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ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia

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Cellular & Molecular Immunology 2024年第2期21卷 203-204页

作者： Sujin Lee tae jin kim Department of Immunology Sungkyunkwan University School of MedicineSuwon16419Republic of Korea

B cells have an essential immunoregulatory function,which is mediated by the secretion of IL-10 and TGFβand interaction with activated CD4^(+)T *** antibody-independent function of B cells contributes to ameliorating autoimmune diseases or infection-induced tissue *** this Cellular and Molecular Immunology issue,Fu et *** that regulatory B(Breg)cells play a critical role in resolving Pseudomonas aeruginosa-induced pneumonia[1].

关键词： metabolism pneumonia Immunology

Memory-centric neuromorphic computing for unstructured data processing

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Nano Research 2021年第9期14卷 3126-3142页

作者： Sang Hyun Sung tae jin kim Hera Shin Hoon Namkung tae Hong Im Hee Seung Wang Keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

The unstructured data such as visual information,natural language,and human behaviors opens up a wide array of opportunities in the field of artificial intelligence(Al).The memory-centric neuromorphic computing(MNC)has been proposed for the efficient processing of unstructured data,bypassing the von Neumann bottleneck of current computing *** development of MNC would provide massively parallel processing of unstructured data,realizing the cognitive Al in edge and wearable *** this review,recent advances in memory-centric neuromorphic devices are discussed in terms of emerging nonvolatile memories,volatile switches,synaptic plasticity,neuronal models,and memristive neural network.

关键词： neuromorphic computing memory-centric memristor artificial synapses artificial neurons memristive neural network

In vitro and in vivo postprandial hypoglycemic effects and comprehensive metabolite profiling of Dangjo chili pepper(Capsicum annuum ***)

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Food Bioscience 2023年第1期51卷 179-188页

作者： Kyeong jin kim Soo-yeon Park jin tae kim Hong jin Lee Sung Keun Jung Young-Jun kim Choong Hwan Lee Sanguine Byun Ji Yeon kim Department of Nano Bio Engineering Seoul National University of Science and Technology232Gongneung-roNowon-guSeoul01811Republic of Korea Department of Food Science and Technology Seoul National University of Science and Technology232Gongneung-roNowon-guSeoul01811Republic of Korea Department of Food Science and Biotechnology Chung-Ang UniversityAnseong17546Republic of Korea School of Food Science and Biotechnology Kyungpook National UniversityDaegu41566Republic of Korea Department of Bioscience and Biotechnology Konkuk UniversitySeoul05029Republic of Korea Department of Biotechnology Yonsei UniversitySeoul03722Republic of Korea

The Dangjo chili pepper(DJ)has been reported to contain various compounds withα-glucosidase inhibitory ***,the hypoglycemic effect of DJ and the active ingredients responsible have not been fully ***,the current study aimed to examine DJ as a novelα-glucosidase inhibitor for the prevention of *** identification of metabolites and the assessment ofα-glucosidase inhibitory activity was conducted in three chili pepper *** uptake inhibition by DJ ethanol extract(DJE)was evaluated in Caco-2 ***,an oral carbohydrate tolerance test was performed in C57BL/6 mice.A total of 18 metabolites were identified in Dangjo,Green,and Cucumber chili *** these,quercitrin was one the most abundant flavonoid in *** DJ showed the highest inhibition ofα-glucosidase activity against both maltose and sucrose compared to other *** addition,isoorientin,quercitrin,and DJE had similar inhibitory activities for both *** uptake was significantly inhibited in the DJE group compared to the control *** mice were orally administered freeze-dried DJ at 150 and 300 mg/kg body weight(B.W.),and blood glucose levels were *** glucose loading,both groups had significantly reduced blood glucose concentration compared to the control group(p=0.001).Under maltose loading,the blood glucose concentration was decreased in the 150 mg/kg *** compared to the control group(p=0.025).These results indicate that Dangjo chili pepper has the potential to function as a postprandial hypoglycemic agent by inhibiting theα-glucosidase activity.

关键词： Dangjo chili pepper Quercitrin Type 2 diabetes mellitus Postprandial blood glucose α-Glucosidase inhibitor

Delayed diagnosis of imperforate hymen with huge hematocolpometra:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8901-8905页

作者： Eunbi Jang Kyeong A So Bomin kim A jin Lee Nae Ri kim Eun Jung Yang Seung-Hyuk Shim Sun Joo Lee tae jin kim Department of Obstetrics and Gynecology Konkuk University School of MedicineSeoul 05030South Korea

BACKGROUND Imperforate hymen is a rare obstructive anomaly of the female reproductive *** is associated with complications,such as cyclical abdominal pain,urinary retention,and pelvic *** SUMMARY A 13-year-old girl presented several times to the emergency room with lower abdominal pain for a *** received conservative treatment,such as pain control,at each *** visited our gynecological clinic for worsening pain,and a 14-cm hematocolpos was found on *** was finally diagnosed with an imperforate hymen with *** was performed,which resulted in event-free regular cyclical *** Imperforate hymen should be considered in a premenarcheal adolescent girl with periodic abdominal pain.

关键词： Hematocolpos Imperforate hymen Abdominal pain Amenorrhea Case report

Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

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Cellular & Molecular Immunology 2024年第4期21卷 393-408页

作者： Sujin Lee Yeunjung Ko Hyun Woo Lee Won Joon Oh Hun Gi Hong Dinuka Ariyaratne Se jin Im tae jin kim Department of Immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of Immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:Immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and IL-10-secreting capacities than did CD80^(low)MZ B ***,CD80^(high)MZ B cells survived 2-Gy whole-body irradiation,whereas CD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of CD80^(low)MZ B cells led to accelerated development of type II collagen(CII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BCRs)that recognized double-stranded DNA or CII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BCR sequences than CD80^(low)MZ B *** transfer experiments showed that CD21^(+)CD23^(+)transitional 2 MZ precursors preferentially generated CD80^(low)MZ B cells and that a proportion of CD80^(low)MZ B cells were converted into CD80^(high)MZ B cells;in contrast,CD80^(high)MZ B cells stably remained CD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their CD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BCR specificity.

关键词： Marginal Zone B Cell CD80 Autoreactivity Radioresistance

Weighting IFT algorithm for off-axis quantized kinoforms of binary objects

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Chinese Optics Letters 2011年第12期9卷 24-27页

作者： jin-tae kim Pavlo Iezhov Alexander Kuzmenko Chosun University Institute of Physics Institute of Applied Optics

The results of experiments on the synthesis of the off-axis quantized kinoforms of binary objects with the use of the weighting iterative Fourier transform （WIFT） algorithm are presented. Kinoforms are registered with a liquid-crystal spatial light modulator （SLM）. A simple procedure to introduce the carrier frequency into the structure of an axial kinoform is proposed. An image reconstructed by an off-axis kinoform is free from the noises with the zero and close frequencies caused by the imperfection of both the phase mode of operation of the SLM and the effects of quantization of the registered phase. Data on the diffraction efficiency are also given.

关键词： Weighting IFT algorithm for off-axis quantized kinoforms of binary objects

Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells

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Cellular & Molecular Immunology 2021年第6期18卷 1395-1411页

作者： jin-Kwan Lee Seo-Young Koo Hye-Mi Nam Jee-Boong Lee Jiwon Ko Kyung-Mo kim Eun-Ji Park tae jin kim Ho Lee Heounjeong Go Chang-Woo Lee Research Institute Curogen TechnologySuwonSouth Korea Department of Molecular Cell Biology Samsung Medical CenterSungkyunkwan University School of MedicineSuwonSouth Korea MOGAM Institute for Biomedical Research GyeonggiSouth Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Department of Immunology Sungkyunkwan University School of MedicineSeoulSouth Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyResearch InstituteNational Cancer CenterGyeonggiSouth Korea

The homeostatic balance between effector T cells and regulatory T cells(Tregs)is crucial for adaptive immunity;however,epigenetic programs that inhibit phosphorylation to regulate Treg development,peripheral expression,and suppressive activity are ***,we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways,including the T-cell receptor and IL-2R pathways,and localizes at the cell *** of Ssu72 in T cells disrupts CD4+T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ,which induce CD4+T-cell activation and differentiation into effector cell *** also found a close correlation between downregulation of Ssu72 and severe defects in mucosal tolerance in ***,Ssu72 forms a complex with PLCγ1,which is an essential effector molecule for T-cell receptor signaling as well as Treg development and ***72 deficiency impairs PLCγ1 downstream signaling and results in failure of Foxp3 ***,our studies show that the Ssu72-mediated cytokine response coordinates the differentiation and function of Treg cells in the periphery.

关键词： Ssu72 Regulatory T cells FoxP3 T cell receptor Autoimmunity

HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee tae-jin kim Jose-Antonio Perez-Simon Maria-Luisa del Rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation

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Cellular & Molecular Immunology 2018年第7期15卷 697-709页

作者： Yuan Zhang tae-jin kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu Department of Pathology University of ChicagoChicagoIL 60637USA Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Korea Committee on Immunology Department of PathologyUniversity of ChicagoChicagoIL 60637USA Department of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research University of ChicagoChicagoIL 60637USA Department of Microbiology Immunology and Molecular GeneticsUniversity of Texas Health Science Center San AntonioSan AntonioTX 78229USA Chinese Academy of Sciences Key Laboratory for Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute of Immunology Tsinghua University School of MedicineBeijing 100084China Department of Pathology University of Texas Southwestern Medical CenterDallasTX 75390USA

Splenomegaly is a well-known phenomenon typically associated with ***,the underlying cause of this phenotype has not been well ***,the splenomegaly phenotype seen in lymphotoxin(LT)signaling-deficient mice is characterized by increased numbers of splenocytes and splenic ***,as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues,is thought to result from the absence of secondary lymphoid tissues in LT-deficient *** now present evidence that mice deficient in LTα1β2 or LTβR develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent *** administration to LTα1β2-or LTβR-deficient mice reduces ***,re-derived germ-free Ltbr−/−mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr−/−*** using various LTβ-and LTβR-conditional knockout mice,we demonstrate that retinoic acid-related orphan receptorγT-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of ***,this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota.

关键词： germ-free lymphotoxin microbiota splenomegaly type 3 innate lymphoid cells