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Consolidation of high replacement ratio stone column-reinforced ground:Analytical solutions incorporating clogging effect

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3311-3326页

作者： Jinxin Sun Mengmeng Lu Baolong Xu jie shan School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou221116China Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou221006China

The utilization of stone columns has emerged as a popular ground improvement strategy,whereas the drainage performance can be adversely hampered by clogging *** the ample progress of calculation methods for the consolidation of stone column-improved ground,theoretical investigations into the clogging effect have not been thoroughly ***,it is imperative to involve the column consolidation deformation to mitigate computational error on the consolidation of composite ground with high replacement *** this context,an analytical model accounting for the initial clogging and coupled time and depth-dependent clogging of stone columns is ***,the resulting governing equations and analytical solutions are obtained under a new flow continuity relationship to incorporate column consolidation *** accuracy and reliability of the proposed model are illustrated by degradation analysis and case studies with good ***,the computed results of the current study are juxtaposed against the existing models,and an in-depth assessment of the impacts of several crucial parameters on the consolidation behavior is *** results reveal that ignoring column consolidation deformation leads to an overestimate of the consolidation rate,with maximum error reaching up to 16%as the replacement ratio ***,the initial clogging also has a significant influence on the consolidation ***,the increment of depth and time-clogging factors a and b will induce a noticeable retardation of the consolidation process,particularly in the later stage.

关键词： Consolidation Composite ground Stone column Clogging effect Ground improvement Analytical model

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Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2298-2316页

作者： jie shan Xu Jin Cong Zhang Muchen Huang Jianghao Xing Qingrong Li Yuyu Cui Qiang Niu Xu Lin Chen Xianwen Wang Department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefei 230032China Division of Gastroenterology the First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China The Second Clinical Medical College Anhui Medical UniversityHefei 230022China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China College and Hospital of Stomatology Anhui Medical UniversityKey Lab.of Oral Diseases Research of Anhui ProvinceHefei 230032China

Bacterial infection hampers wound repair by impeding the healing ***,inflammation at the wound site triggers the production of reactive oxygen species(ROS),causing oxidative stress and damage to proteins and *** can lead to chronic wounds,posing severe ***,eliminating bacterial infection and reducing ROS levels are crucial for effective wound ***,possessing enzyme-like catalytic activity,can convert endogenous substances into highly toxic substances,such as ROS,to combat bacteria and biofilms without inducing drug ***,the current nanozyme model with single enzyme activity falls short of meeting the complex requirements of antimicrobial ***,developing nanozymes with multiple enzymatic activities is ***,we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles(Ru-PC NPs)with diverse enzymatic activities to aid wound healing and combat bacterial *** acidic conditions,due to their glutathione(GSH)depletion and peroxidase(POD)-like activity,Ru-PC NPs combined with H2O2 exhibit excellent antibacterial ***,in a neutral environment,the Ru-PC NPs,with catalase(CAT)activity,decompose H2O2 to O2,alleviating hypoxia and ensuring a sufficient oxygen ***,Ru-PC NPs possess exceptional antioxidant capacity through their superior superoxide dismutase(SOD)enzyme activity,effectively scavenging excess ROS and reactive nitrogen species(RNS)in a neutral *** maintains the balance of the antioxidant system and prevents ***-PC NPs also promote the polarization of macrophages from M1 to M2,facilitating wound *** importantly,Ru-PC NPs show good biosafety with negligible *** vivo wound infection models have confirmed the efficacy of Ru-PC NPs in inhibiting bacterial infection and promoting wound *** focus of this work highlights the quadruple enzymatic activity of Ru-PC NPs and its potential to reduce inf

关键词： Nanozymes Quadruple enzymatic activity Antibacterial therapy Wound therapy RNA-seqAnti-inflammatory Reactive oxygen species Reactive nitrogen species

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Comparison Between Threshold Method and Artificial Intelligence Approaches for Early Warning of Respiratory Infectious Diseases-Weifang City,shandong Province,China,2020-2023

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China CDC weekly 2024年第26期6卷 635-641,I0010,I0011页

作者： Ting Zhang Liuyang Yang Ziliang Fan Xuancheng Hu Jiao Yang Yan Luo Dazhu Huo Xuya Yu Ling Xin Xuan Han jie shan Zhongjie Li Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC)BeijingChina State Key Laboratory of Respiratory Health and Multimorbidity BeijingChina Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College) Ministry of EducationBeijingChina The Third Affiliated Hospital of Kunming Medical University Yunnan Cancer HospitalKunming CityYunnan ProvinceChina School of Data Science Fudan UniversityShanghaiChina Weifang Center for Disease Control and Prevention Weifang CityShandong ProvinceChina School of Health Policy and Management Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

Introduction:Respiratory infectious diseases,such as influenza and coronavirus disease 2019(COVID-19),present significant global public health *** emergence of artificial intelligence(AI)and big data offers opportunities to improve traditional disease surveillance and early warning ***:The study analyzed data from January 2020 to May 2023,comprising influenza-like illness(ILI)statistics,Baidu index,and clinical data from *** methodologies were evaluated:the adaptive dynamic threshold method(ADTM)for dynamic threshold adjustments,the machine learning supervised method(MLSM),and the machine learning unsupervised method(MLUM)utilizing anomaly *** comparison focused on sensitivity,specificity,timeliness,and warning ***:ADTM issued 37 warnings with a sensitivity of 71%and a specificity of 85%.MLSM generated 35 warnings,with a sensitivity of 82%and a specificity of 87%.MLUM produced 63 warnings with a sensitivity of 100%and specificity of 80%.The initial warnings from ADTM and MLUM preceded those from MLSM by five *** Kappa coefficient indicated moderate agreement between the methods,with values ranging from 0.52 to 0.62(P<0.05).Discussion:The study explores the comparison between traditional methods and two machine learning approaches for early warning *** emphasizes the validation of machine learning’s reliability and underscores the unique advantages of each ***,it stresses the significance of integrating machine learning models with various data sources to enhance public health preparedness and response,alongside acknowledging limitations and the need for broader validation.

关键词： specificity integrating utilizing

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软化:城市群生态环境协同立法模式研究

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重庆科技学院学报（社会科学版） 2024年第3期 46-56页

作者：单杰西安建筑科技大学文学院西安710055

以协同概念的辨析与适用作为研究的逻辑起点,从完善立法权配置、最小化立法成本以及践行立法传承与立法国际化等3个方面展开协同立法必要性之证成。基于理论探索和实践考察两个层面,检视共同立法和合作协议区域协同立法模式,其中,低成... 详细信息

以协同概念的辨析与适用作为研究的逻辑起点,从完善立法权配置、最小化立法成本以及践行立法传承与立法国际化等3个方面展开协同立法必要性之证成。基于理论探索和实践考察两个层面,检视共同立法和合作协议区域协同立法模式,其中,低成本、高效率、重灵活的合作协议模式与协同理念高度契合,立法软化是城市群生态环境协同立法的适宜选择。从城市群生态环境合作协议的合宪性与合法性、法律效力、缔结主体以及利益衡量等维度进行论证,以期建立高效公平且具制度约束力的协同立法模式,为城市群生态环境共治提供法治样本。

关键词：城市群生态环境立法生态环境协同立法模式软法合作协议

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Gamma/Hadron Separation Method for the HADAR Experiment

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Research in Astronomy and Astrophysics 2024年第3期24卷 70-74页

作者： Yang-Zhao Ren Tian-Lu Chen You-Liang Feng Dan-Zeng Luo-Bu Yi-Qing Guo Cheng Liu Qi Gao Mao-Yuan Liu Xiang-Li Qian Ya-Ping Wang Zi-Hao Zhang Xin-Long Li Qing-Yuan Hou Heng-Jiao Liu Qing-Qian Zhou shan-jie Shu The Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Intelligent Engineering Shandong Management University

Ground-based arrays of imaging atmospheric Cherenkov telescopes(IACTs)are the most sensitiveγ-ray detectors for energies of approximately 100 Ge V and *** such IACT is the High Altitude Detection of Astronomical Radiation(HADAR)experiment,which uses a large aperture refractive water lens system to capture atmospheric Cherenkov photons(i.e.,the imaging atmospheric Cherenkov technique).The telescope array has a low threshold energy and large field of view,and can continuously scan the area of the sky being observed,which is conducive to monitoring and promptly responding to transient *** process ofγ-hadron separation is essential in very-high-energy(>30 Ge V)γ-ray astronomy and is a key factor for the successful utilization of *** this study,Monte Carlo simulations were carried out to model the response of cosmic rays within the HADAR *** analyzing the Hillas parameters and the distance between the event core and the telescope,the distinction between air showers initiated byγ-rays and those initiated by cosmic rays was ***,a Quality Factor was introduced to assess the telescope’s ability to suppress the background and to provide a more effective characterization of its performance.

关键词： astroparticle physics-telescopes-methods data analysis

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基于对比学习及背景挖掘的少样本语义分割

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计算机系统应用 2024年第9期33卷 261-268页

作者：王善杰南京信息工程大学软件学院南京210044

少样本语义分割是在具有少量标注样本的查询图像的条件下,对潜在对象类别进行分割的计算机视觉任务.然而,现有方法仍然存在两个问题,这对它们构成了挑战.首先是原型偏差问题,这导致原型具有较少的前景目标信息,难以模拟真实的类别统计信... 详细信息

少样本语义分割是在具有少量标注样本的查询图像的条件下,对潜在对象类别进行分割的计算机视觉任务.然而,现有方法仍然存在两个问题,这对它们构成了挑战.首先是原型偏差问题,这导致原型具有较少的前景目标信息,难以模拟真实的类别统计信息.另一个是特征破坏问题,这意味着模型只关注当前类别而不关注潜在类别.本文提出了一个基于对比原型以及背景挖掘的新网络.该网络主要思想是使模型学习更具代表性的原型,并从背景中识别潜在类别.具体而言,特定类学习分支构建了一个大且一致的原型字典,然后使用InfoNCE损失使原型更具区分性.另一方面,背景挖掘分支初始化背景原型,并使用构建的背景原型与字典之间的注意力机制来挖掘潜在类别.在PASCAL-5i和COCO-20i数据集上的实验证明模型有优秀的性能.在使用ResNet-50网络的1-shot设置下,达到了64.9%和44.2%,相较于基准模型分别提升了4.0%和1.9%.

关键词：图像分割少样本语义分割对比学习背景挖掘

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Global Well-posedness and Global Attractor for Two-dimensional Zakharov-Kuznetsov Equation

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Acta Mathematica Sinica,English Series 2020年第9期36卷 969-1000页

作者： Min jie shan Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China

The initial value problem for two-dimensional Zakharov-Kuznetsov equation is shown to be globally well-posed in H^s(R^2)for all 5/7 详细信息

The initial value problem for two-dimensional Zakharov-Kuznetsov equation is shown to be globally well-posed in H^s(R^2)for all 5/7

关键词： Zakharov-Kuznetsov equation global well-posedness global attractor I-method atomic spaces

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Model-fitting of the kinematics of superluminal components in blazar 3C 279

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Research in Astronomy and Astrophysics 2012年第1期12卷 46-62页

作者： shan-jie Qian National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

A precessing jet-nozzle model with a precession period of about 25 yr has been proposed by Qian to interpret the change with time of the ejection position an- gle of the superluminal components observed using very long baseline interferometry （VLBI） in the blazar 3C 279. We discuss the kinematic properties of six superluminal knots （C3, C4, C7a, C8, C9 and C10） and show that their trajectory, core-distance and apparent speed, derived from VLBI observations, can be consistently well fitted by the model. Their intrinsic Lorentz factors of bulk superluminal motion are thus derived, and the evidence shows no relation between Lorentz factor and the precession phase. Interestingly, for the C7a and C8 knots, the fitted core-distance ranges from ,,～0.1 mas to ～0.4 mas and for knots C9 and C10 from ～0.2mas to ～1.0-1.5 mas. For knot C4, its trajectory and apparent velocity are well fitted in the core-distance range from H1 mas to ～5 mas, taking into account a curvature of the trajectory at core-distance larger than ,,～3 mas. The consistent fitting of the kinematics of these components clearly demonstrates that the amplitude function and collimation param- eter adopted in the precession model are appropriate and applicable for both the in- ner and outer parts of the jet in 3C 279, but in some cases the jet curvature in the outer parts （or deviation from the model trajectory） needs to be seriously taken into consideration. With the exception of C4, the ejection position angles derived from the precession model are consistent with the values measured by VLBI observations （within about 3° - 6°）. Undoubtedly, the consistent interpretation of the kinematics in terms of the precession model for these superluminal components, with their ejection time spanning -～24 yr, significantly expands its applicability and implies that regular patterns of trajectories （or rotating channels） could exist in some periods.

关键词： radio continuum -- galaxies: jets -- galaxies: kinematics -- galaxies:individual (blazar 3C 279)

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A possible precession period for superluminal ejection in QSO 3C 279

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Research in Astronomy and Astrophysics 2011年第1期11卷 43-62页

作者： shan-jie Qian National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

The search for periodic features in fiux variability and superluminal ejection in blazars has been an important subject, which is helpful for providing significant clues to the understanding of the structure and kinematics of relativistic jets （physical processes of acceleration and collimation） and their association with central energy engines （black hole/accretion disk systems）. The wobbling of the ejection position angle of VLBI knots in superluminal sources has been interpreted in terms of the precession of the jet ejection nozzle as one of the alternative interpretations. We study the change with time of the initial position angle of superluminal knots in QSO 3C 279, using VLBI-data collected from the literature spanning more than ～30 yr and propose a jet-nozzle precession model which has very small viewing angles （less than 2°） to fit the long-term trends in both variations in the inner-jet position angle （Chatterjee et al.） and the ejection position angle of the VLBI components. It is shown that an ejection-nozzle precession period of ～25 yr could be appropriate to fit the long-term trend in the variation of the ejection position angle. However, the short-term swings and fluctuations in the ejection position angle cause some uncertainties. We also fit a model to the trajectory of component C4, correcting its non-ballistic motion near the core.

关键词： radio continuum -- quasars -- jets -- kinematics -- individual: 3C 279

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Model fitting of the kinematics of ten superluminal components in blazar 3C 279

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Research in Astronomy and Astrophysics 2013年第7期13卷 783-802页

作者： shan-jie Qian National Astronomical Observatories Chinese Academy of Sciences

The kinematics of ten superluminal components （C11-C16, C18, C20, C21 and C24） of blazar 3C 279 are studied from VLBI observations. It is shown that their initial trajectory, distance from the core and apparent speed can be well fitted by the precession model proposed by Qian. Combined with the results of the model fit for the six superluminal components （C3, C4, C7a, C8, C9 and C10） already pub-lished, the kinematics of sixteen superluminal components can now be consistently interpreted in the precession scenario with their ejectiontimes spanning more than 25 yr （or more than one precession period）. The results from model fitting show the possible existence of a common precessing trajectory for these knots within a pro- jected core distance of ～0.2-0.4 mas. In the framework of the jet-precession scenario, we can, for the first time, identify three classes of trajectories which are character-ized by their collimation parameters. These different trajectories could be related to the helical structure of magnetic fields in the jet. Through fitting the model, the bulk Lorentz factor, Doppler factor and viewing angle of these knots are derived. It is found that there is no evidence for any correlation between the bulk Lorentz factor of the components and their precession phase （or ejection time）. In a companion paper, the kinematics of another seven components （C5a, C6, C7, C17, C19, C22 and C23） have been derived from model fitting, and a binary black-hole/jet scenario was envisaged. The precession model proposed by Qian would be useful for understanding the kine- matics of superluminal components in blazar 3C 279 derived from VLBI observations, by disentangling different mechanisms and ingredients. More generally, it might also be helpful for studying the mechanism of jet swing （wobbling） in other blazars.

关键词： radio continuum - galaxies jets - galaxies kinematics - galaxies individual (blazar 3C 279)

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