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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Variation of sea ice and perspectives of the Northwest Passage in the Arctic Ocean

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Advances in Climate Change Research 2021年第4期12卷 447-455页

作者： CHEN jin-Lei kang Shi-Chang GUO Jun-Ming xu Min ZHANG Zhi-Min State Key Laboratory of Cryosphere Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China Centre for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing100101China Gansu Construction Vocational Technology College Lanzhou730000China

The continued warming of the Arctic atmosphere and ocean has led to a record retreat of sea ice in the last *** retreat has increased the probability of the opening of the Arctic Passages in the near *** Northwest Passage(NWP)is the most direct shipping route between the Atlantic and Pacific Oceans,producing notable economic *** variations of sea ice and its influencing factors from a high-resolution unstructured-grid finite-volume community ocean model were investigated along the NWP in 1988-2016,and the accessibility of the NWP was assessed under shared socioeconomic pathways(SSP245 and 585)and two vessel classes with the Arctic transportation acces-sibility model in *** ice thickness has decreased with increasing seawater temperature and salinity,especially within the Canadian Arctic Archipelago(CAA)in 1988-2016,which has facilitated the opening of the *** ship navigation is projected to be possible for polar class 6 ships in August-December in 2021-2025,after when it may extends to July under SSP585 in 2026-2030,while open water ships will not be able to pass through the NWP until September in mid-21st *** navigability of the NWP is mainly affected by the ice within the *** the accessibility of the Parry Channel,the west part is worse than that of the eastern part,especially in the Viscount-Melville Sound.

关键词： Arctic Sea ice Northwest passage Canadian arctic archipelago Strait

Anti-Noise Performance of the FT Continuous Zoom Analysis Method for Discrete Spectrum

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Chinese Journal of Mechanical Engineering 2010年第6期23卷 774-779页

作者： LINHuibin DING kang xu Chuanyan School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510640 China Guangdong Key Lab for Automotive Engineering Guangzhou 510640 China

As a discrete spectrum correction method, the Fourier transform （FT） continuous zoom analysis method is widely used in vibration signal analysis, but little effort had been made on this method＇s anti-noise performance. It is widely believed that the analysis accuracy of the method can be substantially improved by increasing the zoom multiple, however, with the zoom multiple increases, the frequency estimation accuracy may decline sometimes in practices. Aiming at the problems above, this paper analyzes the sources of frequency estimation error when a harmonic signal mixed with and without noise is processed using the FT continuous zoom analysis. According to the characteristics that the local maximum of the zoom spectrum may be wrongly selected when the signal is corrupted with noise, the number of wrongly selected spectrum lines is deduced under different signal-to-noise ratio and local zoom multiple, and then the maximum frequency estimation error is given accordingly. The validity of the presented analysis is confirmed by simulations results. The frequency estimation accuracy of this method will not improve any more under the influence of noise, and there is a best zoom multiple, when the zoom multiple is larger than the best zoom multiple; the maximum frequency estimation error will fluctuate back and forth. The best zoom multiple curves under different signal-to-noise ratios given provide a theoretical basis for the choice of the appropriate zoom multiples of the FT continuous zoom analysis method in engineering applications.

关键词： spectrum spectrum correction zoom analysis anti-noise performance

Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

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Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan Gu Qu Jiang Ziyang Sheng Ruohan Feng Sihong Wang Haoyue Zhang Qianqing xu Zijian Yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao Zhou xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

植被混凝土不同磷石膏掺量对狗牙根根系特性及抗拔力学性能的影响

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三峡大学学报（自然科学版） 2025年第1期47卷 65-72页

作者：杨嘉槊吴彬康柔嘉许亚坤许文年三峡大学土木与建筑学院湖北宜昌443002 水泥基生态修复技术湖北省工程研究中心(三峡大学) 湖北宜昌443002 三峡大学水利与环境学院湖北宜昌443002 三峡大学生物与制药学院湖北宜昌443002

为研究植被混凝土磷石膏含量对基材理化性质、植物根系性征及整株抗拔力的影响,进行了不同磷石膏掺量(0%、3%、4.5%、6%、9%)以及不同生长期(90、120、150d)条件下,基材相关理化指标的测定、狗牙根根系监测和原位整株拉拔试验.结果表明... 详细信息

为研究植被混凝土磷石膏含量对基材理化性质、植物根系性征及整株抗拔力的影响,进行了不同磷石膏掺量(0%、3%、4.5%、6%、9%)以及不同生长期(90、120、150d)条件下,基材相关理化指标的测定、狗牙根根系监测和原位整株拉拔试验.结果表明:磷石膏对基材容重、pH值和土壤磷含量具有显著影响;狗牙根根系网状结构显著增强了抗拔力,整株抗拔力随根系性状的改善而增大,3%掺量下抗拔力120d时高出0%掺量30.25%;适量磷石膏掺入显著促进了根系生长,3%掺量下根系总根长、根体积和根系生物量增加显著,此种情况下狗牙根根系固土效果最好.

关键词：植被混凝土磷石膏根系形态抗拔力

POI Neural-Rec Model via Graph Embedding Representation

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Tsinghua Science and Technology 2021年第2期26卷 208-218页

作者： kang Yang jinghua Zhu xu Guo Department of Computer Science Heilongjiang UniversityHarbin 150080

With the booming of the Internet of Things(Io T)and the speedy advancement of Location-Based Social Networks(LBSNs),Point-Of-Interest(POI)recommendation has become a vital strategy for supporting people’s ability to mine their ***,classical recommendation models,such as collaborative filtering,are not effective for structuring POI recommendations due to the sparseness of user ***,LBSN recommendations are distinct from other recommendation *** respect to user data,a user’s check-in record sequence requires rich social and geographic *** this paper,we propose two different neural-network models,structural deep network Graph embedding Neural-network Recommendation system(SG-Neu Rec)and Deepwalk on Graph Neural-network Recommendation system(DG-Neu Rec)to improve POI *** with embedding representation from social and geographical graph information(called SG-Neu Rec and DG-Neu Rec).Our model naturally combines the embedding representations of social and geographical graph information with user-POI interaction representation and captures the potential user-POI interactions under the framework of the neural ***,we compare the performances of these two models and analyze the reasons for their *** from comprehensive experiments on two real LBSNs datasets indicate the effective performance of our model.

关键词： Point-Of-Interest(POI)recommendation graph embedding neural networks Deepwalk deep learning Location-Based Social Networks(LBSNs)

Anisotropy reduction and mechanical property improvement of additively manufactured stainless steel based on cyclic phase transformation

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Journal of Materials Science & Technology 2024年第17期184卷 1-14页

作者： Bochuan Li kang xu Chao Jiang State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Automotive Engineering Research Institute Byd Auto Industry Company LimitedShenzhen 518000China

Owing to the special layer-by-layer deposition process of directed energy deposition(DED),columnar coarse grains,produced by cyclic reheating with intrinsic directional heat flow along the building direc-tion,are difficult to *** grains result in strong anisotropic characteristics with poor mechanical properties,which restrict the application of DED *** work proposes a novel fabrication strat-egy based on the cyclic-phase-transformation behavior,which can reduce the anisotropy and improve the mechanical properties of DED-printed stainless *** this fabrication strategy,316 L powder(austenitic stainless steel)and 17-4PH powder(martensitic stainless steel)were mixed in different mass ratios to fabricate five types of DED-printed stainless *** the five samples,P70(mixture of 70 wt%17-4PH powder and 30 wt%316 L powder)showed the weakest anisotropy and the best mechanical properties,which can be attributed to the cyclic phase transformation under cyclic reheating treatment and the transformation-induced plasticity(TRIP)effect over a wide range of strains,***-pared with the pure 316 L printed material,the tensile test results of P70 showed that the yield strength(YS)and ultimate tensile strength(UTS)increased by 35.4%and 34.5%,respectively,whereas the uniform elongation(UE)and total elongation(TE)were improved by 63.9%and 31.4%,*** addition,the strength-ductility balance(UTS×UE)increased by as much as 120.4%.The proposed fabrication strategy is expected to reduce the anisotropy in other materials that undergo cyclic-phase-transformation phe-nomena during additive manufacturing.

关键词： Directed energy deposition Anisotropy reduction Cyclic phase transformation Mechanical properties

Countering microplastics pollution with photocatalysis: Challenge and prospects

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Progress in Natural Science:Materials International 2023年第3期33卷 251-266页

作者： Runjing xu Lifeng Cui Shifei kang School of Environment and Architecture University of Shanghai for Science and Technology College of Smart Energy Shanghai Jiao Tong University Institute of Photochemistry and Photofunctional Materials (IPPM) University of Shanghai for Science and Technology

The rapid increase in plastic production and disposal worldwide has adversely and significantly impacted the global environment and biology. Traditional treatment methods are not appropriate for microplastics(MPs) due to their highly polymerized, stable, and complex chemical structure. Photocatalytic degradation of MPs is a relatively new and environmentally friendly approach. This review summarizes the common sources and types of MPs, and covers the various strategies and methods for degrading MPs. It describes the recent developments in the photocatalytic degradation of MPs by transition metals catalysts as well as noble metal catalysts, and discusses the characteristics and limitations of each type of catalyst. It was found out that some photo-catalysts showed very good performance for degradation of MPs, but many of the literature failed to clarify the bond-breaking mechanism during photocatalytic reaction. This review tries to elucidate the bond-breaking mechanisms of various types of MP in photocatalytic process. Advice for future research directions is proposed by investigating the knowledge gaps between those reported literature. The main purpose of this review is to provide a comprehensive summarization for the current research status of photocatalytic degradation of MPs. This work may help researchers explore new photocatalytic methods for future MP control.

关键词： Microplastics Photocatalytic degradation Photocatalysts Bond break mechanism