检索结果-南通市图书馆

Spatial-and spin-resolution ARPES and magnetism beamline at SSRF

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第8期35卷 23-37页

作者： Fang‑Yuan Zhu jie‑Feng Cao Xiang‑Yu Meng Jun‑Qin Li Rui Yu Ya‑mei Wang Shan Qiao Bo Zhao Ming‑Zhu Zhang Zhong‑Kai Liu mei‑Xiao Wang Yong Wang Ren‑Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China ShanghaiTech Laboratory for Topological Physics School of Physical Science and TechnologyShanghai Tech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

The BL07U beamline is a new extreme ultraviolet and soft X-ray beamline housed in the Shanghai Synchrotron Radiation Facility. Beamlines are used in nano-resolved angle-resolved photoemission spectroscopy(nano-ARPES), spin-resolved angle-resolved photoemission spectroscopy(spin-ARPES), X-ray magnetic circular dichroism spectroscopy, and X-ray magnetic linear dichroism spectroscopy for certain scientific research. The BL07U beamline, which is based on a pair of elliptical polarized undulators and a variable-included-angle plane-grating monochromator, delivers circularly or linear polarized X-rays within the energy range of 50–2000 eV. The beamline features two branches: One dedicated to nano-ARPES,which has a minimum spot size of only ~ 200 nm, and another branch comprising spin-ARPES, a vector magnetic field, and superconductive magnetic end-station.

关键词： Soft X-ray beamline Nano-ARPES Spin-ARPES XMCD/XMLD

White matter disease derived from vascular and demyelinating origins

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第4期9卷 344-350页

作者： Lin-jie Zhang De-Cai Tian Li Yang Kaibin Shi Yaou Liu Yilong Wang Fu-dong Shi Department of Neurology Tianjin Medical University General HospitalTianjinTianjinChina National Clinical Research Center for Neurological Diseases of China Beijing Tiantan HospitalCapital Medical UniversityBeijingBeijingChina

Damage or microstructural alterations of the white matter can cause dysfunction of the intrinsic neural networks in a condition termed as white matter disease(WMD).Frequently detected on brain computed tomography and magnetic resonance imaging scans,WMD is commonly presented in inflammatory demyelinating diseases like multiple sclerosis(MS)and vascular diseases such as cerebral small vessel disease(CSVD).Prevention of MS and CSVD progression requires early treatments with drastically different medications and approaches,as such,early and accurate diagnosis of WMD,derived from vascular or demyelinating etiologies,is of paramount ***,the clinical and imaging similarities between MS,especially during the early stage,and CSVD,pose a significant dilemma in differentiating these two *** this review,we attempt to summarize and contrast the distinguishing features of MS and CSVD for aiding accurate diagnosis to ensure timely corresponding management in the early stages of MS and CSVD.

关键词： diagnosis myelin alterations

Computed tomography radiomic features and clinical factors predicting the response to first transarterial chemoembolization in intermediate-stage hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 361-369页

作者： Zhong-Xing Shi Chang-Fu Li Li-Feng Zhao Zhong-Qi Sun Li-Ming Cui Yan-jie Xin dong-Qing Wang Tan-Rong Kang Hui-jie Jiang Department of Interventional Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Digestive Medicine Daqing Longnan HospitalDaqing 163453China Department of Radiology Daqing Longnan HospitalDaqing 163453China Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treatment response can help patients choose a reasonable treatment *** study aimed to investigate the value of the radiomic-clinical model in predicting the efficacy of the first TACE treatment for HCC to prolong patient ***:A total of 164 patients with HCC who underwent the first TACE from January 2017 to September 2021 were *** tumor response was assessed by modified response evaluation criteria in solid tumors(mRECIST),and the response of the first TACE to each session and its correlation with overall survival were *** radiomic signatures associated with the treatment response were identified by the least absolute shrinkage and selection operator(LASSO),and four machine learning models were built with different types of regions of interest(ROIs)(tumor and corresponding tissues)and the model with the best performance was *** predictive performance was assessed with receiver operating characteristic(ROC)curves and calibration ***:Of all the models,the random forest(RF)model with peritumor(+10 mm)radiomic signatures had the best performance[area under ROC curve(AUC)=0.964 in the training cohort,AUC=0.949 in the validation cohort].The RF model was used to calculate the radiomic score(Rad-score),and the optimal cutoff value(0.34)was calculated according to the Youden’s *** were then divided into a high-risk group(Rad-score>0.34)and a low-risk group(Rad-score≤0.34),and a nomogram model was successfully established to predict treatment *** predicted treatment response also allowed for significant discrimination of Kaplan-meier *** Cox regression identified six independent prognostic factors for overall survival,including male[hazard ratio(HR)=0.500,95%confidence interva

关键词： Hepatocellular carcinoma Transarterial chemoembolization Radiomics Treatment response Prediction

Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-onchronic liver failure

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第8期30卷 881-900页

作者： Yu Zhang Xiao-Ling Tian jie-Qun Li dong-Sheng Wu Qiang Li Bin Chen Department of Hepatology Institute of HepatologyThe First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina Department of Liver Transplant Transplant Medical Research CenterThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Surgery The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina

BACKGROUND Immune dysregulation and metabolic derangement have been recognized as key factors that contribute to the progression of hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).However,the mechanisms underlying immune and metabolic derangement in patients with advanced HBV-ACLF are *** To identify the bioenergetic alterations in the liver of patients with HBV-ACLF causing hepatic immune dysregulation and metabolic *** Liver samples were collected from 16 healthy donors(HDs)and 17 advanced HBV-ACLF patients who were eligible for liver *** mitochondrial ultrastructure,metabolic characteristics,and immune microenvironment of the liver were *** focus was given to organic acid metabolism as well as the function and subpopulations of macrophages in patients with *** Compared with HDs,there was extensive hepatocyte necrosis,immune cell infiltration,and ductular reaction in patients with *** patients,the liver suffered severe hypoxia,as evidenced by increased expression of hypoxia-inducible factor-1α.Swollen mitochondria and cristae were observed in the liver of *** number,length,width,and area of mitochondria were adaptively increased in *** metabolomics analysis revealed that mitochondrial oxidative phosphorylation decreased,while anaerobic glycolysis was enhanced in patients with *** findings suggested that,to a greater extent,hepa-tocytes used the extra-mitochondrial glycolytic pathway as an energy *** with HBV-ACLF had elevated levels of chemokine C-C motif ligand 2 in the liver homogenate,which stimulates peripheral monocyte infiltration into the *** and functional analysis of macrophage subsets revealed that patients with ACLF had a high abundance of CD68^(+)HLA-DR^(+)macrophages and elevated levels of both interleukin-1βand transforming growth factor-β1 in their *** abundance of CD206^(+)CD163^(+)macrophag

关键词： Acute-on-chronic liver failure Hypoxia-inducible factor-1α Mitochondria Metabolic phenotype Immune cells

Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第8期37卷 811-822页

作者： Guifang Wang Youzhi Zhang Haiyan Yang Yi Yang Liang dong Peng Zhang jie Liu Xiaodong Chen Yi Gong Department of Respiratory and Critical Care Medicine Quzhou People's HospitalQuzhou 324000ZhejiangChina Department of Respiratory and Critical Care Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Centre of Hydrogen Science Shanghai Jiao Tong University&Key Lab of Hydrogen ScienceShanghai 200240China Department of Respiratory and Critical Care Medicine Shanghai Public Health Clinical CentreFudan UniversityShanghai 201508China

Objective Air pollution is a leading public health *** study investigated the effect of air quality and pollutants on pulmonary function and inflammation in patients with asthma in *** The study monitored 27 asthma outpatients for a year,collecting data on weather,patient self-management[daily asthma diary,peak expiratory flow(PEF)monitoring,medication usage],spirometry and serum *** explore the potential mechanisms of any effects,asthmatic mice induced by ovalbumin(OVA)were exposed to PM_(2.5).Results Statistical and correlational analyses revealed that air pollutants have both acute and chronic effects on *** exposure showed a correlation between PEF and levels of ozone(O_(3))and nitrogen dioxide(NO_(2)).Chronic exposure indicated that interleukin-5(IL-5)and interleukin-13(IL-13)levels correlated with PM_(2.5)and PM_(10)*** asthmatic mouse models,exposure to PM_(2.5)increased cytokine levels and worsened lung ***,PM_(2.5)exposure inhibited cell proliferation by blocking the NF-κB and ERK phosphorylation *** Ambient air pollutants exacerbate asthma by worsening lung function and enhancing Th2-mediated ***,PM_(2.5)significantly contributes to these adverse *** research is needed to elucidate the mechanisms by which PM_(2.5)impacts asthma.

关键词： Ambient air pollutants Acute and chronic effects on asthma PM_(2.5) OVA-induced asthmatic mice

Fabrication and properties of lightweight zirconia with fine closed porosity

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第6期31卷 1449-1458页

作者： Yi-bo Zhang Hua-zhi Gu Lv-ping Fu Ao Huang mei-je Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Lightweight refractory materials with thermal insulation properties and erosion resistance are advantageous for hightemperature *** zirconia refractories were prepared using starch as a pore-forming agent,basic magnesium carbonate as a stabilizer,and nano-zirconia as an *** effects of the nano-zirconia content on the pore and thermal insulation properties of the lightweight zirconia refractories were investigated based on the porosity,phase composition,microstructure,and thermal ***-zirconia was shown to have a high surface energy,and its addition effectively increased the driving force for sintering,reduced the sintering temperature,and promoted the sintering reaction,thereby reducing the apparent porosity and improving the density of the prepared *** to the superplasticity of nano-zirconia,the surface stress caused plastic deformation between particles,which increased the migration rate of grain boundaries and trapped more gas inside the material before it diffused to the surface,thereby enhancing the closed porosity of the *** presence of closed pores could extend the thermal conduction path,decrease the conduction rate,and hinder the conduction effect to effectively reduce the thermal conductivity of the *** a nano-zirconia content of 0.75 wt.%,the prepared lightweight zirconia had the highest closed porosity and the lowest thermal *** apparent porosity,closed porosity,and total porosity of the material were 2.8%,7.0%,and 9.8%,respectively,and the thermal conductivity at 800℃was 1.37 W m^(-1)k^(-1).

关键词： Sintering Nano-zirconia Closed pore:Thermal conductivity Refractory material

Physicochemical principles of hydrogen metallurgy in blast furnace

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第1期31卷 46-63页

作者： Han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China

Based on the stoichiometric method and the free energy minimization method,an ideal model for the reduction of iron oxides by carbon and hydrogen under blast furnace conditions was established,and the reduction efficiency and theoretical energy consumption of the all-carbon blast furnace and the hydrogen-rich blast furnace were *** results show that after the reduction reaction is completed at the bottom of the blast furnace,the gas produced by reduction at 1600℃still has a certain excessive reduction capacity,which is due to the hydrogen brought in by the hydrogen-rich blast as well as the excess carbon monoxide generated by the reaction of the coke and the oxygen brought in by the *** the process of the gas with excessive reduction capacity rising from the bottom of the blast furnace and gas reduction process,the excessive reduction capacity of the gas gradually decreases with the increase in the dydrogen content in the *** the all-carbon blast furnace,the excess gas reduction capacity is the strongest,and the total energy consumption per ton of iron reduction is the *** shows that,for the current operation mode of the blast furnace,adding hydrogen in the blast furnace cannot reduce the consumption of carbon required for reduction per ton of iron,but rather increases the consumption of carbon.

关键词： Hydrogen metallurgy Excess gas reduction capacity Theoretical energy consumption Hydrogen-rich blast furnace Thermodynamic model Gibbs minimum free energy method

Di-and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1089-1105页

作者： Runfa Chen Meng-jie Zhao Yu-Min Li Ao-Hui Liu Ru-Xin Wang Yu-Chao mei Xuefeng Chen Hai-Ning Du Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismHubei Clinical Research Center of Emergency and ResuscitationEmergency Center of Zhongnan HospitalWuhan UniversityWuhan 430072China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is ***,we unveil the distinct roles of H3K36 dimethylation(H3K36me2)and H3K36 trimethylation(H3K36me3)in DSB repair via non-homologous end joining(NHEJ)or homologous recombination(HR).Yeast cells lacking H3K36me2 or H3K36me3 exhibit reduced NHEJ or HR efficiency.y Ku70 and Rfa1 bind H3K36me2-or H3K36me3-modified peptides and chromatin,*** these interactions impairs y Ku70 and Rfa1 recruitment to damaged H3K36me2-or H3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair ***,H3K36me2-enriched intergenic regions and H3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB ***,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with H3K36me2 and H3K36me3 in a conserved *** findings provide valuable insights into how H3K36me2 and H3K36me3 regulate distinct DSB repair pathways,highlighting H3K36 methylation as a critical element in the choice of DSB repair pathway.

关键词： histone H3K36 methylation Ku70 RPA non-homologous end joining homologous recombination

同方期刊数据库

OAAFormer:Robust and Efficient Point Cloud Registration Through Overlapping-Aware Attention in Transformer

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2024年第4期39卷 755-770页

作者： Jun-jie Gao Qiu-jie dong Rui-An Wang Shuang-Min Chen Shi-Qing Xin Chang-He Tu Wenping Wang School of Computer Science and Technology Shandong UniversityQingdao 266237China School of Information and Technology Qingdao University of Science and TechnologyQingdao 266061China College of Engineering Texas A&M UniversityTexasTX 77843U.S.A.

In the domain of point cloud registration,the coarse-to-fine feature matching paradigm has received significant attention due to its impressive *** paradigm involves a two-step process:first,the extraction of multilevel features,and subsequently,the propagation of correspondences from coarse to fine ***,this approach faces two notable ***,the use of the Dual Softmax operation may promote one-to-one correspondences between superpoints,inadvertently excluding valuable ***,it is crucial to closely examine the overlapping areas between point clouds,as only correspondences within these regions decisively determine the actual *** these issues,we propose OAAFormer to enhance correspondence *** the one hand,we introduce a soft matching mechanism to facilitate the propagation of potentially valuable correspondences from coarse to fine *** the other hand,we integrate an overlapping region detection module to minimize mismatches to the greatest extent ***,we introduce a region-wise attention module with linear complexity during the fine-level matching phase,designed to enhance the discriminative capabilities of the extracted *** on the challenging 3DLoMatch benchmark demonstrate that our approach leads to a substantial increase of about 7%in the inlier ratio,as well as an enhancement of 2%-4%in registration ***,to accelerate the prediction process,we replace the Conventional Random Sample Consensus(RANSAC)algorithm with the selection of a limited yet representative set of high-confidence correspondences,resulting in a 100 times speedup while still maintaining comparable registration performance.

关键词： point cloud registration coarse-to-fine overlapping region feature matching Transformer