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Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

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Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian ouyang Xiuping Li Changwei Liu Danmin Lu jie ouyang Fang Zhou Qi Liu Jianan Huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural UniversityChangsha 410128China Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD *** of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

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Targeting Nrf2 signaling in dry eye

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1911-1920页

作者： Yu-Nuo Zhang Wei-jie ouyang Jiao-Yue Hu Zu-Guo Liu Xiamen University Affiliated Xiamen Eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina

Dry eye,the most common ocular surface disease,can cause ocular surface tissue damage and discomfort symptoms and seriously affect people’s quality of *** etiology of dry eye is diverse,and its pathogenesis is *** oxidative stress reaction is considered to be among the important factors in the pathogenesis of dry ***,activating the antioxidant system has a potential therapeutic effect on dry *** factor erythroid 2-related factor 2(Nrf2)signaling pathway is considered the most important antioxidant pathway in the *** activation of the Nrf2 signaling pathway and its interaction with other pathways are important mechanisms to prevent the occurrence and development of dry *** review describes the structure and function of Nrf2,summarizes the changes in the oxidative stress response in dry eye,focuses on the potential mechanism of the Nrf2 signaling pathway in the treatment of dry eye,and,finally,summarizes the drugs that activate the Nrf2 signaling pathway in the treatment of dry eye.

关键词： nuclear factor erythroid 2-related factor 2 Keap1 dry eye oxidative stress

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Spray pyrolysis-derived W-doped MoSe_(2)/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

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Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei Wang Jun-Yu Chen jie ouyang Hong Yin Ao-jie Li Liang Chen Jun-Lin Huang Yu-Can Zhu Gang-Yong Li Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and TechnologyYueyang 414006China School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang414006China Hunan Province Key Laboratory of Materials Surface&Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and TechnologyChangsha 410004China International Iberian Nanotechnology Laboratory(INL) AvMestre Jose Veiga4715-330 BragaPortuga

Two-dimensional MoSe_(2) is a promising candidate for lithium-ion battery ***,its conductivity and lithium storage volumetric effect still need to be *** this work,W-doped MoSe_(2)/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the ***,by utilizing the similar two-dimensional structure between MoSe_(2) and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the ***,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering ***,W-doping not only increases the interlayer spacing of MoSe_(2)(0.73 nm),thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the *** functional theory(DFT)calculations confirm that W-doped MoSe_(2)/rGO exhibits the narrowest bandgap(0.892 eV).Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g^(-1)after 300 cycles at a current density of 1 A·g^(-1).

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics

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Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1614-1620页

作者： Yu-Wen Liu Shu-Jia Guo Jia-Ni Li Yu-Ting Zhang Wei-jie ouyang Yu-Qian Wang Cai-Hong Huang Yi Liao Jiaoyue Hu Zuguo Liu Xiamen University Affiliated Xiamen Eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina

AIM:To psychometrically validate the Chinese version of the dry eye-related quality-of-life score questionnaire(DEQSCHN)among Chinese patients with dry ***:This study involved 231 participants,including 191 with dry eye disease(DED)comprising the dry eye disease group,and 40 healthy participants forming the control *** were required to complete the DEQS-CHN,and Chinese dry eye questionnaire and undergo clinical tests including the fluorescein breakup time(FBUT),corneal fluorescein staining(CFS),and Schirmer I *** assess the internal consistency and retest reliability,Cronbach’sαand the intraclass correlation coefficient(ICC)were *** validity was assessed by item-level content validity index(ICV)and an average scale-level content validity index(S-CVI/Ave).Construct validity was assessed by confirmatory factor *** concurrent validity was assessed by calculating correlations between DEQS-CHN and Chinese dry eye *** validity was evaluated through nonparametric tests,with receiver operating characteristic(ROC)curve serving as conclusive indicators of the questionnaire’s distinguishing ***:The Cronbach’sαcoefficients for frequency and degree of ocular symptoms,impact on daily life,and summary score were 0.736,0.704,0.811,0.818,0.861,and 0.860,respectively,and the ICC were 0.611,0.677,0.715,0.769,0.711,and 0.779,*** I-CVI scores ranged from 0.833 to 1.000,with an S-CVI/Ave of *** factor analysis results exhibited a wellfitting model consistent with the original questionnaire[χ^(2)/df=2.653,incremental fit index(IFI)=0.924,comparative fit index(CFI)=0.924,Tucker-Lewis index(TLI)=0.909,and root mean square error of approximation(RMSEA)=0.065].There was a moderate positive correlation between the DEQS-CHN and the Chinese dry eye questionnaire(r^(2)=0.588).The dry eye group demonstrated significantly higher scores compared to the control group,and the area under

关键词： dry eye quality-of-life questionnaire

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中华民族共同体视域下的云南边疆农场社会融入研究

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西北民族大学学报（哲学社会科学版） 2024年第3期 21-33页

作者：欧阳洁云南民族大学云南省民族研究所云南昆明650504

本文从三个历史阶段梳理了云南国营农场在边疆民族地区的社会融入过程,即农场建立伊始以民族工作队和“场带群”为主要形式的集体嵌入阶段;市场经济背景下,以橡胶为媒有效联结农场和边疆共同利益,农场职工与边疆少数民族个体间频繁交往... 详细信息

本文从三个历史阶段梳理了云南国营农场在边疆民族地区的社会融入过程,即农场建立伊始以民族工作队和“场带群”为主要形式的集体嵌入阶段;市场经济背景下,以橡胶为媒有效联结农场和边疆共同利益,农场职工与边疆少数民族个体间频繁交往交流,社会融入由浅入深阶段;最后随着语言、饮食、通婚等进一步的心理层面交融,形成多元文化互嵌与多民族和谐共生的深度融合阶段。边疆农场七十余年的社会融入过程,不仅是内地政策性移民与云南边疆各族人民不断交往交流交融的历史,也为中华民族共同体构建贡献一个典型个案。

关键词：边疆农场社会融入中华民族共同体交往交流交融

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机场地区高铁站与机场轨道站双枢纽布局模式研究

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铁道运输与经济 2024年第1期46卷 42-50页

作者：欧阳杰梁旭中国民航大学交通科学与工程学院天津300300

随着高速铁路、城际铁路及城市轨道交通逐渐引入机场地区,临空经济区的高铁站与枢纽机场航站区的地面交通中心构成了互联互通、分工协作的空铁双枢纽模式,这类以轨道交通为主体的双枢纽可开展各类空铁联运模式,以满足多元化出行需求,研... 详细信息

随着高速铁路、城际铁路及城市轨道交通逐渐引入机场地区,临空经济区的高铁站与枢纽机场航站区的地面交通中心构成了互联互通、分工协作的空铁双枢纽模式,这类以轨道交通为主体的双枢纽可开展各类空铁联运模式,以满足多元化出行需求,研究其衔接模式及设施布局具有显著的理论指导意义和实践应用价值。研究依托于交通辐射范围特征及其叠合效应提出空铁双枢纽的理论模型,并总结论证了影响双枢纽组合类型的要素,基于国内外临空经济区高铁站与枢纽机场地面交通中心的空间组合实例凝练出空铁双枢纽的空间布局及其衔接模式,分别从交通组织、设施布局、枢纽能级等方面分析各模式的运行效用和优劣特征,以对我国空铁双枢纽模式的应用实践提供理论支撑。

关键词：高铁站枢纽机场轨道交通站场布局双枢纽

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基于谨慎城市更新理论的德国柏林滕博尔霍夫机场综合开发模式的启迪

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国际城市规划 2024年第2期39卷 129-136页

作者：欧阳杰聂晨孙德龙中国民航大学交通科学与工程学院中国民航大学综合交通研究所中国民航大学交通科学与工程学院综合交通研究所天津大学建筑学院

随着旧机场的停航和搬迁,占地广阔的原机场地区亟待转型和再开发,地处城市中心或近郊旧机场地区的城市更新成为推动城市发展新的增长点,但我国旧机场地区有机更新的成熟路径和先进模式尚在探索之中。本文首先剖析了基于谨慎城市更新理... 详细信息

随着旧机场的停航和搬迁,占地广阔的原机场地区亟待转型和再开发,地处城市中心或近郊旧机场地区的城市更新成为推动城市发展新的增长点,但我国旧机场地区有机更新的成熟路径和先进模式尚在探索之中。本文首先剖析了基于谨慎城市更新理论的德国柏林滕博尔霍夫机场地区综合开发案例,其次深入分析了该机场地区城市更新项目的决策过程、实施策略及其开发成效,最后基于滕博尔霍夫机场地区城市更新的理论应用及其实践总结出对我国旧机场地区综合开发的可借鉴之处。

关键词：机场谨慎城市更新综合开发城市绿地公众参与

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南极磷虾粉螺旋梯级干燥工艺优化及验证

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水产学报 2024年第7期48卷 157-168页

作者：欧阳杰马靖松马田田黄天沈建中国水产科学研究院渔业机械仪器研究所上海海洋大学食品学院

为优化南极磷虾粉螺旋干燥工艺参数，获得高质高效的南极磷虾粉干燥工艺，实验采用螺旋干燥实验装置，对南极磷虾梯级干燥工艺进行研究，在单因素试验的基础上以Box-Behnken原理设计优化试验，研究第一梯级干燥温度，梯级干燥切换节点... 详细信息

为优化南极磷虾粉螺旋干燥工艺参数，获得高质高效的南极磷虾粉干燥工艺，实验采用螺旋干燥实验装置，对南极磷虾梯级干燥工艺进行研究，在单因素试验的基础上以Box-Behnken原理设计优化试验，研究第一梯级干燥温度，梯级干燥切换节点，第二梯级干燥温度对干燥时间、脂肪和虾青素含量的影响。结果显示，不同因素对干燥时间、虾青素含量影响顺序为第一梯级干燥温度(A)>第二梯级干燥温度(C)>梯级切换水分含量(B)，对脂肪含量影响顺序为梯级切换水分含量(B)>第一梯级干燥温度(A)>第二梯级干燥温度(C)。响应面得到较优的工艺参数为第一梯级干燥温度105°C、梯级切换水分含量50%、第二梯级干燥温度88°C，在此条件下，干燥时间、脂肪和虾青素含量分别为160 min、16.83%、159.32μg/g，螺旋梯级干燥下的南极磷虾粉品质优于恒温干燥。研究表明，使用优化后的螺旋干燥工艺能在保障干燥效率的同时有效提高虾粉品质。本研究可为南极磷虾高品质生产和南极磷虾粉船载加工技术与关键设备的国产化研制提供技术参考。

关键词：南极磷虾螺旋干燥干燥工艺品质

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Riser Simulation and Radial Porosity Distribution Characterization for Gas-Fluidized Bed of Cork Particles

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Journal of Thermal Science 2014年第4期23卷 368-374页

作者： WU Guorong ouyang jie LI Qiang Department of Mathematics Gansu Normal University for Nationalities School of Science Northwestern Polytechnical University

Numerical simulations are carried out for gas-solid fluidized bed of cork particles, using discrete element method. Results exhibit the existence of a so-called anti core-annular porosity profile with lower porosity in the core and higher porosity near the wall for non-slugging fluidization. The tendency to form this unfamiliar anti core-annular porosity profile is stronger when the solid flux is higher. There exist multiple inflection points in the simulated axial solid volume fraction profile for non-slugging fluidization. Results also show that the familiar core-annular porosity profile still appears for slugging fluidization. In addition, the classical choking phenomenon can be captured at the superficial gas velocity slightly lower than the correlated transport velocity.

关键词： Fluidization Multiphase flow Simulation Discrete element method Anti core-annular regime

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Direct calculation of voidage in the fine-grid CFD-DEM simulation of fluidized beds with large particles

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Particuology 2018年第5期16卷 23-33页

作者： Lihua Wang jie ouyang Chuntao Jiang Department of Applied Mathematics Northwestern Polytechnical UniversityXi'an 710129China

Voidage is important in determining the hydrodynamic behavior of a fluidized bed and estimating the drag force,Exact calculation methods are limited,especially in terms of determining the intersection bf a particle and cell,This paper presents a method of directly calculating ***,a judgment criterion of particle-cell overlap,which relies on the relationship of the distance from the particle to a cell face,edge,or vertex,is *** cases of the overlap volume of a particle and cell are then ascribed to a unified formula in the framework of the cuboid cell,This formula relies on the volume of two kinds of segments named the hemispherical segment and quarter-spherical *** presented method is validated by calculating the voidage of simple cubic ***,a three-dimensional fluidized bed with large particles is simulated and the results of numerical simulation are compared against experimental and simulation results reported in the *** numerical results are in good agreement with corresponding experimental data,and demonstrate the accuracy and reliability of the presented method in the three-dimensional simulation of fluidized beds.

关键词： Voidage Direct calculation Computational fluid dynamics-discrete element method Fluidized beds

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