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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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PHOTO-INDUCED GRAFT POLYMERIZATION OF ACRYLAMIDE ON POLYPROPYLENE MEMBRANE SURFACE IN THE PRESENCE OF DIBENZYL TRITHIOCARBONATE

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Chinese Journal of Polymer Science 2007年第2期25卷 221-226页

作者： Qian Yang jing Tian Zhi-kang xu Institute of Polymer Science and Key Laboratory of Macromolecule Synthesis and Functionalization （Ministry of Education） Zhejiang University Hangzhou 310027 China

Ultraviolet （UV）-induced graft polymerization of acrylamide （AAm） on polypropylene substrates was successfully conducted using dibenzyl trithiocarbonate （DBTTC） as photoinitiator. It was confirmed by chemical analysis and surface morphology observation with attenuated total reflectance Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and scanning electron microscopy. A possible mechanism for this graft process was presented, which suggested that, under UV irradiation, the C： S bond in DBTTC could split and abstract a hydrogen from the polypropylene surface and a surface free radical was then formed, and initiated the graft polymerization of AAm.

关键词： Graft polymerization Surface modification Acrylamide Trithiocarbonate UV.

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Block Copolymer Colloidal Particles with Unique Structures through Three-dimensional Confined Assembly and Disassembly

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Chinese Journal of Polymer Science 2019年第8期37卷 744-759页

作者： Jiang-Ping xu jin-Tao Zhu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Materials Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology (HUST) Wuhan 430074 China State Key Laboratory of Materials Processing and Mold Technology HUST Wuhan 430074 China

Structured block copolymer(BCP) particles have gained increasing attention due to their potential applications in separation,catalysis, controlled release, and other fields. Three-dimensional(3D) confined assembly has been proved as a facile yet robust approach for generating BCP particles with controllable shapes and internal structures. In this feature article, we summarized the preparation of structured polymeric particles through 3D confined self-assembly of BCPs. The effects of interfacial interactions, degree of confinement,and additives on the shape and internal structure of BCP microparticles were comprehensively discussed. In addition, we highlighted the recent progress in using disassembly as a route to synthesize colloidal particles with unique structures. Two strategies were introduced in this part:(a) disassembling the discrete domains resulted in mesoporous microparticles;(b) disassembling the continuous domains led to the dissociation of microparticles into micelle-like nano-objects. The applications of the structured colloidal particles in photonic crystals,controlled release, and directed growth of inorganic materials were also presented. Finally, we discussed the current challenges and future opportunities in this promising area.

关键词： Block copolymers Self-assembly Confinement Polymer particles Nano-objects

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Negative Index Refraction in the Complex Ginzburg-Landau Equation in Connection with the Experimental CIMA Reaction

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Chinese Physics Letters 2012年第9期29卷 110-113页

作者： YUAN xu-jin Electromagnetic Scattering Key laboratory Beijing Institute of Environmental CharacteristicsBeijing 100854

In comparison with the phenomenon of negative index refraction observed in artificial meta-materials,it is interesting to ask if this type of behavior also exists or not in reaction-diffusion systems that support nonlinear chemical *** studies indicate that the negative index refraction could occur on a interface between a medium of a normal wave and a medium that supports *** we investigate the phenomenon in the complex Ginzburg–Landau equation(CGLE)in a close relationship with the quantitative model for the chlorite-iodide-malonic acid(CIMA)*** amplitude equation CGLE is deduced from the CIMA reaction,and simulations with mapped parameters from the reaction-diffusion equation reveal that the competition between normal waves and anti-waves on the interface determines whether the negative index refraction occurs or not.

关键词： reaction. refraction Landau

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An analysis method for ISL of multilayer constellation

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Journal of Systems Engineering and Electronics 2022年第4期33卷 961-968页

作者： xu Xiaoyi WANG Chunhui jin Zhonghe Micro-Satellite Research Center Zhejiang UniversityHangzhou 310027China

The multilayer satellite network has high spatial spectrum utilization, flexible networking, strong survivability, and diversified functions. The inter-satellite links(ISLs) and crosslayer ISLs(CLISLs) enable direct communication paths between satellites, which improves the spatial autonomy of the constellation. Due to the existence of perturbation, ISLs are affected for a long time, which impacts reliable inter-satellite transmission. The stability and complexity of ISL establishment are related to the static and dynamic characteristics of range and azimuth. This paper presents a model of ISLs in a perturbed multilayer constellation. Series of theoretical derivation, simulation, and numerical calculation are carried out. A more comprehensive multilayer constellation ISL model is obtained. The work of this paper provides some theoretical foundations for constellation networking research.

关键词： satellite network multilayer constellation inter-satellite link(ISL)

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Resolution Enhancement in Ultrasonic TOFD Imaging by Combining Sparse Deconvolution and Synthetic Aperture Focusing Technique(Sparse-SAFT)

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Chinese Journal of Mechanical Engineering 2022年第5期35卷 141-149页

作者： xu Sun Li Lin Shijie jin School of Materials Science and Engineering Dalian University of TechnologyDalianChina

The shallow subsurface defects are difficult to be identified and quantified by ultrasonic time-of-flight diffraction(TOFD)due to the low resolution induced by pulse width and beam *** this paper,Sparse-SAFT is proposed to improve the time resolution and lateral resolution in TOFD imaging by combining sparse deconvolution and synthetic aperture focusing technique(SAFT).The mathematical model in the frequency domain is established based on the l1 and l2 norm constraints,and the optimization problem is solved for enhancing time *** this basis,SAFT is employed to improve lateral resolution by delay-and-sum *** simulated and experimental results indicate that the lateral wave and tip-diffracted waves can be decoupled with *** shallow subsurface defects with a height of 3.0 mm at the depth of 3.0 mm were detected quantitatively,and the relative measurement errors of flaw heights and depths were no more than 10.3%.Compared to conventional SAFT,the time resolution and lateral resolution are enhanced by 72.5 and 56%with Sparse-SAFT,***,the proposed method is also suitable for improving resolution to detect the defects beyond dead zone.

关键词： Time resolution Lateral resolution Time-of-flight diffraction(TOFD) Sparse deconvolution Synthetic aperture focusing technique(SAFT) Sparse-SAFT

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Design, analysis and optimization of random access inter-satellite ranging system

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Journal of Systems Engineering and Electronics 2020年第5期31卷 871-883页

作者： xu Xiaoyi WANG Chunhui jin Zhonghe Micro-Satellite Research Center Zhejiang UniversityHangzhou 310027China

In this paper, a random access inter-satellite ranging(RAISR) system is designed. The ranging accuracy is optimized by an algorithm to greatly improve the ranging accuracy. This paper verifies the feasibility of the RAISR system through a series of theoretical analysis, numerical simulation, hardware system design and testing. The research work brings the solution to the design and accuracy optimization problem of the RAISR system,which eliminates the main error caused by the satellite dynamic characteristics and frequency source drift of the RAISR *** accuracy of the measurement system has been significantly improved.

关键词： satellite ranging random access distributed network

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Lightweight Mutual Authentication Scheme for Protecting Identity in Insecure Environment

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China Communications 2018年第6期15卷 158-168页

作者： xu Wu jin xu Binxing Fang School of Cyberspace Security Beijing University of Posts and Telecommunications Key Laboratory of Trustworthy Distributed Computing and Service (BUPT) Ministry of Education

Many improved authentication solutions were put forward, on purpose of authenticating more quickly and ***, neither the overuse of hash function,or additional symmetric encryption, can truly increase the overall security. Instead,extra computation cost degraded the *** were still vulnerable to a variety of threats, such as smart card loss attack and impersonation attack, due to hidden loopholes and flaws. Even worse, user's identity can be parsed in insecure environment, even became traceable. Aiming to protect identity, a lightweight mutual authentication scheme is proposed. Redundant operations are removed,which make the verification process more explicit. It gains better performance with average cost compared to other similar *** shows the proposed scheme can resist common attacks and achieve user *** security is further verified by using the widely accepted Automated Validation of Internet Security Protocols and Applications(AVISPA) tool.

关键词： identify authentication light-weight authentication session key agreement user anonymity

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Two-dimensional material separation membranes for renewable energy purification, storage, and conversion

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Green Energy & Environment 2021年第2期6卷 193-211页

作者： Liheng Dai kang Huang Yongsheng Xia Zhi xu State Key Laborutory of Chemical Engineering Schood of Chemical Engineering East China University of Science and Technology 130 Meilong RoadShanghai200237China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech Universiy30 Puzhu Road(S)Nanjing211816China

The current energy crisis has prompted the development of new energy sources and energy storage/conversion devices. Membranes, as the key component, not only provide enormous separation potential for energy purification but also guarantee stable and high-efficiency operation for rechargeable batteries and fuel cells. Remarkably, two-dimensional(2D) material separation membranes have attracted intense attention on their excellent performance in energy field applications, owing to high mechanical/chemical stability, low mass transport resistance, strict sizeexclusion, and abundant modifiable functional groups. In this review, we concentrate on the recent progress of 2D membrane and introduce 2D membranes based on graphene oxide(GO), MXenes, 2D MOFs, 2D COFs, and 2D zeolite nanosheets, which are applied in membrane separation(H2 collection and biofuel purification) and battery separators(vanadium flow battery, Li–S battery, and fuel cell). The mass transport mechanism, selectivity mechanism, and modification methods of these 2D membranes are stated in brief, mainly focusing on interlayer dominant membranes(GO and MXenes) and pore dominant membranes(MOFs, COFs, and zeolite nanosheets). In conclusion, we highlight the challenges and outlooks of applying 2D membranes in energy fields.

关键词： Two-dimensional materials Membranes Separation New energy

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