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Plastid phylogenomics provides new insights into the systematics,diversification,and biogeography of Cymbidium(Orchidaceae)

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Plant Diversity 2024年第4期46卷 448-461页

作者： Hai-Yao Chen Zhi-Rong Zhang Xin Yao Ji-Dong Ya Xiao-hua jin Lin Wang Lu Lu De-Zhu Li Jun-Bo Yang Wen-Bin Yu Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Huairou DistrictBeijing 101408China Plant Germplasm and Genomics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory of Plant Diversity and Specility Crops Institute of BotanyChinese Academy of SciencesHaidian DistrictBeijing 100093China School of Pharmaceutical Sciences Yunnan Key Laboratory of Pharmacology for Natural Productsand Yunnan College of Modern Biomedical IndustryKunming Medical UniversityKunmingYunnan 650500China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the ***,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this *** this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate *** dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle *** *** to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene *** analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon *** hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle *** transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification *** study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.

关键词： Cymbidium East Asia Asian monsoons Climate change Biogeographical patterns

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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-Dan Xu Min-hua Deng Shi-Hui Hao Jie-Wei Chen Xiao-Dan Ma Wei-Tao Zhuang jing-hua Cao Yong-Rui Lv jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

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Spatial structural characteristics of the Deda ancient landslide in the eastern Tibetan Plateau:Insights from Audio-frequency Magnetotellurics and the Microtremor Survey Method

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China Geology 2024年第2期7卷 188-202页

作者： Zhen-dong Qiu Chang-bao Guo Yi-ying Zhang Zhi-hua Yang Rui-an Wu Yi-qiu Yan Wen-kai Chen Feng jin Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Faculty of Engineering China University of GeosciencesWuhan 430074China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China Research Center of Neotectonism and Crustal Stability China Geological SurveyBeijing 100081China China Water Resources Beifang Investigation Design and Research Co.Ltd.Tianjin 300222China

It is of crucial importance to investigate the spatial structures of ancient landslides in the eastern Tibetan Plateau’s alpine canyons as they could provide valuable insights into the evolutionary history of the landslides and indicate the potential for future *** study examines the Deda ancient landslide,situated in the Chalong-ranbu fault zone,where creep deformation suggests a complex underground *** integrating remote sensing,field surveys,Audio-frequency Magnetotellurics(AMT),and Microtremor Survey Method(MSM)techniques,along with engineering geological drilling for validation,to uncover the landslide’s spatial feature *** research indicates that a fault is developed in the upper part of the Deda ancient landslide,and the gully divides it into Deda landslide accumulation zoneⅠand Deda landslide accumulation zoneⅡin *** distinctive geological characteristics detectable by MSM in the shallow subsurface and by AMT in deeper *** findings include the identification of two sliding zones in the Deda I landslide,the shallow sliding zone(DD-I-S1)depth is approximately 20 m,and the deep sliding zone(DD-I-S2)depth is 36.2-49.9 *** sliding zone(DD-Ⅱ-S1)depth of the DedaⅡlandslide is 37.6-43.1 m.A novel MSM-based method for sliding zone identification is proposed,achieving less than 5%discrepancy in depth determination when compared with drilling *** results provide a valuable reference for the spatial structural analysis of large-deepseated landslides in geologically complex regions like the eastern Tibetan Plateau.

关键词： Ancient landslide Remote sensing Audio-frequency Magnetotellurics(AMT) Microtremor Survey Method(MSM) Geological drilling engineering Spatial structure Tibetan Plateau Geological hazard survey engineering

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科技安全概念演化、问题辨析与体系构建研究

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科学学研究 2024年第9期42卷 1824-1832,1876页

作者：傅晋华中国科学技术发展战略研究院北京100038

科技安全是我国国家安全体系的重要组成部分,科技要素在支撑保障国家安全中发挥关键作用。本文从国家安全视角对科技安全概念演化和内涵特征进行解析,分析提出科技安全问题的研判标准和内在逻辑,并以“卡脖子”问题案例加以佐证。在此... 详细信息

科技安全是我国国家安全体系的重要组成部分,科技要素在支撑保障国家安全中发挥关键作用。本文从国家安全视角对科技安全概念演化和内涵特征进行解析,分析提出科技安全问题的研判标准和内在逻辑,并以“卡脖子”问题案例加以佐证。在此基础上,本文利用系统要素分析方法研究构建我国科技安全体系,结果表明:科技安全体系主要包括科技安全构成要素子系统、科技安全输出子系统、科技安全环境子系统和科技安全治理子系统4个主要组成部分,其共同构成国家科技安全体系。

关键词：国家安全科技安全科技安全问题科技安全体系

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Efficacy of 3%diquafosol combined with azelastine hydrochloride in allergic conjunctivitis patients with dry eye

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Advances in Ophthalmology Practice and Research 2024年第2期4卷 47-51页

作者： Lin Lin Yirui Zhu Kelan Yuan Yujie mou Hanhe Zhao Yayin Wu Xiuming jin Eye Center of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhouChina

Dear Editor,We would like to present you an effective therapy for allergic conjunctivitis(AC)patients with dry eye that uses 3%diquafosol com-bined with azelastine hydrochloride ophthalmic ***,the main therapy for AC involves anti-allergic,anti-inflammatory medicines,artificial tears,and mast cell combination antihistamine ***-ventional treatment agents for dry eye include artificial tears,cortico-steroids,and immunosuppressant cyclosporine eye drops.1 However,no adequate therapeutic options are available to treat this multifactorial disease at *** with artificial tears and anti-inflammatory medicine alone is inadequate for improving symptoms in some patients with AC and dry eye.

关键词： allergic patients artificial

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Sarcopenia adversely impacts clinical outcomes in patients undergoing pancreaticoduodenectomy: A systematic review and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1857-1870页

作者： Qi-Hui Zhang jin-Dong Ma Yan-Min Lu Run-Nan Zhang Zhong-hua Zhao Ya-Tong Li Qiang-Pu Chen Department of Clinical Nutrition Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

BACKGROUND Sarcopenia is a syndrome marked by a gradual and widespread reduction in skeletal muscle mass and strength,as well as a decline in functional ability,which is associated with malnutrition,hormonal changes,chronic inflammation,distur-bance of intestinal flora,and exercise *** is a com-monly employed clinical intervention for conditions such as pancreatic head cancer,ampulla of Vater cancer,and cholangiocarcinoma,among others,with a notably high rate of postoperative *** is frequent in patients undergoing ***,data regarding the effects of sarcopenia in patients undergoing pancreaticoduodenectomy(PD)are both limited and *** PubMed,Cochrane Library,Web of Science,and Embase databases were screened for studies published from the time of database inception to June 2023 that described the effects of sarcopenia on the outcomes and complications of *** researchers independently assessed the quality of the data extracted from the studies that met the inclusion ***-analysis using RevMan 5.3.5 and Stata 14.0 software was *** and funnel plots were used,respectively,to demonstrate the outcomes of the sarcopenia group vs the non-sarcopenia group after PD and to evaluate potential publication *** Sixteen studies encompassing 2381 patients were included in the *** patients in the sarcopenia group(n=833)had higher overall postoperative complication rates[odds ratio(OR)=3.42,95%confidence interval(CI):1.95-5.99,P<0.0001],higher Clavien-Dindo class≥Ⅲ major complication rates(OR=1.41,95%CI:1.04-1.90,P=0.03),higher bacteremia rates(OR=4.46,95%CI:1.42-13.98,P=0.01),higher pneumonia rates(OR=2.10,95%CI:1.34-3.27,P=0.001),higher pancreatic fistula rates(OR=1.42,95%CI:1.12-1.79,P=0.003),longer hospital stays(OR=2.86,95%CI:0.44-5.28,P=0.02),higher mortality rates(OR=3.17,95%CI:1.55-6.50,P=0.002),and worse overall survival(hazard ratio=2.81,95%CI:1.4

关键词： Pancreaticoduodenectomy Sarcopenia Postoperative complications Length of stay Meta-analysis

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教育家精神的历史根源、内涵特质与培育路径

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中国教育科学（中英文） 2024年第1期7卷 46-54页

作者：金兢牟凌刚浙江师范大学杭州321400 浙江省教育厅教师工作处杭州321400

从教育家精神的历史根脉来看,中华优秀传统文化是教育家精神的文化根基,中华传统教育哲学是教育家精神的价值依据,新时代教师教育政策话语是教育家精神的理论指引。教育家精神的内涵特质为以思想立场为根本原则、以师德师风为第一标准... 详细信息

从教育家精神的历史根脉来看,中华优秀传统文化是教育家精神的文化根基,中华传统教育哲学是教育家精神的价值依据,新时代教师教育政策话语是教育家精神的理论指引。教育家精神的内涵特质为以思想立场为根本原则、以师德师风为第一标准、以仁智统一为育人宗旨、以实践创新为专业内核、以奉献仁爱为师者情怀,以文化自信为立德途径。教育家精神是加快我国教育现代化进程的现实需要、落实立德树人根本任务的客观要求和推进高质量教师队伍建设的内在标准,培育教育家精神需结合本土文化资源激发教师成长动力,迭代“优师强师”的培育机制;坚持自我教育与外部支持相结合,创设尊师重教的整体氛围。

关键词：教育家精神教育强国教师队伍建设立德树人

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X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

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World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-hua Yang jin-Zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-hua Pan Wan-Qing Liao Tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of Dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(XP)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,XP combines various medicinal ***-performance liquid chromatography(HPLC)identified XP’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether XP participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between XP-treated and control *** docking clarified XP’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** XP notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following XP *** identified 21 primary XP components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** XP significantly promotes wound healing in STZ-induced diabetic *** XP’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

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Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

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Research in Astronomy and Astrophysics 2024年第6期24卷 156-169页

作者： Hu-Bing Xiao Hai-Tao Cao Rui Xue jin-Ting Cai Ge-Ge Wang Marina Manganaro Shao-hua Zhang Zhi-Hao Ouyang Li-Ping Fu Jun-Hui Fan Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China School of Information Engineering Guangzhou Panyu PolytechnicGuangzhou 511483China Department of Physics Zhejiang Normal UniversityJinhua 321004China College of Mathematics and Physics Guangxi Minzu UniversityNanning 530006China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China Department of Physics University of RijekaRijeka 51000Croatia Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory for Astronomical Observation and Technology of Guangzhou Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China

The location ofγ-ray emission of blazars remains a contested topic,inspiring the development of numerous investigative techniques to address this *** this work,we analyzed Fermiγ-ray light curves in the GeV and MeV bands,employing the discrete cross-correlation function method to discern time lags between the two *** 4C+21.35,Ton 599,B21420+32,and PKS 1510-089,we identified a time lag spanning several days,while for PKS 1441+25,the time lag was not statistically *** results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources,whereas for PKS1441+25,they seem to be sourced mainly from the broad-line *** analysis of the opacity(τγγ)and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the BLR to avoid significant ***,for PKS 1441+25,the emission region is also posited to lie outside yet proximate to the *** parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation *** findings suggest that for the five TeV FSRQs,during Te V flaring events,the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources,with the exceptions of 4C+21.35 and PKS1441+*** terms of the overall jet power,particle energy is the dominant contributor,and the observed blazar radiation cannot be solely attributed to the magnetic field,except in the case of 4C+***,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies:active gamma-rays:galaxies galaxies:jets

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Rare earth element-modified MOF materials:synthesis and photocatalytic applications in environmental remediation

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Rare Metals 2024年第4期43卷 1390-1406页

作者： Shu-Kun Le Qi-Jie jin Jia-Ao Han hua-Cong Zhou Quan-Sheng Liu Fu Yang Jie Miao Pei-Pei Liu Cheng-Zhang Zhu Hai-Tao Xu Inner Mongolia Key Laboratory of High-Value Functional Utilization of Low Rank Carbon Resources Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot010050China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing210009China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications MontrealQCJ3X 1P7Canada

Metal-organic framework-like materials(MOFs)have been developed in the fields of photocatalysis for their excellent optical properties and physicochemical properties,including environmental remediation,CO_(2)photoreduction,water splitting,and so *** their important roles in various fields,rare earth elements have received growing interests from *** MOFs with rare earth elements for modification allows broadening the absorption spectrum,while the active electrons on their empty 4f orbitals can act as traps to capture photoexcited carriers to inhibit the recombination of electron-hole pairs,thus promoting photocatalytic ***,rare earth elements modified MOFs provide an attractive way to achieve their high value *** this mini-review,the synthesis of rare earth element-modified MOFs photocatalysts and corresponding applications in the removal of antibiotics,CO_(2)reduction,and hydrogen production are constructively summarized and ***,the latest advancements and current difficulties of these materials as well as the application prospects are also provided.

关键词： Rare earth metals MOFs Photocatalytic CO_(2) reduction Environmental remediation Water splitting

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