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Wedelolactone attenuates sepsis-associated acute liver injury by regulating the macrophage M1/M2 polarization balance through the PI3K/AKT/NF-κB signalling pathway

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Traditional Medicine Research 2024年第11期9卷 1-11页

作者： Wang-Ting Li jin-yi chen Shao-Jie Huang Dong-Mei Hu Xing-Ru Tao Fei Mu jing-yi Zhao Chao Guo Jia-Lin Duan jing-Wen Wang Department of Pharmacology Shaanxi University of Chinese MedicineXianyang 712046China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710032China Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710032China.

Background:Liver injury caused by sepsis seriously impairs the normal physiology of the ***(WED)has an obvious anti-inflammatory effect against liver damage caused by various ***,further research is needed to determine if WED might mitigate acute liver damage linked to sepsis by influencing macrophage ***:We first assessed the effect of WED on lipopolysaccharides-triggered liver injury by biochemistry assay and tissue *** factors were assessed using the ELISA *** expression of Cluster of Differentiation 86(CD86)and Cluster of Differentiation 206(CD206)was measured by immunofluorescence *** protein levels of inducible nitric oxide sythase(iNOS),Arginase 1(Arg-1),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),PI3K phosphorylation(p-PI3K),AKT phosphorylation(p-AKT),inhibitor of kappa B kinase(IKK),inhibitor of kappa B(IκB),and nuclear factor kappa-B(NF-κB)p65 were quantified by western blot ***:WED decreased the level of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and malondialdehyde,and increased the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX).Moreover,WED exerted effective anti-inflammatory effects by decreasing the level of Tumor necrosis factor-α(TNF-α)and Interleukin 6(IL-6)and increasing the level of Interleukin 10(IL-10)in serum and *** not only decreased CD86 and iNOS expression but also increased CD206 and Arg-1 *** also downregulated the increased expression of PI3K,AKT,p-PI3K,p-AKT,IKK,and NF-κB p65 induced by lipopolysaccharides,while up-regulated the decreased expression of Iκ***,LY294002 with WED decreased the expression of protein PI3K,AKT,p-PI3K,p-AKT,IKK and NF-κB p65,and raised the expression of IκBα.Conclusion:Wedelolactone could attenuate sepsis-associated acute liver injury,and its mechanism may be associated with balancing pro-inflammatory and anti-inflamm

关键词： Wedelactone sepsis liver injury macrophage polarization PI3K/AKT/NF-κB

RESEARCH ON STABILITY OF OPEN BOTTOM STORAGE PLATFORM

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Journal of Hydrodynamics 1999年第2期11卷 14-19页

作者： Qi Xin-yuan jin chen-yi chen Wei-qi chen Juan-fang(China Ship Scientific Research Center, Wuxi 214082, P. R. China) China Ship Scientific Research Cent Wuxi China

In this paper, we present a new type of offshore structure, open bottomstorage platform, and its theoretical and experimental studies of its stability. In order tooptimize the design of column length and storage tank of the open bottom storage platform, we discuss the effect of air chamber length and storage on the stability of open bottom storage platform.

关键词： ocean engineering open bottom storage platform stability

Lipase and photodecarboxylase coexpression: A potential strategy for alkane-based biodiesel production from natural triglycerides

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Chinese Journal of Chemical Engineering 2024年第3期67卷 238-246页

作者： Yong-yi Zeng Xin-yi Xu jin-Xuan Xie Wen-Li chen Lan Liu Xin-Jian yin Bi-Shuang chen School of Marine Sciences Sun Yat-Sen UniversityZhuhai 519080China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Alkane-based biodiesel is considered the next generation of biodiesel owing to its potential environmental benefits and the fact that it exhibits much higher specific caloric values than traditional ***,the formidable obstacle impeding the commercialization of this cutting-edge fuel alternative lies in the cost associated with its *** this study,an engineered strain Escherichia coli(***)showcasing harmonized coexpression of a lipase(from Thermomyces lanuginosus lipase,TLL)and a fatty acid photodecarboxylase(from Chlorella variabilis,CvFAP)was first constructed to transform triglycerides into *** potential of *** BL21(DE3)/pRSFDuet-1-TLL-CvFAP for alkane synthesis was evaluated with tripalmitin as a model substrate under various process *** a comprehensive examination of the reaction parameters,the scope of the biotransformation was expanded to‘real’substrates(vegetable oils).The results showed that bioderived oils can be transformed into alkanes with high yields(0.80-10.20 mmol·L^(-1))under mild conditions(35℃,pH 8.0,and 36 h)and blue light *** selected processes were performed on an increased lab scale(up to 100 ml)with up to 24.77 mmol·L^(-1) tripalmitin,leading to a yield of 18.89 mmol·L^(-1) *** the employment of a method for efficiently producing alkanes under mild conditions and a simple procedure to isolate alkanes from the reaction system,the utilization of sustainable biomass as a fundamental feedstock emerges as the primary solution to lower the cost of alkane-based ***,this study proposes a readily implementable and highly effective approach for alkane-based biodiesel production.

关键词： Alkane-based biodiesel Renewable biomass Co-overexpression Lipase Photodecarboxylase

Flexible and multifunctional triboelectric nanogenerator based on liquid metal/polyvinyl alcohol hydrogel for energy harvesting and self-powered wearable human-machine interaction

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Rare Metals 2024年第3期43卷 1186-1196页

作者： Hou-Wang Zhou Cong Zhao Ze-Yu Zhao Jun-chen Jiang Hui-Le jin Shun Wang Shuang Pan Min-yi Xu yi-Huang chen Hai-Ming jin Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China Dalian Key Laboratory of Marine Micro/Nano Energy and Self-Powered Systems Marine Engineering CollegeDalian Maritime UniversityDalian116026China

Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic ***,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its ***,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional ***,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG *** LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine *** work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.

关键词： Liquid metal Hydrogel Wearable TENG Multifunctionality Human-machine interaction

Separation of Insecticidal Ingredient of Paecilomyces cicadae (Miquel) Samson

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Agricultural Sciences in China 2007年第11期6卷 1352-1358页

作者： CHAI yi-qiu jin yi-wei chen Guan-ju LIU You-gao LI Xiao-la WANG Gen-e Zhejiang Institute of Subtropical Crops Wenzhou 325005 P.R.China

In this study, the insecticidal active substance of the fruiting body of Paecilomyces cicadae （Miquel） Samson that can kill the larvae of Plutella xylostella （Lepidoptera： Plutellidae） was isolated and purified by combined separation with biology experiments for the first time. By means of bioactive guided isolation of 40% ethanol-H2O, dichloromethane, ethyl acetate, n-butyl ethanol, macroporous adsorption resin column, high performance liquid chromatography, and sephadex A-20 column, the insecticidal active compound was purified,and a white powder compound was obtained. The compound was active against the third instar larvae ofP. xylostella in 24, 48, and 72 h at the concentration of 10.0 mg mL-1 with a corrective mortality of （95.1 ± 1.8）, （97.7 ± 1.6）, and （99.1 ± 1.7）%, respectively. The compound was strongly sensitive to the larvae. It was stable at acid environment, and was not sensitive to pepsin, and other chracteristics were studied.

关键词： Paecilomyces cicadae (Miquel) Samson Plutella xylostella (Lepidoptera: Plutellidae) extracts of the fruitbody insecticidal activity

Three-dimensionally oriented organization of hexagonal MIL-96 microplates toward superior film microstructure

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Chinese Journal of Chemical Engineering 2024年第8期72卷 69-73页

作者： Sixing chen Xinmiao jin Yuyang Wu Taotao Ji Fei Wang yi Liu State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Dalian Key Laboratory of Membrane Materials and Membrane Processes Dalian University of TechnologyDalian 116024China

Preferential orientation control of metal—organic framework(MOF)films is advantageous for maximizing pore uniformity and minimizing grain-boundary ***,the preparation of MOF films with both in-plane and out-of-plane orientations remains a grand *** this study,we reported the preparation of three-dimensionally oriented MIL-96 layers through combining morphology control of MIL-96 seeds with addition of polyvinylpyrrolidone surfactants and arachidonic *** three-dimensionally oriented MIL-96 film was readily obtained through in-plane epitaxial *** is anticipated that the aforementioned protocol can be effective for obtaining diverse MOF films with a three-dimensionally oriented organization.

关键词： Metaleorganic framework Film Orientation Epitaxial growth Morphological control

Self-adaptive gas flow and phase change behaviors during hydrate exploitation by alternate injection of N_(2) and CO_(2)

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Petroleum Science 2024年第3期21卷 2120-2129页

作者： Bo-Jian Cao yi-Fei Sun Hong-Nan chen jin-Rong Zhong Ming-Long Wang Ming Wang Chang-Yu Sun Guang-jin chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China School of Chemistry and Chemical Engineering Changsha University of Science&TechnologyChangsha410114HunanChina

Since hydrate resources play a part of the stratigraphic framework structure in sediments,establishing a safe and economic method for hydrates exploitation remains the primary challenge to this *** the proposed methods,the spontaneous displacement of CH_(4) from hydrate cages by CO_(2) seems to be a perfect mechanism to address gas production and CO_(2) storage,especially in today's strong demand for carbon reduction and replacing clean *** extensive lab researches,in the past decade,injecting a mixture of CO_(2) and small molecule gas has become a key means to enhance displacement efficiency and has great potential for ***,there is a lack of in-depth research on gas flow in the reservoir,while the injected gas always passes through low-saturated hydrate areas with high permeability and then occurs gas channel in a short term,finally resulting in the decreases in gas production efficiency and produced gas ***,we explored a new injection-production mode of alternate injection of N2 and CO_(2) in order to fully coordinate the advantages of N_(2) in enhanced hydrate decomposition and CO_(2) in solid storage and heat *** alternate"taking"and"storing"processes perfectly repair the problem of the gas channel,achieving self-regulation effect of CH_(4) recovery and CO_(2) *** 3-D experimental results show that compared to the mixed gas injection,CH_(4) recovery is increased by>50%and CO_(2) storage is increased by>70%.Additionally,this alternate injection mode presented a better performance in CH_(4) concentration of produced gas and showed outstanding N_(2) utilization ***,we analyzed its self-adaptive gas flow mechanism and proposed an application model of"one injection and multiple production".We look forward to this study accelerating the application of CO_(2)-CH_(4) replacement technology.

关键词： Hydrate Replacement CH_(4)recovery CO_(2)storage Reservoir remediation

Highly efficient room temperature phosphorescent liquid crystalline polymer optical waveguides for advanced optoelectronics

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Science China Chemistry 2024年第10期67卷 3450-3457页

作者： Jie Li Yan Guan Wei Xia jin-Kang chen Jiang Huang yi chen Qi Lin Er-Qiang chen He-Lou Xie Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education and Key Laboratory of Advanced Functional Polymer Materials of CollegesUniversities of Hunan Province and College of ChemistryXiangtan UniversityXiangtan 411105China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Active organic optical waveguide materials(OOWMs)incorporating room temperature phosphorescence(RTP)hold significant promise for diverse applications in photonic and optoelectronic *** this potential,realizing active RTP optical waveguides with large-sized ordered structures and minimal light loss remains a formidable *** address this issue,we present a groundbreaking thermoplastic active OOWM with low light loss,leveraging room temperature phosphorescent liquid crystalline polymer(LCP).This innovative material can be easily synthesized through the copolymerization of phosphorescent and liquid crystalline *** resulting RTP copolymer exhibits a nematic liquid crystal phase with a phosphorescence lifetime of approximately 0.15 ms and an afterglow duration of around 1 *** the excellent processability of LCP,we successfully produce meter-scale fibers via melt *** RTP LCP fibers,characterized by a high orientation of mesogens along the fiber axis,demonstrate superior light confinement and efficient light conduction compared to unoriented samples,resulting in a low optical loss coefficient of 0.13 dB/***,the thermal responsiveness of the RTP LCP optical waveguide enables its use as a photo *** pioneering work paves the way for the design of new OOWMs tailored for advanced photonics and optoelectronics devices.

关键词： room temperature phosphorescence liquid crystalline polymer active optical waveguide

Boundary slip and lubrication mechanisms of organic friction modifiers with effect of surface moisture

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Friction 2024年第7期12卷 1483-1498页

作者： Xiaobin yi Haiyu XU Ge jin Yang LU Biqiang chen Shaofeng XU Junqin SHI Xiaoli FAN State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072China Xi’an Thermal Power Research Institute Co. Ltd.Xi’an 710054China NingboTech University Ningbo 315000China

Surface moisture or humidity impacting the lubrication property is a ubiquitous phenomenon in tribological systems,which is demonstrated by a combination of molecular dynamics(MD)simulation and experiment for the organic friction modifier(OFM)-containing *** stearic acid and poly-α-olefin 4cSt(PAO4)were chosen as the OFM and base oil molecules,*** physical adsorption indicates that on the moist surface water molecules are preferentially adsorbed on friction surface,and even make OFM adsorption film thoroughly leave surface and mix with base *** shear process,the adsorption of water film and desorption OFM film are further enhanced,particularly under higher shear *** simulated friction coefficient(that is proportional to shear rate)increases firstly and then decreases with thickening water film,in good agreement with experiments,while the slip length shows a contrary *** wear increases with humidity due to tribochemistry revealing the continuous formation and removal of Si–O–Si *** tribological discrepancy of OFM-containing lubricant in dry and humid conditions is attributed to the slip plane’s transformation from the interface between OFM adsorption film and lubricant bulk to the interface between adsorbed water *** work provides a new thought to understand the boundary lubrication and failure of lubricant in humid environments,likely water is not always harmful in oil lubrication systems.

关键词： organic friction modifier(OFM) boundary lubrication boundary slip surface moisture