a voltage-and state-independent manner,which may mostlikely be the major mechanism of papaverine-induced cardiac arrhythmia reportedin humans.

关键词： papaverine HERG cardiac action potential

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Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第13期18卷 1525-1530页

作者： Hye Ran Yang Hae Ryoung Kim Myung jin Kim Jae Sung Ko jeong Kee Seo Department of Pediatrics Seoul National University College of MedicineSeoul 110-744South Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnam-siGyonggi-do 463-707South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam-siGyonggi-do 464-894 South Korea

AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild(stage 0-1)vs significant fibrosis(stage 2-4).Clinical and laboratory parameters were evaluated in each *** aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST/platelet ratio index(APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index(PNFI)were ***:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant *** noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis(APRI:0.67±0.54 vs 0.78±0.38,P=0.032 and FIB4:0.24±0.12 vs 0.31±0.21,P=0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index(0.73),APRI(0.70),NAFLD fibrosis score(0.58),AST/ALT ratio(0.53),PGA score(0.45),and PNFI(0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD.

关键词： Fatty liver Hepatic fibrosis Noninvasive Obesity Child

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Effect of Asiasari radix on osteoblastic differentiation of stem cells derived from gingiva

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Journal of Traditional Chinese Medicine 2016年第6期36卷 756-759页

作者： Su-Hyeon jeong Ji-Eun Lee Seong-Ho jin Youngkyung Ko Jun-Beom Park Department of Rehabilitation Medicine of Korean Medicine Chungju Hospital of Korean MedicineCollege of Korean Medicine Semyung University Development of Periodontics College of MedicineThe Catholic University of Korea

OBJECTIVE: To examine the dose-dependent impact of Asiasari Radix(A. radix) on the cell viability,differentiation and mineralization of stem cells derived from ***: Stem cells that were derived from gingiva were grown in the presence of A. radix at final concentrations that ranged from 0.001 to 10 μg/m L. The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed by using Cell Counting Kit-8(CCK-8) on day 1. The alkaline phosphatase activity test was used to assess differentiation and Alizarin red S staining was used to assess mineralization of treated ***: The control group showed spindleshaped, fibroblast-like morphology and the shapesof the cells in 0.001, 0.01, 0.1, 1 and 10 μg/mL of *** were similar to that of the control group at day 1. The cultures growing in the presence of0.001 μg/m L of A. radix at day 1 showed an increase in the CCK-8 value(P 0.05). Mineralized extracellular deposits were observed after Alizarin Red S staining and the cultures grown in the presence of 0.001 μg/m L of A. radix showed the highest value for quantitative results for bound dye(P < 0.05).CONCLUSION: Within the limits of this study, A. radix influenced the proliferation of stem cells derived from the gingiva and low concentrations of *** might enhance osteogenic differentiation of the stem cells.

关键词： Cell differentiation Plant roots Plant extracts Stem cells Drugs,Chinese herbal

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Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function

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Neural Regeneration Research 2023年第11期18卷 2497-2503页

作者： Yeonghoon Son Hye-jin Park Ye Ji jeong Hyung-Do Choi Nam Kim Hae-June Lee Division of Radiation Biomedical Research Korea Institute of Radiological&Medical SciencesSeoulKorea Department of EMF Research Team Radio and Broadcasting Technology LaboratoryElectronics and Telecommunications Research InstituteDaejonKorea School of Electrical and Computer Engineering Chungbuk National UniversityCheongjuKorea

We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including *** examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 *** conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain *** confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-β*** expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed ***,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated *** radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by *** res

关键词： 5×FAD Alzheimer’s disease CSF1R long term exposure microglial function neuroinflammation radiofrequency electromagnetic fields therapeutic effect

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Relation between preoperative hyperopia and surgical outcome in infantile esotropia

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1963-1967页

作者： Haeng jin Lee jeong-Ah Kim Seong-Joon Kim Young Suk Yu Department of Ophthalmology Seoul National University College of Medicine Seoul Artificial Eye Center Seoul National University Hospital Clinical Research Institute

AIM: To evaluate the relation between preoperative hyperopia and surgical outcomes of infantile esotropia in patients younger than 24 months of ***: Medical records of patients who underwent bilateral medial rectus muscle recession for infantile esotropia between November 1, 2002 and December 1, 2011 were retrospectively reviewed. Patients were divided into two groups according to the degree of preoperative hyperopia. Group I had less than +3.0 diopter(D) of hyperopia and group II had between +3.0 and +5.0 D of hyperopia. Postoperative alignments were evaluated 1 wk, 3, 6 mo, and 1 y after surgery. Following the 1-year postoperative visit, patients were monitored yearly. Relationships between preoperative factors including hyperopia and postoperative outcomes were evaluated. RESULTS: Forty-six patients were included, with 33 patients in group I and 13 patients in group II. The preoperative mean refractive error was +0.88 D in group I and +3.45 D in group II. Surgical outcomes were not significantly different between groups at any postoperative time point examined. Cumulative probability of surgical success, prevalence of inferior oblique overaction, dissociated vertical deviation, and re-operation rate were not significantly different between ***: Preoperative moderate hyperopia(less than +5.0 D) did not affect the surgical outcome of infantile esotropia. Therefore, the surgical correction of esotropia should be considered when the angle of esodeviation is unchanged following hyperopia correction, even in children with moderate hyperopia.

关键词： infantile esotropia hyperopia medial rectus muscle recession

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Incidence of venous thromboembolism and the role of D-dimer as predictive marker in patients with advanced gastric cancer receiving chemotherapy:A prospective study

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World Journal of Gastrointestinal Oncology 2017年第4期9卷 176-183页

作者： Kwonoh Park Baek-Yeol Ryoo Min-Hee Ryu sook Ryun Park Myoung Joo Kang jeong Hye Kim Seungbong Han Yoon-Koo Kang Medical Oncology and Hematology Department of Internal medicinePusan National University Yangsan Hos-pital Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Clinical Epidemiology and Biostatics Asan Medical CenterUniversity of Ulsan College of Medicine

To investigated the incidence and risk factors of venous thromboembolism (VTE) in patients with advanced gastric cancer (AGC) receiving chemotherapy. METHODSAll consecutive chemotherapy-naïve patients with AGC who would receive palliative chemotherapy between November 2009 and April 2012 in our hospital were recruited. Their pretreatment clinical and laboratory variables, including D-dimer, were recorded. The frequency of VTE development and survival rates during each chemotherapy cycle and regularly thereafter were assessed. RESULTSA total of 241 patients enrolled between November 2009 and April 2012 were analyzed. During a median follow-up duration of 10.8 mo (95%CI: 9.9-11.7), 27 patients developed VTE and the incidence of VTE was 17.5% (95%CI: 10.5-24.0, 12.0 events/100 person-years). The 6-mo and 1-year cumulative incidences were 7.8% (95%CI: 4.2%-11.4%) and 12.4% (95%CI: 7.3-17.2), respectively. Thirteen (48.1%) patients were symptomatic and the other 14 (51.9%) patients were asymptomatic. In multivariate analysis, pretreatment D-dimer level was the only marginally significant risk factor associated with VTE development (hazard ratio = 1.32; 95%CI: 1.00-1.75, P = 0.051). CONCLUSIONThe incidence of VTE is relatively high in patients with AGC receiving chemotherapy, and pretreatment D-dimer level might be a biomarker for risk stratification of VTE.

关键词： Advanced gastric cancer D-dimer Venous thromboembolism

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High-temperature Oxidation Behavior of Zircaloy-4 and Zirlo in Steam Ambient

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Journal of Materials Science & Technology 2010年第9期26卷 827-832页

作者： Hyung Hoon Kim Jun Ho Kim jin Young Moon Ho Seong Lee jeong Joo Kim Young Suck Chai School of Materials Science and Engineering Kyungpook National University School of Mechanical Engineering Yeungnam University214-1 Dae-dongGyeongsan-si

The oxidation characteristics for Zircaloy-4 and Zirlo in the temperature range of 700-1200°C under steam supply condition were investigated by using a modified thermo-gravimetric *** specimens were oxidized for 3600 s at each temperature and then quenched in a *** oxidation rate constants were measured from the weight gains to evaluate the oxidation behavior in Zircaloy-4 and *** weight gain rates of Zirlo were lower than those of Zircaloy-4,leading to the low rate *** different oxidation behaviors between both cladding materials were considered to be due to the difference in their chemical compositions.

关键词： Zircaloy-4 Zirlo Oxidation

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Preoperative considerations, operative preparation,and postoperative care for rib cartilage use in rhinoplasty

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Plastic and Aesthetic Research 2019年第3期6卷 26-32页

作者： Jong sook Yi Dr.jin's Premium Nose Clinic Seoul 06524South Korea

Rib cartilage is the most reliable material for structural support and dorsal augmentation in Asian rhinoplasty with its robust strength and bountiful amount. Its value is incomparable especially in complex, cartilage-depleted revision surgery or major reconstruction. There are many articles regarding harvesting and carving of rib cartilage in rhinoplasty,however, only few has focused on preoperative and postoperative issues. Preoperatively, evaluating cartilage availability, assessing quality and quantity of cartilage, and choosing the cartilage to harvest are necessary. Although easily overlooked, proper postoperative management of rib cartilage rhinoplasty patients is key to prevent infection and heighten patient satisfaction. Here in, I would like to introduce how I evaluate rib cartilage rhinoplasty patients preoperatively and manage them postoperatively to maximize the surgical results.

关键词： Rib cartilage rhinoplasty autologous graft preoperative evaluation postoperative management

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Electrochemical and structural evolution of structured V_(2)O_(5) microspheres during Li-ion intercalation

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Journal of Energy Chemistry 2021年第4期30卷 108-113页

作者： Sul Ki Park Puritut Nakhanivej jeong Seok Yeon Kang Ho Shin Wesley M.Dose Michael De Voider jin Bae Lee Hae jin Kim Ho Seok Park School of Chemical Engineering Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea Institute for Manufacturing Department of EngineeringUniversity of CambridgeCambridge CB30FSUnited Kingdom Department of Chemistry University of CambridgeLensfield RoadCambridge CB21EWUnited Kingdom Research Center for Materials Analysis Korea Basic Science InstituteDaejeonRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University2066SeoburoJangan-guSuwon440-746South Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea

With the development of stable alkali metal anodes,V_(2)O_(5) is gaining traction as a cathode material due to its high theoretical capacity and the ability to intercalate Li,Na and K ***,we report a method for synthesizing structured orthorhombic V_(2)O_(5) microspheres and investigate Li intercalation/deintercalation into this *** industry adoption,the electrochemical behavior of V_(2)O_(5) as well as structural and phase transformation attributing to Li intercalation reaction must be further *** synthesized V_(2)O_(5) microspheres consisted of small primary particles that were strongly joined together and exhibited good cycle stability and rate capability,triggered by reversible volume change and rapid Li ion *** addition,the reversibility of phase transformation(a,e,d,c and xLixV_(2)O_(5))and valence state evolution(5+,4+,and 3.5+)during intercalation/de-intercalation were studied via in-situ X-ray powder diffraction and X-ray absorption near edge structure analyses.

关键词： Lithium ion batteries Vanadium pentoxide(V2O5) In-situ analysis Phase transformation Intercalation/de-intercalation

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