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Thoracic spine infection caused by Pseudomonas fluorescens:A case report and review of literature

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World Journal of Clinical Cases 2024年第12期12卷 2099-2108页

作者： Liang Li Bao-Hua Zhang jin-Feng cao Li-jin Zhang Ling-Ling Guo Department of Traditional Chinese Medicine Zibo Central HospitalZibo 255000Shandong ProvinceChina Department of Pathology Zibo Central HospitalZibo 255000Shandong ProvinceChina Department of Medical Imaging Zibo Central HospitalZibo 255000Shandong ProvinceChina

BACKGROUND The clinical incidence of spinal infection is gradually increasing,and its onset is insidious,easily leading to missed diagnosis and misdiagnosis,which may lead to serious complications such as nervous system dysfunction,spinal instability and/or deformity,and cause a huge burden on society and *** identification of the causative agent and precision medicine will greatly reduce the suffering of *** present,the main pathogenic bacteria that cause spinal infection are Staphylococcus aureus,Streptococcus,Pneumococcus,Escherichia coli,and *** are no reports of spinal infection caused by Pseudomonas *** SUMMARY We report a 32-year-old female patient with spinal *** presented with flank pain,initially thought to be bone metastases or bone tuberculosis,and had a family background of *** clinical features and changes in imaging and laboratory tests led to the suspicion of thoracic spine *** of the lesion showed inflammation,tissue culture of the lesion was negative several times,and the possible pathogen-Pseudomonas fluorescens was found after gene sequencing of the *** patient recovered completely after a full course of antibiotic *** This report increases the range of pathogens involved in spinal infections,highlights the unique advantages of gene sequencing technology in difficult-todiagnose diseases,and validates conservative treatment with a full course of antibiotics for spinal infections without complications.

关键词： Thoracic spine infection Pseudomonas fluorescens Spinal infection Case report

Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation

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Asian Journal of Andrology 2024年第1期26卷 25-33页

作者： Kun Zhang Xiu-Hua Xu Jian Wu Ning Wang Gang Li Gui-Min Hao jin-Feng cao Hebei Key Laboratory of Infertility and Genetics Department of Reproductive MedicineSecond Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Reproductive Medicine Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000China Department of Neurology The 980th Hospital of the People's Liberation Army Joint Logistics Support Force(Bethune International Peace Hospital)Shijiazhuang 050000China.

The sperm DNA fragmentation index(DFI)is a metric used to assess DNA fragmentation within *** in vitro fertilizationembryo transfer(IVF-ET),high sperm DFI can lead to a low fertilization rate,poor embryo development,early miscarriage,etc.A kinase anchoring protein(AKAP)is a scaffold protein that can bind protein kinase A(PKA)to subcellular sites of specific substrates and protects the biophosphorylation *** protein antigen 17(SPA17)can also bind to *** study intends to explore the reason for the decreased fertilization rate observed in high sperm DFI(H-DFI)patients during *** addition,the study investigates the expression of AKAP,protein kinase A regulatory subunit(PKARIl),and SPA17 between H-DFI and low sperm DFI(L-DFI)***17 at the transcriptional level is abnormal,the translational level increases in H-DFI patients,and the expression of AKAP4/PKARIl protein decreases.H,O,has been used to simulate oxidative stress damage to spermatozoa during the formation of sperm *** indicates that H,O,increases the expression of sperm SPA17 protein and suppresses AKAP4/PKARIl protein *** processes inhibit sperm capacitation and reduce acrosomal *** culture data and IVF outcomes have been *** H-DFI group has a lower fertilization ***,the results indicate that the possible causes for the decreased fertilization rate in the H-DFI patients have included loss of sperm AKAP4/PKARIl proteins,blocked sperm capacitation,and reduced occurrence of acrosome reaction.

关键词： AKAP PKA SPA17 sperm capacitation sperm DNA fragmentation index

Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

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Food Science and Human Wellness 2024年第3期13卷 1513-1530页

作者： Mingzhi Zhu Bohao Shang Fang Zhou Yong Yuan Feiyan Yin jin cao Jianan Huang Kunbo Wang Xin Zeng Maiquan Li Zhonghua Liu College of Horticulture Hunan Agricultural UniversityChangsha 410128China College of Life Sciences Huaibei Normal UniversityHuaibei 235000China Hunan Tea Group Co. Ltd.Changsha 410128China School of Food Science and Technology Hunan Agricultural UniversityChangsha 410128China

Golden-flower fungus,the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea,is considered a potential probiotic fungus based on its anti-obesity ***,the classification of golden-flower fungi is still controversial;the anti-obesity effect of golden-flower fungus polysaccharides remains *** this study,we identify a golden-flower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis,which resolves the controversy of ***,we find *** polysaccharides(ACPS)attenuate obesity in *** modulate gut bacterial *** which Akkermansia,Akkermansia muciniphila,Bacteroides,Romboutsia,Blautia,and Desulfovibrio are considered the core microbes regulated by *** increase fecal total short-chain fatty acid content and serum,hepatic,and fecal total bile acid ***,ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity,according to a fecal transplantation ***,ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.

关键词： Golden-flower fungus Aspergillus cristatus Polysaccharides Obesity Gut microbiota

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传播政治经济学国际视野与在地经验的思考

南京大学学报（哲学．人文科学．社会科学） 2024年第2期61卷 109-113页

作者：曹晋复旦大学新闻学院上海市200433

近年来,在数字化变革的浪潮中跨学科融合发展的趋势愈发明显,传播政治经济学作为政治经济学批判理论与传播学、社会学、文化研究等学科的交叉研究领域,其重要性日益彰显,从媒介产业的市场结构分析到平台资本的批判性反思,从日常生活的... 详细信息

近年来,在数字化变革的浪潮中跨学科融合发展的趋势愈发明显,传播政治经济学作为政治经济学批判理论与传播学、社会学、文化研究等学科的交叉研究领域,其重要性日益彰显,从媒介产业的市场结构分析到平台资本的批判性反思,从日常生活的文化表征考察到社会权力结构的深刻揭示,均有传播政治经济学的介入并有力推动了相关研究。《南京大学学报》编辑部于2023年12月15—17日在南京举办了“传播政治经济学理论与实践”学术工作坊,邀请国内在相关领域耕耘多年的学者,对传播政治经济学的国际视野与在地经验、理论面向与阐释维度、传播学自主知识体系建构、传播政治经济学与文化研究的接合趋势等重大理论问题以及数字平台、数字游民等具体的实践问题进行了深入热烈的探讨。本期本专栏推出六篇笔谈文章,是此次学术工作坊研讨成果的展示,在一定程度上显示了该领域的多元面貌、理论前沿及其实践应用,希望以此推动这一新兴交叉学科领域的发展创新。

关键词：传播政治经济学工作坊国际视野文化表征媒介产业在地经验南京大学学报理论与实践

Study on improving hematopoietic function of rats with blood deficiency syndrome by Shengxuebao mixture

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Traditional Medicine Research 2024年第8期9卷 35-46页

作者： Yan Shu Hong-Na Liu Yang Zhao jin-Yi cao Yue Chen Yi Qiao Hui Guo Zhi-Fu Yang College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Tsing Hua De Ren Xi’an Happiness Pharmaceutical Co. Ltd.Xi’an 710400China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710000China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of PharmacySchool of Stomatologythe Fourth Military Medical UniversityXi’an 710000China

Background:Shengxuebao mixture(SXBM)is a novel herbal drug approved by China State Food and Drug Administration for the treatment of Leukopenia and iron deficiency anemia caused by radiotherapy and ***:To explore the mechanism of SXBM in treating blood deficiency syndrome(BDS).Firstly,network pharmacology and in vivo experiments were used to screen candidate targets and important signaling pathways of SXBM,GO functional enrichment and KEGG pathway analysis were ***,a BDS rat model was established to verify the results of the analysis of network pharmacological *** and routine peripheral blood examination were *** expressions of tumor necrosis factor-α,interleukin(IL)-6,HIF-1αand NF-κB were detected by Western blot,and the expressions of IL-6,IL-1βwere detected by ***:62 bioactive components,66 potential targets and 131 signaling pathways of BDS were successfully identified by network *** docking simulation techniques showed that key targets tumor necrosis factor-α,IL-6,IL-1βcan dock well with crucial components,and the BDS-related signaling pathways HIF-1 and JAK-STAT play a vital *** combined model experiment of acetylphenylhydrazine and cyclophosphamide showed that the model group had obvious blood deficiency,and the histopathology and blood routine were effectively restored after *** findings indicate that SXBM’s therapeutic effect on BDS primarily involves the mediation of the HIF-1α/NF-κB signaling pathway and the regulation of hematopoietic factor ***:This study not only affirmed the protective properties of SXBM against BDS but also provided insights into a potential mechanism for blood replenishment in the treatment of BDS using SXBM.

关键词： network pharmacology molecular docking technology blood deficiency syndrome hematopoietic factors HIF-1α/NF-κB

Mechanism analysis of regulating Turing instability and Hopf bifurcation of malware propagation in mobile wireless sensor networks

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Chinese Physics B 2024年第6期33卷 125-140页

作者：黄习习肖敏 Leszek Rutkowski 包海波黄霞曹进德 College of Automation&College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China Systems Research Institute of the Polish Academy of Sciences 01-447 WarsawPoland College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China School of Mathematics Southeast UniversityNanjing 210096China

A dynamical model is constructed to depict the spatial-temporal evolution of malware in mobile wireless sensor networks(MWSNs). Based on such a model, we design a hybrid control scheme combining parameter perturbation and state feedback to effectively manipulate the spatiotemporal dynamics of malware propagation. The hybrid control can not only suppress the Turing instability caused by diffusion factor but can also adjust the occurrence of Hopf bifurcation induced by time delay. Numerical simulation results show that the hybrid control strategy can efficiently manipulate the transmission dynamics to achieve our expected desired properties, thus reducing the harm of malware propagation to MWSNs.

关键词： mobile wireless sensor networks reaction-diffusion Hopf bifurcation hybrid control

Arthroscopic M-shaped suture fixation for tibia avulsion fracture of posterior cruciate ligament: A modified technique and case series

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World Journal of Orthopedics 2024年第7期15卷 642-649页

作者： Xiao-Hui Zhang Jian Yu Meng-Yao Zhao jin-Hui cao Bing Wu Dan-Feng Xu Department of Orthopaedic Surgery Shaoxing Central HospitalShaoxing 312000Zhejiang ProvinceChina Department of Orthopaedic Surgery The Central Hospital of Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Central Laboratory Shaoxing Central HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Tibial avulsion fractures of the posterior cruciate ligament(PCL)are challenging to treat and compromise knee stability and *** open surgery often requires extensive soft tissue dissection,which may increase the risk of *** response to these concerns,arthroscopic techniques have been *** aim of this study was to introduce a modified arthroscopic tech-nique utilizing an M-shaped suture fixation method for the treatment of tibial avulsion fractures of the PCL and to evaluate its outcomes through a case *** To evaluate the effects of arthroscopic M-shaped suture fixation on treating tibia avulsion fractures of the *** We developed a modified arthroscopic M-shaped suture fixation technique for tibia avulsion fractures of the *** case series included 18 patients who underwent the procedure between January 2021 and December *** patients were assessed for range of motion(ROM),Lysholm score and International knee documentation committee(IKDC)*** complications were also *** The patients were followed for a mean of 13.83±2.33 *** patients showed radiographic *** the final follow-up,all patients had full ROM and a negative posterior drawer *** mean Lysholm score significantly improved from 45.28±8.92 preoperatively to 91.83±4.18 at the final follow-up(P<0.001),and the mean IKDC score improved from 41.98±6.06 preoperatively to 90.89±5.32 at the final follow-up(P<0.001).CONCLUSION The modified arthroscopic M-shaped suture fixation technique is a reliable and effective treatment for tibia avulsion fractures of the PCL,with excellent fracture healing and functional recovery.

关键词： Posterior cruciate ligament Avulsion fracture Arthroscopic Case series Suture fixation

镱原子超精细诱导5d6s^(3)D_(1,3)→6s^(2)^(1)S_(0)E2跃迁及超精细常数的精确计算

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物理学报 2024年第9期73卷 58-69页

作者：赵国栋曹进梁婷冯敏卢本全常宏中国科学院国家授时中心西安710600 时间基准及应用重点实验室西安710600 中国科学院大学天文与空间科学学院北京101408 合肥国家实验室合肥230026

在镱原子中,利用5d6s^(3)D_(1)→6s^(2)^(1)S_(0)跃迁探索宇称破缺效应已经得到了深入的研究.但是5d6s^(3)D_(1)态与基态6s^(2)^(1)S_(0)之间的M1跃迁和超精细诱导E2跃迁很大程度上影响了宇称破缺信号的探测.因此,很有必要精确计算5d6s^... 详细信息

在镱原子中,利用5d6s^(3)D_(1)→6s^(2)^(1)S_(0)跃迁探索宇称破缺效应已经得到了深入的研究.但是5d6s^(3)D_(1)态与基态6s^(2)^(1)S_(0)之间的M1跃迁和超精细诱导E2跃迁很大程度上影响了宇称破缺信号的探测.因此,很有必要精确计算5d6s^(3)D_(1)态与基态6s^(2)^(1)S_(0)之间的M1跃迁和超精细诱导E2跃迁的跃迁概率.本文利用多组态Dirac-Hartree-Fock理论精确计算了5d6s^(3)D_(1)→6s^(2)^(1)S_(0) M1跃迁和超精细诱导5d6s^(3)D_(1),3→6s^(2)^(1)S_(0) E2跃迁的跃迁概率.计算时详细分析了电子关联效应对跃迁概率的影响.此外,还分析了不同微扰态和不同超精细相互作用对跃迁概率的影响.本文计算的^(3)D_(1,2,3)和^(1)D_(2)态的超精细常数与实验测量结果符合得很好,从而证明了本文所用计算模型的合理性.结合实验测量的超精细常数和本文理论计算所得的核外电子在原子核处的电场梯度,重新评估了^(173)Yb原子核电四极矩Q=2.89(5)b,评估结果与目前被推荐的结果符合得很好.

关键词：超精细诱导跃迁镱原子超精细常数多组态Dirac-Hartree-Fock方法

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城市轨道交通通信智能维修系统应用研究

科技资讯 2024年第7期22卷 24-26页

作者：曹进中铁第四勘察设计院集团有限公司湖北武汉434000

主要针对轨道交通通信系统的智能运维进行深入探讨,结合当前城市轨道交通的发展趋势和实际运维现状,分析了智能运维的必要性和可行性。随着技术的进步,传统的运维方法已无法满足现代轨道交通的高效、安全运营需求。通过引入先进的技术... 详细信息

主要针对轨道交通通信系统的智能运维进行深入探讨,结合当前城市轨道交通的发展趋势和实际运维现状,分析了智能运维的必要性和可行性。随着技术的进步,传统的运维方法已无法满足现代轨道交通的高效、安全运营需求。通过引入先进的技术和管理手段,提高轨道交通通信系统的运维水平,降低运营成本,并为城市轨道交通的可持续发展提供有力支持。

关键词：轨道交通通信系统智能维修故障预测