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Treatment of acute dacryocystitis by translacrimal canalicular drainage and D-silicone intubation

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1628-1632页

作者： jin-jing he jing-Wen Gong Jia-Ni Zhou jin Jiang Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina Xianju People’s Hospital Zhejiang Southeast Campus of Zhejiang Provincial People’s HospitalAffiliated Xianju’s HospitalHangzhou Medical CollegeTaizhou 317300Zhejiang ProvinceChina

AIM:To demonstrate the outcomes of translacrimal canalicular drainage using a lacrimal probe and intranasal drainage by D-silicone intubation for acute dacryocystitis(AD).METHODS:This retrospective study included 23 patients with AD and had undergone abscess decompression with the use of lacrimal probe and intranasal drainage by D-silicone intubation between January 2019 and December *** received abscess decompression and systemic antibiotic-corticosteroid from the time of diagnosis.D-silicone tube was inserted within 10d after diagnosis and removed 3-6mo after *** procedure and outcomes of this method were ***:All patients showed improvement of signs and symptoms of AD within *** intraoperative and postoperative complications were *** recurrence of lacrimal sac abscesses occurred after D-silicone tube ***:Lacrimal probe and D-silicone intubation appear to be a feasible,minimally invasive,safe,and effective method,which could be a reasonable choice in the treatment of AD.

关键词： acute dacryocystitis treatment translacrimal canalicular drainage D-silicone intubation

Optogenetics in oral and craniofacial research

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 656-671页

作者： Qinmeng ZHANG Luyao SONG Mengdie FU jin he Guoli YANG Zhiwei JIANG Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310000China Zhejiang University School of Medicine Hangzhou 310058China

Optogenetics combines optics and genetic engineering to control specific gene expression and biological functions and has the advantages of precise spatiotemporal control,noninvasiveness,and high *** modified photosensory sensors are engineered into proteins to modulate conformational changes with light ***,optogenetic techniques can provide new insights into oral biological processes at different levels,ranging from the subcellular and cellular levels to neural circuits and behavioral ***,we introduce the origins of optogenetics and highlight the recent progress of optogenetic approaches in oral and craniofacial research,focusing on the ability to apply optogenetics to the study of basic scientific neural mechanisms and to establish different oral behavioral test models in vivo(orofacial movement,licking,eating,and drinking),such as channelrhodopsin(ChR),archaerhodopsin(Arch),and halorhodopsin from Natronomonas pharaonis(NpHR).We also review the synergic and antagonistic effects of optogenetics in preclinical studies of trigeminal neuralgia and maxillofacial *** addition,optogenetic tools have been used to control the neurogenic differentiation of dental pulp stem cells in translational *** the scope of optogenetic tools is increasing,there are limited large animal experiments and clinical studies in dental *** future directions include exploring therapeutic strategies for addressing loss of taste in patients with coronavirus disease 2019(COVID-19),studying oral bacterial biofilms,enhancing craniomaxillofacial and periodontal tissue regeneration,and elucidating the possible pathogenesis of dry sockets,xerostomia,and burning mouth syndrome.

关键词： Lasers Cell differentiation Bacterial virulence Nervous system Neurophysiology Behavioral science

Static recrystallization behaviors and mechanisms of 7Mo super-austenitic stainless steel with undissolved sigma precipitates during double-stage hot deformation

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Journal of Iron and Steel Research International 2024年第2期31卷 475-487页

作者： Shi-guang Xu jin-shan he Run-ze Zhang Fu-cheng Zhang Xi-tao Wang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina Shandong Provincial Key Laboratory for High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Science)Jinan250353ShandongChina

Static recrystallization(SRX)behaviors and corresponding recrystallization mechanisms of 7Mo super-austenitic stainless steel were studied under different deformation *** order of influence of deformation parameters on static recrystallization behaviors,from high to low,is followed by temperature,first-stage strain and strain ***,the effect of holding time on static recrystallization behaviors is significantly controlled by *** addition,with the increase in temperature from 1000 to 1200°C,the static recrystallization mechanism evolves from discontinuous static recrystallization and continuous static recrystallization(cSRX)to metadynamic recrystallization and cSRX,and finally to *** cSRX exists at all *** is because high stacking fault energy(56 mJ m−2)promotes the movement of dislocations,making the deformation mechanism of this steel is dominated by planar slip of *** undissolved sigma precipitates promote static recrystallization through particle-stimulated ***,small strain-induced precipitates at grain boundaries hinder the nucleation of conventional SRX and the growth of recrystallized grains,while the hindering effect decreases with the increase in temperature.

关键词： 7Mo super-austenitic stainless steel Double-stage hot deformation Conventional static recrystallization Metadynamic recrystallization Strain-induced precipitation

Alpine grassland degradation intensifies the burrowing behavior of small mammals:evidence for a negative feedback loop

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Integrative Zoology 2024年第2期19卷 240-252页

作者： Zaiwei WANG Jiawen YAN Amy MARTIN Dianne HBRUNTON Jiapeng QU jin-Sheng he Weihong JI Zhibiao NAN State Key Laboratory of herbage Improvement and Grassland Agro-Ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhouChina Manaaki Whenua-Landcare Research LincolnNew Zealand School of Natural Sciences Massey University(Albany Campus)AucklandNew Zealand Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningChina Qinghai Haibei National Field Research Station of Alpine Grassland Ecosystem Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningChina Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijingChina

Globally,grassland degradation is an acute ecological *** alpine grassland on the Tibetan Plateau,increased densities of various small mammals in degraded grassland are assumed to intensify the degradation process and these mammals are subject to lethal ***,whether the negative impact of small mammals is solely a result of population size or also a result of activity and behavior has not been *** this study,we use plateau pika as a model to compare population size,core area of colony,and the number of burrow entrances and latrines between lightly and severely degraded *** test whether the alleged contribution of pika to grassland degradation is a result of increased population size or increased burrowing activities of individuals in response to lower food *** found that grassland degradation resulted in lower plant species richness,plant height,and ***,the overall population size of pika was not significantly affected by location in lightly and severely degraded ***,pika core areas in severely grassland degradation were significantly larger and had significantly higher densities of burrows and *** study provides convincing evidence that habitat-induced changes in the behavior of small,burrowing mammals,such as pika,can exacerbate grassland *** finding has significant implications for managing small mammals and restoring degraded grassland ecosystems.

关键词： burrowing behavior grassland degradation plateau pika population size small mammals

Effect of microalloying on wettability and interface characteristics of Zr-based bulk metallic glasses with W substrate

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China Foundry 2024年第4期21卷 352-359页

作者： Zhen Zhang Lin-na Feng jin-he Wang Zheng-kun Li Hua-meng Fu Hong Li Zheng-wang Zhu Hai-feng Zhang School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110004China

The infiltration casting method is widely employed for the preparation of ex-situ composite ***,the production of composite materials using this method must necessitates a comprehensive understanding of the wettability and interface characteristics between the reinforcing phase and the bulk metallic glasses(BMGs).This work optimized the composition of Zr-based BMGs through microalloying methods,resulting in a new set of Zr-based BMGs with excellent glass-forming *** experiments between the Zr-based BMGs melts and W substrates were conducted using the traditional sessile drop method,and the interfaces were characterized utilizing a scanning electron microscope(SEM)equipped with energy dispersive X-ray spectroscopy(EDS).The work demonstrates that the microalloying method substantially enhances the wettability of the Zr-based BMGs ***,the incorporation of Nb element impedes the formation of W-Zr phases,but the introduction of Nb element does not alter the extent of interdiffusion between the constituent elements of the amorphous matrix and W element,indicating that the influence of Nb element on the diffusion of individual elements is minute.

关键词： Zr-based BMGs infiltration casting method wettability interface characteristics W-Zr phases

Oxidation behavior of Ni-based superalloy GH4738 under tensile stress

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Rare Metals 2024年第8期43卷 3913-3920页

作者： Ji-Chong Hu Hai-Liang Huang Chong-Chong Wu Xiao-Yu Sun Jie Wang Yan-Hong Yang jing-Long Qu Liang Jiang jin-he Dou Yang Chen Institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China Department of Management and Engineering Linkoping University58183LinkopingSweden Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Gaona Aero Material Co. LtdBeijing 100081China College of Artificial Intelligence and Big Data Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117China

Revealing the oxidation behavior of superalloys is crucial for optimizing material properties and extending service *** study investigated the oxidation behavior of superalloy GH4738 under stress states at 850℃.High-throughput specimens were fabricated to withstand different stresses at the same *** oxidation s amples were analyzed using the mass gain method to obtain oxidation kinetic *** results show that the external stress below 200 MPa could improve the oxidation resistance of the *** tensile stress increasing,the oxide layer becomes thinner,denser and more complete,while internal oxidation *** tensile stress alters the structure of the external oxide layer from a two-layer to a threelayer *** Cr_(2)O_(3) oxide layer inhibits the outward diffusion of Ti,leading to Ti enrichment at the oxide-matrix interface and altering the oxidation mechanism of GH4738.

关键词： Ni-based Superalloy Oxidation behavior Tensile stress Oxide layer

Clinical and genetic heterogeneity of adult polyglucosan body disease caused by GBE1 biallelic mutations in China

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Genes & Diseases 2024年第5期11卷 17-20页

作者： Yikun Chen Yan Shi Yuan Gao Yan Hu Linying Zhou jingmei Hong Shirui Gan Xiang Lin Wanjin Chen Guorong Xu jin he Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Fujian Key Laboratory of Molecular Neurology Institute of NeuroscienceFujian Medical UniversityFuzhouFujian 350005China Electron Microscopy Lab of Public Technology Service Center Fujian Medical UniversityFuzhouFujian 350005China

Adult polyglucosan body disease(APBD)is a rare and highly heterogeneous glycogen storage disorder due to biallelic variants in GBE1.1 Typical APBD presentations include gait abnormalities with polyneuropathy,leukodystrophy,neurogenic bladder,and mild cognitive *** diagnosis of APBD encompasses a large spectrum of conditions including axonal and demyelinating sensorimotor polyneuropathy,progressive spastic paraparesis,and leukodystrophies.

关键词： GBE bladder diagnosis

Human circBOULE RNAs as potential biomarkers for sperm quality and male infertility

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The Journal of Biomedical Research 2024年第05期 473-484+397-402页

作者： Liping Cheng he jin Tianheng Xiao Xiaoyu Yang Tingting Zhao Eugene Yujun Xu State Key Laboratory of Reproductive Medicine and Offspring health Nanjing Medical University Center for Clinical Reproduction the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital Cellular Screening Center the University of Chicago

Reliable molecular biomarkers to predict fertility remain scarce. The current study investigated the potential of testis-specific circBOULE RNAs as biomarkers for male infertility and sperm quality. Using reverse transcription-PCR and real-time reverse transcription-PCR assays, we identified seven circular RNAs from the human BOULE gene in human sperm. We observed that the expression level of circEx3-6 was significantly reduced in asthenozoospermia, while the expression levels of both circEx2-6 and circEx2-7 were decreased in teratozoospermia, compared with the controls. Furthermore, we demonstrated that the expression level of circEx2-6 was negatively correlated with the sperm DNA fragmentation index, and the expression level of circEx2-7 was correlated with both fertilization and cleavage rates in those treated with the assisted reproductive *** functional analyses in a transgenic fly model supported the roles of circBOULE RNAs in sperm development and human male fertility. Collectively, our findings support that sperm circBOULE RNAs may serve as diagnostic biomarkers for assessing sperm motility and DNA quality. Therefore, clinical application and significance of sperm circBOULE RNAs in the assisted reproductive technologies warrant further investigation.

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Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

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Zoological Research 2024年第3期45卷 648-662页

作者： Dan Yang Bin-Bin Nie jin-Gang he Zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie Wang Ju-Xiang Chen Tao Tao Department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong 524045China Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei 430071China Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghai 200082China Department of Nutrition and Food Hygiene Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Institute of Neuroscience and Brain Diseases/Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei 441021China Songjiang Hospital and Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghai 201600China Department of Anesthesiology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability *** PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely *** potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced *** this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term *** indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury *** kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of ***,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying ***,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for *** studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.

关键词： Post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics fMRI Cerebellum