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机械应力调控血管平滑肌细胞的凋亡

中国组织工程研究 2025年第5期29卷 1064-1072页

作者：徐飞闫金强柴守栋北京航空航天大学生物与医学工程学院北京市100083 聊城市人民医院中心实验室山东省聊城市252000 聊城市人民医院病理科山东省聊城市252000 聊城市人民医院心外科山东省聊城市252000

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的... 详细信息

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的研究现状,寻找临床治疗潜在靶分子和信号通路,以期改善临床动脉粥样硬化及再狭窄等心血管疾病的临床治疗效果。方法:检索1992年1月至2023年5月在中国知网、PubMed及ScienceDirect数据库收录的文献。中文检索词为“血管平滑肌细胞,机械应力,剪切力,牵张力,凋亡”;英文检索词为“vascular smooth muscle cell,mechanical stress,shear stress,stretch stress,apoptosis”,最终纳入63篇文献进行综述分析。结果与结论:①血管平滑肌细胞的生理性和病理性凋亡都是为了适应血管力学变化而发生的适应性重构。不同部位的平滑肌细胞承受不同的力学刺激,其发病机制也不同。②低剪切力、生理剪切力和高剪切力可通过直接与平滑肌细胞表面分子、受体及蛋白等作用调控凋亡信号分子和抑制增殖实现对血管平滑肌细胞凋亡的调控,该部分未对促进增殖的研究进行综述。③低牵张力、生理牵张力和高牵张力可导致平滑肌细胞凋亡,但仍存在争议。平滑肌表面存在多种力学感受分子(如整合素及受体络氨酸激酶等)可以将力学信号转导为细胞内的化学信号(如Hippo通路),启动平滑肌细胞的凋亡信号,调控平滑肌细胞的凋亡。④总之,不同力学刺激通过多种信号分子,启动多个信号通路共同作用,调控平滑肌细胞的凋亡,例如剪切力主要通过刺激分泌前列腺素、转化生长因子等影响Fas/FasL、Akt通路;而牵张力主要通过Yes相关蛋白等调控YAP通路和Notch通路等。这些分子在不同的作用时间,或不同作用强度下可能发挥相反的双向作用,比如,小鼠血管平滑肌细胞受到10%生理牵张1 h时,其增殖增加;然而,人的血管平滑肌细胞牵张12 h后可以减少其增殖。临床可以通过寻找其关键作用时间点干扰力学转导关键分子,达到预防和治疗临床心血管疾病的目的。

关键词：血管平滑肌细胞机械应力凋亡牵张力剪切应力整合素受体络氨酸激酶 G蛋白偶联受体和G蛋白离子通道

山姜素调节cAMP/PKA/CREB信号通路促进骨质疏松性骨折大鼠骨折愈合

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中国组织工程研究 2025年第12期29卷 2438-2443页

作者：陆飞周静金涛连云港市第一人民医院康复医学科江苏省连云港市222000 南京医科大学康达学院康复医学部江苏省连云港市222000 中国人民解放军东部战区总医院健康医学科江苏省南京市210018

背景:山姜素具有抗炎、抗肿瘤、抗菌等作用,已被证实能够缓解骨质疏松症,但山姜素对骨质疏松性骨折的影响及机制仍不清楚。目的:探讨山姜素调节环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路对骨质疏松性骨折大鼠的改善作... 详细信息

背景:山姜素具有抗炎、抗肿瘤、抗菌等作用,已被证实能够缓解骨质疏松症,但山姜素对骨质疏松性骨折的影响及机制仍不清楚。目的:探讨山姜素调节环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路对骨质疏松性骨折大鼠的改善作用。方法:采用双侧卵巢切除手术构建骨质疏松症骨折大鼠模型,将成功造模大鼠依据随机数字表法分为山姜素低、中、高剂量组、抑制剂组和模型组,另选12只大鼠作为假手术组。骨折造模当天,山姜素低、中、高剂量组大鼠灌胃7.5,15,30 mg/kg的山姜素+腹腔注射等量的生理盐水,抑制剂组灌胃30 mg/kg的山姜素+腹腔注射5 mg/kg的H-89(通路抑制剂),模型组与假手术组给予(灌胃+腹腔注射)等量生理盐水,1次/d,连续8周。放射性检查评估大鼠骨折愈合情况并进行愈合评分;骨密度扫描仪测定骨折处骨密度;通过三点弯曲实验和压缩实验评估大鼠股骨生物力学状况;苏木精-伊红染色观察大鼠骨折处病理损伤;酶联免疫吸附(ELISA)法检测血清碱性磷酸酶、骨钙素和Ⅰ型胶原交联C-末端肽、环磷酸腺苷水平的变化;Western blot检测股骨组织中骨形态发生蛋白2和环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白通路蛋白表达。结果与结论:①相较于假手术组,模型组大鼠骨折愈合评分、骨密度、最大负荷、最大应力、碱性磷酸酶、骨钙素、环磷酸腺苷水平、骨形态发生蛋白2、磷酸化蛋白激酶A/蛋白激酶A、磷酸化环磷酸腺苷反应元件结合蛋白/环磷酸腺苷反应元件结合蛋白表达下降,Ⅰ型胶原交联羧基末端肽水平增加(P<0.05);与模型组比较,山姜素各剂量组大鼠上述各项指标呈现相反的变化(P<0.05);与山姜素高剂量组比较,抑制剂组大鼠上述指标变化均被逆转(P<0.05)。②结论:山姜素可能通过激活环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路加速骨质疏松症骨折大鼠的骨折愈合。

关键词：山姜素环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白骨质疏松骨折愈合大鼠

Control synthesis of linear distributed parameter switched systems

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Journal of Systems Engineering and Electronics 2015年第3期26卷 565-572页

作者： Leping Bao Shumin fei Lin chai School of Automation Southeast University Department of Automation Taiyuan Institute of Technology

The control synthesis for switched systems is extended to distributed parameter switched systems in Hilbert space. Based on semigroup and operator theory, by means of multiple Lyapunov method incorporated average dwell time approach, sufficient con- ditions are derived in terms of linear operator inequalities frame- work for distributed parameter switched systems. Being applied to one dimensional heat propagation switched systems, these lin- ear operator inequalities are reduced to linear matrix inequalities subsequently. In particular, the state feedback gain matrices and the switching law are designed, and the state decay estimate is explicitly given whose decay coefficient completely depends on the system＇s parameter and the boundary condition. Finally, two numerical examples are given to illustrate the proposed method.

关键词： distributed parameter switched systems multiple Lya-punov method stabilization linear operator inequalitie average dwell time.

Semi-Global Stabilization via Homogeneous Output Feedback for a Class of Nonlinear Time-Delay Systems

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Journal of Systems Science & Complexity 2016年第6期29卷 1538-1552页

作者： WANG Pan chai Lin fei Shumin Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of Education School of Automation Southeast University

The semi-global stabilization problem for a class of nonlinear systems with state time-delay is addressed in this paper. By using Lyapunov-Krasovskii functional method and homogeneous dom- ination approach, a homogeneous observer and an output feedback controller with a scaling gain are designed. Then the sealing gain is adjusted such that the closed-loop system is semi-global asymptoti- cally stable. A numerical example is presented to illustrate the effectiveness of the obtained results in this paper.

关键词： Homogeneous domination approach Lyapunov-Krasovskii functional nonlinear time-delay systems output feedback semi-global.

Asymmetric chlorophyll responses enhanced by internal waves near the Dongsha Atoll in the South China Sea

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Journal of Oceanology and Limnology 2023年第2期41卷 418-426页

作者： Meilin WU Huijie XUE fei chai State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of SciencesGuangzhou 510301China

Internal waves(IWs)are small-scale physical processes that occur frequently in stratified marginal *** are ubiquitous and well documented in the northern South China Sea(n SCS),but few studies have explored the ecosystem responses to the *** chlorophyll-a(Chl-a)data from 2002 to 2014 were used to examine the distribution of Chl a near the Dongsha Atoll(DSA).Composite Chl a from about 40 IWs during spring and summer showed stronger response on the northern side than on the southern side of the *** day after the passage of IWs,composite surface Chl a on the northern side increased from 0.11 mg/m3 to a maximum mean value of 0.18 mg/*** decreased to 0.13 mg/m3 after two days and maintained that level for several days after the passage of *** enhanced surface Chl a likely caused subsurface Chl-a maximum and nutrients in the surface *** 64%of the increase in surface Chl a was due to the uplift of the subsurface Chl-a maximum one day after the passage of IWs,while nutrient-induced new phytoplankton growth contributed about 18%of the increase a few days *** the IWs occurred frequently in spring and summer,Chl-a level on the northern side was about 30%higher than that on the southern *** dissipation and its impact on nutrients and chlorophyll were stronger on the northern side of the DSA than on the south,which caused a north-south asymmetric distribution of Chl a in the region.

关键词： internal waves(IWs) phytoplankton nutrients Dongsha Atoll northern South China Sea

Adaptive control for a class of discrete-time time-delay systems with regard to delay parameter

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Journal of Systems Engineering and Electronics 2009年第1期20卷 159-167页

作者： chai Lin Cheng Ming fei Shumin Zhai Junyong Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of Education School of Automation Southeast Univ. Nanjing 210096 P. R. China School of eleetrics Southeast Univ. Nanjing 210096 P. R. China

The memory state feedback control problem for a class of discrete-time systems with input delay and unknown state delay is addressed based on LMIs and Lyapunov-Krasovskii functional method. Under the action of our designed adaptive control law, the unknown time-delay parameter is included in memory state feedback controller. Using LMI technique, delay-dependent sufficient conditions for the existence of the feedback controller are obtained. Finally, the effectiveness of the proposed design method is demonstrated by a numerical example.

关键词： discrete-time time-delay systems adaptive control linear matrix inequality.

MICROSTRUCTURAL EVOLUTION DURING COMBUSTION SYNTHESIS OF TiC-Fe CERMET

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中国有色金属学会会刊：英文版 1999年第2期9卷 82-87页

作者： Quncheng, Fan Huifen, chai Zhihao, jin Xi'an Jiaotong Univ Xi'an China

１ＩＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅｉｔｗａｓｄｉｓｃｏｖｅｒｅｄｉｎ１９６７，ｔｈｅｃｏｍｂｕｓｔｉｏｎｓｙｎｔｈｅｓｉｓｈａｓｂｅｅｎｕｓｅｄｆｏｒｓｙｎｔｈｅｓｉｚｉｎｇａｖａｒｉｅｔｙｏｆｃｏｍｐｏｕｎｄｓ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅｉｔｗａｓｄｉｓｃｏｖｅｒｅｄｉｎ１９６７，ｔｈｅｃｏｍｂｕｓｔｉｏｎｓｙｎｔｈｅｓｉｓｈａｓｂｅｅｎｕｓｅｄｆｏｒｓｙｎｔｈｅｓｉｚｉｎｇａｖａｒｉｅｔｙｏｆｃｏｍｐｏｕｎｄｓａｎｄｃｏｍｐｏｓｉｔｅｓ，ｅｇＴ...

关键词： microstructural evolutionTiCFe cermetcombustion synthesis

A kinetic study and factor analysis of solar thermochemical membrane reactors for syngas production

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Science China Technological Sciences 2025年第1期 207-221页

作者： Jiaxin XING Chao XU Xiangyu SUN Xin XIA fei jin Qiongqiong JIANG Jiale GAO Key Laboratory of Power Station Energy Transfer Conversion and System of MOE School of Energy Power and Mechanical EngineeringNorth China Electric Power University Department of Chemistry University College London School of Chemistry and Chemical Engineering Ningxia Key Laboratory of Solar Chemical Conversion TechnologyState Ethnic Affairs CommissionNorth Minzu University

Solar thermochemical conversion technologies are promising for effectively utilizing solar energy by capturing the full spectrum of solar radiation. To overcome the challenges of low energy conversion efficiency and intermittency faced by solar thermochemical conversion, these technologies can be effectively integrated with membrane reactor technology. Although the performance of solar thermochemical membrane reactors has been experimentally tested, the chemical reactions and oxygen transport mechanisms during the energy conversion process remain poorly understood. This study introduces a resistance network model to elucidate the interactions between interfacial reactions and bulk diffusion during simultaneous oxidationreduction reactions on both sides of the membrane. We analyzed the oxygen flux of the membrane reactor under various operating conditions using this model to identify the reaction/transport-limiting side of the overall process. The most effective solar membrane reactor configuration utilizes natural gas and CO2, facilitating clean conversion of fossil fuels with significant advantages in fuel production and energy efficiency. Introducing CH4lowers the overall reaction temperature, maintains low oxygen partial pressure on the sweep side, and produces a synthesis gas with a 2:1 H2/CO molar ratio. Finally, a sensitivity analysis was used to explore the relationship between overall fuel production performance and operational parameters,highlighting the critical role of this research in enhancing the reaction and transport performance of membrane reactors and advancing the development of solar-driven thermochemical fuel production technologies.

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Long-term trend of oceanic surface carbon in the Northwest Pacific from 1958 to 2017

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Acta Oceanologica Sinica 2022年第5期41卷 90-98页

作者： Xuanliang Ji fei chai Peng Xiu Guimei Liu Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterMinistry of Natural ResourcesBeijing100081China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China School of Marine Sciences University of MaineOronoME04469USA State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China

Contrasting decrease and increase trends of sea surface temperature(SST)have been documented in the western Subarctic(WSA)and the rest of the Northwest Pacific(NWP)from 1958 to 2017,***,more(less)total carbon dioxide(TCO_(2))due to ocean cooling(warming)is transported to the surface,which leads to increase(decrease)of oceanic surface partial pressure of carbon dioxide(pCO_(2)).With the combined influence of the rising atmospheric carbon dioxide(CO_(2))level and changing ocean conditions,a prominent increase in oceanic surface pCO_(2) occurred with different rates of increase in summer and winter in the *** oceanic surface pCO_(2) is mainly controlled by the variation of TCO_(2) at the interdecadal timescale and by SST at the seasonal *** results also indicate that increasing SST tends to strengthen the capability of ocean in absorbing anthropogenic CO_(2) in the NWP,while ocean’s uptaking ability is weakened in the cooling area of the WSA.

关键词： sea surface temperature oceanic surface pCO_(2) ocean cooling(warming) control factor