检索结果-南通市图书馆

Secular trend analysis of lung cancer incidence in Sihui city,China between 1987 and 2011

Chinese Journal of Cancer 2015年第8期34卷 365-372页

作者： jin-lin du Xiao lin Li-Fang Zhang Yan-Hua Li Shang-Hang Xie Meng-Jie Yang Jie Guo Er-Hong lin Qing Liu Ming-Huang Hong Qi-Hong Huang Zheng-Er Liao Su-Mei Cao Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Cancer Prevention Research Sun Yat-sen University Cancer Center School of Public Health Guangdong Medical University Sihui Cancer Institute Department of Clinical Trial Center Sun Yat-sen University Cancer Center Department of Cancer Screening Sun Yat-sen University Cancer Center

Background:With industrial and economic development in recent decades in South China,cancer incidence may have changed due to the changing lifestyle and ***,the trends of lung cancer and the roles of smoking and other environmental risk factors in the development of lung cancer in rural areas of South China remain *** purpose of this study was to explore the lung cancer incidence trends and the possible causes of these ***:Joinpoint regression analysis and the age-period-cohort(APC) model were used to analyze the lung cancer incidence trends in Sihui,Guangdong province,China between 1987 and 2011,and explore the possible causes of these ***:A total of 2,397 lung cancer patients were involved in this study.A 3-fold increase in the incidence of lung cancer in both sexes was observed over the 25-year *** regression analysis showed that while the incidence continued to increase steadily in females during the entire period,a sharp acceleration was observed in males starting in *** full APC model was selected to describe age,period,and birth cohort effects on lung cancer incidence trends in *** age cohorts in both sexes showed a continuously significant increase in the relative risk(RR)of lung cancer,with a peak in the eldest age group(80-84 years).The RR of lung cancer showed a fluctuating curve in both *** birth cohorts identified an increased trend in both males and females;however,males had a plateau in the youngest cohorts who were born during ***:Increasing trends of the incidence of lung cancer in Sihui were dominated by the effects of age and birth *** aging,smoking,and environmental changes may play important roles in such trends.

关键词：发病率四会市肺癌中国队列研究发病趋势回归分析社会老龄化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of hypoxia on retinal progenitor and ganglion cells in human induced pluripotent stem cell-derived retinal organoids

引用

International Journal of Ophthalmology(English edition) 2023年第10期16卷 1574-1581页

作者： jin-lin du Li-Xiong Gao Tao Wang Zi Ye Hong-Yu Li Wen Li Quan Zeng Jia-Fei Xi Wen Yue Zhao-Hui Li Medical School of Chinese PLA Beijing 100853China Senior Department of Ophthalmology the Third Medical Center of Chinese PLA General HospitalBeijing 100039China Departement of Ophthalmology the 6^(th)Medical Center of PLA General HospitalBeijing 100048China Stem Cell and Regenerative Medicine Lab Beijing Institute of Radiation MedicineBeijing 100850China

AIM:To observe the effect of low oxygen concentration on the neural retina in human induced pluripotent stem cell(hiPSC)-derived retinal organoids(ROs).METHODS:The hiPSC and a three-dimensional culture method were used for the *** embryoid bodies(EBs)were randomly and equally divided into hypoxic and normoxic *** of the EBs were taken on days 38,45,and 52,and the corresponding volume of EBs was ***,samples were collected at these three timepoints,followed by fixation,sectioning,and ***:The proportion of Ki67-positive proliferating cells increased steadily on day 38;this proliferationpromoting effect tended to increase tissue density rather than tissue *** days 45 and 52,the two groups had relatively similar ratios of Ki67-positive *** immunofluorescence analysis showed that the ratio of SOX2-positive cells significantly increased within the neural retina on day 52(P0.05).Moreover,the proportion of PAX6-/TUJ1+cells within the neural retinas increased considerably(P<0.01,<0.05,<0.05 respectively).CONCLUSION:Low oxygen promotes stemness and proliferation of neural retinas,suggesting that hypoxic conditions can enlarge the retinal progenitor cell pool in hiPSC-derived ROs.

关键词： hypoxia retinal organoid retinal progenitor cells retinal ganglion cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Subtype distribution and long-term titer luctuation patterns of serum anti-Epstein–Barr virus antibodies in a non-nasopharyngeal carcinoma population from an endemic area in South China:a cohort study

引用

Chinese Journal of Cancer 2016年第9期35卷 447-454页

作者： jin-lin du Sui-Hong Chen Qi-Hong Huang Shang-Hang Xie Yan-Fang Ye Rui Gao Jie Guo Meng-Jie Yang Qing Liu Ming-Huang Hong Su-Mei Cao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuang-zhou 510060GuangdongP.R.China. Department of Cancer Prevention Research Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China. School of Public Health Sun Yat-sen UniversityGuang-zhou 510080GuangdongP.R.China. School of Public Health Guangdong Medical UniversityDongguan 523808GuangdongP.R.China. Sihui Cancer Institute Sihui 526200GuangdongP.R.China. Department of Clinical Trial Center Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China.

Background: Serum immunoglobulin A antibodies against Epstein–Barr virus(EBV), viral capsid antigen(VCA?Ig A) and early antigen(EA?Ig A), are used to screen for nasopharyngeal carcinoma(NPC) in endemic areas. However, their routine use has been questioned because of a lack of specificity. This study aimed to determine the distributions of different subtypes of antibody and to illustrate how the natural variation patterns affect the specificity of screening in non?NPC ***: The distribution of baseline VCA?IgA was analyzed between sexes and across 10?year age groups in 18,286 non?NPC participants using Chi square tests. Fluctuations in the VCA?IgA level were assessed in 1056 non?NPC participants with at least two retests in the first 5?year period(1987–1992) after the initial screening using the Kaplan–Meier ***: The titers of VCA?Ig A increased with age(P during the 5?year follow?up. However, seroconversions were common; 85.2% of the participants with a VCA?Ig A?positive status at baseline con?verted to negative, and all VCA?Ig A?negative participants changed to positive at least once during the 5?year follow?up. The EA?Ig A status had a high seroconversion probability(100%) from positive to negative; however, it had a low probability(19.6%) from negative to ***: Age? and sex?specific cutoff titer values for serum anti?EBV antibodies as well as their specific titer fluc?tuation patterns should be considered when defining high NPC risk criteria for follow?up diagnostics and monitoring.

关键词：病毒抗体波动模式鼻咽癌血清学中国南方地区队列研究亚型人群

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

引用

Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng du Wang Rongjie lin Weihong Xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enantio-divergent C–H borylation with two different ligands from a single chiral source

引用

Science China Chemistry 2025年第1期68卷 226-232页

作者： Rongrong du Senmiao Xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关键词： asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

引用

Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： jin-Peng Wang Guo-Cui Mao Hui-lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

值得关注的“四大亮点”和“一个未来”

引用

印制电路信息 2008年第1期16卷 6-11页

作者：林金堵 CPCA

随着电子设备的小型化、高性能化、多功能化和信号传输高频(速)化的发展进程,PCB产品也开始从传统的产品走向更高密度的HDI/BUM板、IC封装基(载)板、埋嵌元件板和刚-挠性板的发展,而终将走到印制电路板的"极限",这必然导致从"电传输信号... 详细信息

随着电子设备的小型化、高性能化、多功能化和信号传输高频(速)化的发展进程,PCB产品也开始从传统的产品走向更高密度的HDI/BUM板、IC封装基(载)板、埋嵌元件板和刚-挠性板的发展,而终将走到印制电路板的"极限",这必然导致从"电传输信号"走向"光传输信号"的"质变"上来,以印制光路板取代印制电路板。

关键词：传统印制板高密度印制板 “质”的变化印制光-电路板印制光路板

来源：

维普期刊数据库

同方期刊数据库评论