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Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study

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World Journal of Gastroenterology 2007年第21期13卷 2973-2977页

作者： Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song Department of Internal Medicine University of Soonchunhyang at CheonanCheonan & Seoul & BucheonRepublic of Korea Department of Internal Medicine University of Yonsei at SeoulSeoul & WonjuRepublic of Korea Department of Internal Medicine University of Sungkyunkwan at SeoulSeoulRepublic of Korea Department of Internal Medicine University of Kyunghee at SeoulSeoulRepublic of Korea Department of Internal Medicine University of Ulsan at SeoulSeoulRepublic of Korea Department of Internal Medicine University of Youngnam at TaeguTaeguRepublic of Korea Department of Internal Medicine University of Ewha at SeoulSeoulRepublic of Korea Department of Internal Medicine University of Korea at SeoulSeoul & AnsanRepublic of Korea Department of Internal Medicine University of Catholic at BucheonBucheonRepublic of Korea Department of Internal Medicine University of Hanyang at KuriKuriRepublic of Korea Department of Preventive Medicine University of KwandongKangneungRepublic of Korea

AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early ( 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB.

关键词： Colonoscopic polypectomy Bleeding submucosal injection Saline Epinephrine

LO-CAT工艺技术在天然气净化中的应用及研究进展

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江苏化工 2007年第2期26卷 11-14页

作者：龙增兵刘瑾蒋树林西南石油大学四川成都610500 西南油气田分公司川中气矿四川遂宁629100

阐述了LO-CAT工艺原理,常规LO-CAT工艺和LO-CATⅡ自动循环工艺流程及其在天然气净化中的应用现状;重点介绍了LO-CAT工艺的研究进展和工艺改进;并对我国以后的技术改进和研究方向提出了建议。

关键词： LO-CAT工艺天然气净化应用研究进展

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基于WSN的高速汽车动态载荷信号处理方法

微型机与应用 2011年第9期30卷 62-66页

作者：吴义魁王琪江民俊金帅南昌航空大学信息工程学院江西南昌330063

针对高速动态称重中低频动态载荷严重影响真实轴重称量的问题,通过引入无线传感器网络(WSN)技术,构建智能化称重传感器网络,提出了一种测量高速汽车载荷的系统方案及数据处理方法。分析称重系统采集的汽车动态载荷的振动频率,并构建信... 详细信息

针对高速动态称重中低频动态载荷严重影响真实轴重称量的问题,通过引入无线传感器网络(WSN)技术,构建智能化称重传感器网络,提出了一种测量高速汽车载荷的系统方案及数据处理方法。分析称重系统采集的汽车动态载荷的振动频率,并构建信号模型,通过基于三参数对动态载荷正弦波曲线进行拟合,建立线性方程组,采用高效算法和信息处理得到精确的称重数据。仿真实验结果表明,该方法平均误差低,数据稳定性较高,而且对高速具有很好适应性,对解决高速动态汽车称重精度问题具有一定的意义。

关键词：动态称重无线传感器网络动态载荷参数估计

Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies

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World Journal of Gastroenterology 2015年第38期21卷 10874-10882页

作者： Hyoung Su Kim Hyung Joon Yim Myoung Kuk jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee jin-Woo Lee In Hee Kim Tae Yeob Kim jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang Department of Internal Medicine Hallym University College of Medicine Department of Internal Medicine Korea University Ansan Hospital Department of Internal Medicine Korea University Medical College Department of Internal Medicine Bundang Jesaeng Hospital Department of Internal Medicine Soon Chun Hyang University College of Medicine Department of Internal Medicine Inha University School of Medicine Department of Internal Medicine Chonbuk National University Medical School Department of Internal Medicine Hanyang University College of Medicine Department of Internal Medicine Seoul National University College of Medicine Department of Internal Medicine Gachon University School of Medicine Department of Internal Medicine CHA Bundang Medical CenterCHA University

AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,***: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable ***: If tenof

关键词： Adefovir Chronic hepatitis B Entecavir Lamivudine

2016~2020年太原市空气质量时空变化研究

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四川环境 2023年第2期42卷 83-91页

作者：姜洪进段嘉瑞马祥爱山西农业大学资源环境学院太原030031 太原市小井峪街道办事处太原030024

为了分析太原市空气质量现状、变化规律和治理成效,通过综合指数法、Kriging插值法、聚类分析、斯皮尔曼相关系数法研究2016~2020年太原市空气质量变化,分析气象因素对空气质量的影响。结果表明:2016~2020年太原市空气质量综合指数总体... 详细信息

为了分析太原市空气质量现状、变化规律和治理成效,通过综合指数法、Kriging插值法、聚类分析、斯皮尔曼相关系数法研究2016~2020年太原市空气质量变化,分析气象因素对空气质量的影响。结果表明:2016~2020年太原市空气质量综合指数总体呈下降趋势,重污染天数减少;AQI逐月变化近似呈“W”型变化,除O_(3)外其他污染物浓度呈“∨”型变化;NO_(2)小时浓度变化呈“单谷”型,O_(3)呈“单峰单谷”型,AQI和其他污染物呈“双峰双谷”型;污染物浓度空间变化主要呈“南高北低、东高西低、中心城区高”的特点;除O_(3)外,全年其它五种污染物与温度、风速均呈显著负相关,与大气压则呈显著正相关。分析表明:太原市空气质量逐年好转,污染物有明显的时空分布,空气质量与气象因素关系密切;应加强颗粒物和O_(3)协同治理,建立区域联防联控机制,加强采暖期重污染天气应急工作。

关键词：十三五空气质量太原市

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Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett's esophagus

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World Journal of Gastroenterology 2013年第41期19卷 7089-7096页

作者： Nam Seok Ham Jae Young jang Sung Woo Ryu Ji Hye Kim Eui Ju Park Woong Cheul Lee Kwang Yeun Shim Soung Won Jeong Hyun Gun Kim Tae Hee Lee Sung Ran Jeon Jun Hyung Cho Joo Young Cho So Young jin Ji Sung Lee Institution for Digestive Research Digestive Disease CenterDepartment of Internal MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Pathology Soonchunhyang University HospitalSeoul 140-743South Korea Biostatistical Consulting Unit Soonchunhyang University HospitalSeoul 140-743South Korea

AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×*** magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s ***,a 0.5%solution of methylene blue(MB)was sprayed over columnar *** patterns of the magnified image and MB staining were *** were obtained from the regions previously observed by magnifying endoscopy and MB ***:Three of five patients with a typeⅤ(villous)epithelial pattern had SIM,whereas 21 patients with a non-typeⅤepithelial patterns did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting SIM were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had SIM,whereas 14patients with negative MB staining did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting SIM were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting SIM by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of SIM.

关键词： Short-segment Barrett’s esophagus Magnifying endoscopy Methylene blue chromoendoscopy Specialized intestinal metaplasia Dysplasia Esophageal adenocarcinoma Diagnosis

具有高效降解地塞米松能力的伯克霍尔德菌CQ001株的分离及功能基因组学分析

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第三军医大学学报 2017年第13期39卷 1352-1359页

作者：斯丹杨致邦蒋任举张进熊玉霞马廉举王毅重庆医科大学基础医学院病原生物学教研室重庆400016 重庆医科大学药学实验教学中心重庆400016 重庆医科大学基础医学院免疫学教研室重庆400016

目的研究细菌对地塞米松类甾体激素的降解作用及其分子机制,为构建清除水环境医源性地塞米松类药物污染的工程菌奠定基础。方法采用富集培养法从医院废水中分离降解地塞米松的细菌,采用固相萃取-高效液相色谱(HPLC)法检测细菌对地塞米... 详细信息

目的研究细菌对地塞米松类甾体激素的降解作用及其分子机制,为构建清除水环境医源性地塞米松类药物污染的工程菌奠定基础。方法采用富集培养法从医院废水中分离降解地塞米松的细菌,采用固相萃取-高效液相色谱(HPLC)法检测细菌对地塞米松的降解效能,通过16S r DNA序列测定进行鉴定。用Illumina Hiseq4000结合第三代测序技术对降解菌的全基因组测序,并进行序列组装、注释和分析,对降解地塞米松相关基因进行RT-q PCR验证。结果分离到1株对地塞米松有较高降解作用的细菌,经鉴定属于伯克霍尔德菌属(Burkholderia),命名为Burkholderia ***001。该菌对地塞米松磷酸钠及地塞米松的降解率分别为84.8%和77.11%。全基因组测序表明Burkholderia ***001包含2条染色体和4个巨型质粒,与代谢相关基因大部分集中在2号染色体上,共3 260 157 bp。生物信息学分析表明,该菌含有甾体代谢通路中许多重要酶类的编码基因,其中与地塞米松降解相关的有ABC转运子,3-甾酮-9α-脱氢酶等,这些基因在以地塞米松磷酸钠为碳源的培养条件下表达量不同程度地高于以蔗糖为碳源的培养条件。结论 Burkholderia ***001是一株具有强大的代谢功能和代谢途径丰富的细菌,具有降解地塞米松类甾体激素的性能,该菌株为后续研究甾体激素的降解机制和构建清除水环境医源性地塞米松类药物污染的工程菌提供了菌种。

关键词：地塞米松降解伯克霍尔德菌全基因组

中国吉林省和韩国野生大豆的遗传多样性及遗传关系分析

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大豆科学 2009年第2期28卷 181-185页

作者：朴向民张圣珍许建金弘植赵龙九刘宪虎延边大学农学院农学系吉林龙井133400 韩国忠北大学农业生命环境学院清州忠北361-763

利用9对多样性较高的SSR引物分析了来自中国吉林省(36份)和韩国(40份)野生大豆材料的遗传多样性。结果表明:在全部76份材料中,共检测到172个等位基因,每对引物平均获得19.1个。其中,在韩国的野生大豆资源中,每对引物检测到等位基因数11... 详细信息

利用9对多样性较高的SSR引物分析了来自中国吉林省(36份)和韩国(40份)野生大豆材料的遗传多样性。结果表明:在全部76份材料中,共检测到172个等位基因,每对引物平均获得19.1个。其中,在韩国的野生大豆资源中,每对引物检测到等位基因数11～18个,平均13.7个。中国吉林省的野生大豆资源中,每对引物检测到等位基因数5～16个,平均12.3个。不论中国吉林省还是韩国的野生大豆都具有较高的多态性信息含量(PIC),分别为0.821和0.868,两者遗传多样性并没有明显差异。聚类分析结果表明可将中国吉林省与韩国的野生大豆分为两大类群。

关键词：野生大豆遗传多样性 SSR标记聚类分析

铜绿假单胞菌碱性蛋白酶AprA及其抑制剂AprI的表达、纯化和初步的活性验证

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军事医学 2016年第12期40卷 974-977,1012页

作者：曹润高亚萍刘玉刘成华靳鹏马远方杨光河南大学医学院河南开封475004 军事医学科学院基础医学研究所分子免疫学研究室北京100850

目的利用大肠杆菌BL21(DE3)重组表达铜绿假单胞菌(Pseudomonas aeruginosa,PAE)重要毒力因子碱性蛋白酶(AprA)、碱性蛋白酶抑制剂(AprI)和鞭毛蛋白(flagellin),并检测AprA和AprI的生物学活性。方法以该菌PAO1的基因组为模板,PCR扩增apr ... 详细信息

目的利用大肠杆菌BL21(DE3)重组表达铜绿假单胞菌(Pseudomonas aeruginosa,PAE)重要毒力因子碱性蛋白酶(AprA)、碱性蛋白酶抑制剂(AprI)和鞭毛蛋白(flagellin),并检测AprA和AprI的生物学活性。方法以该菌PAO1的基因组为模板,PCR扩增apr A、apr I和flic基因,构建重组表达载体p ET-28a-AprA、p ET-28a-AprI和p ET-28a-鞭毛蛋白,转化至大肠杆菌BL21(DE3),利用IPTG诱导表达,将包涵体变性、复性后纯化获得AprA蛋白,通过镍亲和树脂纯化获得AprI和鞭毛蛋白。利用SDS-PAGE检测AprA裂解鞭毛蛋白活性。结果重组蛋白AprA以包涵体的形式表达,AprI和鞭毛蛋白以可溶性形式表达。AprA能裂解鞭毛蛋白,加入AprI可抑制AprA裂解鞭毛蛋白。结论 PAE分泌的AprA蛋白具有裂解鞭毛蛋白的活性,该活性能被AprI抑制。该研究为深入研究PAE的AprA的致病机制奠定了基础。

关键词：铜绿假单胞菌碱性蛋白酶碱性蛋白酶抑制剂鞭毛蛋白