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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei jin Liu Tao Zhu Cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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Operational limits of a non-homogeneous dielectric elastomer transducer

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International Journal of Smart and Nano Materials 2017年第4期8卷 214-231页

作者： Anup Teejo Mathew Soo jin Adrian koh Department of Mechanical Engineering National University of SingaporeSingaporeSingapore

Operation of a dielectric elastomer(DE)transducer is limited by the way it fails,and any other limits imposed by the *** example,material rupture and dielectric breakdown are two examples of transducer failure,while tension loss is a user-imposed *** instability may or may not result in transducer failure,but is often considered as a boundary to denote the onset of state *** a DE undergoing homogeneous deformation,constructing operational limits on work-conjugate state diagrams are rather ***,for DE subjected to non-homogeneous deformation,the process is more *** present a method to plot the operational boundaries of a DE subject to non-homogeneous deformation,known commonly as the Universal Muscle Actuator or the loudspeaker *** analysis show that tension loss need not be imposed as a hard operational limit,and that there is further operational space for the transducer,post tension *** plotting the operational limits on work-conjugate planes,we determine an optimal inner-to-outer ring ratio and the required pre-stretches that maximize energy conversion.

关键词： Dielectric elastomer non-homogeneous operational limits loudspeaker configuration

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Fabrication of La,Ce co-doped ZnO nanorods for improving photodegradation of methylene blue

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Journal of Rare Earths 2024年第1期42卷 76-83,I0003页

作者： Erfan Hakim Azmal Zaid jin-Chung sin Sze-Mun Lam Abdul Rahman Mohamed School of Chemical Engineering Universiti Sains Malaysia(USM)14300Nibong TebalPenangMalaysia College of Environmental Science and Engineering Guilin University of TechnologyGuilin541004China Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control Guilin University of TechnologyGuilin541004China Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area Guilin University of TechnologyGuilin541004China Faculty of Engineering and Green Technology Universiti Tunku Abdul RahmanJalan UniversitiBandar Barat31900KamparPerakMalaysia

La,Ce co-doped ZnO nanorods(ZnLC)were synthesized through a one-step solvothermal *** photocatalysts were characterized by X-ray diffraction,Raman spectroscopy,field-emission scanning electron microscopy,energy dispersive X-ray,transmission electron microscopy,UV-vis diffuse reflectance spectroscopy and photo luminescence *** La and Ce doping enhanced the visible light absorption ability of ZnLC and a red shift was detected for *** simulated solar light irradiation,the ZnO doped with 3 at%La and 1 at%Ce(ZnLC1)degrades methylene blue(MB)more effectively than those of pure ZnO,La-doped ZnO(ZnL)and commercially available *** improved photocatalytic performance of ZnLC1 can be attributed to the high charge separation efficiency as demonstrated by the photoluminescence ***,the photocatalytic experiments reveal that several parameters have their own impact on the MB *** a variety of radical scavengers,it is discovered that superoxide anion radical plays a crucial role in the degradation of *** ZnLC1 is also reused several times without noticeable decrease of photoactivity,indicating that it has a substantial potential for environmental remediation applications.

关键词： ZnO Lanthanum Cerium Co-doping Photodegradation Rare earths

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高质量发展是全面建设社会主义现代化国家的首要任务

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 43-49,F0002页

作者：金碚中国社会科学院工业经济研究所北京100006

党的二十大报告提出以中国式现代化全面推进中华民族伟大复兴,形成对中国式现代化的系统性认知,强调高质量发展是全面建设社会主义现代化国家的首要任务。改革开放以来,在中国共产党的领导下,我国逐步摆脱观念桎梏和教条约束,坚持一切... 详细信息

党的二十大报告提出以中国式现代化全面推进中华民族伟大复兴,形成对中国式现代化的系统性认知,强调高质量发展是全面建设社会主义现代化国家的首要任务。改革开放以来,在中国共产党的领导下,我国逐步摆脱观念桎梏和教条约束,坚持一切从国情出发,创造了人类文明新形态。经济全球化势不可挡,世界必然是和而不同的全球格局,不同文明形态、不同经济体制、不同行为方式共存形成人类命运共同体。这是中国式现代化的底层逻辑,体现了中国经济高质量发展的世界意义。从中国式现代化视角透视高质量发展的深刻叙事,有助于深刻诠释中国式现代化的核心意涵。

关键词：高质量发展中国式现代化体制机制供需相宜因地制宜新质生产力

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui Chen Zuo-Tang Liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

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Advances of machine learning in materials science: Ideas and techniques

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Frontiers of physics 2024年第1期19卷 155-194页

作者： Sue sin Chong Yi Sheng Ng Hui-Qiong Wang jin-Cheng Zheng Department of New Energy Science and Engineering Xiamen University MalaysiaSepang 43900Malaysia Engineering Research Center of Micro-nano Optoelectronic Materials and Devices Ministry of EducationFujian Key Laboratory of Semiconductor Materials and ApplicationsCI Center for OSEDand Department of PhysicsXiamen UniversityXiamen 361005China

In this big data era, the use of large dataset in conjunction with machine learning (ML) has been increasingly popular in both industry and academia. In recent times, the field of materials science is also undergoing a big data revolution, with large database and repositories appearing everywhere. Traditionally, materials science is a trial-and-error field, in both the computational and experimental departments. With the advent of machine learning-based techniques, there has been a paradigm shift: materials can now be screened quickly using ML models and even generated based on materials with similar properties;ML has also quietly infiltrated many sub-disciplinary under materials science. However, ML remains relatively new to the field and is expanding its wing quickly. There are a plethora of readily-available big data architectures and abundance of ML models and software;The call to integrate all these elements in a comprehensive research procedure is becoming an important direction of material science research. In this review, we attempt to provide an introduction and reference of ML to materials scientists, covering as much as possible the commonly used methods and applications, and discussing the future possibilities.

关键词： machine learning materials science

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Harmonic Dark Pulse Emission in Erbium-Doped Fiber Laser

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Chinese Physics Letters 2015年第3期32卷 49-51页

作者： Zian Cheak Tiu Arman Zarei sin jin Tan Harith Ahmad Sulaiman Wadi Harun Department of ElectricM Engineering Faculty of Engineering University of Malaya Kuala Lumpur 50603 Malaysia Photonics Research Center University of Malaya Kuala Lumpur 50603 Malaysia School Of Engineering KDU University College Petaling Jaya 47400 Malaysia

A harmonic dark pulse generation in an erbium-doped fiber laser is demonstrated based on a figure-of-eight configuration. It is found that the harmonic dark pulse can be shifted from the fundamental to the 5th order harmonic by increasing the pump power with an appropriate polarization controller orientation. The fundamental repetition rate of 2O kHz is obtained at the pump power of 29 m W. The highest pulse energy of 42.6 n3 is obtained at the fundamental repetition rate. The operating frequency of the dark pulse trains shifts to 2nd, 3rd, 4th and 5th harmonic as the pump powers are increased to 34mW, 50mW, 59mW and 137mW, respectively.

关键词： Harmonic Dark Pulse Emission in Erbium-Doped Fiber Laser EDF DSF kHz

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Q-Switching Pulse Generation with Thulium-Doped Fiber Saturable Absorber

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Chinese Physics Letters 2014年第12期31卷 56-58页

作者： Zian Cheak Tiui Arman Zarei sin jin Tan Harith Ahmad Sulaiman Wadi Harun Department of Electrical Engineering Faculty of Engineering University of Malaya Kuala Lumpur 50603 Malaysia Photonics Research Center University of Malaya Kuala Lumpur 50603 Malaysia School of Engineering KDU University College SS22/41 Damansara Jaya PetMing Jaya 47400 Selangor Darul Ehsan Malaysia

Q-switched pulsed laser systems operating in the eye-safe wavelength region （λ〉 1.4 μm） are promis- ing for applications such as light detection and ranging （lidar）, differential absorption lidar, optical communi- cation, sensor and instrumentations. Fiber lasers are particularly attractive for such applications due to the fact that the beam quality can be independent of output power and they can be robustly engineered. There is an increasing interest in Q-switched erbium- doped fiber lasers （EDFLs）, which can be generated by using either active or passive techniques. Com- pared with the actively Q-switched ones, passively Q- switched EDFLs have attracted much attention for their advantages of compactness, low cost, flexibility and simplicity of design. Different kinds of saturable absorbers, such as the transition metal-doped crys- tals and semiconductor quantum-well structures, have been applied to realize Q-switched ***- ever, when they are used in the laser cavity, additional alignment devices, such as lens, mirrors or U-bench units, have to be applied. This may increase the in- sertion loss and the complexity of the laser cavity.

关键词： Q-switching THULIUM DOPED semiconductors FIBER lasers ABSORPTION LASER pumping

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Nonlinear Polarization Rotation-Based Mode-Locked Erbium-Doped Fiber Laser with Three Switchable Operation States

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Chinese Physics Letters 2014年第9期31卷 76-78页

作者： Zian Cheak Tiu sin jin Tan Arman Zarei Harith Ahmad Sulaiman Wadi Harun Department of Electrical Engineering Faculty of Engineering University of Malaya Kuala Lumpur 0603 Malaysia Photonics Research Center University of Malaya Kuala Lumpur 50603 Malaysia School of Engineering KDu University Collegel Petaling Jaya 47400 Malaysia

A simple mode-locked erbium-doped fiber laser （EDFL） with three switchable operation states is proposed and demonstrated based on nonlinear polarization rotation. The EDFL generates a stable square pulse at a third harmonic pulse repetition rate of 87kHz as the 1480 nm pump power increases from the threshold of 17.5 m W to 34.3mW. The square pulse duration increases from 105 ns to 245ns as the pump power increases within this region. The pulse operation switches to the second operation state as the pump power is varied from 48.2mW to *** W. The laser operates at a fundamental repetition rate of 29 kHz with a fixed pulse width of 8.5 μs within the pump power region. At a pump power of ***, the average output power is 3.84mW, which corresponds to the pulse energy of 131.5 ng. When the pump power continues to increase, the pulse train experiences unstable oscillation before it reaches the third stable operation state within a pump power region of 138.9 m W to 145.0 m W. Within this region, the EDFL produces a fixed pulse width of 2.8 μs and a harmonic pulse repetition rate of 58 kHz.

关键词： NONLINEAR theories RESEARCH POLARIZATION (Nuclear physics) FIBER lasers HARMONICS (Electric waves) ERBIUM

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