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Chinese Chemical Letters 2011年第1期22卷 97-100页

作者： Ru Song Zhao Xia Wang jin Peng Yuan shan shan Wang Chuan Ge Cheng Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of shandong Province Analysis and Test Center Shandong Academy of Sciences Jinan 250014 China

A novel temperature controlled ionic liquid dispersive liquid phase microextracfion （TCIL-DLPME） coupled with rapid resolution liquid chromatography-electrospray tandem mass spectrometry （RRLC-ESI-MS-MS） has been developed for the enrichment and determination of three hexabromocyclododecane diastereomers （HBCDs） in water samples. Green solvent ionic liquid （IL） was used as extraction solvent instead of toxic organic solvents. This technique also avoided the usage of dispersive solvent. Some important parameters that might affect the extraction efficiency were optimized. Under the optimum conditions, good linear relationship, sensitivity and reproducibility were obtained. All the limits of detection for the three diastereomers were 0.1 ng/ mL. The linear range was obtained in the range of 1-100 ng/mL for the total amount of three HBCD diastereomers. It was satisfactory to analyze real environmental water samples with the recoveries ranging from 77.2% to 99.3%. The main advantage of the method is toxic organic solvent-free.

关键词： Hexabromocyclododecane Temperature controlled ionic liquid dispersive liquid phase microextraction Rapid resolution liquidchromatography-electrospray tandem mass spectrometry

Characteristics of the HIV/AIDS Epidemic in Women Aged 15-49 Years from 2005 to 2012 in China

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Biomedical and Environmental Sciences 2015年第10期28卷 701-708页

作者： ZHANG Xia Yan HUANG Tao FENG Yi Bing LI Meng CHEN Fang Fang LI Yin Ge jin shan shan BU Kai WANG Lu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention shandong Provincial Center for Disease Control and Prevention College of Public Health University of South Florida

Objective To describe the characteristics of the HIV/AIDS epidemic in women aged 15-49 years in China. Methods HIV/AIDS cases from 2005 to 2012 that fulfilled the inclusion and exclusion criteria were identified on the Chinese HIV/AIDS case reporting system. Descriptive and spatial analyses were performed. Results A total of 103,559 female HIV/AIDS cases were included in our study. Based on the descriptive analysis, between 2005 and 2012, the proportion of heterosexually acquired HIV infection among women （15-49 years） increased rapidly from 35.8% to 87.4%. Approximately 60% of these cases were infected through non-marital heterosexual contact. Among older women （40-49 years）, a slightly increasing trend was identified. The spatial analysis detected ＇hot spots＇ in the Xinjiang, Yunnan, Sichuan, Guangxi, and Chongqing provinces. The epidemic trends in these areas were predominately driven by heterosexual transmission. Conclusion Non-marital heterosexual contact is a very important factor in the HIV/AIDS epidemic in women aged 15-49 years, and the HIV infection rate in older women is increasing. Several epidemic hot spots were detected in northwestern and southwestern China. Efficient interventions are needed to control the spread of HIV/AIDS among women living in these areas.

关键词： AIDS Women Epidemiology China

Correlates of Condom-use Self-efficacy on the EPPM-based Integrated Model among Chinese College Students

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Biomedical and Environmental Sciences 2017年第2期30卷 97-105页

作者： jin shan shan BU Kai CHEN Fang Fang XU Hui Fang LI Yi ZHAO Dong Hui XU Fang LI jing Yan HAN Meng Jie WANG Ning WANG Lu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510440GuangdongChina Heilongjiang Provineial Center for Disease Control and Prevention Harbin 150030HeilongjiangChina Tianjin University of Traditional Chinese Medicine Tianjin 300193China Lingnan Partners Community Support Center Guangzhou 510000GuangdongChina

Objective To explore the predictors of condom-use self-efficacy in Chinese college students according to the extended parallel process model （EPPM）-based integrated model. Methods A total of 3,082 college students were anonymously surveyed through self-administered questionnaires in Guangzhou and Harbin, China. A structural equation model was applied to assess the integrated model. Results Among the participants, 2,387 （46.7%） were male, 2,586 （53.3%） were female, and the average age was 18.6 years. The final integrated model was acceptable. Apart from the direct effect （r = 0.23）, perceived severity had two indirect effects on condom-use self-efficacy through the attitude to HIV education （r = 0.40） and intention to engage in premarital sex （r = -0.16）, respectively. However, the perceived susceptibility mediated through the intention to engage in premarital sex （intent-to-premarital-sex） had a poor indirect impact on condom-use self-efficacy （total effect was -0.06）. Furthermore, attitude toward HIV health education （r = 0.49） and intent-to-premarital-sex （r = -0.32） had a strong direct effect on condom-use self-efficacy. In addition, male students perceived higher susceptibility, stronger intent-to-premarital-sex, and lower condom-use self-efficacy than female students. Conclusion The integrated model may be used to assess the determinants of condom-use self-efficacy among Chinese college students. Future research should focus on raising the severity perception, HIV-risk-reduction motivation, and the premarital abstinence intention among college students. Furthermore, considering the gender differences observed in the present survey, single-sex HIV education is required in school-based HIV/sex intervention.

关键词： HIV infection Condom-use self-efficacy Chinese college students

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绳锯线弓角静态测量方法的研究

工程设计学报 2016年第4期23卷 309-315,344页

作者：金闪闪邹航郭桦华侨大学脆性材料加工技术教育部工程研究中心福建厦门361021 华侨大学制造工程研究院福建厦门361021

金刚石绳锯在切割圆弧板材时,受到进给方向的阻力,形成"线弓角",使板材中部产生"过切",严重时导致材料报废.为解决这一问题,提出了线弓角的概念,从理论上提出了一种基于悬臂式力传感器的绳锯线弓角的静态测量方法,通过轴力传感器输出的... 详细信息

金刚石绳锯在切割圆弧板材时,受到进给方向的阻力,形成"线弓角",使板材中部产生"过切",严重时导致材料报废.为解决这一问题,提出了线弓角的概念,从理论上提出了一种基于悬臂式力传感器的绳锯线弓角的静态测量方法,通过轴力传感器输出的电压值计算出线弓角度.试验在自行设计和搭建的绳锯线弓角测量平台上进行,用钢丝绳模拟串珠绳产生线弓角,并进行导轮受力与线弓角关系的静态测量试验分析,以验证该方法测量线弓角的可行性.试验结果表明:在一定范围内,串珠绳初始张紧力越大,线弓角的计算值越接近理论值.因此,采用所提出的测量方法,当装有轴力传感器的导轮处在刚好与钢丝绳接触的状态下,选择合适的初始张紧力,可以测得较准确的角度值.

关键词：绳锯轴力传感器线弓角

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

中晚期非小细胞肺癌患者培美曲塞联合铂类化疗前后免疫抑制细胞检测及意义

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中华肿瘤防治杂志 2018年第22期25卷 1583-1587页

作者：金珊珊束永前南京医科大学第一附属医院肿瘤科江苏南京210029

目的研究表明,在恶性肿瘤患者体内,普遍存在着免疫抑制和免疫逃逸的一种微环境,使患者免疫系统的功能存在不同程度的抑制。本研究将检测中晚期非小细胞肺癌患者应用培美曲塞联合铂类化疗前后外周血中髓源抑制细胞(myeloid-derived suppr... 详细信息

目的研究表明,在恶性肿瘤患者体内,普遍存在着免疫抑制和免疫逃逸的一种微环境,使患者免疫系统的功能存在不同程度的抑制。本研究将检测中晚期非小细胞肺癌患者应用培美曲塞联合铂类化疗前后外周血中髓源抑制细胞(myeloid-derived suppressor cells,MDSC)和调节性T细胞(Tregs)的比例,分析其对肺癌患者免疫功能的影响及临床意义。方法选择2016-05-01-2018-02-01南京医科大学第一附属医院肿瘤生物治疗中心就诊的中晚期非小细胞肺癌患者43例及2017年江苏省人民医院进行体检的健康人40名,肺癌患者均接受培美曲塞单药或联合铂类化疗,每例患者至少治疗4个周期后评价疗效。采用流式细胞仪检测肺癌患者化疗前后及健康体检者外周血中MDSC和Treg细胞的比例。结果根据化疗后的疗效评价,43例患者分为疾病进展组和疾病控制组,CR、PR、SD统称为疾病控制组。与健康对照组相比,肺癌患者化疗前外周血中MDSC为(4.89±1.86)%,明显高于对照组的(0.75±0.24)%;Treg细胞化疗前为(11.54±2.44)%,高于对照组的(5.76±0.77)%,P<0.001;在治疗4个周期后,患者外周血中MDSC(2.3±1.64)%和Treg细胞(6.4±0.98)%的比例下降,差异有统计学意义,P值分别为0.004和0.003;疾病控制组患者MDSC(1.39±0.99)%和Treg细胞(5.83±0.55)%比例均较化疗前降低;疾病进展组患者MDSC(3.68±1.45)%和Treg细胞(7.43±0.63)%的比例均低于化疗前。无论是化疗前,还是化疗后,中晚期非小细胞肺癌患者外周血中MDSC与Treg细胞之间均存在正相关关系,均P<0.001。结论中晚期非小细胞肺癌患者的免疫功能低下与外周血中MDSC和Treg细胞的比例相关,培美曲塞单药或联合铂类治疗能够抑制MDSC和Treg细胞的比例,增强机体抗肿瘤免疫。检测外周血中MDSC和Treg细胞比例可评估患者的免疫功能状态,对患者临床疗效具有指导意义。

关键词：非小细胞肺癌培美曲塞 MDSC Treg肿瘤免疫抑制

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水泥砂浆孔结构分形特征的研究

建筑材料学报 2011年第1期14卷 92-97,105页

作者：金珊珊张金喜陈春珍陈炜林北京工业大学交通工程北京市重点实验室北京100124

利用压汞仪测定了不同水灰比及龄期水泥砂浆的孔结构,通过基于热力学关系的分形模型计算得到了水泥砂浆的孔表面积分形维数,并探讨了孔表面积分形维数与微观孔隙率、孔表面积、平均孔径、中值孔径等其他孔结构参数及砂浆强度之间的关系... 详细信息

利用压汞仪测定了不同水灰比及龄期水泥砂浆的孔结构,通过基于热力学关系的分形模型计算得到了水泥砂浆的孔表面积分形维数,并探讨了孔表面积分形维数与微观孔隙率、孔表面积、平均孔径、中值孔径等其他孔结构参数及砂浆强度之间的关系.结果表明:基于热力学关系的分形模型能够很好地表征水泥砂浆孔隙的复杂程度;孔表面积分形维数与微观孔隙率的相关性较差,而与孔表面积、平均孔径、中值孔径以及强度之间有较好的相关关系;随着孔表面积分形维数的增大,平均孔径和中值孔径减小,孔表面积增加,水泥砂浆的抗折强度及抗压强度增加.基于热力学关系的分形模型计算得到的孔表面积分形维数可作为水泥砂浆孔结构特征的综合评价指标,并且分形维数与其宏观力学性能相关性良好.

关键词：分形维数孔砂浆模型热力学

Establishing a new testing protocol of the electrochemical stability window for electric double-layer capacitors

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Science China Chemistry 2025年第1期68卷 217-225页

作者： Ruilin Hou Xiaoxi Zhao Tingting Liang Qingyun Dou shan Xu Xingbin Yan School of Materials Science and Engineering Sun Yat-sen University Laboratory of Clean Energy Chemistry and Materials Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Engineering and Applied Sciences Nanjing University Center of Industrial Analysis and Testing Guangdong Academy of Science

The electrochemical stability window(ESW) is crucial for determining the energy density of electric double-layer capacitors(EDLCs). However, current ESW testing protocols of EDLCs are strongly affected by artificial factors, thereby leading to unreliable result. To solve this problem, we first identify the key shortcomings of the traditional protocols by analyzing their test principles. Subsequently, taking an aqueous carbon-based EDLC as an example, we design a side reaction descriptor to represent the response difference in the charging capacitance to side reactions between the cyclic voltammetry and galvanostatic chargedischarge methods. With the aid of this descriptor, we propose a new ESW testing protocol, which is not only able to completely avoid the adverse influence of subjective factors but also fully consider the operating condition limitations. The protocol can be extended from the single electrode to the full device. This work proposes a more rigorous definition of ESW and provides a reliable protocol for evaluating the ESW of EDLCs.

关键词： electric double-layer capacitors electrochemical stability window testing protocol side reaction descriptor operating limitation

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

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低品质骨料混凝土冻融特性及机理研究

建筑材料学报 2007年第4期10卷 386-391页

作者：张金喜李亚宁金珊珊范猛北京工业大学交通工程重点实验室北京100022

对不同品质骨料配制的混凝土的抗冻融耐久性和8种骨料(满足或不满足JTGF30—2003规范品质要求)以及3种砂浆在冻融循环过程中的变形特性进行实验,并对骨料微观构造进行观察.结果表明:单纯以骨料表观密度和吸水率来判断其所配制的混凝土... 详细信息

对不同品质骨料配制的混凝土的抗冻融耐久性和8种骨料(满足或不满足JTGF30—2003规范品质要求)以及3种砂浆在冻融循环过程中的变形特性进行实验,并对骨料微观构造进行观察.结果表明:单纯以骨料表观密度和吸水率来判断其所配制的混凝土的抗冻融耐久性存在不确定性,某些超出JTG F30—2003规范要求骨料配制的混凝土也具有良好的抗冻融耐久性.在混凝土冻融循环过程中骨料和砂浆出现累计残留变形差异,从而对周围砂浆产生压力,使砂浆内部形成拉应力.当砂浆内部拉应力接近或大于砂浆抗拉强度时,混凝土就发生破坏.骨料微观构造对骨料性能产生重大影响.

关键词：低品质骨料残留变形冻融特性