检索结果-南通市图书馆

CpG island methylator phenotype and Helicobacter pylori infection associated with gastric cancer

World Journal of Gastroenterology 2012年第36期18卷 5129-5134页

作者： Ji-Bin Liu Xu-Ming Wu jin Cai jin-Ye zhang jin-lin zhang Shu-Hui Zhou Min-Xin Shi Fu-lin Qiang Tumor Institute Nantong Tumor Hospital Nantong 226361 Jiangsu Province China School of Radiology and Public Health Soo- chow University Suzhou 215123 Jiangsu Province China

AIM： To investigate the association between the CpG island methylator phenotype （CIMP） and serum Helico- bacter pylori （H. pylori） levels for clinical prediction of gastric cancer （GC） progression. METHODS： We analyzed the serum ClMP status of 75 patients with GC using a methylation marker panel and a methylation-specific polymerase chain reaction. Serum samples from 40 healthy persons were examined at the same time. The genes examined were APC, WIF-1, RUNX-3, DLC-1, SFRP-1, DKK and E-cad. H. pylori infec- tion in serum was assayed with an anti-H, pylori immu- noglobulin G antibody test and a rapid urease test. RESULTS： The frequencies of high-level methylation in GC tissues for the seven genes were： 48% for APC, 57.33% for WIF-1, 56% for RUNX-3, 50.67% for DLC-1, 52% for SFRP-1, 54.67% for DKK, and 48% for *** frequencies in GC serum were 30.67% for APC, 34.67% for WIF-1, 37.33% for RUNX-3, 29.33% for DLC-1, 33.33% for SFRP-1, 32% for DKK, and 26.67% for E-cad. CIMP＋（defined as ≥ 3 methylated genes） was associated with 47 （62.67%） GC tissue samples and 44 （58.67%） GC serum samples. CIMP＋ was not associated with non-neoplastic mucosal tissues or the serum of healthy persons. Of the 75 GC cases, 51 （68%） were H. pylori＋, and 24 （32%） were H. pylori-. Of the 51 H. pylori＋ cases, 36 were CIMP＋ and 15 were CIMP-. In contrast, for the 24 H. pylori- cases, 11 were CIMP＋, and 13 were CIMP-. The difference was signifi- cant between the H. pylori＋ and H. pylori- groups χ2 = 4.27, P 〈 0.05）. Of the 51 H. pylori＋ GC patients, 34 were CIMP＋ and 17 were CIMP-, while among the 24 H. pylori- GC cases, 10 were CIMP＋ and 14 were CIMP-. The difference was significant between the H. pylori＋ and H. pylori- groups （χ2 = 4.21, P 〈 0.05）. A 2-year follow-up showed significant difference in the rates of metastasis and recurrence between H. pylori＋/CIMP＋ cases and the H. pylori＋/CIMP- cases or CIMP- cases associated with H. pylori assayed in serum （P 〈 0.05）. However, there were no s

关键词： CpG island methylator phenotype Helico-bacterpylori Serum Prognosis Gastric cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of bias voltage on structure,mechanical and corrosion properties of reactively sputtered nanocrystalline TiN films

引用

Journal of Iron and Steel Research International 2017年第12期24卷 1223-1230页

作者： Chun-lin He jin-lin zhang Guo-feng Ma Zhao-fu Du Jian-ming Wang Dong-liang Zhao Liaoning Provincial Key Laboratory of Advanced Materials Shenyang UniversityShenyang 110044LiaoningChina Research Institute of Functional Materials Central Iron&Steel Research InstituteBeijing 100081China

Nanocrystalline TiN films were prepared by DC reactive magnetron *** influence of substrate biases on structure,mechanical and corrosion properties of the deposited films was studied using X-ray diffraction,field emission scanning electron microscopy,nanoindentation and electrochemical *** deposited films have a columnar structure,and their preferential orientation strongly depends on bias *** preferential orientations change from（200）plane at low bias to（111）plane at moderate bias and then to（220）plane at relatively high *** H,elastic modulus E,H/E＊and H3/E＊2 ratios,and corrosion resistance of the deposited films increase first and then decrease with the increase in bias *** the best values appear at bias of-120 V,attributing to the film with a fine,compact and less defective *** demonstrates that there is a close relation among microstructure,mechanical and corrosion properties of the TiN films,and the film with the best mechanical property can also provide the most effective corrosion protection.

关键词： TiN film Nanocrystalline Bias voltage Microstructure Mechanical property Corrosion resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Herbicidal Activity of Mutant Isolates from Botrytis cinerea

引用

Agricultural Sciences in China 2006年第8期5卷 622-628页

作者： zhang jin-lin zhang Li-hui LIU Ying-chao MA Juan LI Chuan DONG jin-gao Mycotoxin Laboratory Hebei Agricultural University Baoding 071001 P.R.China

Fifteen mutant isolates were obtained by ultraviolet mutation from parent isolate Botrytis cinerea BC-4. Among them three mutant isolates, BC4-1, BC4-2, and BC4-15, showed strong herbicidal activity. BC4-1 showed maximum herbicidal activity for inhibition of germination and growth of Digitaria sanguinalis L. and Arnaranthus retroflexus L. The results also showed that herbicidal activity was influenced by differing pH of PD media, with pH value of 4.0 being the optimum. The crude toxin was extracted using chloroform, petroleum ether, and ethyl acetate, respectively, and the ethyl acetate extracts showed the strongest inhibitory activity on the germination and growth of D. sanguinalis L. and A. retroflexus L. Using HPLC, one fraction with an absorption peak at 271 nm was separated from the crude toxin. This fraction could strongly inhibit the growth of D. sanguinalis L. at a concentration of 100 mg L^-1 and could completely inhibit the seed germination of D. sanguinalis L. and A. retroflexus L. at a concentration of 50 mg L^-1 .

关键词： Botrytis cinerea toxin ultraviolet mutation herbicide activity separation and purification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives

引用

Chinese Chemical Letters 2016年第9期27卷 1547-1550页

作者： jing-Qian Huo Liu-Yong Ma Zhe zhang Zhi-jin Fan jin-lin zhang Tetyana V. Beryozkina Vasiliy A. Bakulev College of Plant Protection Agricultural University of Hebei Baoding 071001 China State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University Tianjin 300071 China The Ural Federal University Named after the First President of Russia B.N. Yeltsin Ekaterinburg 620002 Russia

A series of novel N-（3-furan-2-yl-l-phenyl-lH-pyrazol-5-yl） amides derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis （L） Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis. In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii.

关键词： Amides derivative Pyrazole Furan Synthesis Herbicidal activity Fungicidal activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure,mechanical and corrosion properties of TiN/Ni nanomultilayered films

引用

Rare Metals 2019年第10期38卷 979-988页

作者： Chun-lin He jin-lin zhang Lei-Peng Xie Guo-Feng Ma Zhao-Fu Du Jian-Ming Wang Dong-Liang Zhao Liaoning Provincial Key Laboratory of Advanced Materials Shenyang UniversityShenyang 110044China Research Institute of Functional Materials Central Iron and Steel Research InstituteBeijing 100081China

Nanomultilayered TiN/Ni thin films with different bilayer periods(57.8-99.7 nm) and Ni single-layer thickness(3.9-19.2 nm) were prepared by alternatively sputtering Ti and Ni targets in N2 gas *** micros tructure,mechanical and corrosion properties of the multilayer films were investigated by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),X-ray photoelectron spectroscopy(XPS),nanoindenter and electrochemical *** multilayer films are fine with a mean grain size of ~8-9 nm independent of the bilayer ***,the smoothness and compactness seem to decrease with the bilayer period *** hardness(H) and elastic modulus(E) of the multilayer films gradually decrease as the bilayer period increases,and the multilayer film with bilayer period of 57.8 nm exhibits higher H,ratios of(H/E^*and H^3/E^*2)(E^*is effective Young’s modulus)than the monolithic TiN film and the other *** multilayer films exhibit an obvious passivation phenomenon in 10% H2SO4 solution,and the passive current and corrosion current densities decrease,whereas the corrosion potential increases when the bilayer period or Ni single-layer thickness *** is found that the passivating behavior and corrosion potential of the multilayers are more sensitive to Ni single-layer thickness than the bilayer *** corrosion pits and lamellar flaking could be found on the films with larger bilayer period or Ni single-layer thickness.

关键词： TiN/Ni Multilayer film Reactive sputtering Microstructure Mechanical property Corrosion resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polyoxovanadate-based metal-organic frameworks consisted of open vanadium sites for selective catalytic oxidation of sulfides

引用

Tungsten 2023年第2期5卷 261-269页

作者： jin-lin zhang Qi-Xin Zhao Meng-Yuan Cheng Wei-Min Xuan Yan Liu College of Chemistry and Chemical Engineering and State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai201620China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Three novel polyoxovanadate-based metal-organic frameworks(POV-MOFs),[Co_(2)(1,4-dtzb)_(3)]{V_(4)O_(12)}(V-Co-MOF_(1),1,4-dtzb=1,4-di(4H-1,2,4-triazol-4-yl)benzene],[Co_(3)(1,3-dtzb)_(2)][{V_(6)O_(18)}(V-Co-MOF_(2),1,3-dtzb=1,3-di(4H-1,2,4-triazol-4-yl)benzene],[Co_(4)(4,4’-bdtzb)_(2)]{V_(8)O_(24)}(V-Co-MOF_(3),4,4’-bdtzb=4,4’-(1,1’-biphenyl)-4,4’-diylbis(4H-1,2,4-triazole)benzene]were facilely synthesized and structurally ***-crystal X-ray diffraction analysis indicates that all the POV-MOFs possess open V sites lined on POV clusters of{V_(4)O_(12)}/{V_(6)O_(18)}/{V_(8)O_(24)}that uniformly distribute on the robust three-dimensional *** unique structural feature allows them to show high performance for sulfidesulfoxide transformation when performing the reaction in MeOH at 50℃ for 45 min using H_(2)O_(2) as green ***,V-Co-MOF1 exhibited the highest catalytic efficiency,with a conversion>99% and selectivity up to 97% for a series of sulfide *** reaction demonstrated the catalytically active centers are the open V sites while the MOF skeleton constructed from Co^(2+)and ligands also contributes to enhance the conversion and selectivity via synergistic ***,V-Co-MOF1 can be used as a stable heterogeneous catalyst,and both the structural integrity and catalytic performance were well reserved after five cycles,demonstrating their great potential for advanced catalytic oxidation.

关键词： Polyoxovanadates Polyoxometalate-based metal-organic framework Sulfoxide Catalytic oxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metal-film-assisted ultra-clean transfer of single-walled carbon nanotubes

引用

Nano Research 2014年第7期7卷 981-989页

作者： Yujun He Dongqi Li Tianyi Li Xiaoyang lin jin zhang Yang Wei Peng Liu lina zhang Jiaping Wang Qunqing Li Shoushan Fan Kaili Jiang State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics & Tsinghua-Foxconn Nanotechnology ResearchCenter Tsinghua University Beijing 100084 China

Transfer printing of nanomaterials onto target substrates has been widely used in the fabrication of nanodevices, but it remains a challenge to fully avoid contamination introduced in the transfer process. Here we report a metal-film- assisted method to realize an ultra-clean transfer of single-walled carbon nanotubes （SWCNTs） mediated by poly（methyl methacrylate）（PMMA）. The amount of PMMA residue can be greatly reduced due to its strong physical adhesion to the metal film, leading to ultra-clean surfaces of both the SWCNTs and the substrates. This metal-film-assisted transfer method is efficient, nondestructive, and scalable. It is also suitable for the transfer of graphene and other nanostructures. Furthermore, the relatively low temperature employed allows this technique to be compatible with nanomaterial-based flexible electronics.

关键词： metal-film-assisted single-walled carbonnanotube transfer flexible substrate Schottky barrier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

引用

Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao Li-Jun zhang Yue-Mei Zhao Lei Chen jin-lin zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Successful Ablation of Cavo-tricuspid Isthmus Dependent Atrial Flutter in a Patient with Senning Operation

引用

Chinese Medical Journal 2015年第16期128卷 2267-2268页

作者： jin-lin zhang Cheng Tang Yong-Hua zhang Xi Su Department of Cardiology Wuhan Asian Heart Hospital Wuhan Hubei 430022 China

To the Editor：Intraatrial reentry tachycardia （IART） has been reported to occur in 2% to 10% of Mustard and Senning patients at 10 years＇ *** reported a case in which the cavo-tricuspid isthmus （CTI） in both the systemic venous atrium （SVA） and pulmonary venous atrium （PVA） was necessarily targeted in a patient following Senning operation.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Decametric Response to the Great Impacts

引用

紫金山天文台台刊 1996年第2期15卷 3-9页

作者： Han jin-lin,zhang Zi-zhen,Chen Hong-sheng,Li Qi-binBeijing Astronomical Obseruatory,Chinese Academy of Sciences,Beijing 100080,P.R.China

During the impact week,we monitored the decametric responses of collisions of fragments of comet Shoemaker-Levy 1993e (SL-9) on Jupiter,three strong bursts which are undoubtedly related to the impacts of fragments of ... 详细信息

关键词： Jupiter P/comet/SL9.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：