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Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 62-88页

作者： jie-zhuang huang Jian-Di Li Gang Chen Rong-Quan He Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Transcatheter arterial embolisation(TACE)is the primary treatment for intermediate-stage hepatocellular carcinoma(HCC)patients while some HCC cases have shown resistance to *** To investigate the key genes and potential mechanisms correlated with TACE refractoriness in *** The microarray datasets of TACE-treated HCC tissues,HCC and non-HCC tissues were collected by searching multiple public *** respective differentially expressed genes(DEGs)were attained via limma R *** gene co-expression network analysis was employed for identifying the significant modules related to TACE *** refractoriness-related genes were obtained by intersecting up-regulated TACE-associated and HCC-associated DEGs together with the genes in significant modules related to TACE *** key genes expression in the above two pairs of samples was compared respectively via Wilcoxon tests and standard mean differences *** prognostic value of the key genes was evaluated by Kaplan-Meier *** analysis was utilised to investigate the independent prognostic factor in key ***-cell RNA(scRNA)sequencing analysis was conducted to explore the cell types in *** refractoriness-related genes activity was calculated via AUCell *** CellChat R package was used for the investigation of the cell–cell communication between the identified cell *** HCC tissues of TACE non-responders(n=66)and TACE responders(n=81),HCC(n=3941)and non-HCC(n=3443)tissues were *** five key genes,DLG associated protein 5(DLGAP5),Kinesin family member 20A(KIF20A),Assembly factor for spindle microtubules(ASPM),Kinesin family member 11(KIF11)and TPX2 microtubule nucleation factor(TPX2)in TACE refractoriness-related genes,were *** five key genes were all up-regulated in the TACE non-responders group and the HCC *** expression of the five key genes predicted poor prognosis in *** the key genes,TP

关键词： Hepatocellular carcinoma Transcatheter arterial embolisation refractoriness Weighted gene co-expression network analysis Single-cell RNA sequencing AUCell CellChat

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Earth's core-mantle boundary shaped by the crystallization of a hydrous terrestrial magma ocean

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National Science Review 2024年第7期11卷 73-75页

作者： Qingyang Hu jie Deng Yukai zhuang Zhenzhong Yang Rong huang Center for High Pressure Science and Technology Advanced Research(HPSTAR) Shanghai Advanced Research in Physical Sciences(SHARPS) Department of Geosciences Princeton University Institute of Atomic and Molecular Physics Sichuan University Key Laboratory of Polar Materials and Devices Department of Electronics East China Normal University

A water-rich global magma ocean(MO)likely existed in the early Hadean eon and subsequently cooled and *** water is an oxidant and is known to fundamentally affect liquid crystallization, the role of primordial water d... 详细信息

关键词： CROSSOVER MELT

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Distributed Nash Equilibrium Seeking on Compact Action Sets over Jointly Strongly Connected Switching Networks

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Journal of Systems Science & Complexity 2024年第1期37卷 63-81页

作者： HE Xiongnan huang jie Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China.

This paper studies the distributed Nash equilibrium seeking(DNES)problem for games whose action sets are compact and whose network graph is switching satisfying the jointly strongly connected *** keep the actions of all players in their action sets all the time,one has to resort to the projected gradient-based *** the assumption that the unique Nash equilibrium is the unique equilibrium of the pseudogradient system,an algorithm is proposed that is able to exponentially find the Nash ***,the authors also consider the distributed Nash equilibrium seeking problem for games whose actions are governed by high-order integrator dynamics and belong to some compact *** examples are used to illustrate the proposed approach.

关键词： Compact action sets jointly strongly connected switching graphs Nash equilibrium seeking projected gradient-based algorithm.

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Quantum vector DC magnetometry via selective phase accumulation

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 12-22页

作者： Min zhuang Sijie Chen Jiahao huang Chaohong Lee Institute of Quantum Precision Measurement State Key Laboratory of Radio Frequency Heterogeneous IntegrationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China Laboratory of Quantum Engineering and Quantum Metrology School of Physics and AstronomySun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Precision measurement of magnetic fields is a crucial issue in both fundamental scientific research and practical sensing *** sensitive detection of a vector magnetic field poses a significant challenge in quantum magnetometry,particularly in estimating a vector DC magnetic field with high ***,we propose a comprehensive protocol for quantum vector DC magnetometry,utilizing selective phase accumulation in both non-entangled and entangled quantum *** upon the principles of Ramsey interferometry,our protocol enables the selective accumulation of phase for a specific magnetic field component by incorporating a meticulously designed pulse *** the individual measurement scheme,we employ three individual quantum interferometries to independently estimate each of the three magnetic field ***,in the simultaneous measurement scheme,the application of a pulse sequence along different directions enables the simultaneous estimation of all three magnetic field components using only one quantum ***,by employing an entangled state(such as the Greenberger-Horne-Zeilinger state)as the input state,the measurement precisions of all three components may reach the Heisenberg *** study not only establishes a general protocol for measuring vector magnetic fields using quantum probes,but also presents a viable pathway for achieving entanglement-enhanced multi-parameter estimation.

关键词： magnetometry quantum interferometry entanglement-enhanced quantum metrology

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Classifying Chinese Medicine Constitution Using Multimodal Deep-Learning Model

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Chinese Journal of Integrative Medicine 2024年第2期30卷 163-170页

作者： GU Tian-yu YAN zhuang-zhi JIANG jie-hui School of Communication&Information Engineering Shanghai UniversityShanghai(200444)China School of Life Science Shanghai UniversityShanghai(200444)China

Objective:To develop a multimodal deep-learning model for classifying Chinese medicine constitution,i.e.,the balanced and unbalanced constitutions,based on inspection of tongue and face images,pulse waves from palpation,and health information from a total of 540 ***:This study data consisted of tongue and face images,pulse waves obtained by palpation,and health information,including personal information,life habits,medical history,and current symptoms,from 540 subjects(202 males and 338 females).Convolutional neural networks,recurrent neural networks,and fully connected neural networks were used to extract deep features from the *** fusion and decision fusion models were constructed for the multimodal ***:The optimal models for tongue and face images,pulse waves and health information were ResNet18,Gate Recurrent Unit,and entity embedding,*** fusion was superior to decision *** multimodal analysis revealed that multimodal data compensated for the loss of information from a single mode,resulting in improved classification ***:Multimodal data fusion can supplement single model information and improve classification *** research underscores the effectiveness of multimodal deep learning technology to identify body constitution for modernizing and improving the intelligent application of Chinese medicine.

关键词： Chinese medicine constitution classification multimodal deep learning tongue image face image pulsewave health information

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Progress on Bionic Textured Cutting Tools:A Review and Prospects

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Journal of Bionic Engineering 2024年第1期21卷 19-55页

作者： Hong Wei Guangjun Chen zhuang Chen Zhiwei Yu Jiashuai huang Tianjin Key Laboratory of High Speed Cutting and Precision Processing Tianjin 300222China School of Mechanical Engineering Tianjin University of Technology and EducationTianjin 300222China

Cutting tools are known as the“productivity”of the manufacturing industry,which affects the production efficiency and quality of the workpiece,and has become the focus of research and attention in academia and ***,traditional cutting tools often suffer from adhesion or wear during the cutting process,which considerably reduces the cutting efficiency and service life of the tools,and makes it difficult to meet current production *** solve the above problems,scholars have introduced bionics into the tool’s design,applying the microscopic structure of the biological surface to the tool surface to alleviate the tool’s *** paper mainly summarizes the research progress of bionic textured cutting ***,categorize whether the bionic texture design is inspired by a single organism or multiple ***,it is discussed that the non-smooth surface of the biological surface has five characteristics:hydrophilic lubricity,wear resistance,drag reduction and hydrophobicity,anti-adhesion,and arrangement,and the non-smooth structure of these different characteristics are applied to the surface of the tool is designed with bionic ***,the cutting performance of bionic textured cutting tools is *** anti-friction and wear-resisting mechanism of bionic textured cutting tools is ***,some pending problems and perspectives have been proposed to provide new inspirations for the design of bionic textured cutting tools.

关键词： Bionic textured cutting tools Biological microstructure characteristics Cutting performance Anti-friction and wear-resisting mechanism

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Aberrant protamination in sperm correlates to anomalous nuclear and cytoplasmic architectures in infertile males with sperm dysmorphology

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Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan Jiang Chu-jie huang Department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin ***,its effects on sperm cytoplasmic maturation remain largely *** relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their *** concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World Health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(PI)*** protamine expressions(P1 and P2)were detected by western *** damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both P<0.01).P1 level,P1/P2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the P2 level decreased(all P

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

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“Co-coordination force”assisted rigid-flexible coupling crystalline polymer for high-performance aqueous zinc-organic batteries

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Chinese Chemical Letters 2024年第9期35卷 501-506页

作者： Jun Guo Zhenbang zhuang Wanqiang Liu Gang huang School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Key Laboratory of Automobile Materials Ministry of EducationDepartment of Materials Science and EngineeringJilin UniversityChangchun 130022China

Organic electrode materials(OEMs)have attracted substantial attention for aqueous zinc-ion batteries(AZIBs)due to their advantages in relieving resource and environmental ***,the potential of OEMs is plagued by their low achievable capacity and high ***,we have proposed a new concept of“co-coordination force”and designed a rigid-flexible coupling crystalline polymer that can overcome the abovementioned *** obtained crystalline polymer(BQSPNs)with multiredox centres makes the BQSPNs exist intermolecular hydrogen bonds(HB)among-C=O,-C=N,and-NH and consequently exhibits transverse two-dimensional arrays and longitudinalπ-πstacking ***,in-situ FTIR,Raman,variable temperature FTIR spectra,and 2D nuclear overhauser effect spectroscopy(NOESY)well capture the existence and evolution process of HB during the electrochemistry reaction process of BQSPNs,uncovering the effect of HB in stabilizing the structure and promoting the reaction *** a result,the BQSPNs with rationally designed“co-coordination force”deliver a high capacity of 459.6 m Ah/g and a stable cycling lifetime for more than 100,000 cycles at 10 A/g in *** results disclose the HB effect and provide a brand-new strategy for high-performance OEMs design.

关键词： Co-coordination force Crystalline polymer Hydrogen bonds Organic electrode materials Aqueous zinc-ion batteries

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Precisely Control Relationship between Sulfur Vacancy and H Absorption for Boosting Hydrogen Evolution Reaction

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Nano-Micro Letters 2024年第4期16卷 14-24页

作者： Jing Jin Xinyao Wang Yang Hu zhuang Zhang Hongbo Liu jie Yin Pinxian Xi College of Chemistry and Chemical Engineering Frontiers Science Center for Rare IsotopesState Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000People’s Republic of China

Ef fective and robust catalyst is the core of water splitting to produce ***, we report an anionic etching method to tailor the sulfur vacancy(VS) of NiS_(2) to further enhance the electrocatalytic performance for hydrogen evolution reaction(HER). With the VS concentration change from 2.4% to 8.5%, the H* adsorption strength on S sites changed and NiS_(2)-VS 5.9% shows the most optimized H* adsorption for HER with an ultralow onset potential(68 m V) and has long-term stability for 100 h in 1 M KOH media. In situ attenuated-total-reflection Fourier transform infrared spectroscopy(ATR-FTIRS) measurements are usually used to monitor the adsorption of intermediates. The S-H* peak of the Ni S_(2)-VS 5.9% appears at a very low voltage, which is favorable for the HER in alkaline media. Density functional theory calculations also demonstrate the Ni S_(2)-VS 5.9% has the optimal |ΔG^(H*)| of 0.17 e V. This work offers a simple and promising pathway to enhance catalytic activity via precise vacancies strategy.

关键词： Hydrogen evolution reaction S vacancies Nanosheet H Adsorption

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Dynamic coverage of mobile multi-target in sensor networks based on virtual force

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The Journal of China Universities of Posts and Telecommunications 2024年第4期31卷 83-94页

作者： huang Qingdong Wang Mei Chen Chen Han zhuang School of Communication and Information Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China

A distributed self-control coverage method for mobile multi-target based on virtual force(MMTVF)is proposed to monitor dynamic targets using a mobile sensor network(MSN).The dynamic coverage method is introduced to maintain network connectivity and optimize the coverage of moving *** method consists of two parts,one is the virtual force model which is proposed for motion control,and the other is the whale optimization algorithm which is improved to optimize node positions and achieve a steady state *** virtual resultant force stretches the network towards uncovered targets using its multi-target attractive force,maintains network connectivity during network stretching using its attractive force,and prevents node collisions while nodes are moving using its repulsive *** operating mechanism of the multi-target attractive force and other forces is thoroughly *** criteria for the model in different application scenarios are also *** comparisons demonstrate MMTVF has significant advantages over other similar approaches.

关键词： mobile sensor network(MSN) dynamic coverage virtual force moving targets

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