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An experimental and thermodynamic equilibrium investigation of the Pb,Zn,Cr,Cu,Mn and Ni partitioning during sewage sludge incineration

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Journal of Environmental Sciences 2015年第9期27卷 43-54页

作者： Jingyong Liu jiewen fu Xun'an Ning Shuiyu Sun Yujie Wang Wuming Xie Shaosong Huang Sheng Zhong School of Environmental Science and Engineering Guangdong University of Technology

The effects of different chlorides and operational conditions on the distribution and speciation of six heavy metals（Pb, Zn, Cr, Cu, Mn and Ni） during sludge incineration were investigated using a simulated laboratory tubular-furnace reactor. A thermodynamic equilibrium investigation using the Fact Sage software was performed to compare the experimental results. The results indicate that the volatility of the target metals was enhanced as the chlorine concentration increased. Inorganic-Cl influenced the volatilization of heavy metals in the order of Pb 〉 Zn 〉 Cr 〉 Cu 〉 Mn 〉 Ni. However, the effects of organic-Cl on the volatility of Mn, Pb and Cu were greater than the effects on Zn, Cr and *** increasing combustion temperature, the presence of organic-Cl（PVC） and inorganic-Cl（NaCl） improved the transfer of Pb and Zn from bottom ash to fly ash or fuse gas. However,the presence of chloride had no obvious influence on Mn, Cu and Ni. Increased retention time could increase the volatilization rate of heavy metals; however, this effect was insignificant. During the incineration process, Pb readily formed Pb SiO4 and remained in the bottom ash. Different Pb compounds, primarily the volatile PbCl2, were found in the gas phase after the addition of NaCl; the dominant Pb compounds in the gas phase after the addition of PVC were PbCl2, Pb（ClO4）2and Pb Cl2O4.

关键词： Sludge incineration Heavy metal Chlorine Thermodynamic equilibrium calculations

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二联体亲子鉴定罕见案例分析及应对策略

西南医科大学学报 2024年第3期47卷 231-235页

作者：郭侃付杰文宋炳辉钱捷罗章成竞梁何涛傅俊江西南医科大学医学基础研究中心表观遗传与肿瘤四川省高校重点实验室泸州646000 西南医科大学司法鉴定中心DNA法医物证实验室泸州646000

目的对亲子鉴定中二联体罕见案例进行分析并给出应对策略。方法对罕见案例样本进行DNA提取,使用AGCU EX-22试剂盒进行二联体和三联体检测;使用阅微基因36A试剂盒进行二联体检测。通过遗传测序仪进行电泳分析,GeneMapper ID-X软件进行数... 详细信息

目的对亲子鉴定中二联体罕见案例进行分析并给出应对策略。方法对罕见案例样本进行DNA提取,使用AGCU EX-22试剂盒进行二联体和三联体检测;使用阅微基因36A试剂盒进行二联体检测。通过遗传测序仪进行电泳分析,GeneMapper ID-X软件进行数据分析得到短串联重复序列(short tandem repeats,STR)图谱和相应的基因座数据,并计算其累积亲权指数。结果采用AGCU EX-22试剂盒进行被检父和孩子二联体鉴定,获得累积亲权指数为7.0516×10^(2),这个值既大于0.0001又小于10000。根据《亲权鉴定技术规范》(GB/T 37223-2018),其结果是既不支持、又不能排除被检父为孩子的生物学父亲,不能出具明确的鉴定意见;增加孩子母亲样本,改为三联体鉴定后,使用相同的试剂盒进行鉴定,获得的累积亲权指数为2.6327×10^(8),大于10000,支持被检父为孩子的生物学父亲。与此同时,增加STR基因座位点,使用阅微基因36A试剂盒进行被检父和孩子的二联体鉴定,获得累积亲权指数为1.0378×10^(9),同样大于10000,亦能出具明确的鉴定意见。结论在二联体亲子鉴定中,通过增加孩子生母做三联体亲子鉴定或者是增加STR位点进行检测,都能提高累积亲权指数,帮助罕见疑难亲子鉴定案例出具明确的鉴定意见。

关键词：短串联重复序列二联体亲权鉴定三联体亲权鉴定累积亲权指数

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The Speckle-type POZ protein(SPOP) inhibits breast cancer malignancy by destabilizing TWIST1

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The Speckle-type POZ protein(SPOP) inhibits breast cancer ma...

Impacts of transmembrane serine protease 4 expression on susceptibility to severe acute respiratory syndrome coronavirus 2

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Chunli Wei Junjiang fu Xiaoyan Liu Jingliang Cheng jiewen fu Southwest Medical University

Epithelial-mesenchymal transition(EMT) inducing transcription factor TWIST1 plays a vital role in cancer *** the tumor-suppressive E3 ligase,Speckle-type POZ protein(SPOP),regulates TWIST1 in breast cancer remains *** this study,we report that SPOP physically interacts with,ubiquitinates,and destabilizes *** promotes K63-and K48-linked ubiquitination of TWIST1,predominantly at K73,thereby suppressing cancer cell migration and *** SPOP significantly enhances EMT,which accelerates breast cancer cell migration and invasiveness in vitro and lung metastasis in ***,SPOP is negatively correlated with the levels of TWIST1 in highly invasive breast *** SPOP expression,along with elevated TWIST1 levels,is associated with poor prognosis in advanced breast cancer patients,particularly those with metastatic triple-negative breast cancer(TNBC).Taken together,we have disclosed a new mechanism linking SPOP to TWIST1 *** SPOP may serve as a prognostic marker and a potential therapeutic target for advanced TNBC patients.

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Chinese Medical Journal 2023年第7期136卷 860-862页

作者： Qi Tan jiewen fu Zhiying Liu Haoyue Deng Lianmei Zhang Jiayue He Xiaotao Li Junjiang fu Key Laboratory of Epigenetics and Oncology The Research Center for Preclinical MedicineSouthwest Medical UniversityLuzhouSichuan 646000China Department of Pathology The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical UniversityHuai’anJiangsu 223300China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China

To the Editor:Transmembrane serine protease 4(TMPRSS4;OMIM:606565),which encodes a member of the serine protease family,is involved in various biological processes related to diseases such as cancer and pediatric neur... 详细信息

关键词： protease diseases respiratory

雪盖指数法提取积雪范围信息的不确定性研究——以玛纳斯上游地区为例

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遥感技术与应用 2014年第2期29卷 293-299页

作者：赵军付杰文付鹏西北师范大学地理与环境科学学院甘肃兰州730070

基于2006年9月10日空间分辨率为30m的TM影像与DEM数据,通过雪盖指数法自动提取积雪范围与目视解译结果进行对比,以粗糙度为度量,定性、定量分析影响其不确定性的地表覆被和地形因素。结果表明:①当NDSI阈值取0.57~0.72和0.4~0.8时,结果... 详细信息

基于2006年9月10日空间分辨率为30m的TM影像与DEM数据,通过雪盖指数法自动提取积雪范围与目视解译结果进行对比,以粗糙度为度量,定性、定量分析影响其不确定性的地表覆被和地形因素。结果表明:①当NDSI阈值取0.57~0.72和0.4~0.8时,结果有明显差异,取0.57~0.72时漏分像元比0.4~0.8稍多,但是误分像元大幅减少;②同处于阴影区裸地的光谱曲线与积雪的光谱曲线相似,造成阴影区的积雪与裸地不能正确区分,此外处于阴影区域的植被由于反射率较低,使其NDSI刚好在阈值范围内,被误分为积雪;③半阴坡雪盖指数法提取积雪的不确定性最小,而阳坡、半阳坡雪盖指数法提取积雪的不确定性最大;④雪盖指数法提取积雪的不确定性随着坡度的增加呈下降趋势,即坡度越大不确定性越小。

关键词：不确定性雪盖指数雪冰遥感玛纳斯河

Authentication of cancer cell lines by short tandem repeat(STR) analysis and DNA sequencing

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Authentication of cancer cell lines by short tandem repeat(S...

COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2

2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛

作者： Xiaoyan Liu Jingliang Cheng jiewen fu Jun Li Chunli Wei Xiaoli Zheng Tao He Junjiang fu 西南医科大学医学基础研究中心

Aims: Cancer cell lines are used worldwide in biomedical researches, and data interpretation solely depends on unambiguous attribution of those respective cell lines to its original ***-third of all cell lines have an origin other than that assumed, leading to invalid results. It is necessary to characterize the origin of cell lines. Methods: STR fingerprinting and Sanger sequencing were used for characterization of genetic identity in cultured cell lines. Results: We showed the fingerprinting profiles in a summed and unidentified human cancer cell line comparison to HCC1954,revealing marked alterations in DNA fingerprinting profiles up to fourteen STR loci from 16 *** sequencing showed no c.3140 A>G heterozygous mutation in PIK3 CA gene. We also showed the fingerprinting profiles in an unidentified cancer cell line comparison to SiHa, revealing same DNA fingerprinting profiles. Conclusions: We have successfully authenticated and identified suspected HCC1954 and SiHa cell line by STR analysis and DNA sequencing, which may be very useful to evaluate genotypes of cancer cell lines, as well as in judicial authentication and forensic sciences.

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COVID-19 disease and malignant cancers: The impact for the f...

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Jingliang Cheng dabing Li Xiaoyan Liu lianmei Zhang Xianmao Chen shuguang Liu jiewen fu shangyi fu hanchun Chen Junjiang fu Southwest Medical University 南京医科大学附属淮安第一人民医院 Baylor College of Medicine 中南大学

furin is a proprotein convertase that activates different kinds of regulatory proteins, including SARS-CoV-2 spike protein which contains an additional furin-specific cleavage site. It is essential to foretell the cancer patients’ susceptibility to SARS-CoV-2 and the disease outcomes through evaluating furin expressions in tumor tissues. In this study, we analyzed the furin expression, methylation,mutations, functional enrichment, survivals and COVID-19 outcomes in normal and tumor tissues through online databases and IHC. As results, furin presented the biased expression profiles in normal tissues, showing 12.25-fold higher than ACE2 in the lungs. The furin expressions in tumors were significantly increased in ESCA and TGCT;decreased in DLBC and THYM, indicating furin may play critical roles for COVID-19 viral entry in these cancer patients. Line with furin over/downexpression, furin promoter hypo-/hyper-methylation may be the regulatory mechanism and in pathogenesis of ESCA and THYM. furthermore, usage of fuRIN-201 isoform with functional domains(Proprotein, Peptidase8 and S8ro-domain) is the highest in all cancer types,demonstrating this isoform role in tumorigenesis and SARS-Cov-2 entry into tumor tissues. Meanwhile, furin mutation frequency was highest in UCES, and its mutation elevated ACE2 expression in LUAD and UCEC, reduced ACE2 expression in COAD;elevated HSPA5 expression in PAAD;elevated TMPRSS2 expression in BRCA. These results showed that furin mutations mostly increased expression of ACE2, HSPA5 and TMPRSS2 in some cancers, indicating the possible network roles of furin mutation for COVID-19 viral entry for cancer patients. In addition, high expression of furinwas significantly reverse correlated with long overall survival(OS) in LGG;significantly correlated with long OS in COAD and KIRC, indicating that it may serve as a favorable prognostic marker for those cancer patient’s survivals. Moreover, GO and KEGG demonstrated that furin was mostly enriched

关键词： COVID-19 furin malignant cancers SARS-CoV-2 susceptibility

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石羊河流域水源涵养功能定量评估及空间差异

生态学报 2018年第13期38卷 4637-4648页

作者：王玉纯赵军付杰文魏伟西北师范大学地理与环境科学学院兰州730000

水源涵养功能是流域生态系统的重要服务功能之一和可持续发展的关键因素。采用In VEST模型,通过参数本地化,定量评估了石羊河流域产水量及水源涵养功能,在此基础上对水源涵养功能重要性进行分级,通过模拟不同退耕情景,分析其产水量及水... 详细信息

水源涵养功能是流域生态系统的重要服务功能之一和可持续发展的关键因素。采用In VEST模型,通过参数本地化,定量评估了石羊河流域产水量及水源涵养功能,在此基础上对水源涵养功能重要性进行分级,通过模拟不同退耕情景,分析其产水量及水源涵养功能的差异。结果表明:(1)In VEST模型中的Zhang系数为2.1时,研究区产水量模拟效果最佳;研究区2015年单元平均产水深度值为60.90 mm,产水总量为24.71×10~8m^3;单元平均水源涵养量为23.97 mm,水源涵养总量为1.35×10~8m^3;单元产水深度与单元平均水源涵养量空间分布均呈现出南高北低的趋势;研究区不同地类单元水源涵养能力以林地最强,草地的水源涵养总量最大。(2)研究区内水源涵养功能一般重要级别区域占总面积的53.94%,极重要和高度重要级别共占总面积的22.40%。(3)根据不同退耕模式情景模拟结果,研究区林地面积最大时,单元水源涵养量及水源涵养总量均最高;随着林地、草地面积的增加,产水量有所减少,且林地面积最大时,产水量最少;基于最小模糊度法,确定了研究区合理退耕还林还草模式。

关键词：水源涵养 INVEST模型产水量石羊河流域退耕还林还草

A Tutorial on Quantized Feedback Control

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 5-17页

作者： Minyue fu IEEE the School of System Design and Intelligent Manufacturing Shenzhen Key Laboratory of Control Theory and Intelligent Systems and Centre for Control Science and TechnologySouthern University of Science and TechnologyShenzhen 518055China

In this tutorial paper, we explore the field of quantized feedback control, which has gained significant attention due to the growing prevalence of networked control systems. These systems require the transmission of feedback information, such as measurements and control signals, over digital networks, presenting novel challenges in estimation and control design. Our examination encompasses various topics, including the minimal information needed for effective feedback control, the design of quantizers, strategies for quantized control design and estimation,achieving consensus control with quantized data, and the pursuit of high-precision tracking using quantized measurements.

关键词： Consensus control high-precision control networked control quantized estimation quantized feedback control robust control