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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： jinmei Ye Cong Duan Jiaxin han jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Comprehensive constraints on fermionic dark matter-quark tensor interactions in direct detection experiments

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Chinese Physics C 2024年第12期48卷 37-49页

作者： jin-han Liang Yi Liao Xiao-Dong Ma Hao-lin Wang Key Laboratory of Atomic and Subatomic Structure and Quantum Control(MOE) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of MatterInstitute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China

Effective field theory(EFT)provides a model-independent framework for interpreting the results of dark matter(DM)direct detection *** this study,we demonstrate that the two fermionic DM-quark tensor operators(χiσ^(μν)γ^(5)χ)(qσ_(μν)q)and(χσ_(μν)χ)(qσ_(μν)q)can contribute to the DM electric and magnetic dipole moments via nonperturbative QCD effects,in addition to the well-studied contact DM-nucleon *** then investigate the constraints on these two operators by considering both the contact and dipole contributions using the XENON1T nuclear recoil and Migdal effect *** also recast other existing bounds on the DM dipole operators,derived from electron and nuclear recoil measurements in various direct detection experiments,as constraints on the two tensor *** m_(χ)■1GeV,our results significantly extend the reach of constraints on the DM-quark tensor operators to masses as low as 5MeV,with the bound exceeding that obtained by the Migdal effect with only contact interactions by approximately an order of *** particular,for the operator(χσ^(μν)iγ5χ)(qσ_(μν)q)with DM mass m_(χ)■10GeV,the latest PandaX constraint on the DM electric dipole moment puts more stringent bounds than the previous direct detection *** also briefly discuss the constraints obtained from experiments other than direct detection.

关键词： fermionic dark matter effective field theories tensor interactions

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Investigation of the level spectra of nuclei in the northeast region of doubly magic^(40)Ca with intruder orbit g_(9/2)

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Nuclear Science and Techniques 2023年第6期34卷 115-123页

作者： jin-Zhong han Shuai Xu Amir Jalili han-Kui Wang School of Physics and Telecommunication Engineering Zhoukou Normal UniversityZhoukou466000China Department of Physics Zhejiang SCI-TECH UniversityHangzhou310018China School of Physics Nankai UniversityTianjin300071China School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai200240China

This study utilizes large-scale shell model calculations with the extended pairing and multipole–multipole force model(EPQQM)to investigate low-lying states in the nuclei of^(42)Ca,^(42)Sc,and^(42−44)*** model space in this study includes the fp shell as well as the intruder g_(9/2)orbit,which accurately reproduces the positive parity levels observed in the aforementioned nuclei and predicts high energy states with negative parity coupled with the intruder g_(9/2).The study further predicts two different configurations in^(43)Ti at around 6 MeV,specificallyπf_(7/2)^(2)νg_(9/2)andπf_(7/2)g_(9/2)νf_(7/2),both of which involve the intruder orbit g_(9/2).The levels coupled with the intruder g_(9/2)in^(44)Ti are predicted to lie between 7 and 11 *** inclusion of the intruder orbit g_(9/2)is crucial for the exploration of high energy states in the northeast region of the doubly magic nucleus^(40)Ca.

关键词： Shell model Doubly magic Level structure

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

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Oxidation behavior of artificial magnetite pellets

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International Journal of Minerals,Metallurgy and Materials 2017年第6期24卷 603-610页

作者： han-quan Zhang jin-tao Fu School of Resource and Civil Engineering Wuhan Institute of Technology Wuhan 430205 China Western Mining Company Xi’ning 810001 China

The oxidation behavior of artificial magnetite pellets was investigated through measurements of the oxidation degree and mineralogical analysis. The results show that artificial magnetite pellets are much easier to oxidize than natural magnetite. The oxidation is controlled through two different reaction mechanisms. The oxidation of artificial magnetite is dominated by internal diffusion, with an activation energy of 8.40 kJ/mol, at temperatures less than 800°C, whereas it is controlled by chemical reaction, with a reaction activation energy of 67.79 kJ/mol, at temperatures greater than 800°C. In addition, factors such as the oxygen volume fraction and the pellet diameter strongly influence the oxidation of artificial magnetite: a larger oxygen volume fraction and a smaller pellet diameter result in a much faster oxidation process.

关键词： artificial magnetite pellets oxidation reaction mechanisms

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The Extraction,Isolation and Identification of Exudates from the Roots of Flaveria bidentis

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Journal of Integrative Agriculture 2014年第1期13卷 105-114页

作者： YANG Xing ZhanG Li-hui SHI Cui-ping ShanG Yan ZhanG jin-lin han Jian-min DONG jin-gao Molecular Plant Pathology Laboratory College of Life ScienceAgricultural University of Hebei

Large amounts ofFlaveria bidentis＇s root culturing solution were obtained by using DFT （deep flow technique） equipment and these solution which was vacuum concentrated （10, 20 mg mL-~） can have a certain inhibition on Triticum aestivum, Cucumis sativus, Raphanus sativus, Amaranthus retroflexus, Setaria viridis, Chenopodium album, Echinochloa crusgalli and Chloris virgata. This outcome suggested some active compounds in the root exudates ofFIaveria bidentis can inhibit the germination, seedling elongation and root length. The dichloromethane extract of root exudates was identificated by GC-MS, and 29 kinds of compounds, including esters, hydrocarbons, ketones, thiazole, amines, etc. were obtained and the phthalate n-octyl ester, phthalate 2-ethylhexyl ester were proved to be allelochemicals. The culturing solution of root exudates was separated through the resin column and silica gel column and a component inhibiting seedling height, root length and fresh weight of wheat was got. There were 6 kinds of organic compounds in this component including dioctyl phthalate, 1,2-phthalate, mono（2-ethylhexyl） ester by GC-MS.

关键词： extraction isolation identification exudates Flaveria bidentis

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The First Ground-based White Light Lunar Polarization Imaging:A New Kind of FeO Observation on the Near Side of the Moon

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Research in Astronomy and Astrophysics 2024年第6期24卷 1-6页

作者： Wei-Nan Wang jin-Song Ping Ming-Yuan Wang Wen-Zhao Zhang han-lin Ye Xing-Wei han Song-Feng Kou Changchun Observatory National Astronomical ObservatoriesChinese Academy of SciencesChangchun 130117China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Astronomy Department Beijing Normal UniversityBeijing 100875China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nanjing Institute of Astronomical Optics and Technology Chinese Academy of SciencesNanjing 210042China

Lunar optical polarization is a fascinating phenomenon that occurs when sunlight reflects off the surface of the Moon and becomes *** study employs a novel split-focus plane polarimetric camera to conduct the initial white light polarimetric observations on the near side of the *** obtained the linear degree of polarization(DOP)parameters of white light by observation from the eastern and western hemispheres of the *** findings indicate that the white light polarization is lower in the lunar highland than in the lunar maria *** the analysis of lunar soil samples,we noticed and determined that the DOP parameters of white light demonstrate high consistency with iron oxide on the *** study may serve as a new diagnostic tool for the Moon.

关键词： techniques:photometric polarization methods:observational Moon

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Microstructure and mechanical properties of WC-20wt% Co/ZrO_2(3Y)cermet composites

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Journal of University of Science and Technology Beijing 2006年第2期13卷 174-177页

作者： lin An jingtao han Jan Chen Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China Shougang Dongxing Industry Corporation Yantan 264006 China

The cermet composites WC-20wt%Co/ZrO2（E6）with four different comtents of ZrO2（3Y）were prepared by normal vacuum sinter processing;the optical microscope and SEMwere used to characterize their *** *** strength and impact toughness of the specimens were *** experimental results show that ZrO2（3Y） particles in WC-20wt%Co matrix are sphcrical particles in different sizes which are distributed uniformly in Co phases and WC phases,the bending strength and impact toughness of the WC-20wt%Co cermet composites added ZrO2（3Y）improve *** the hardness values have little change.

关键词： ZrO2(3Y) cermet composites mechanical properties microstructure normal vacuum sinter

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Microgravity may help future organ/tissue manufacture

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Science China(Life Sciences) 2016年第8期59卷 850-853页

作者： jin han Jianwu Dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101China

Stem cells are a group of multipotent or pluripotent cells which could differentiate into specialized cells or could self-renew to duplicate themselves. During the body devel- oping period, stem cells differentiated into specialized cells to build the whole body. In the adult organisms, stem cells live in seclusion and are ready to repair the injuries of tis- sues. Within one tissue, stem cells could differentiate in to all types of somatic cells of the tissue, for example,

关键词： manufacture specialized pluripotent differentiate duplicate renew repair themselves ready injuries

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Effect of six years of nitrogen additions on soil chemistry in a subtropical Pleioblastus amarus forest, Southwest China

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Journal of Forestry Research 2018年第6期29卷 1657-1664页

作者： Guan-tao Chen Li-hua Tu Guang-sheng Chen jin-yao Hu Zhou-lin han Ecological Security and Protection Key Laboratory of Sichuan Province Mianyang Normal University College of Forestry Sichuan Agricultural University

Soil chemistry influences plant health and carbon storage in forest ecosystems. Increasing nitrogen(N) deposition has potential effect on soil chemistry. We studied N deposition effects on soil chemistry in subtropical Pleioblastus amarus bamboo forest ecosystems. An experiment with four N treatment levels(0, 50, 150,and300 kg N ha-1a-1,applied monthly, expressed as CK,LN,MN, HN,respectively) in three replicates. After6 years of N additions, soil base cations, acid-forming cations, exchangeable acidity(EA), organic carbon fractions and nitrogen components were measured in all four seasons. The mean soil pH values in CK,LN,MN and HN were 4.71, 4.62, 4.71, and 4.40, respectively, with a significant difference between CK and HN. Nitrogen additions significantly increased soil exchangeable Al3+,EA, and Al/Ca,and exchangeable Al3+ in HN increased by 70%compared to CK. Soil base cations(Ca2+, Mg2+, K+, and Na+) did not respond to N additions. Nitrogen treatments significantly increased soil NO3--N but had little effect on soil total nitrogen, particulate organic nitrogen, or NH4~+-N. Nitrogen additions did not affect soil total organic carbon, extractable dissolved organic carbon,incorporated organic carbon, or particulate organic *** study suggests that increasing N deposition could increase soil NO3--N, reduce soil pH, and increase mobilization of Al3+. These changes induced by N deposition can impede root grow and function, further may influence soil carbon storage and nutrient cycles in the future.

关键词： Base cations Carbon fractions Nitrogen deposition Soil chemistry Soil acidification

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