Pulmonary tuberculosis is an opportunistic infection that can be reactivated in immunocompromised conditions, for example, in malignancy or after liver transplantation. Hepatocellular carcinoma (HCC) has a high mortal...
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Pulmonary tuberculosis is an opportunistic infection that can be reactivated in immunocompromised conditions, for example, in malignancy or after liver transplantation. Hepatocellular carcinoma (HCC) has a high mortality rate because it is frequently diagnosed at an advanced stage. Although surgical resection is the established curative measure for HCC, it is only feasible for earlystage HCC. Transcatheter arterial chemoembolization (TACE) is the most common treatment modality for patients with unresectable HCC. However, repeated TACE sessions and, occasionally, the tumor itself can further impair the reserve hepatic function and immunity. We report 3 recent cases of HCC with reactivation of pulmonary tuberculosis after TACE.
To investigate the effects of topically applied 17β-estradiol on the expression of extracellular matrix proteins in aged human skin, 17β-estradiol (0.01%) and its vehicle (70%propylene glycol, 30%ethanol) were appli...
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To investigate the effects of topically applied 17β-estradiol on the expression of extracellular matrix proteins in aged human skin, 17β-estradiol (0.01%) and its vehicle (70%propylene glycol, 30%ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17β-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo. In addition, MMP-1 protein levels were reduced by topical 17β-estradiol. The expressions of TGF-β1,TGF-βtype II receptor, and Sma and Mad related (Smad)3 were increased by topical 17β-estradiol in aged human skin, and TGF-β1 neutralizing antibody inhibited 17β-estradiol-induced procollagen synthesis in cultured fibroblasts. We also found that the expressions of tropoelastin and fibrillin-1 mRNA and protein, and elastic fibers in aged skin were also increased by topical 17β-estradiol. Topical 17β-estradiol also increased keratinocyte proliferation and the epidermal thickness in aged human skin. We also observed the same effects of topical 17β-estradiol in young skin. In conclusion, our results suggest that topical 17β-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness.
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