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Single-atom catalysis for advanced oxidation and reduction systems in water decontamination

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Rare Metals 2024年第8期43卷 3576-3606页

作者： Jie Teng jin-hui xu Wen-Xin Sun xue-Feng Liu Xia xu Guo-Shuai Liu School of Urban Construction Changzhou UniversityChangzhou 213164China School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China

Water scarcity is an escalating global crisis,posing a severe threat to populations ***,exploring various materials to remove emerging contaminants from freshwater sources has garnered significant *** this regard,single-atom catalysis(SACs) has emerged as a catalyst of scientific progress in water purification and treatment methodologies during recent *** exhibit exceptional catalytic activity,selectivity and stability,due to their near-perfect atom utilization,highly unsaturated coordination environment and uniform reaction ***,a comprehensive and critical review encompassing the successful integration of SACs into water purification processes needs to be *** review aims to accentuate recent trends by presenting the synthesis,structure,and environment and energy application-relevant properties of *** results show that a comprehensive and multi-perspective summary of the advantages of SACs in environmental remediation can have significant benefits,such as fast kinetics,costeffectiveness,*** oxidation and reduction processes of SACs and functional SACs materials in water purification were ***,the last section is devoted to the current research gaps and further perspectives on the application of SACs in water treatment,which are summarized and analyzed.

关键词： Single-atom catalysis Water treatment Oxidation Reduction

Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals

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Neural Regeneration Research 2021年第1期16卷 166-171页

作者： jin-hui xu xu-Zhen Qin Hao-Nan Zhang Yan-Xia Ma Shi-Bin Qi Hong-Cheng Zhang jin-jin Ma Xin-Ya Fu Ji-Le Xie Saijilafu Department of Orthopedics The First Affiliated Hospital of Soochow UniversityOrthopedic InstituteSoochow UniversitySuzhouJiangsu ProvinceChina

Axonal regeneration plays an important role in functional recovery after nervous system ***,after axonal injury in mammals,regeneration is often *** deletion of Krüppel-like factor-4(Klf4)has been shown to promote axonal regeneration in retinal ganglion ***,the effects of Klf4 deletion on the corticospinal tract and peripheral nervous system are *** this study,using a mouse model of sciatic nerve injury,we show that the expression of Klf4 in dorsal root ganglion sensory neurons was significantly reduced after peripheral axotomy,suggesting that the regeneration of the sciatic nerve is associated with *** vitro,dorsal root ganglion sensory neurons with Klf4 knockout exhibited significantly enhanced axonal ***,the regeneration of the sciatic nerve was enhanced in vivo following Klf4 ***,AAV-Cre virus was used to knockout the Klf4 gene in the *** deletion of Klf4 enhanced regeneration of the corticospinal tract in mice with spinal cord ***,our findings suggest that regulating KLF4 activity in neurons is a potential strategy for promoting axonal regeneration and functional recovery after nervous system *** study was approved by the Animal Ethics Committee at Soochow University,China(approval ***20200316A01).

关键词： axonal regeneration corticospinal tract dorsal root ganglion Klf4 peripheral nervous system sciatic nerve crush sensorimotor cortex spinal cord crushl

Clinicopathological Characteristics of Synchronous Multiple Gastric Cancers in Chinese:An Analysis of 44 Cases

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Chinese Journal of Cancer Research 2009年第2期21卷 130-134页

作者： Rui-shan Zhang Cai-gang Liu Yang Lu Feng jin hui-mian xu Ping Lu Department of Surgical Oncology First Hospital China Medical University Shenyang 110001 China

Objective： To investigate the clinicopathologic characteristics of the primary synchronous multiple gastric cancers （SMGC） in Chinese. Methods： Clinicopathologic data of patients with histologically confirmed gastric cancer who received surgical operations in our department between 1993 and 2002 were retrospectively collected and analyzed. Clinicopathologic characteristics including gender, age, tumor location, differentiation and staging between patients with SMGC and those with solitary gastric cancer （SGC） were compared. Synchronous multiple and solitary gastric cancers were diagnosed and classified based on radiography upper endoscopy and histology. All the cases were followed up after the operation and 5-year survival rate between the two groups was compared. Results： A total of 871 patients with gastric cancer were included. Synchronous multiple gastric cancers were found in 44 （5.1%） of these cases. More of the diagnose in the early stage to SMGC than to SGC. SMGC were more likely to be located at the lower third stomach and of a low grade differentiation, compared to SGC. However, there were no significant differences in the rates of lymph node metastasis and lymphatic vessel invasion between multiple and solitary gastric cancers. In addition, the 5-year survival rate did not difference between the two groups. Conclusion： The whole stomach should be detected carefully to avoid missing out the multiple gastric cancers. Concerning the treatment of multiple gastric cancer, the sufficient extent of the stomach wall resection was necessary, and the extent of lymphadenectomy was supposed to follow the operation for the solitary gastric cancer according to the staging of the cancer lesions.

关键词： Multiple gastric cancer Solitary gastric cancer Radical gastrectomy Ciinicopathologic characteristics

Primary pancreatic peripheral T-cell lymphoma:A case report

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1668-1675页

作者： Yan-Liang Bai Li-Jie Wang hui Luo Ya-Bin Cui jin-hui xu hui-Jie Nan Pei-Yao Yang Jun-Wei Niu Ming-Yue Shi Department of Hematology Zhengzhou University People's Hospital and Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Hematology Henan University People's Hospital and Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008Henan ProvinceChina

BACKGROUND Primary pancreatic lymphoma(PPL)is an exceedingly rare tumor with limited mention in scientific *** clinical manifestations of PPL are often nonspecific,making it challenging to distinguish this disease from other panc-reatic-related *** remains the primary treatment for these *** SUMMARY In this case study,we present the clinical details of a 62-year-old woman who initially presented with vomiting,abdominal pain,and dorsal *** further evaluation through positron emission tomography-computed tomography,the patient was considered to have a pancreatic head ***,subsequent endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA)revealed that the patient had pancreatic peripheral T-cell lymphoma,not otherwise specified(PTCL-NOS).There was a substantial decrease in the size of the pancreatic mass after the patient underwent a cycle of chemotherapy comprised of brentuximab vedotin,decitabine,and oxaliplatin(brentuximab vedotin and Gemox).The patient had significant improvement in radiological findings at the end of the first *** Primary pancreatic PTCL-NOS is a malignant and heterogeneous lymphoma,in which the clinical manifestations are often *** is difficult to diagnose,and the prognosis is *** can only be used for auxiliary diagnosis of other *** the help of immunostaining,EUS-FNA could be used to aid in the diagnosis of *** a clear diagnosis,chemotherapy is still the first-line treatment for such patients,and surgical resection is not recommended.A large number of recent studies have shown that the CD30 antibody drug has potential as a therapy for several types of ***,identifying new CD30-targeted therapies for different types of lymphoma is urgently *** the future,further research on antitumor therapy should be carried out to improve the survival prognosis of such patients.

关键词： Pancreatic cancer Lymphoma Chemotherapy Primary pancreatic lymphoma Case report

Annexin A2 promotes choroidal neovascularization by increasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization

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Chinese Medical Journal 2010年第6期123卷 713-721页

作者： ZHAO Shi-hong PAN Dong-yan ZHANG Yuan WU jin-hui LIU Xin xu Yu Department of Ophthalmology Changhai HospitalSecond Military Medical UniversityShanghai 200433China

Background Choroidal neovascularization （CNV） is a common cause of visual loss in the elderly patients with age-related macular degeneration and represents the growth of subretinal new vessels in the macular region. This study aimed to investigate the relationship between annexin A2 （ANXA2） and vascular endothelial growth factor （VEGF） in *** In a rat model of argon laser coagulation-induced CNV, the mRNA expressions of the annexins and VEGF protein expression in the retina were detected using fluorescent real-time polymerase chain reaction （PCR） and immunohistochemistry, respectively. The interactions between ANXA2 and VEGF in both a retinal pigment epithelial cell line RPE-J and the rat model of CNV were examined by means of RNA interference, real-time PCR, Western blotting, enzyme-linked immunosorbent assay （ELISA） and histopathological examinations. Results Fundus fluorescein angiography （FFA） showed that argon laser coagulation of the retina induced stable CNV models in the rats. Two to three weeks after the coagulation, ANXA2. and VEGF expressions in the coagulated area in the retina and choroid increased to the peak level, while the other annexin members （ANXA4, ANXA5, ANXA7 and ANXA11） showed no obvious changes. In RPE-J cells and the CNV model, RNA interference of ANXA2 gene significantly lowered the VEGF protein and mRNA expressions, and application of an adenoviral vector containing ANXA2 gene markedly increased VEGF expressions in the rat model of CNV, but produced no significant effects on the expressions of the kinase insert domain-containing receptor （KDR） or the fms-like tyrosine kinase （Fit-l）. The expression of KDR inhibited the increment in ANXA2 expression, but VEGF and Rt-1 did not directly affect ANXA2 expression. Conclusion Besides the role as a plasminogen and the receptor of tissue plasminogen activator, ANXA2, which is under regulation of KDR via a negative feedback mechanism, also participates in neovascularization by regulating VE

关键词： annexin A2 vascular endothelial growth factor choroid neovascularization

Distribution of solitary Iymph nodes in primary gastric cancer:A retrospective study and clinical implications

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World Journal of Gastroenterology 2007年第35期13卷 4776-4780页

作者： Cai-Gang Liu Ping Lu Yang Lu Feng jin hui-Mian xu Shu-Bao Wang Jun-Qing Chen Department of Surgical Oncology First Affiliated Hospital of China Medial University Heping Shenyang110001 Liaoning Province China

AIM： To investigate the distribution pathway of metastatic lymph nodes in gastric carcinoma as a foundation for rational lymphadenectomy. METHODS： We investigated 173 cases with solitary or single station metastatic lymph nodes （LN） from among 2476 gastric carcinoma patients. The location of metastatic LN, histological type and growth patterns were analyzed retrospectively. RESULTS： Of 88 solitary node metastases cases, 65 were limited to perigastric nodes （N1）, while 23 showed skipping metastasis. Among 8 tumors in the upper third stomach, 3 involved right paracardial LN （station number： No.1）, and one in the greater curvature was found in No.1. In the 28 middle third stomach tumors, 10 were found in LN of the lesser curvature （No.3） and 6 in LN of the left gastric artery （No.7）; 5 of the 20 cases on the lesser curvature spread to No.7, while 2 of the 8 on the greater curvature metastasized to LN of the spleen hilum （No.10）. Of 52 lower third stomach tumors, 13 involved in No.3 and 19 were detected in inferior pyloric LN （No.6）; 9 of the 29 cases along the lesser curvature were involved in No.6. CONCLUSION： Transversal and skipping metastases of sentinel lymph nodes （SLN） are notable, and rational lymphadenectomy should, therefore, be performed.

关键词： Gastric cancer Metastatic lymph node,Lymph node dissection Rational lymphadenectomy Sentinel lymph node

Assessing recent recurrence after hepatectomy for hepatitis Brelated hepatocellular carcinoma by a predictive model based on sarcopenia

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World Journal of Gastroenterology 2024年第12期30卷 1727-1738页

作者： Hong Peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue Huang Xiao-Feng Wang jin-hui xu Xin-Hua Luo Department of Infectious Diseases Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Hepatobiliary Surgery Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

BACKGROUND Sarcopenia may be associated with hepatocellular carcinoma(HCC)following *** traditional single clinical variables are still insufficient to predict *** still lack effective prediction models for recent recurrence(time to recurrence5 cm(HR=2.222,95%CI:1.285-3.842,P<0.05),and hepatitis B virus DNA level≥2000 IU/mL(HR=2.1,95%CI:1.407-3.135,P<0.05)were independent risk factors associated with postoperative recurrence of *** on the sarcopenia to assess the RFS model of hepatectomy with hepatitis B-related liver cancer disease(SAMD)was established combined with other the above risk *** area under the curve of the SAMD model was 0.782(95%CI:0.705-0.858)in the training cohort(sensitivity 81%,specificity 63%)and 0.773(95%CI:0.707-0.838)in the validation ***,a SAMD score≥110 was better to distinguish the high-risk group of postoperative recurrence of *** Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-rel

关键词： Alpha-fetoprotein Hepatitis B virus Hepatectomy Hepatocellular carcinoma Nomogram Predictive models Recurrence Recurrence-free survival Risk factors Sarcopenia

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang xuan Cheng hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： jin-Peng Wang Guo-Cui Mao hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface