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山姜素调节cAMP/PKA/CREB信号通路促进骨质疏松性骨折大鼠骨折愈合

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中国组织工程研究 2025年第12期29卷 2438-2443页

作者：陆飞周静金涛连云港市第一人民医院康复医学科江苏省连云港市222000 南京医科大学康达学院康复医学部江苏省连云港市222000 中国人民解放军东部战区总医院健康医学科江苏省南京市210018

背景:山姜素具有抗炎、抗肿瘤、抗菌等作用,已被证实能够缓解骨质疏松症,但山姜素对骨质疏松性骨折的影响及机制仍不清楚。目的:探讨山姜素调节环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路对骨质疏松性骨折大鼠的改善作... 详细信息

背景:山姜素具有抗炎、抗肿瘤、抗菌等作用,已被证实能够缓解骨质疏松症,但山姜素对骨质疏松性骨折的影响及机制仍不清楚。目的:探讨山姜素调节环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路对骨质疏松性骨折大鼠的改善作用。方法:采用双侧卵巢切除手术构建骨质疏松症骨折大鼠模型,将成功造模大鼠依据随机数字表法分为山姜素低、中、高剂量组、抑制剂组和模型组,另选12只大鼠作为假手术组。骨折造模当天,山姜素低、中、高剂量组大鼠灌胃7.5,15,30 mg/kg的山姜素+腹腔注射等量的生理盐水,抑制剂组灌胃30 mg/kg的山姜素+腹腔注射5 mg/kg的H-89(通路抑制剂),模型组与假手术组给予(灌胃+腹腔注射)等量生理盐水,1次/d,连续8周。放射性检查评估大鼠骨折愈合情况并进行愈合评分;骨密度扫描仪测定骨折处骨密度;通过三点弯曲实验和压缩实验评估大鼠股骨生物力学状况;苏木精-伊红染色观察大鼠骨折处病理损伤;酶联免疫吸附(ELISA)法检测血清碱性磷酸酶、骨钙素和Ⅰ型胶原交联C-末端肽、环磷酸腺苷水平的变化;Western blot检测股骨组织中骨形态发生蛋白2和环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白通路蛋白表达。结果与结论:①相较于假手术组,模型组大鼠骨折愈合评分、骨密度、最大负荷、最大应力、碱性磷酸酶、骨钙素、环磷酸腺苷水平、骨形态发生蛋白2、磷酸化蛋白激酶A/蛋白激酶A、磷酸化环磷酸腺苷反应元件结合蛋白/环磷酸腺苷反应元件结合蛋白表达下降,Ⅰ型胶原交联羧基末端肽水平增加(P<0.05);与模型组比较,山姜素各剂量组大鼠上述各项指标呈现相反的变化(P<0.05);与山姜素高剂量组比较,抑制剂组大鼠上述指标变化均被逆转(P<0.05)。②结论:山姜素可能通过激活环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路加速骨质疏松症骨折大鼠的骨折愈合。

关键词：山姜素环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白骨质疏松骨折愈合大鼠

Endoscopic full-thickness resection vs surgical resection for gastric stromal tumors: Efficacy and safety using propensity score matching

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 95-105页

作者： Si-Qiao Zhao Si-Yao Wang Nan Ge jin-tao Guo Xiang Liu Guo-Xin Wang Lei Su Si-Yu Sun Sheng Wang Endoscopy Center Shengjing Hospital of China Medical UniversityShenyang 110000LiaoningChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Endoscopic full-thickness resection(EFTR)is increasingly used for treating gastrointestinal stromal tumors(GISTs)in the *** To compare the efficacy,tolerability,and clinical outcomes of EFTR vs surgical resection(SR)for gastric *** We collected clinical data from patients diagnosed with GISTs who underwent either EFTR or SR at our hospital from October 2011 to July *** were matched in a 1:1 ratio based on baseline characteristics and tumor clinical-pathological features using propensity score *** analyzed perioperative outcomes and follow-up *** primary outcome measure was progressionfree survival(PFS).RESULTS Out of 912 patients,573 met the inclusion *** matching,each group included 95 *** EFTR group demonstrated statistically significant advantages over the SR group in average operative time(P<0.001),length of hospital stay(P<0.001),time to resume liquid diet(P<0.001),incidence of adverse events(P=0.031),and hospitalization costs(P<0.001).The en bloc resection rate was significantly different,with SR group at 100%and EFTR group at 93.7%(P=0.038).The median follow-up was 2451.50 *** occurred in 3 patients in the EFTR group and 4 patients in the SR group,with no statistically significant difference(P=1.000).Factors associated with PFS included age,tumor size,high-risk category in the modified National Institutes of Health(NIH)risk score,and resection *** status was identified as an independent prognostic factor for PFS(P=0.0173,hazard ratios=0.0179,95%CI:0.000655-0.491).Notably,there was no statistically significant difference in PFS between the two *** This study is a non-inferiority *** EFTR group significantly outperformed the SR group in terms of operative time,length of hospital stay,time to resume a liquid diet,incidence of adverse events,and hospitalization costs,demonstrating its higher economic efficiency and better ***

关键词： Endoscopic full-thickness resection Gastrointestinal stromal tumors Surgical resection Propensity score matching Efficacy Progression-free survival

融合学习者行为特征的群体聚类与知识共享差异研究——以知乎编程话题为例

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成人教育 2025年第3期45卷 10-17页

作者：陶金虎董伟田依林清华大学教育研究院北京100084 天津大学教育学院天津300350 广西民族师范学院经济与管理学院广西崇左532200

理解学习者行为特征及其知识共享规律是加强虚拟学习社区服务的重要前提。在抽取知乎3个编程话题区域数据基础上,通过PCA、Mini-batch Kmeans以及多元统计方法进行深入分析,结果显示,学习者类型差异直接影响了知识共享行为的意愿和效果... 详细信息

理解学习者行为特征及其知识共享规律是加强虚拟学习社区服务的重要前提。在抽取知乎3个编程话题区域数据基础上,通过PCA、Mini-batch Kmeans以及多元统计方法进行深入分析,结果显示,学习者类型差异直接影响了知识共享行为的意愿和效果。学习者可被分为综合型、成就型、关注型以及普通型,其知识共享总量依次递减。普通型学习者知识共享总量虽超过关注型,但受认可程度相对较低,这两类学习者知识共享总量不足综合型或成就型的一半。四类学习者信息表露越多,知识共享总量越大。主体知识共享程度越高,在性别、地区、教育类型、会员身份等变量上的显著性愈多,特征分布规律愈一致。未来应该对不同类型学习者进行精细化管理,构建多样化激励与“同行评审”机制,加强学习者画像功能建设。

关键词：虚拟学习社区学习者聚类知识共享差异分析

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道路桥梁施工中新材料与智能技术应用探索

智能建筑与智慧城市 2025年第2期 159-161页

作者：廖金涛中铁二十四局集团南昌铁路工程有限公司

为加快我国道路桥梁施工行业变革速度,合理应用新材料与智能技术尤为重要。文章研究了道路桥梁施工中新材料与智能技术的应用方法,在掌握道桥施工特点的基础上,从钢纤维混凝土、新型复合改性热熔沥青桥面防水涂料、高强度聚合物修补砂... 详细信息

为加快我国道路桥梁施工行业变革速度,合理应用新材料与智能技术尤为重要。文章研究了道路桥梁施工中新材料与智能技术的应用方法,在掌握道桥施工特点的基础上,从钢纤维混凝土、新型复合改性热熔沥青桥面防水涂料、高强度聚合物修补砂浆三个方面,分析了道路桥梁施工中常见的几种新材料,同时,以智能监控系统为主,强调了其在道路桥梁施工安全、施工质量、施工设备管理以及施工进度方面的应用路径,通过该智能化手段,有助于转变传统道路桥梁施工方式,提高工程建设效率与质量,从而助力行业健康发展。

关键词：道路桥梁新材料智能技术智能监控系统施工应用

Radar emitter signal recognition method based on improved collaborative semi-supervised learning

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Journal of Systems Engineering and Electronics 2023年第5期34卷 1182-1190页

作者： jin tao ZHANG Xindong College of Electronic Science and Engineering Jilin UniversityChangchun 130012China

Rare labeled data are difficult to recognize by using conventional methods in the process of radar emitter *** solve this problem,an optimized cooperative semi-supervised learning radar emitter recognition method based on a small amount of labeled data is ***,a small amount of labeled data are randomly sampled by using the bootstrap method,loss functions for three common deep learning net-works are improved,the uniform distribution and cross-entropy function are combined to reduce the overconfidence of softmax ***,the dataset obtained after sam-pling is adopted to train three improved networks so as to build the initial *** addition,the unlabeled data are preliminarily screened through dynamic time warping(DTW)and then input into the initial model trained previously for *** the judg-ment results of two or more networks are consistent,the unla-beled data are labeled and put into the labeled data ***,the three network models are input into the labeled dataset for training,and the final model is *** revealed by the simula-tion results,the semi-supervised learning method adopted in this paper is capable of exploiting a small amount of labeled data and basically achieving the accuracy of labeled data recognition.

关键词： emitter signal identification time series bootstrap semi supervised learning cross entropy function homogeniza-tion dynamic time warping(DTW)

深圳市工业用地高质量管理及“工业上楼”模式研究

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城市建筑 2025年第4期22卷 117-120页

作者：金韬孙泊洋深圳市光明区建筑工务署深圳市龙岗区城市更新和土地整备局

随着城市的快速发展和急剧扩张,目前深圳市已进入用地紧缺的高集中度发展时期,文章通过研究工业用地的利用与“工业上楼”模式的有机结合,探索深圳市工业用地高质量管理及“工业上楼”模式的可行性。在回顾了深圳市工业发展史、充分调... 详细信息

随着城市的快速发展和急剧扩张,目前深圳市已进入用地紧缺的高集中度发展时期,文章通过研究工业用地的利用与“工业上楼”模式的有机结合,探索深圳市工业用地高质量管理及“工业上楼”模式的可行性。在回顾了深圳市工业发展史、充分调研深圳市现有工业用地及工业建筑存在的问题后,深入研究实施“工业上楼”模式的必要性、可行性及重大意义,从而为深圳市工业用地管理及“工业上楼”模式顺利推进提供参考。旨在创建以“工业上楼”模式为主导,全面提升工业用地的效率和效益的未来发展模式,进一步提升深圳市工业竞争力和影响力。

关键词：深圳市工业用地高质量管理 “工业上楼”模式土地资源优化工业建筑发展展望

Interaction Mechanism of Nano-silicon Dioxide Modified by Poly（amidoamine） Dendrimers

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Chinese Journal of Chemical Physics 2012年第5期25卷 592-604,I0004页

作者： tao jin Xiao-yu Li College of Material Science and Engineering Shandong University of Science and TechnologyQingdao 265590China College of Material Science and Engineering Beijing University of Chemical TechnologyBeifing100020China

To gain insight into the attachment of =Si^＋（SC） ion （regarded as guest） to the lowest generation, NH2-terminated poly（amidoamine）（PAMAM） dendrimers （regarded as host） in the liquid phase, density functional theory is used to investigate the structures and energetics of the host-guest complex. The effect of solvent on the structures and energetics is also investigated. Various initial configurations of the ion bound to PAMAM are tested, and two stable conformers are found, i.e, types A （=Si^＋ is bound to the amine site） and C （=Si^＋ is bound to the amide site）. Types A and C are the most stable due to the chemical bond formations of Si-N° （amine nitrogen atoms） and Si-O, respectively. The IR spectra for the lowest energy conformers are thoroughly analyzed and compared with the available experimental data.

关键词： Poly(amidoamine) Nano-silicon dioxide Configuration Density functionaltheory

Timed RR-interval Scatter Plots and Reverse Technology

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Current Medical Science 2020年第6期40卷 1191-1202页

作者： jin-tao XIANG Department of Cardiology Remin HospitalWuhan UniversityWuhan 430060China

Lorenz-RR scatter plot has an obvious shortcoming in that it does not indicate the time when the scatter point *** the Lorenz RR scatter plot,one cannot know the time during which the cardiac rhythms take *** occurrence of cardiac rhythms is time-related,time should be introduced to such *** this study,time was used as abscissa and RR interval(the time interval between the previous RR wave and the R wave)as the ordinate and time was compressed into a visually observable length,and thereby a timed RR-interval scatter plot,or t-RR scatter plot,for short,was *** t-RR scatter plot,the patterns were band-shaped or were of linear *** the t-RR plot,the sinus rhythm presented bands of various widths,with the spiculate or burred upper and lower boundaries,having diurnal *** beats showed separate layers(“stratification”),the layer number corresponding the number of *** simple premature beats,the layers were clearly *** parasystole rhythm,the upper and lower bands or layers might become *** arial premature beats,the space or distance between layers *** premature beats presented equal space or distance between *** tachycardia,the lower layer became a“solid”*** atrial fibration,the“stratification”disappeared,presenting thicker or widened layers or bands,with neat lower *** atrial flutter,the layers went parallel,with the layers being evenly separated or some distances being exact multiples of *** second degree atrioventricular block displayed two layers,the lower and upper bands being equally away from the X-axis,presenting a straight line(pacing at a fixed rate)or a thicker or wider bands,with a neat upper boundary(the lowest pacing rate).When the scatter plot presented uncharacteristic patterns or had some scattered points,which rendered diagnosis difficult,a reverse technology could be ***,upon selection of scattered points,they were subje

关键词： electrocardiogram dynamic electrocardiogram review timed RR-interval scatter plot methodology

Block Copolymer Colloidal Particles with Unique Structures through Three-dimensional Confined Assembly and Disassembly

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Chinese Journal of Polymer Science 2019年第8期37卷 744-759页

作者： Jiang-Ping Xu jin-tao Zhu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Materials Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology (HUST) Wuhan 430074 China State Key Laboratory of Materials Processing and Mold Technology HUST Wuhan 430074 China

Structured block copolymer(BCP) particles have gained increasing attention due to their potential applications in separation,catalysis, controlled release, and other fields. Three-dimensional(3D) confined assembly has been proved as a facile yet robust approach for generating BCP particles with controllable shapes and internal structures. In this feature article, we summarized the preparation of structured polymeric particles through 3D confined self-assembly of BCPs. The effects of interfacial interactions, degree of confinement,and additives on the shape and internal structure of BCP microparticles were comprehensively discussed. In addition, we highlighted the recent progress in using disassembly as a route to synthesize colloidal particles with unique structures. Two strategies were introduced in this part:(a) disassembling the discrete domains resulted in mesoporous microparticles;(b) disassembling the continuous domains led to the dissociation of microparticles into micelle-like nano-objects. The applications of the structured colloidal particles in photonic crystals,controlled release, and directed growth of inorganic materials were also presented. Finally, we discussed the current challenges and future opportunities in this promising area.

关键词： Block copolymers Self-assembly Confinement Polymer particles Nano-objects