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去泛素化酶在肾细胞癌中的作用

生物化学与生物物理进展 2024年第2期51卷 276-299页

作者：罗霞金晓锋宁波大学医学部生物化学与分子生物学系浙江省病理生理学技术研究重点实验室宁波315211

肾细胞癌(renal cell carcinoma,RCC)是成人肾脏的原发性恶性肿瘤。泛素-蛋白酶体系统(ubiquitinproteasome system,UPS)对控制蛋白质水平和调节生理病理过程至关重要。去泛素化酶(deubiquitinases,DUBs)是UPS的关键成分,特别是从靶蛋... 详细信息

肾细胞癌(renal cell carcinoma,RCC)是成人肾脏的原发性恶性肿瘤。泛素-蛋白酶体系统(ubiquitinproteasome system,UPS)对控制蛋白质水平和调节生理病理过程至关重要。去泛素化酶(deubiquitinases,DUBs)是UPS的关键成分,特别是从靶蛋白中去除泛素链,通过严格调节正常生理学中泛素化和去泛素化之间的平衡,对蛋白质稳态和质量控制显示出至关重要的作用。越来越多的研究表明,功能异常的DUBs与RCC的进展和转移有关。根据底物的不同,一些DUB可能会抑制RCC,而另一些则促进。本文综述了RCC相关DUB的最新研究进展,描述了其分类、功能作用,总结了DUB在RCC中的作用和作用机制,并讨论了靶向DUBs用于癌症治疗。

关键词：肾细胞癌泛素-蛋白酶体系统去泛素化酶

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基于AI的充电桩火灾预警系统的应用研究

阀门 2024年第5期 639-642页

作者：肖金凤沈阳科技学院辽宁沈阳110167

为了及时发现和预防充电桩火灾,基于人工智能的火灾预警系统备受关注。本文针对该问题展开研究,通过综述充电桩火灾的发生原因、现有火灾预警系统以及基于人工智能的预警系统的发展现状,探讨了如何提高预警系统的准确性和时效性,并结合... 详细信息

为了及时发现和预防充电桩火灾,基于人工智能的火灾预警系统备受关注。本文针对该问题展开研究,通过综述充电桩火灾的发生原因、现有火灾预警系统以及基于人工智能的预警系统的发展现状,探讨了如何提高预警系统的准确性和时效性,并结合实际充电桩场景进行了系统性能的评估。研究表明,基于人工智能的火灾预警系统在提高预警准确性和时效性方面具有显著潜力,然而,仍需解决误报率和漏报率等问题。未来的研究应致力于进一步改进系统性能,以实现更安全可靠的充电桩火灾预警。

关键词：充电桩火灾预警系统人工智能火灾预警

REAL-TIME FLOOD FORECASTING METHOD WITH 1-D UNSTEADY FLOW MODEL

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Journal of Hydrodynamics 2007年第2期19卷 150-154页

作者： MU jin-bin ZHANG xiao-feng State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan 430072China

A real-time forecasting method coupled with the I-D unsteady flow model with the recursive least-square method was developed. The 1-D unsteady flow model was modified by using the time-variant parameter and revising it dynamically through introducing a variable weighted forgetting factor, such that the output of the model could be adjusted for the real time forecasting of floods. The application of the new real time forecasting model in the reach from Yichang to Luoshan of the Yangtze River was demonstrated. Computational result shows that the forecasting accuracy of the new model is much higher than that of the original 1-D unsteady flow model. The method developed is effective for flood forecasting, and can be used for practical operation in the flood forecasting.

关键词： unsteady flow hydraulic model least squares,time variant forgetting factor real-time forecasting

Risk factors for mortality after coronary artery bypass grafting in patients with low left ventricular ejection fraction

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Chinese Medical Journal 2007年第4期120卷 317-322页

作者： WANG jin xiao feng REN Jian LI Yan ZHANG Ming-li Department of Cardiac Surgery Peking University First Hospital Beijing 100034 China

Background We managed to assess and confirm the risk factors for mortality after coronary artery bypass grafting （CABG） operations so as to map out the proper guidance of surgical strategy especially in patients with low left ventncular ejection fraction （LVEF） in domestic polyclinic like ours. Methods Five hundred and forty-eight consecutive patients underwent CABG from December 1999 through August 2005 were analyzed retrospectively. Eighty-nine cases had an LVEF of 40% or less. All together twenty-two candidate factors were evaluated for their association with perioperative death using univariate and multivariate stepwise Logistic analysis. Results When data from all the patients who had undergone CABG were taken into account, LVEF, left ventricular end diastolic diameter （LVEDD）, mitral regurgitation, aneurysm of the heart wall, mitral repair/replacement, resection of aneurysm, concomitant aortic valve replacement, and perioperative intra-aortic balloon counter-pulsation （IABP）, left ventricular assist device （LVAD） and cardiopulmonary bypass （CPB） all showed an association with perioperative death in univariate analysis, while an LVEF of 〉40%, on the other hand, appeared to be a protective factor. In multivariate analysis, moderate to severe mitral regurgitation, aneurysm of the heart wall, repair of septal perforation and aortic regurgitation were proved to be risk factors. When the analysis was restricted to patients with an LVEF of 40% or less, such variables as age, LVEDD, mitral regurgitation, mitral repair/replacement, IABP, and CPB were qualified as risk factors in a univariate analysis. Age, moderate mitral regurgitation, aneurysm of the heart wall, CPB, left main coronary artery disease and female were associated with pefioperative death in a multivariate logistic regression analysis. Conclusions Concerning the prognosis, patients who undergo CABG would have different risk factors when data from all the enrolled patients or data from patients with

关键词： ventricular dysfunction, left coronary artery bypass risk factors

Growth and Interface Structure of Mn on InP (001)

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Chinese Physics Letters 1998年第10期15卷 730-731页

作者： DONG Guo-sheng CHEN Yan SHEN xiao-liang jin xiao-feng Laboratory of Surface Physics Fudan UniversityShanghai 200433 Analysis and Measurement Center Fudan UniversityShanghai 200433

An attempt to grow single crystalline thin films of body-centered-cubic(bcc)Mn on InP(001)has been carried out by molecular beam *** situ reflection high energy electron diffraction and ex situ x-ray diffraction are used to characterize the film and interface *** is found that the metastable phase of bcc Mn fails to stabilize on the substrate despite of their perfect *** result suggests again the importance of interface structure in the epitaxy of 3d metals on semiconductors.

关键词： interface cubic perfect

自制复合细化剂对废杂黄铜制备铜锭组织性能的影响

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铸造设备与工艺 2024年第4期 51-56页

作者：欧阳好肖金锋王东朱鹏飞宁波金田铜业(集团)股份有限公司浙江宁波315034

主要研究自主开发的JT-1复合细化剂对于废杂黄铜熔炼组织性能的影响,重点分析废杂黄铜熔炼过程的JT-1复合细化剂在解决细化中毒问题的机理,同时探究了JT-1复合细化剂使用量的变化对于晶粒细化、消除枝晶、均匀化组织以及改善熔体流动性... 详细信息

主要研究自主开发的JT-1复合细化剂对于废杂黄铜熔炼组织性能的影响,重点分析废杂黄铜熔炼过程的JT-1复合细化剂在解决细化中毒问题的机理,同时探究了JT-1复合细化剂使用量的变化对于晶粒细化、消除枝晶、均匀化组织以及改善熔体流动性的影响。研究结果表明,JT-1复合细化剂加入质量分数在0.03%~0.04%,可以构建多重细化环境,废杂黄铜熔炼熔体凝固结晶晶粒度由100μm以上降低到35μm,同时熔体流动性也得到明显改善,铸锭抛光硬质点也在2个以内达到一级以上的标准,完成满足废杂黄铜生产环保卫浴铜锭产品质量要求。

关键词： JT-1复合细化剂废杂黄铜晶粒度流动性硬质点

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苦参饮片不良反应分析

中国合理用药探索 2024年第7期21卷 95-98页

作者：靳晓峰李富云张兆芳靳子明甘肃中医药大学附属医院兰州730000 杨锡仓全国名老中医药专家传承工作室兰州730000

目的:探讨苦参饮片不良反应发生的规律和特点,为临床安全合理用药提供参考。方法:从苦参不良反应文献、患者性别与年龄、用法用量、累及系统或器官等方面对某院门诊所收集记录的2例苦参饮片不良反应加以分析。结果:患者性别与年龄无实... 详细信息

目的:探讨苦参饮片不良反应发生的规律和特点,为临床安全合理用药提供参考。方法:从苦参不良反应文献、患者性别与年龄、用法用量、累及系统或器官等方面对某院门诊所收集记录的2例苦参饮片不良反应加以分析。结果:患者性别与年龄无实际指导意义;超剂量用药可能引起苦参饮片不良反应;苦参饮片不良反应主要对消化系统和心血管系统损害较为明显。结论:临床医生以及药师应当重视苦参饮片不良反应,并加强用药监管力度,保证临床用药的安全性和合理性。

关键词：苦参饮片不良反应用法用量累及系统或器官用药安全

Surface Magnetism of One Monolayer Mn Atoms on GaAs(001)Surface

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Chinese Physics Letters 1999年第5期16卷 381-383页

作者： YANG Zong-xian jin xiao-feng ZHANG Kai-ming XIE Xi-de Department of Physics Henan Normal UniversityXinxiang 453002 Surface Physics Laboratory(National Key Laboratory) fudan UniversityShanghai 200433

The surface magnetism of one monolayer Mn atoms on GaAs(001)surface is studied by the self-consistent tight-binding linear muffin-tin orbital *** is found that the magnetic ordered phases(ferromagnetic and antiferromagnetic)are more favorable than the paramagnetic one,the density of states peak far below the Fermi level observed in synchrotron radiation photoemission study has been identified as due to the contribution of Mn 3d majority states.

关键词： method ferromagnetic Fermi

Endoscope-assisted Transoral Approach for Parapharyngeal Space Tumor Resection

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Chinese Medical Journal 2017年第18期130卷 2267-2268页

作者： Jian Wang Wu-Yi Li Da-Hai Yang xiao-feng jin Yan-Yan Niu Department of Otorhinolaryngology Peking Union Medical College Hospital Beijing 100730 China

To the Editor：The parapharyngeal space is a potential neck space between prevertebral fascia and buccopharyngeal *** space tumors account for 0.5% of all head and neck neoplasms,of which 80% are benign. Surgical excision is the primary *** procedures vary depending on the tumor type,location,size,and its relationship with the neighboring nerves and ***,an external approach was often selected,mainly through the neck,parotid gland,mandible,or orbitozygomatic structure. However,following the development of endoscopic and robotic surgery,several surgeons have explored natural orifice transluminal endoscopic surgery （NOTES） to remove the parapharyngeal space tumor,which reduces complications,shortens hospital stay,and leaves no visible scar.[2,3] This study retrospectively reviewed 31 cases of a transoral approach in resecting parapharyngeal space tumors.

关键词： SURGERY