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Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma

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Current Medical Science 2024年第5期44卷 890-901页

作者： Bi-qiong ZHANG Feng-qing WANG jie YIN Xiao-tan YU Zheng-xi HU Liang-hu GU qing-yi TONG Yong-hui ZHANG Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult lymphohematopoietic *** the limitations of current therapies,there is a pressing need to develop new and effective drugs for DLBCL *** A series of pyrrolidone derivatives were synthesized,and their antitumor activities were assessed,particularly against DLBCL cell ***-activity relationship(SAR)analysis was conducted to identify key structural components essential for *** most promising compound,referred to as compound 7,was selected for further mechanistic *** expression levels of relevant mRNA and protein were detected by RT-qPCR and Western blotting,and the expression of mitochondrial membrane potential and ROS was detected using flow cytometry for further assessment of cell cycle arrest and *** The compound 7 exhibited good antitumor activity among the synthesized derivatives,specifically in DLBCL cell *** analysis highlighted the critical role ofα,β-unsaturated ketones in the antitumor efficacy of these ***,compound 7 was found to induce significant DNA damage,trigger an inflammatory response,cause mitochondrial dysfunction,and disrupt cell cycle progression,ultimately leading to apoptosis of DLBCL *** The compound 7 has good antitumor activity and can induce multiple cellular mechanisms leading to cancer cell *** findings warrant further investigation of the compound 7 as a potential therapeutic agent for DLBCL.

关键词： pyrrolidone analogs Michael acceptor DNA damage mitochondrial dysfunction apoptosis

Helicity-dependent time delays in multiphoton ionization by two-color circularly polarized laser fields

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Frontiers of physics 2021年第5期16卷 3-9页

作者： qing-Hua Ke Yue-Ming Zhou Yi-jie Liao Jin-Tai Liang Yong Zhao Jia tan Min Li Pei-Xiang Lu School of Physics and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan430205China CAS Center for Excellence in Ultra-intense Laser Science Shanghai201800China

By numerically solving the three-dimensional time-dependent Schrödinger equation,we have investigated multiphoton ionization of hydrogen atom in the two-color circularly polarized(TCCP)laser fields consisting of a strong 400 nm and a much weaker 800 nm *** to the presence of perturbative 800 nm laser pulse,sideband peaks emerge between the above-threshold ionization rings in the photoelectron momentum *** numerical results show that the sideband peaks exhibit one-lobe structure in the co-rotating TCCP laser fields,while it displays the three-lobe structure in the counter-rotating TCCP laser ***,the photoelectron yield of sidebands in the co-rotating TCCP fields is much higher than those of the counter-rotating TCCP *** phenomena could be well explained from the perspective of the photon-absorption channels via the selection ***,an obvious phase shift between the sidebands of different orders from the co-rotating and counter-rotating TCCP fields is *** shift indicates the helicity-dependent time delay in the one-photon continuum-continuum transition process.

关键词： helicity-dependent time delay TCCP multiphoton ionization

Exact Travelling Solutions of Discrete sine-Gordon Equation via Extended tanh-Function Approach

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Communications in Theoretical Physics 2006年第1X期46卷 23-27页

作者： DAI Chao-qing ZHANG jie-Fang Department of Information Physics School of Sciences Zhejiang Forestry University Lin'an 311300 China Institute of Nonlinear Physics Zhejiang Normal University Jinhua 321004 China

In this paper, we generalize the extended tanh-function approach, which was used to find new exact travelling wave solutions of nonlinear partial differential equations or coupled nonlinear partial differential equations, to nonlinear differential-difference equations. As illustration, two series of exact travelling wave solutions of the discrete sine-Gordon equation are obtained by means of the extended tanh-function approach.

关键词： discrete sine-Gordon equation exact travelling wave solution extended tanh-function approach

Two new C18-norditerpenoid alkaloids from Aconitum delavayi

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Chinese Chemical Letters 2007年第4期18卷 409-411页

作者： Shan Hao Jiang Hai qing Wang Yi Ming Li Shuang Jun Lin Jun jie tan Da Yuan Zhu State Key Laboratory of Drug Research Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China

Further phytochemical investigation of the unique C 18-norditerpenoid alkaloids from the roots ofAconitum delavayi Franch led to the isolation of two new norditerpenoid alkaloids, delavaconitine F 1 and delavaconitine... 详细信息

关键词： Aconitum delavayi Ranunculaceae Norditerpenoid alkaloid Delavaconitine F Delavaconitine G

Wave Dissipation Characteristics of A Mountain-Type Breakwater

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China Ocean Engineering 2020年第6期34卷 863-870页

作者： GONG Ye-jun ZHAN jie-min HU Wen-qing FAN qing CAI Wen-hao MOE-LCSM School of Mathematics and StatisticsHunan Normal UniversityChangsha 410081China Department of Applied Mechanics and Engineering Sun Yat-sen UniversityGuangzhou 510275China

One mountain-type breakwater consisting of two inclined plates and one vertical plate is proposed based on several types of traditional free surface breakwaters, including the horizontal plate, curtain wall, and trapezoidal barriers. The interaction between the regular waves and the fixed free surface mountain-type breakwater is measured in one wave flume(15.0 m×0.6 m×0.7 m). The wave propagation, reflection, and transmission process are simulated using the VOF method and the hybrid SAS/laminar method. The simulated wave profiles are consistent with the experimental observations. For waves with a length smaller than four times width of the mountain-type breakwater, the reflected wave amplitudes are slightly larger than those of the vertical-plate breakwater, while the wave transmission coefficients are all smaller than 0.5, and the wave loss coefficients are larger than 0.7. The wave energy is dissipated by wave breaking on the windward inclined plate, and turbulent flow around the vertical plate and the leeward inclined plate.

关键词： wave-structure interaction mountain-type breakwater free surface breakwater

Metal-free C(sp^(2))-H perfluoroalkylsulfonylation and configuration inversion:Stereoselective synthesis ofα-perfluoroalkylsulfonyl E-enaminones

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Chinese Chemical Letters 2021年第11期32卷 3514-3517页

作者： qing Yu Yunyun Liu jie-Ping Wan College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China

The perfluoroalkylsulfonylation(CF_(3)SO_(2),C_(2)F_(5)SO_(2)and CHF_(2)SO_(2))in the enaminone C-H bonds has been developed simply via the promotion of molecular iodine by using stable and cheap sodium perfluoroalkyl sulfinates as coupling *** stereoselective synthesis of E-configuratedα-perfluoroalkylsulfonyl enaminones has been realized via unprecedented C-H bond elaboration and C=C double bond configuration inversion by free radical process.

关键词： C-H Functionalization Enaminone Perfluoroalkyl sulfonylation Metal-free Configuration inversion

Influence of mechanical alloying time on the properties of Fe_3Al intermetallics prepared by spark plasma sintering

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Journal of University of Science and Technology Beijing 2007年第4期14卷 331-334页

作者： Chengchang Jia qing He jie Meng Lina Guo Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China

The Fe3Al-based intermetallics were prepared by mechanical alloying and spark plasma sintering （SPS）, and the influence of milling time on the properties of materials was investigated. The phase identification was investigated by X-ray, and the surface morphology and fractography were observed by scanning electron microscope （SEM）. The mechanical properties such as bending strength, strain, and microhardness were tested. The results show that Fe reacts with Al completely to form Fe3Al during short SPS processing time. The relative densities of the sintered samples were nearly 100%. The mechanical properties of the sintered samples can be improved along with the milling time. The representative values are the bend strength of 1327 MPa and the microhardness of 434.

关键词： Fe3A1 intermetallics mechanical properties mechanical alloying and milling powder metallurgy

A multi-source data fusion modeling method for debris flow prevention engineering

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Journal of Mountain Science 2021年第4期18卷 1049-1061页

作者： XU qing-yang YE Jian LYU Yi-jie Faculty of Geoscience and Environmental Engineering Southwest Jiao tong UniversityChengdu 611756China

The Digital Elevation Model(DEM)data of debris flow prevention engineering are the boundary of a debris flow prevention simulation,which provides accurate and reliable DEM data and is a key consideration in debris flow prevention ***,this paper proposes a multi-source data fusion ***,we constructed 3D models of debris flow prevention using virtual reality technology according to the relevant *** 3D spatial data generated by 3D modeling were converted into DEM data for debris flow prevention ***,the accuracy and applicability of the DEM data were verified by the error analysis testing and fusion testing of the debris flow prevention ***,we propose the Levels of Detail algorithm based on the quadtree structure to realize the visualization of a large-scale disaster prevention *** test results reveal that the data fusion method controlled the error rate of the DEM data of the debris flow prevention engineering within an allowable range and generated 3D volume data(obj format)to compensate for the deficiency of the DEM data whereby the 3D internal entity space is not ***,the levels of detailed method can dispatch the data of a large-scale debris flow hazard scene in real time to ensure a realistic 3D *** summary,the proposed methods can be applied to the planning of debris flow prevention engineering and to the simulation of the debris flow prevention process.

关键词： Debris flow prevention Level of detail Debris flow simulation Multi platform fusion Multi source data fusion

Automatic acquisition of pattern collocations in GO

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The Journal of China Universities of Posts and Telecommunications 2008年第1期15卷 61-67页

作者： LIU Zhi-qing DOU qing LI Wen-hong LU Ben-jie The School of Software Engineering Beijing University of Posts and Telecommunications Beijing 100876 China School of Software Engineering Yunnan University Yunnan 650000 China

The quality, quantity, and consistency of the knowledge used in GO-playing programs often determine their strengths, and automatic acquisition of large amounts of high-quality and consistent GO knowledge is crucial for successful GO playing. In a previous article of this subject, we have presented an algorithm for efficient and automatic acquisition of spatial patterns of GO as well as their frequency of occurrence from game records. In this article, we present two algorithms, one for efficient and automatic acquisition of pairs of spatial patterns that appear jointly in a local context, and the other for deter- mining whether the joint pattern appearances are of certain significance statistically and not just a coincidence. Results of the two algorithms include 1 779 966 pairs of spatial patterns acquired automatically from 16 067 game records of professsional GO players, of which about 99.8% are qualified as pattern collocations with a statistical confidence of 99.5% or higher.

关键词： computer games automatic knowledge acquisition,spatial patterns recognition pattern collocations