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Co-assembly of FeTPP@Fe_(3)O_(4) nanoparticles with photo-enhanced catalytic activity for synergistic tumor therapy

Nano Research 2022年第10期15卷 9114-9124页

作者： Tian Tian Jianshuai Bao Jinghan wang jiefei wang Yan Ge Zengyin Li Shanqing Gao Zhongqi You Xiaoyan Yang Yong Zhong Feng Bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-efficiency Display and Lighting TechnologySchool of Materials Science and EngineeringCollaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China Henan-Macquarie University Joint Centre for Biomedical Innovation School of Life SciencesHenan UniversityKaifeng 475004China

Chemodynamic therapy(CDT)offers a promising alternative to conventional cancer treatment.However,the limited acidity and H_(2)O_(2) concentration in tumor microenvironment(TME)severely impair the anticancer effects of CDT.In this study,we report a microemulsion-assisted coassembly method to prepare iron(III)tetraphenylporphyrin(FeTPP)and magnetic(Fe_(3)O_(4))nanocomposite material(FeTPP@Fe_(3)O_(4)),using photoactive FeTPP and Fe_(3)O_(4) nanocrystals as building blocks.The selfassembling nature of FeTPP results in disordered aggregation and fluorescence quenching,leading to a high light-to-heat conversion efficiency.Continuously,the photo-thermal effect enhances the catalytic decomposition of hydrogen peroxide(H_(2)O_(2))in the Fenton reaction on Fe_(3)O_(4) nanocrystals to generate highly toxic hydroxyl radicals(·OH)to destroy cancer cells.This cascade reaction produces a synergistic therapeutic effect between CDT and photothermal therapy(PTT),which significantly amplifies the therapeutic effect and enhances the treatment outcome of cancer patients.The highly efficient tumor catalytic therapy in vivo results confirmed that this nanomedicine treatment is an excellent biocompatible catalytic nanomedicine therapy achieved through a photo-enhanced Fenton reaction activity approach.

关键词： porphyrin photo-enhanced nanocatalyst synergistic therapy

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Measuring Zak phase in room-temperature atoms

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Light(Science & Applications) 2022年第10期11卷 2530-2539页

作者： Ruosong Mao Xingqi Xu jiefei wang Chenran Xu Gewei Qian Han Cai Shi-Yao Zhu Da-Wei wang Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentationand Zhejiang Province Key Laboratory of Quantum Technology and DeviceSchool of PhysicsZhejiang UniversityHangzhou 310027China College of Optical Science and Engineering Zhejiang UniversityHangzhou 310027China Hefei National Laboratory Hefei 230088China CAS Center of Excellence in Topological Quantum Computation 100190 BeijingChina

Cold atoms provide a flexible platform for synthesizing and characterizing topological matter,where geometric phases play a central role.However,cold atoms are intrinsically prone to thermal noise,which can overwhelm the topological response and hamper promised applications.On the other hand,geometric phases also determine the energy spectra of particles subjected to a static force,based on the polarization relation between Wannier-Stark ladders and geometric Zak phases.By exploiting this relation,we develop a method to extract geometric phases from energy spectra of room-temperature superradiance lattices,which are momentum-space lattices of timed Dicke states.In such momentum-space lattices the thermal motion of atoms,instead of being a source of noise,provides effective forces which lead to spectroscopic signatures of the Zak phases.We measure Zak phases directly from the anti-crossings between Wannier-Stark ladders in the Doppler-broadened absorption spectra of superradiance lattices.Our approach paves the way of measuring topological invariants and developing their applications in room-temperature atoms.

关键词： topological momentum invariants

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数字经济推动新质生产力发展的理论逻辑及实现路径

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烟台大学学报(哲学社会科学版) 2024年第2期37卷 1-12页

作者：姚树洁王洁菲辽宁大学李安民经济研究院重庆大学经济与工商管理学院湖南工商大学经济与贸易学院

以数字经济和人工智能为基本特征的新工业革命正在以前所未有的速度推动人类社会经济活动、生产方式、生活形态发生革命性的变化。新质生产力的提出在全国引起强烈反响，短短几个月，学术界已从不同视角解读了新质生产力的概念、理论逻... 详细信息

以数字经济和人工智能为基本特征的新工业革命正在以前所未有的速度推动人类社会经济活动、生产方式、生活形态发生革命性的变化。新质生产力的提出在全国引起强烈反响，短短几个月，学术界已从不同视角解读了新质生产力的概念、理论逻辑和实现路径。数字经济和人工智能是新时代技术进步的根本性标识，在互联网、区块链、人工智能、智能制造、现代交通、新能源、新材料、新医药等战略性新兴产业和未来产业技术同步推动下，形成了与传统生产力有着本质性区别的新质生产力。因此，充分理解数字经济发展的内在逻辑，深入剖析新质生产力的内涵特征，厘清数字经济和新质生产力的互动关系，是发展新质生产力、实现中国式现代化的重要理论和实践创新。为此，一是需要阐释中国发展数字经济和新质生产力的理论逻辑；二是需要从信息化、互联网和数字交易发展三个层面具体分析数字经济内涵特征，测度各省市自治区数字经济发展水平；三是需要从劳动者、劳动对象和生产资料三个不同维度研究新质生产力的内涵特征。因此可以说，科技创新、制度优化和要素协同是借助数字经济推动新质生产力发展的重要实现路径。

关键词：数字经济新质生产力科技创新经济高质量发展

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Tenofovir disoproxil fumarate therapy in patients with chronic hepatitis B and advanced fibrosis or compensated cirrhosis

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iLIVER 2022年第3期1卷 145-153页

作者： Huiying Rao Jia Shang Qing Xie Jianqi Lian Pujun Gao Junping Shi Xinyue Chen jiefei wang Min Xu Liaoyun Zhang Yingren Zhao QingMao Maorong wang Wei Zhao Zong Zhang Jidong Jia Hong Tang Jiming Zhang Xin Zheng Chang Liu Lai Wei Peking University People's Hospital Peking University Hepatology InstituteBeijingChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhouHenanChina Ruijin Hospital Shanghai Jiaotong University School of MedicineDepartment of Infectious DiseasesShanghaiChina Department of Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anShaanxiChina Jilin University First Hospital The First Hospital of Jilin UniversityChangchunChina Department of Liver Disease The Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiangChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijingChina Department of Severe Hepatology Shanghai Public Health Clinical CentreFudan UniversityShanghaiChina Department of Infectious Diseases Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Department Infectious Disease First Hospital of Shanxi Medical UniversityTaiyuanChina Department of Infectious Diseases and Hepatology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Infectious Diseases Southwest HospitalArmy Medical UniversityChongqingChina Liver Disease Center General HospitalEastern Theater Command of PLANanjingChina Department of Liver Disease The Second Hospital of NanjingMedical SchoolSoutheast UniversityNanjingChina Shandong Public Health Clinical Centre Shandong UniversityJinanChina Liver Research Centre Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases West China HospitalSichuan UniversityChengduChina Department of Infectious Diseases Huashan HospitalFudan UniversityShanghaiChina Department of Infectious Disease Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuaZhong University of Science and TechnologyWuhanChina GlaxoSmithKline(China)R&D Company Limited ShanghaiChina Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalInstitute fo

Background and aims:Tenofovir disoproxil fumarate(TDF)is the first-line therapy for chronic hepatitis B.This interim analysis presents the efficacy and safety data for TDF at Week 144 in patients with chronic hepatitis B and advanced fibrosis or compensated cirrhosis from China.Methods:Patients were assessed for incidence of newly diagnosed hepatocellular carcinoma(HCC)and disease progression,liver stiffness measurement(LSM),virological suppression(serum hepatitis B virus DNA<20 IU/mL),alanine aminotransferase normalization,hepatitis B e antigen(HBeAg)loss and seroconversion,histological liver fibrosis score,and safety at Week 144.Results:Overall,197 patients were enrolled.At Week 144,the incidence of newly diagnosed HCC was observed in 2.1%patients,and the incidence of disease progression was observed in 3.6%patients.The mean(standard deviation)change in LSM from baseline was5.1(5.85)kPa.Serum hepatitis B virus DNA<20 IU/mL was observed in 94.1%patients,alanine aminotransferase normalization in 33.5%patients,HBeAg loss in 35.6%patients,and HBeAg seroconversion in 14.4%patients.Among patients with stage F3 or F4 fibrosis at baseline by LSM,38.3%patients regressed to stage F0/1,and 22.0%of patients regressed to stage F2 at Week 144.Overall,67.7%patients experienced≥1 adverse events,13.8%patients experienced TDF-related adverse events,and 16.4%patients experienced serious(none were TDF-related).Conclusions:At Week 144 of TDF treatment,low incidence of HCC and disease progression were reported.Virological suppression was observed in 94.1%patients,which was associated with fibrosis regression.No new safety events were identified.

关键词： Chronic hepatitis B Disease progression Hepatocellular carcinoma nucleos(t)ide analogs

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Protein-protein interaction analysis in crude bacterial lysates using combinational method of ^19F site-specific incorporation and ^19F NMR

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Protein & Cell 2017年第2期8卷 149-154页

作者： Dong Li Yanan Zhang Yao He Chengwei Zhang jiefei wang Ying Xiong Longhua Zhang Yangzhong Liu Pan Shi Changlin Tian Hefei National Laboratory for Physical Science at the Microscale School of Life Science University of Science and Technology of China Hefei 230026 Anhui China School of Chemistry University of Science and Technology of China Hefei 230026 Anhui China

Protein-protein interactions （PPI） are essential for a variety of cellular functions. Many PPI analyses were conducted in vitro, using purified proteins. In this report, the unnatural amino acid tfmF was site-specifically incorporated into several different sites of two Phox-Beml （PB1） domains from two mitogen activated protein kinases （MEKK3 and/ or MEK5） in the E. coil cells.

关键词： Nuclear Magnetic Resonance Chemical Shift Change Nuclear Magnetic Resonance Method Crude Lysate Crude Cell Lysate

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Efficacy and Safety of All-oral Emitasvir and Sofosbuvir in Patients with Genotype 1b HCV Infections without Cirrhosis

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 255-261页

作者： Huiying Rao Xingxiang Yang Youwen Tan Qin Ning Daokun Yang jiefei wang Yongfeng Yang Sujun Zheng Dongliang Yang Jinlin Hou Qing Xie Caiyan Zhao Lunli Zhang Xiaorong Mao Tong Sun Lang Bai Fuchun Zhang Jinglan Jin Yingren Zhao Maorong wang Wen Xie Yingjie Ma Jun Quan Xuebing Yan Ping An Feng Lin Jidong Jia Xiaoxuan Hu Zuojiong Gong Jie Wu Yongping Chen Zhansheng Jia Minghua Lin Guiqiang wang Yueyong Zhu Yingjun Zhang Hongming Xie Lin Luo Qingyun Ren Rui Huang Lai Wei Peking University People’s Hospital Peking University Hepatology InstituteNational Clinical Research Center for Infectious DiseaseBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina Department of Infectious Diseases Sichuan Provincial People’s HospitalChengduSichuanChina Department of Hepatology The Third People’s Hospital of ZhenjiangZhenjiangJiangsuChina Department of Infectious Diseases Tongji HospitalTongji Medical College Huazhong University of Science and TechnologyWuhanHubeiChina Department of Infectious Diseases The First Affiliated Hospital of Xinxiang Medical CollegeXinxiangHenanChina Shanghai Public Health Clinical Center ShanghaiChina Department of Hepatology The Second Hospital of NanjingNanjingJiangsuChina Center of Artificial liver Beijing Youan HospitalCapital Medical UniversityBeijingChina Department of Infectious Disease Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Infectious Diseases Ruijin Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Infectious Diseases The Third Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Infectious Diseases The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases Wuxi Fifth People’s HospitalWuxiJiangsuChina Infectious Diseases Center West China HospitalSichuan UniversityChengduSichuanChina Department of Hepatology Guangzhou Eighth People’s HospitalGuangzhouGuangdongChina Department of Hepato-Biliary-Pancreatic Diseases The First Hospital of Jilin UniversityChangchunJilinChina Department of Infectious Diseases Xi’an Ji

Publications>Journals>Journal of Clinical and Translational Hepatology>Article Full Text ORIGINAL ARTICLE OPEN ACCESS Efficacy and Safety of All-oral Emitasvir and Sofosbuvir in Patients with Genotype 1b HCV Infections without Cirrhosis Huiying Rao1,Xingxiang Yang2,Youwen Tan3,Qin Ning4,Daokun Yang5,jiefei wang6,Yongfeng Yang7,Sujun Zheng8,Dongliang Yang9,Jinlin Hou10,Qing Xie11,Caiyan Zhao12,Lunli Zhang13,Xiaorong Mao14,Tong Sun15,Lang Bai16,Fuchun Zhang17,Jinglan Jin18,Yingren Zhao19,Maorong wang20,Wen Xie21,Yingjie Ma22,Jun Quan23,Xuebing Yan24,Ping An25,Feng Lin26,Jidong Jia27,Xiaoxuan Hu28,Zuojiong Gong29,Jie Wu30,Yongping Chen31,Zhansheng Jia32,Minghua Lin33,Guiqiang wang34,Yueyong Zhu35,Yingjun Zhang*,36,Hongming Xie36,Lin Luo36,Qingyun Ren36,Rui Huang1 and Lai Wei*,37 Author information Journal of Clinical and Translational Hepatology 2020;8(3):255-261DOI:10.14218/JCTH.2020.00031 Abstract Background and Aims:Emitasvir is a new type of hepatitis C virus(HCV)nonstructural protein 5A(NS5A)inhibitor,and the data of phase 2 trial has shown emitasvir-sofosbuvir to have good safety and tolerance.We conducted this phase 3 trial to further verify the efficacy and safety.Methods:We evaluated the antiviral activity and safety of a 12-week regimen of emitasvir phosphate(100 mg)combined with sofosbuvir(400 mg)once daily in non-cirrhotic patients with genotype 1 HCV infection.The primary endpoint was a sustained virological response at 12 weeks(SVR12)after the end of treatment.Results:Of the 362 patients enrolled in the trial,39.8%were male,99.2%had HCV genotype 1b,0.8%had genotype 1a and 79.8%were treatment-naïve.The average age was 47.2 years.All patients completed the treatment and follow-up.All 3 patients with genotype 1a achieved SVR.Two genotype 1b treatment-naïve patients experienced virologic relapse.The rate of SVR12 was 99.7%(358/359),and SVR24 was 99.4%(357/359)in genotype 1b.Overall,36.2%had resistance-associated substitutions(RASs)in NS5A and 98.3%had RASs in NS5B at baseline.The RASs at baseline had no ef

关键词： Hepatitis C virus Genotype 1 Direct acting antivirals Emitasvir Sofosbuvir Combination treatment

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Erratum to： Protein-protein interaction analysis in crude bacterial lysates using combinational method of ^19F site-specific incorporation and ^19F NMR

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Protein & Cell 2018年第6期9卷 592-592页

作者： Dong Li Yanan Zhang Yao He Chengwei Zhang jiefei wang Ying Xiong Longhua Zhang Yangzhong Liu Pan Shi Changlin Tian Hefei National Laboratory for Physical Science at the Microscale School of Life Science University of Science and _ Technology of China Hefei 230026 China School of Chemistry University of Science and Technology of China Hefei 230026 China

ERRATUM TO： PROTEIN CELL 2017, 8（2）：149-154 DOI 10.1007/S13238-016-0336-8In the original publication of this article the correspondence authors＇ e-mail has been missed out. The missing e-mail addresses are provided in this erratum.OPEN ACCESS This article is distributed under the terms of the Creative Commons Attribution 4.0 international License （http：//***/ licenses/by/4.0/）, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author（s） and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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中医杂志 2024年第12期65卷 1262-1268页

作者：余思邈孙克伟张振刚李瀚旻李秀惠杨宏志李芹王林周小舟毛德文过建春卓蕴慧王宪波邓欣王介非曹武奎张淑芹张明香李筠宫嫚周超中国人民解放军总医院第五医学中心北京市丰台区100039 北京中医药大学湖南中医药大学第一附属医院华中科技大学附属同济医院湖北省中医院首都医科大学附属北京佑安医院中山大学附属第三医院福建医科大学孟超肝胆病医院成都市公共卫生临床医疗中心深圳市中医院广西中医药大学第一附属医院杭州市西溪医院上海中医药大学附属曙光医院首都医科大学附属北京地坛医院深圳市第三人民医院上海公共卫生临床中心天津市第二人民医院吉林省肝胆病医院沈阳市第六人民医院

目的探讨乙型肝炎病毒相关慢加急性肝衰竭(HBV-ACLF)不同分期患者证素、证型的演变规律。方法收集2012年1月1日至2015年2月28日来自全国18家临床中心的HBV-ACLF住院患者1058例的临床资料,包括早期患者618例,中期患者355例,晚期患者85例... 详细信息

目的探讨乙型肝炎病毒相关慢加急性肝衰竭(HBV-ACLF)不同分期患者证素、证型的演变规律。方法收集2012年1月1日至2015年2月28日来自全国18家临床中心的HBV-ACLF住院患者1058例的临床资料,包括早期患者618例,中期患者355例,晚期患者85例。设计乙型肝炎相关慢加急性肝衰竭中医证候临床调查表,调查患者基本信息、中医四诊信息(症状、舌象、脉象),统计四诊信息出现的频率。基于因子分析及聚类分析,对早期、中期、后期HBV-ACLF患者的病性证素、病位证素、证型进行判定。结果1058例HBV-ACLF患者四诊信息76个,以出现频率≥5%的四诊信息53个作为因子分析条目,其中症状信息36个、舌象信息12个、脉象信息5个。得到HBV-ACLF中医证型4个,分别为肝胆湿热证、气虚血瘀证、肝肾阴虚证、脾肾阳虚证。早期的病性证素分布以热(39.4%,359/912)、湿(27.5%,251/912)多见,证型主要以肝胆湿热证(74.6%,461/618)为主;中期的病性证素分布以湿(30.2%,187/619)、血瘀(20.7%,128/619)多见,证型以肝胆湿热证(53.2%,189/355)、气虚血瘀证(27.6%,98/355)多见;晚期的病性证素分布以气虚(26.3%,40/152)、阴虚(20.4%,31/152)多见,证型以气虚血瘀证(36.5%,31/85)、肝胆湿热证(25.9%,22/85)多见。结论HBV-ACLF不同分期的证素、证型分布差异较大,整体呈现湿热→血瘀→气血阴阳亏虚的虚实夹杂、由实转虚的证候演变趋势。

关键词：慢加急性肝衰竭乙型肝炎病毒证候证素横断面研究

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Cooperative Zinc oxide fullerene electron selective layers for planar perovskite solar cells

Cooperative Zinc oxide fullerene electron selective layers f...

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第四届新型太阳能电池学术研讨会

作者： jiefei wang Hao Gu Xiaotao Liu Yiqiang Zhang State Centre for International Cooperation on Designer Low-Carbon and Environmental Material (SCICDLCEM) Zhengzhou University

Perovskite solar cells(PSCs) are awesome compared to silicon solar cells due to their low cost and easy fabrication.We report that ZnO and fullerenes can work cooperatively to further boost the performance of perovskite solar cells.We find that fullerenes can be redissolved during perovskite deposition, allowing ultra-thin fullerenes to be retained at the interface and some dissolved fullerenes infiltrate into perovskite grain boundaries.The ZnO layer blocks holes effectively;whereas, the fullerenes promote electron transfer and passivate both the ZnO/perovskite interface and perovskite grain boundaries.We find that the partial dissolving of fullerenes during perovskite deposition is the key for fabricating high-performance perovskite solar cells based on metal oxide/fullerene electron selective layers(ESLs).

关键词： perovskite solar cells ZnO election selective layers

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收入差距、努力指数与居民主观幸福感

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南开经济研究 2022年第4期 3-21页

作者：王洁菲姚树洁湖南工商大学经济与贸易学院 410000 辽宁大学李安民经济研究院 110036 重庆大学经济与工商管理学院 400044

本文基于2018年中国家庭追踪调查数据(CFPS),运用Ordered Probit、IV Probit、2SLS和OLS模型研究收入差距、收入差距主观评价对居民主观幸福感的影响,通过构造努力指数探讨了收入差距主要来源之一的努力因素对居民幸福感的影响。其结果... 详细信息

本文基于2018年中国家庭追踪调查数据(CFPS),运用Ordered Probit、IV Probit、2SLS和OLS模型研究收入差距、收入差距主观评价对居民主观幸福感的影响,通过构造努力指数探讨了收入差距主要来源之一的努力因素对居民幸福感的影响。其结果表明:(1)社会客观收入差距越高、居民对社会收入差距主观评价越高,居民主观幸福感越低。(2)收入差距扩大会损害城乡居民主观幸福感,城市居民对收入差距的主观评价会通过“负向预期”作用机制削弱其对未来生活的信心,损害当下幸福感。(3)努力指数对城乡、不同收入阶层居民主观幸福感的影响存在异质性。努力指数对最低收入组居民的主观幸福感影响不显著,一是因为受教育程度较低、劳动技能不足等原因,努力程度的提高并不能有效提高这类居民收入水平;二是对于部分努力程度较低的最低收入居民来说,政府转移支付可以在一定程度上抵消没有劳动报酬所产生的负幸福效应。

关键词：收入差距收入差距主观评价主观幸福感努力程度 “扶志”困境

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