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面向分布式传感的散射增强光纤研究进展

光学学报 2024年第1期44卷 201-213页

作者：谭滔田野张建中哈尔滨工程大学物理与光电工程学院纤维集成光学教育部重点实验室黑龙江哈尔滨150001 哈尔滨工程大学烟台研究院先进光纤传感技术研发中心山东烟台264006

基于光纤后向散射的光纤传感技术具有全分布、长距离等特点,在诸多领域受到广泛关注,被认为是一种变革性技术。散射光随着传输距离增加逐渐减弱,信噪比降低导致感知性能下降,成为限制其在长距离应用的主要因素。通过光纤掺杂、写入弱光... 详细信息

基于光纤后向散射的光纤传感技术具有全分布、长距离等特点,在诸多领域受到广泛关注,被认为是一种变革性技术。散射光随着传输距离增加逐渐减弱,信噪比降低导致感知性能下降,成为限制其在长距离应用的主要因素。通过光纤掺杂、写入弱光栅等方式增加光纤散射强度可以有效缓解该问题。然而对于数千米的超长距应用,散射增加意味光纤损耗的增强,通过增加散射来提升信噪比的方法失效。本课题组提出一种增加光纤后向散射强度但不增加光纤本征损耗的散射收集能力增强光纤。本文分别从增强光纤散射能力和增强后向收集能力两个方向总结了散射增强光纤的几种方法,论述了各种方法的优缺点,并进行了简要展望。

关键词：光纤光学分布式传感散射增强光纤辐照光纤微结构光纤掺杂光纤超长锥形光纤

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水系锌离子电池负极改性策略研究进展

有色金属科学与工程 2024年第4期15卷 513-526页

作者：徐杰阮挺婷马全新孙蓉路胜利浙江科技学院生物与化学工程学院杭州310023 江西理工大学材料冶金化学学部江西赣州341000

水系锌离子电池因其安全性高、离子导电率高、理论比容量高、成本低廉等优点,成为一类颇有前景的规模化储能材料。然而,锌负极在充放电过程中难以避免会出现枝晶生长和析氢腐蚀等棘手问题,严重制约了水系锌离子电池的循环寿命与实际应... 详细信息

水系锌离子电池因其安全性高、离子导电率高、理论比容量高、成本低廉等优点,成为一类颇有前景的规模化储能材料。然而,锌负极在充放电过程中难以避免会出现枝晶生长和析氢腐蚀等棘手问题,严重制约了水系锌离子电池的循环寿命与实际应用的推广。本文首先分析了上述关键问题的成因和基本机制,系统阐述了目前锌负极的改性策略的4个方向,包括:负极材料构筑、涂层表面钝化、隔膜改性、电解液优化,重点论述了4类改性策略的设计要点与改性原理,并对锌负极的发展趋势进行了展望,为推动高性能水系锌离子电池发展提供参考。

关键词：水系锌离子电池锌负极锌枝晶涂层隔膜电解液

综合物探方法在碎屑岩地区找水中的应用——以云南宣威大路边村为例

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中国岩溶 2024年第2期43卷 432-440页

作者：郑智杰曾洁甘伏平陈吉礼卢秀华中国地质科学院岩溶地质研究所/自然资源部、广西岩溶动力学重点实验室/联合国教科文组织国际岩溶研究中心广西桂林541004 合肥工业大学安徽合肥230009 广西平果喀斯特生态系统国家野外科学观测研究站广西平果531406 广西壮族自治区三〇七核地质大队广西贵港537100

为探索地球物理方法在碎屑地区找水应用的有效性,文章以云南宣威大路边村为研究对象,选取高密度电阻率法、联合剖面法、音频大地电磁法对碎屑岩层进行找水研究。结果表明:三叠系上统飞仙关组(T1f)碎屑岩富水性中等,含水性较均匀;受地面... 详细信息

为探索地球物理方法在碎屑地区找水应用的有效性,文章以云南宣威大路边村为研究对象,选取高密度电阻率法、联合剖面法、音频大地电磁法对碎屑岩层进行找水研究。结果表明:三叠系上统飞仙关组(T1f)碎屑岩富水性中等,含水性较均匀;受地面场地狭窄限制,高密度电法及联合剖面法测线长度有限,探测深度较浅,受碎屑岩电阻率小的影响,其找水应用效果不佳,在可探测的深度范围内较难识别基岩裂隙等找水有效异常,需结合其他物探方法甄别异常;音频大地电磁法找水应用效果相对较好,具有较高的横向分辨率,可有效识别碎屑岩中的断裂破碎带及构造裂隙带,表现为相对低阻异常特征;视电阻率单支测深曲线能有效分辨不同深度的岩土层结构,具有较高的纵向分辨率,对裂隙破碎带有较好指示意义。在地面场地较为狭窄的碎屑岩地区开展找水工作,音频大地电磁法结合视电阻单支测深曲线能取得较好效果,以音频大地电磁法确定碎屑岩地区中的裂隙发育带位置,以视电阻单支测深曲线确定裂隙发育带的深度。

关键词：高密度电阻率法联合剖面法音频大地电磁法视电阻率测深曲线碎屑岩找水

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Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin

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Chinese Chemical Letters 2024年第3期35卷 384-388页

作者： Yi-Jing Li Lingze Zhang Ming-Hao Pang Pei-Pei Yang lu-Ming Guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Peptide drugs are known for their high biological ***,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in ***,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide *** displaying random peptides were screened using fluorescent labeled human serum *** beads with specific binding to albumin were isolated for *** selected ABPs can effectively bind to albumin,thus possessing the long circulation of *** dissociation constant(K_(D))of ABPs to albumin is up to 1×10^(-8)mol/*** one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in *** OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs.

关键词： One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin

IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy

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Chinese Chemical Letters 2024年第1期35卷 305-309页

作者： Songtao Zhou Hao Tian jie Yan Zhan Zhang Guohao Wang Xinying Yu Wei Sang Bei Li Greta S.P.Mok jie Song Yunlu Dai Cancer Center and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Biomedical Imaging Laboratory(BIG) Department of Electrical and Computer EngineeringFaculty of Science and TechnologyUniversity of MacaoMacao 999078China

Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ROS) to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT. However, the photosensitizer and chemotherapy drugs used in PDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.

关键词： Metal phenolic network IR780 Photodynamic therapy Breast cancer Gemcitabine

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政府非税收入法治化的国际比较与借鉴

国际税收 2024年第3期 75-81页

作者：谭建淋国家税务总局税务干部学院(长沙)

随着非税收入征管职责划转基本完成,我国“税费皆重”工作格局基本形成,但非税收入法治化建设仍面临挑战。本文通过借鉴日本、法国和加拿大等发达国家在非税收入法治化管理方面的经验,结合我国非税收入征管实际,建议在非税收入项目确立... 详细信息

随着非税收入征管职责划转基本完成,我国“税费皆重”工作格局基本形成,但非税收入法治化建设仍面临挑战。本文通过借鉴日本、法国和加拿大等发达国家在非税收入法治化管理方面的经验,结合我国非税收入征管实际,建议在非税收入项目确立、标准制定、收支预算管理、审计监督、资金使用及信息公开等方面加强科学性、规范性和合法性。

关键词：非税收入税务部门财税体制法治化

Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathway

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Traditional Medicine Research 2024年第8期9卷 47-58页

作者： Yu-jie Gao Xi-Pei Wu Bin-Bin Ye Yong-Zhao Dai Yao-Zhong Zhao Xiu-Xiu Liao Ke Nie School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced *** this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia was discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory ***:A rat model of chemotherapy-induced anorexia was established using *** study evaluated the therapeutic effects of LJZD by observing the weight,food intake,and intestinal pathology of *** impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,was investigated through gut microbiota analysis and targeted *** anti-inflammatory and intestinal protective effects of LJZD were assessed by examining the expression of intestinal tight junction proteins associated with the inflammatory ***:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along with reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and ***,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the *** the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathway,leading to a downregulation in the transcriptional activity of IL-6 and IL-1β,as well as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression ***:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4

关键词： Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat

Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

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World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： Xi Chen Ya-Nan Zhou Xiao-Zi lu Ren-Jiao Li Yi-Fan Xiong Xia Sheng Wei-Wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(Pluding attention/alertness and learning ability(P0.05).CONCluSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

基于无监督学习方法的细胞膜内单分子扩散运动分析:胆固醇对模型膜和活细胞膜流动性的不同影响

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物理学报 2024年第18期73卷 278-288页

作者：谭金鹏张婉婷徐成卢雪梅朱文圣杨恺元冰东北师范大学数学与统计学院长春130024 松山湖材料实验室东莞523808 苏州大学物理科学与技术学院软凝聚态物理及交叉研究中心苏州215006 苏州城市学院光学与电子信息学院苏州215104 苏州大学前沿材料物理与器件省高校重点实验室苏州215006

单分子运动追踪是研究软物质体系尤其是生命体系动力学过程和分子相互作用的重要方法,但如何理解生命体系中单分子运动行为的复杂性仍是一个巨大的挑战.针对这一问题,本工作提出了一种可对单分子轨迹进行高效识别和分类的、基于无监督... 详细信息

单分子运动追踪是研究软物质体系尤其是生命体系动力学过程和分子相互作用的重要方法,但如何理解生命体系中单分子运动行为的复杂性仍是一个巨大的挑战.针对这一问题,本工作提出了一种可对单分子轨迹进行高效识别和分类的、基于无监督学习的“两步归类法”:首先利用熵约束最小二乘法对扩散轨迹的受限程度进行区分,继而通过统计检验将非受限轨迹划分为亚扩散、正常扩散和超扩散等不同运动模式类型.利用该方法,本工作解析了DOPC模型细胞膜和活细胞膜内的单分子扩散运动特征,揭示了胆固醇成分对二者的差异影响.结果显示:模型膜和活细胞膜均包含多种不同的扩散模式;在DOPC模型膜体系中,胆固醇成分会阻碍膜内的分子扩散运动,且阻碍程度与胆固醇含量正相关;在活细胞体系中,分子运动速率显著低于模型膜体系,并且,胆固醇的去除会进一步减慢分子扩散速率.本研究有助于从单分子运动角度深入理解生物分子运动行为的复杂性及其对体系环境的依赖性.

关键词：单分子运动无监督学习模型细胞膜胆固醇