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2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2748-2764页

作者： Fu Peng Minru Liao Wenke jin Wei Liu Zixiang Li Zhichao Fan Ling Zou Siwei Chen Lingjuan Zhu Qian Zhao Gu Zhan Liang Ouyang Cheng Peng bo Han jin Zhang Leilei Fu West China School of Pharmacy and Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China School of Traditional Chinese Materia Medica Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(NAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP *** evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis,myocardial fibrosis and even heart failure(HF),through its deacetylation ***,discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently ***,we identified a new small-molecule activator of SIRT3(named 2-APQC)by the structure-based drug designing strategy.2-APQC was shown to alleviate isoproterenol(ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat ***,in SIRT3 knockout mice,2-APQC could not relieve HF,suggesting that 2-APQC is dependent on SIRT3 for its protective ***,2-APQC was found to inhibit the mammalian target of rapamycin(mTOR)-p70 ribosomal protein S6 kinase(p70S6K),c-jun N-terminal kinase(JNK)and transforming growth factor-β(TGF-β)/small mother against decapentaplegic 3(Smad3)pathways to improve ISO-induced cardiac hypertrophy and myocardial *** upon RNA-seq analyses,we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1(PYCR1)axis was closely assoiated with *** activating PYCR1,2-APQC was shown to enhance mitochondrial proline metabolism,inhibited reactive oxygen species(ROS)-p38 mitogen activated protein kinase(p38MAPK)pathway and thereby protecting against ISO-induced mitochondrialoxidative ***,activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase(AMPK)-Parkin axis to inhibit ISO-induced ***,our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis,which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.

关键词： SIRT3 homeostasis metabolism

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Microfluidic preparation of surfactant-free ultrafine DAAF with tunable particle size for insensitive initiator explosives

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Defence Technology（防务技术） 2024年第9期39卷 42-52页

作者： bo Yang Rui Li Wei Cao Si-min He jincan Zhu Qi Wu Heng Ding jin Chen Weimiao Wang Zhiqiang Qiao Xiaodong Li Guangcheng Yang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Southwest University of Science and Technology Mianyang 621010China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

High purity and ultrafine DAAF(u-DAAF)is an emerging insensitive charge in *** there are many ways to obtain u-DAAF,developing a preparation method with stable operation,accurate control,good quality consistency,equipment miniaturization,and minimum manpower is an inevitable requirement to adapt to the current social technology development *** reported is the microfluidic preparation of u-DAAF with tunable particle size by a passive swirling *** the guidance of recrystallization growth kinetics and mixing behavior of fluids in the swirling microreactor,the key parameters(liquid flow rate,explosive concentration and crystallization temperature)were screened and optimized through screening *** the condition that no surfactant is added and only experimental parameters are controlled,the particle size of recrystallized DAAF can be adjusted from 98 nm to 785 nm,and the corresponding specific surface area is 8.45 m^(2)·g^(-1)to 1.33 m^(2)·g^(-1).In addition,the preparation method has good batch stability,high yield(90.8%-92.6%)and high purity(99.0%-99.4%),indicating a high practical application *** explosion derived flyer initiation tests demonstrate that the u-DAAF shows an initiation sensitivity much lower than that of the raw DAAF,and comparable to that of the refined DAAF by conventional spraying crystallization *** study provides an efficient method to fabricate u-DAAF with narrow particle size distribution and high reproducibility as well as a theoretical reference for fabrication of other ultrafine explosives.

关键词： Microfluidic preparation Screening crystallization conditions Narrow particle size distribution Low initiation sensitivity Ultrafine DAAF

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue jin Yusong Yuan bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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载流电枢与感应电枢电磁线圈发射器系统特性比较

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高压物理学报 2016年第6期30卷 517-525页

作者：金洪波曹延杰王成学王慧锦海军航空工程学院五系山东烟台264001

电枢是电磁线圈发射器的关键能量转换部分,针对感应实体电枢、感应线圈电枢、串联载流线圈电枢和并联载流线圈电枢4种电磁发射器的发射原理和结构特点,推导了4种发射器的系统数学模型。根据等效电路方法,利用MATLAB建立仿真系统,对影响... 详细信息

电枢是电磁线圈发射器的关键能量转换部分,针对感应实体电枢、感应线圈电枢、串联载流线圈电枢和并联载流线圈电枢4种电磁发射器的发射原理和结构特点,推导了4种发射器的系统数学模型。根据等效电路方法,利用MATLAB建立仿真系统,对影响电磁线圈发射器系统特性的电枢尺寸、实体电枢材料、线圈电枢线径、电枢初始位置与初速度、多级发射器电枢位置序列等因素进行了仿真计算和比较分析。结果表明:感应电枢发射器在初级和末级驱动线圈电流下降阶段存在磁力拖拽效应,使得发射体速度在发射管出口处下降明显,而载流电枢发射器不存在拖拽效应;增大感应线圈电枢和串联载流线圈电枢线径,或减小并联载流线圈电枢线径,可以有效提高发射出口速度;载流电枢适用于低速较少级数发射系统。研究方法和结论对电磁发射器电枢结构选择和方案设计具有一定的指导意义。

关键词：电磁发射器感应电枢载流电枢仿真

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载流电枢电磁线圈发射器运行特性分析

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弹道学报 2016年第2期28卷 79-86页

作者：金洪波曹延杰王成学王慧锦海军航空工程学院五系山东烟台264001

电枢是电磁线圈发射器能量转换的关键部分,以此为研究对象,提出串联载流电枢发射器和并联载流电枢发射器的结构模型,通过分析2种载流电枢发射器的工作原理和结构特点,得到了系统微分方程,并利用MATLAB建立了载流电枢发射器的系统仿真模... 详细信息

电枢是电磁线圈发射器能量转换的关键部分,以此为研究对象,提出串联载流电枢发射器和并联载流电枢发射器的结构模型,通过分析2种载流电枢发射器的工作原理和结构特点,得到了系统微分方程,并利用MATLAB建立了载流电枢发射器的系统仿真模型,分析了发射器的运行特性。分析结果表明,载流电枢发射器发射过程无拖拽效应,串联载流电枢发射器适于载荷在20 m/s以下的加速段使用,适于选用低压的电容器电源;并联载流电枢发射器可用于载荷在50 m/s以上的加速段使用,适于选用高电压电容器。研究结果对电磁线圈发射器电枢结构设计具有一定的指导意义。

关键词：电磁线圈发射器载流电枢特性

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MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： Qi-Ying Wei Feng jin Zhong-Yu Wang Bing-Jie Li Wen-bo Cao Zhi-Yan Sun Sai-Jun Mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths *** increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality ***,there is currently no specific and effective marker to predict and treat metastasis in ***(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in *** are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of ***,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic *** review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

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面向非视距环境的室内定位算法

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电子学报 2016年第5期44卷 1174-1179页

作者：毛科技邬锦彬金洪波苗春雨夏明陈庆章浙江工业大学计算机科学与技术学院浙江杭州310023 浙江师范大学行知学院浙江金华321004

节点位置信息在无线传感器网络中起着至关重要的作用.大多数定位算法在视距(Line-of-Sight,LOS)环境下能够取得较高的定位精度,然而在非视距(Non-Line-of-Sight,NLOS)环境下,由于障碍物的阻挡,无法取得理想的定位精度.针对室内环境中普... 详细信息

节点位置信息在无线传感器网络中起着至关重要的作用.大多数定位算法在视距(Line-of-Sight,LOS)环境下能够取得较高的定位精度,然而在非视距(Non-Line-of-Sight,NLOS)环境下,由于障碍物的阻挡,无法取得理想的定位精度.针对室内环境中普遍存在的非视距传播现象,提出了基于RTT(Round Trip Time)和AOA(Angle Of Arrival)混合测距方式的室内定位方法,一种轻量级基于网格的聚类算法(Lightweight Grid-Based Cluster,LGBC)被用来生成移动节点的定位区域.算法不需要获取室内环境的先验信息.仿真结果表明,LGBC算法复杂度低,计算开销小,并且与同类算法相比,定位精度提高约65%.

关键词：无线传感器网络室内定位非视距环境聚类

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Cognitive impairment in patients with bipolar disorder alone versus those with bipolar disorder comorbid with borderline personality disorder

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World Journal of Psychiatry 2024年第8期14卷 1174-1181页

作者： Chao-Min Wang Hua Xue bo Xin Kun Zhang Shuo Wang jin-Cheng Wang Cui-Xia An Na Li Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental *** often coexists with borderline personality disorders,making the condition more *** To explore the differences in cognitive impairment between patients with BD and those with BD comorbid with borderline personality *** Eighty patients with BD and comorbid borderline personality disorder and 80 patients with BD alone were included in groups A and B,respectively,and 80 healthy volunteers were included as *** function in each group was evaluated using the Chinese version of the repeatable battery for the assess-ment of neuropsychological status(RBANS),the Stroop color-word test,and the Wechsler intelligence scale-revised(WAIS-RC).RESULTS The indices of the RBANS,Stroop color-word test,and WAIS-RC in groups A and B were significantly lower than those of the control group(Pborderline personality disorder is lower than that of patients with BD.

关键词： Bipolar disorder borderline personality disorder Cognitive impairment Chinese-version repeatable neuropsychological status test Stroop color-word test Wechsler intelligence scale

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