检索结果-南通市图书馆

Aberrant protamination in sperm correlates to anomalous nuclear and cytoplasmic architectures in infertile males with sperm dysmorphology

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan jiang Chu-jie Huang Department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin condensation.Yet,its effects on sperm cytoplasmic maturation remain largely unexplored.The relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their samples.Sperm concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World Health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(PI)staining.Sperm protamine expressions(P1 and P2)were detected by western blot.DNA damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both P<0.01).P1 level,P1/P2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the P2 level decreased(all P

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

Computed tomography radiomic features and clinical factors predicting the response to first transarterial chemoembolization in intermediate-stage hepatocellular carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 361-369页

作者： Zhong-Xing Shi Chang-Fu Li Li-Feng Zhao Zhong-Qi Sun Li-Ming Cui Yan-jie Xin Dong-Qing Wang Tan-Rong Kang hui-jie jiang Department of Interventional Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Digestive Medicine Daqing Longnan HospitalDaqing 163453China Department of Radiology Daqing Longnan HospitalDaqing 163453China Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treatment response can help patients choose a reasonable treatment plan.This study aimed to investigate the value of the radiomic-clinical model in predicting the efficacy of the first TACE treatment for HCC to prolong patient survival.Methods:A total of 164 patients with HCC who underwent the first TACE from January 2017 to September 2021 were analyzed.The tumor response was assessed by modified response evaluation criteria in solid tumors(mRECIST),and the response of the first TACE to each session and its correlation with overall survival were evaluated.The radiomic signatures associated with the treatment response were identified by the least absolute shrinkage and selection operator(LASSO),and four machine learning models were built with different types of regions of interest(ROIs)(tumor and corresponding tissues)and the model with the best performance was selected.The predictive performance was assessed with receiver operating characteristic(ROC)curves and calibration curves.Results:Of all the models,the random forest(RF)model with peritumor(+10 mm)radiomic signatures had the best performance[area under ROC curve(AUC)=0.964 in the training cohort,AUC=0.949 in the validation cohort].The RF model was used to calculate the radiomic score(Rad-score),and the optimal cutoff value(0.34)was calculated according to the Youden’s index.Patients were then divided into a high-risk group(Rad-score>0.34)and a low-risk group(Rad-score≤0.34),and a nomogram model was successfully established to predict treatment response.The predicted treatment response also allowed for significant discrimination of Kaplan-Meier curves.Multivariate Cox regression identified six independent prognostic factors for overall survival,including male[hazard ratio(HR)=0.500,95%confidence interval(CI):0.260–0.962,P=0.038],alpha-fetoprotein(HR=

关键词： Hepatocellular carcinoma Transarterial chemoembolization Radiomics Treatment response Prediction

Prevalence and clinical impact of sarcopenia in liver transplant recipients:A meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第8期30卷 956-968页

作者： Min-jie jiang Mu-Chen Wu Zhong-hui Duan Jing Wu Xiao-Tong Xu Juan Li Qing-Hua Meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Emergency Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND The prevalence of sarcopenia in patients undergoing liver transplantation(LT)remains to be determined partly because of different diagnostic criteria.Sarcopenia has recently been recognized as a new prognostic factor for predicting outcomes in LT candidates.AIM To estimate the prevalence of sarcopenia and evaluate its clinical effect on LT candidates.METHODS This systematic search was conducted in PubMed,Web of Science,Embase,and Cochrane Library for original English-language articles that investigated the prevalence and influence of sarcopenia in patients undergoing LT from database inception to November 30,2022.Cohort studies of the definition of sarcopenia that estimate sarcopenia prevalence and evaluate its effect on clinical outcomes and the risk of mortality were included.RESULTS Twenty-five studies involving 7760 patients undergoing LT were included.The pooled prevalence of sarcopenia in patients undergoing LT was 40.7%[95%confidence intervals(95%CI):32.1-49.6].The 1-,3-,and 5-year cumulative probab-ilities of post-LT survival in patients with preoperative sarcopenia were all lower than those without sarcopenia(P<0.05).Sarcopenia was associated with an increased risk of post-LT mortality in patients undergoing LT(adjusted hazard ratio:1.58;95%CI:1.21-2.07).Patients with preoperative sarcopenia had a longer intensive care unit stay,a high risk ratio of sepsis,and serious post-LT complications than those without sarcopenia.CONCLUSION Sarcopenia is prevalent in a substantial proportion of patients undergoing LT and is strongly and independently associated with higher a risk of mortality risk.

关键词： Sarcopenia Liver transplantation Mortality Clinical outcomes

Do nocturnal birds use acoustic and visual cues to avoid predation by bats?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第3期19卷 524-537页

作者： Lixin GONG Huan WU Zhiqiang WANG hui WU jiang FENG Tinglei jiang Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization Northeast Normal UniversityChangchunChina Key Laboratory of Vegetation Ecology of Education Ministry Institute of Grassland ScienceNortheast Normal UniversityChangchunChina College of Life Science Jilin Agricultural UniversityChangchunChina

Anti-predation strategies are critical to animal survival and are fundamental to deciphering predator–prey interactions.As an important defense strategy,sensory predator detection(such as through acoustic and visual cues)enables animals to assess predation risk and execute predator-avoidance behavior;however,there are limited studies on the anti-predation behavior of nocturnal animals.The prey of bats provides an excellent representative system for examining the anti-predation behavior of nocturnal animals.Here,we broadcasted different types of echolocation calls of the bird-eating bat Ia io to two wild passerine birds,namely,Zosterops japonicus and Sinosuthora webbiana,that are preyed upon by I.io,and presented the birds with individual bats under different light intensities.The results showed that both bird species were able to perceive the low-frequency audible portion of the bats’echolocation calls;however,they did not exhibit escape responses to the acoustic stimuli.In the dark and under moonlit conditions,both bird species were unable to respond to active bats at close range and the birds only exhibited evasive flight behavior when bats approached or touched them.These results suggest that nocturnal passerine birds may not be able to use acoustic or visual cues to detect bats and adopt evasive maneuvers to avoid predation.This work suggests that bat predation pressure may not elicit primary predator-avoidance responses in nocturnal passerine birds.The results provide new insights into the anti-predation behavior of nocturnal animals.

关键词： anti-predation behavior nocturnal animals sensory cues sensory defenses

Photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第2期67卷 587-594页

作者： Fangming Chen Lvqi jiang Chunyang Hu jie Liu Wenbin Yi School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Organofluorine Chemistry Shanghai Institute Organic ChemistryChinese Academy of SciencesShanghai200032China

Since the first report of sodium trifluoromethanesulfinate(CF_(3)SO_(2)Na) as an electrophilic trifluoromethylthiolation reagent in 2015,there has been no breakthrough in research in this field.Herein,we disclose an unprecedented usage of CF_(3)SO_(2)Na as a radical trifluoromethylthiolation reagent.A photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na in the presence of PPh_(3) and catalytic copper has been developed.Interestingly,either Ir[(p-Fppy)_(2)(bpy)]PF_6 or Ir(ppy)_(3) could facilitate this transformation.Mechanistic studies indicate that initiation of the radical chain proceeded via two different photocatalytic quenching mechanisms.This protocol provides a practical method for the construction of diverse vicinal ditrifluoromethylthiolated compounds.

关键词： trifluoromethylthiolation photocatalysis radical difunctionalization alkenes

Blockchain-based immunization against kleptographic attacks

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第7期67卷 172-183页

作者： Changsong jiang Chunxiang XU jie CHEN Kefei CHEN School of Computer Science and Engineering University of Electronic Science and Technology of China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Department of Mathematics Hangzhou Normal University

Adversarial implementations of cryptographic primitives called kleptographic attacks cause the leakage of secret information. Subliminal channel attacks are one of the kleptographic attacks. In such attacks, backdoors are embedded in implementations of randomized algorithms to elaborately control randomness generation, such that the secrets will be leaked from biased outputs. To thwart subliminal channel attacks, double-splitting is a feasible solution, which splits the randomness generator of a randomized algorithm into two independent generators. In this paper, we instantiate double-splitting to propose a secure randomness generation algorithm dubbed SRG using two physically independent generators: ordinary and public randomness generators. Based on public blockchains, we construct the public randomness generator,which can be verified publicly. Hashes of a sufficient number of consecutive blocks that are newly confirmed on a blockchain are used to produce public randomness. In SRG, outputs from the two generators are taken as inputs of an immunization function. SRG accomplishes immunization against subliminal channel attacks.Additionally, we discuss the application strategies of SRG for symmetric and public-key encryption.

关键词： kleptographic attacks subliminal channel blockchain immunization randomized algorithm

Study on a conical bearing for acceleration-sensitive equipment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2024年第1期23卷 103-128页

作者： Pang hui Xu Wen Dai Junwu jiang Tao Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China School of Civil Engineering and Transportation Beihua UniversityJilin 132013China

Seismic isolation effectively reduces seismic demands on building structures by isolating the superstructure from ground vibrations during earthquakes.However,isolation strategies give less attention to acceleration-sensitive systems or equipment.Meanwhile,as the isolation layer’s displacement grows,the stiffness and frequency of traditional rolling and sliding isolation bearings increases,potentially causing self-centering and resonance concerns.As a result,a new conical pendulum bearing has been selected for acceleration-sensitive equipment to increase self-centering capacity,and additional viscous dampers are incorporated to enhance system damping.Moreover,the theoretical formula for conical pendulum bearings is supplied to analyze the device’s dynamic parameters,and shake table experiments are used to determine the proposed device’s isolation efficiency under various conditions.According to the test results,the newly proposed devices have remarkable isolation performance in terms of minimizing both acceleration and displacement responses.Finally,a numerical model of the isolation system is provided for further research,and the accuracy is demonstrated by the aforementioned experiments.

关键词： seismic isolation acceleration-sensitive equipment the conical pendulum bearing shake table tests isolation performance,numerical model

The fast method and convergence analysis of the fractional magnetohydrodynamic coupled flow and heat transfer model for the generalized second-grade fluid

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第4期67卷 919-950页

作者： Xiaoqing Chi hui Zhang Xiaoyun jiang School of Mathematics and Statistics Shandong UniversityWeihai 264209China School of Mathematics Shandong UniversityJinan 250100China

In this paper,we first establish a new fractional magnetohydrodynamic(MHD)coupled flow and heat transfer model for a generalized second-grade fluid.This coupled model consists of a fractional momentum equation and a heat conduction equation with a generalized form of Fourier law.The second-order fractional backward difference formula is applied to the temporal discretization and the Legendre spectral method is used for the spatial discretization.The fully discrete scheme is proved to be stable and convergent with an accuracy of O(τ^(2)+N-r),whereτis the time step-size and N is the polynomial degree.To reduce the memory requirements and computational cost,a fast method is developed,which is based on a globally uniform approximation of the trapezoidal rule for integrals on the real line.The strict convergence of the numerical scheme with this fast method is proved.We present the results of several numerical experiments to verify the effectiveness of the proposed method.Finally,we simulate the unsteady fractional MHD flow and heat transfer of the generalized second-grade fluid through a porous medium.The effects of the relevant parameters on the velocity and temperature are presented and analyzed in detail.

关键词： fractional MHD coupled flow and heat transfer model generalized second-grade fuid fast method convergence analysis numerical simulation

Growth of Ag/g-C_(3)N_(4) nanocomposites on nickel foam to enhance photocatalytic degradation of formaldehyde under visible light

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 432-442页

作者： Ze Wang Zhi Huang jiang Yu Xiao Shao Weidong Peng jie Yu Yinying jiang Department of Environmental Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Institute of New Energy and Low Carbon Technology Sichuan UniversityChengdu 610065China School of Agriculture and Environment University of Western AustraliaPerth 6907Western AustraliaAustralia Yibin Institute of Industrial Technology Sichuan UniversityYibin 644000China

Formaldehyde is a pollutant that significantly affects the indoor air quality.However,conventional remediation approaches can be challenging to deal with low-concentration formaldehyde in an indoor environment.In this study,Photocatalysts of Ag/graphitic carbon nitride(g-C_(3)N_(4))/Ni with 3D reticulated coral structure were prepared by thermal polymerization and liquid phase photo-deposition,using nickel foam(NF)as the carrier.Experiments demonstrated that when the Ag concentration was 3%,and the relative humidity was 60%,the Ni/Ag/g-C_(3)N_(4)showed the maximum degradation rate of formaldehyde at 90.19%under visible light irradiation,and the formaldehyde concentration after degradation was lower than the Hygienic standard stated by the Chinese Government.The porous structure of Ni/Ag/g-C_(3)N_(4)and the formation of Schottky junctions promoted the Adsorption efficiency and degradation of formaldehyde,while the nickel foam carrier effectively promoted the desorption of degradation products.Meanwhile,the degradation rate was only reduced by3.4%after 16 recycles,the three-dimensional porous structure extended the lifetime of the photocatalyst.This study provides a new strategy for the degradation of indoor formaldehyde at low concentrations.

关键词： Graphitic carbon nitride(g-C_(3)N_(4)) Nickel foam(NF) Ag Formaldehyde Photocatalysis