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Dysbiosis of oral and gut microbiota and its association with metabolites in patients with different degrees of coronary artery stenosis

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Chinese Medical Journal 2024年第9期137卷 1121-1123页

作者： Zekun Wang long Li Chenyang Wang Qian Wang Fengzhi Wang Xin xu xuedong Zhou State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041China Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduSichuan 610041China Department of Cardiology Shanxi Provincial Key Laboratory of Cardiovascular Disease DiagnosisTreatment and Clinical PharmacologyThe Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China

To the Editor:Coronary atherosclerotic heart disease(CAD)arises from coronary atherosclerosis(CAS)plaque buildup,resulting in coronary stenosis(CS)and occlusion,ultimately causing myocardial ischemia,hypoxia,or *** showed that the high-grade CS may be an important predictor of ST segment elevation myocardial infarction in subsequent months.

关键词： coronary stenosis occlusion

The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms

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BIOCELL 2024年第6期48卷 889-896页

作者： MINGYUE HUANG JUNFEI DAI XIANLIANG ZHONG jin WANG JIANZHONG xu BO DU School of Medicine Southern University of Science and TechnologyShenzhen518055China Department of Emergency Shenzhen People’s HospitalThe Second Clinical Medical College of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and TechnologyShenzhen518055China

Chronic subdural hematoma(CSDH)is a disease characterized by capsuled blood products that progressively occupy the intracranial space,causing intracranial hypertension and compression in the *** frequently occurs in all demographics,especially in the elderly,but the pathogenesis of CSDH remains *** this review,we discuss the origin,development,and current treatment strategies of *** theﬁrst time,we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation,a complex early-stage interactive event in hematoma *** hypothesize that in patients with CSDH,dural border cells(DBCs)might be induced to synthesize collagen or serum proteins might accumulate at the dura and arachnoid layers at the site of injury,thereby encapsulating the *** formation may trigger inﬂammatory responses after subdural hemorrhage,promotingﬁbroblast-involved extracellular matrix(ECM)deposition and aberrant angiogenesis within the outer ***,ECM deposition and angiogenesis mutually inﬂuence each other and are modulated by inﬂammatory *** illustrating the complex and interactive mechanism of neomembrane formation,we aim to provide a novel insight into CSDH pathogenesis and propose directions for future research as well as advancements in treatment strategies for this disease.

关键词： Chronic subduralhematoma Inflammation Angiogenesis Extracellular matrix Hyperfibrinolysis

Relationship between dietary niacin intake and erectile dysfunction:a population-based study

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Asian Journal of Andrology 2024年第4期26卷 382-388页

作者： Wei-long Lin Cheng Zheng Hao-xu Wang Wei Zhang Ming-En Lin Department of Urology The First Affiliated Hospital of Shantou University Medical CollegeMedical College of Shantou UniversityShantou 515041China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510260China.

Existing research on the precise link between dietary niacin intake and erectile dysfunction(ED)is ***,this study aimed to investigate the potential association between dietary niacin intake and the risk of *** logistic regression and restricted cubic splines(RCSs)were used to examine the relationship between dietary niacin intake and *** interaction analysis was performed to assess the impact of different subgroups on the study *** addition,1:1 propensity score matching(PSM)was employed to adjust for potential confounding factors,ensuring the reliability of the *** analyzed data were collected from the 2001–2004 National Health and Nutrition Examination Survey(NHANES)in the *** study encompassed 3184 adults,among whom 863 participants were identified as having *** adjustments for potential confounders,the findings revealed that higher niacin intake,specifically in the highest tertile,was associated with a decreased risk of ED compared to that in the lowest tertile,showing an odds ratio(OR)of 0.56(95%confidence interval[CI]:0.37–0.85).Analysis of dose–response curves illustrated a negative correlation between dietary niacin intake and the risk of *** and interaction analyses fortified the consistency of these ***,PSM corroborated the validity of the *** study suggests an inverse association between dietary niacin intake and the risk of ***,establishing a cause-and-effect relationship remains elusive,and defining the safe threshold of niacin intake to prevent ED requires further investigation.

关键词： dietary niacin erectile dysfunction National Health and Nutrition Examination Survey propensity score matching

Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2298-2316页

作者： Jie Shan xu jin Cong Zhang Muchen Huang Jianghao Xing Qingrong Li Yuyu Cui Qiang Niu xu Lin Chen Xianwen Wang Department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefei 230032China Division of Gastroenterology the First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China The Second Clinical Medical College Anhui Medical UniversityHefei 230022China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China College and Hospital of Stomatology Anhui Medical UniversityKey Lab.of Oral Diseases Research of Anhui ProvinceHefei 230032China

Bacterial infection hampers wound repair by impeding the healing ***,inflammation at the wound site triggers the production of reactive oxygen species(ROS),causing oxidative stress and damage to proteins and *** can lead to chronic wounds,posing severe ***,eliminating bacterial infection and reducing ROS levels are crucial for effective wound ***,possessing enzyme-like catalytic activity,can convert endogenous substances into highly toxic substances,such as ROS,to combat bacteria and biofilms without inducing drug ***,the current nanozyme model with single enzyme activity falls short of meeting the complex requirements of antimicrobial ***,developing nanozymes with multiple enzymatic activities is ***,we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles(Ru-PC NPs)with diverse enzymatic activities to aid wound healing and combat bacterial *** acidic conditions,due to their glutathione(GSH)depletion and peroxidase(POD)-like activity,Ru-PC NPs combined with H2O2 exhibit excellent antibacterial ***,in a neutral environment,the Ru-PC NPs,with catalase(CAT)activity,decompose H2O2 to O2,alleviating hypoxia and ensuring a sufficient oxygen ***,Ru-PC NPs possess exceptional antioxidant capacity through their superior superoxide dismutase(SOD)enzyme activity,effectively scavenging excess ROS and reactive nitrogen species(RNS)in a neutral *** maintains the balance of the antioxidant system and prevents ***-PC NPs also promote the polarization of macrophages from M1 to M2,facilitating wound *** importantly,Ru-PC NPs show good biosafety with negligible *** vivo wound infection models have confirmed the efficacy of Ru-PC NPs in inhibiting bacterial infection and promoting wound *** focus of this work highlights the quadruple enzymatic activity of Ru-PC NPs and its potential to reduce inf

关键词： Nanozymes Quadruple enzymatic activity Antibacterial therapy Wound therapy RNA-seqAnti-inflammatory Reactive oxygen species Reactive nitrogen species

Influence of Polyaluminum Chloride Residue on the Strength andMicrostructure of Cement-Based Materials

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1299-1312页

作者： Ping xu Zhiwei Zhang Zhenguo Hou Mankui Zheng jin Tong School of Civil Engineering Henan Polytechnic UniversityInternational Joint Research Laboratory of Henan Province for Underground Space Development and Disaster PreventionJiaozuo454003China China Construction Seventh Engineering Division Co. Ltd.Zhengzhou450004China China Construction Seventh Engineering Division Co. Ltd.General Contracting CompanyZhengzhou450004China

In this paper,cement and dechlorinated Polyaluminum Chloride Residue(PACR)have been used to prepare a net slurry and mortar *** hydration activity indicators have been used to quantitatively analyze the dechlorinated PACR hydration *** particular,the effect of dechlorinated PACR content on the compressive strength of mortar has been assessed by means of compressive strength ***,X-ray diffraction(XRD)and scanning electron microscopy(SEM)have been employed to observe the microstructure of the considered hydration *** following results have been *** 28th day activity index of the dechlorinated PACR is 75%,and therefore it meets the criterion for the use of active *** increase in the content of the dechlorinated PACR tends to reduce the compressive strength of mortar specimens,however,it is beneficial to its later strength *** the content is not greater than 10%,the strength remains unchanged,otherwise,it *** PACR does not form a new crystalline phase in the cement slurry,and the dechlorinated PACR remains active until the age of the 28th *** inclusion of the PACR mainly deteriorates the early strength of the cement slurry,but it promotes the production of hydration products in the cement slurry after the 7th day.

关键词： Dechlorinated polyaluminum chloride residue activity index strength microstructure hydration product

Clinical efficacy of laparoscopic cholecystectomy combined with endoscopic papillary balloon dilation in treatment of gallbladder stones with common bile duct stones: A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1700-1708页

作者： Hong-Dan Liu Qi Zhang Wen-Si xu Shuang jin Department of Gastroenterology The Third Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina

BACKGROUND The incidence of cholelithiasis has been on the rise in recent years,but the choice of procedure is *** To investigate the efficacy of laparoscopic cholecystectomy(LC)combined with endoscopic papillary balloon dilation(EPBD)in patients with gallbladder stones(GS)with common bile duct stones(CBDS).METHODS The clinical data of 102 patients with GS combined with CBDS were selected for retrospective analysis and divided into either an LC+EPBD group(n=50)or an LC+endoscopic sphincterotomy(EST)group(n=52)according to surgical ***-related indexes,postoperative recovery,postoperative complications,and expression levels of inflammatory response indexes were compared between the two *** Total surgical time,stone free rate,rate of conversion to laparotomy,and successful stone extraction rate did not differ significantly between the LC+EPBD group and LC+EST *** hemorrhage,time to ambulation,and length of hospitalization in the LC+EPBD group were lower than those of the LC+EST group(P<0.05).The rate of total complications of the two groups was 9.80%and 17.65%,respectively,and the difference was not statistically *** serious complications occurred in either *** 48 h postoperatively,the expression levels of interleukin-6,tumor necrosis factor-α,high-sensitivity Creactive protein,and procalcitonin were lower in the LC+EPBD group than in the LC+EST group(P<0.05).At 3 d postoperatively,the expression levels of aspartate transaminase,alanine transaminase,and total bilirubin were lower in the LC+EPBD group than in the LC+EST group(P<0.05).CONCLUSION LC combined with EPBD and LC combined with EST are both effective procedures for the treatment of GS with CBDS,in which LC combined with EPBD is beneficial to shorten the patient’s hospitalization time,reduce the magnitude of elevated inflammatory response indexes,and promote postoperative recovery.

关键词： Gallbladder stone Common bile duct stone Endoscopic papillary balloon dilation Laparoscopic cholecystectomy Endoscopic sphincterotomy

Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

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Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： Ying-Ying xu Chan jin Meng Wu Jian-Ye Zhou Hui-Ling Wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

Highly efficient photo-thermal synergistic catalysis of CO_(2)methanation over La1-xCexNiO_(3)perovskite-catalyst

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Nano Research 2024年第9期17卷 7945-7956页

作者： Ting Li Zhen-Yu Zhang De-Cun Luo Bo-Yu xu Rong-Jiang Zhang Ji-long Yao Dan Li Tao Xie Institute of Industrial Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Solar-driven photo-thermal catalytic CO_(2)methanation reaction is a promising technology to alleviate the problems posed by greenhouse gases ***,designing advanced photo-thermal catalysts remains a research challenge for CO_(2)methanation *** this work,a series of ABO3(A=lanthanide,B=transition metal)perovskite catalysts with Ce-substituted LaNiO3(La1-xCexNiO3,x=0,0.2,0.5,0.8,1)were synthesized for CO_(2)*** La0.2Ce0.8NiO3 exhibited the highest CH4 formation rate of 258.9 mmol·g^(-1)·hcat-1,CO_(2)conversion of 55.4%and 97.2%CH4 selectivity at 300℃with the light intensity of 2.9 W·cm^(-2).Then the catalysts were thoroughly analyzed by physicochemical structure and optical properties *** partial substitution of the A-site provided more active sites for the adsorption and activation of CO_(2)/H_(2).The sources of the active sites were considered to be the oxygen vacancies(Ov)created by lattice distortions due to different species of ions(La^(3+),Ce^(4+),Ce^(3+))and exsolved Ni0 by H_(2)*** catalysts have excellent light absorption absorbance and low electron-hole(e-/h+)recombination rate,which greatly contribute to the excellent performance in photo-thermal synergistic catalysis(PTC)CO_(2)*** results of in situ irradiated electron paramagnetic resonance spectrometer(ISI-EPR)and ISI-X-ray photoelectron spectroscopy(XPS)indicated that the aggregation of unpaired electrons near the defects and Ni metal(from La and Ce ions to Ov and Ni0)accelerated adsorption and activation of CO_(2)/H_(2).At last,the catalyst properties and structure were correlated with the proposed reaction mechanism from the in situ diffuse reflection infrared Fourier transform spectrum(DRIFTS)*** in situ precipitation of the B-site enhanced the dispersion of Ni,while its enriched photoelectrons upon illumination further promote hydrogen *** H^(*)spillover accelerated the rate-determining step(RDS)of H

关键词： photo-thermal catalysis CO_(2)methanation perovskite A-site substitution in situ diffuse reflection infrared Fourier transform spectrum(DRIFTS)

Protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by Lipopolysaccharide in Mice through Endothelial Barrier Repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： xu Han xu Si-cong LI Li-yan WU Yu-huang TAN Yin-feng CHEN long LIU Pei LIANG Chang-fu HE Xiao-ning LI Yong-hui Hainan Provincial Key Lab of Research&Development on Tropic Herbs Hainan Medical UniversityHaikou571199China Department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in mice and explore the ***:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=12),including control(normal saline),LPS(5 mg/kg),LPS+DMS 2.5 mL/kg,LPS+DMS 5 mL/kg,LPS+DMS 10 mL/kg,and LPS+Dexamethasone(DXM,5 mg/kg) *** pretreatment with DMS and DXM,the ALI mice model was induced by LPS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory *** lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was *** levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1βin BALF of mice were detected by enzyme linked immunosorbent *** expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot ***:DMS pre-treatment significantly ameliorated lung histopathological *** with the LPS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(P<0.05 or P<0.01).The number of cells in BALF and myeloperoxidase(MPO) activity decreased significantly after DMS pretreatment(P<0.05 or P<0.01).DMS pre-treatment decreased the levels of TNF-α,IL-6 and IL-1β(P<0.01).Meanwhile,DMS activated the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) pathway and reversed the expressions of Claudin-5,VE-cadherin and VEGF(P<0.01).Conclusions:DMS attenuated LPS-induced ALI in mice through repairing endothelial *** might be a potential therapeutic drug for LPS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis