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免疫治疗联合化疗治疗PD-L1高表达晚期非小细胞肺癌的疗效观察

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中国实用医刊 2024年第5期51卷 5-7页

作者：邓迎丽崔杰安康市中心医院呼吸二科安康725000 安康市中心医院肿瘤内科安康725000

目的探究免疫治疗联合化疗治疗程序性死亡受体配体1(PD-L1)高表达晚期非小细胞肺癌的疗效。方法回顾性抽取安康市中心医院2020年1月至2022年12月收治的PD-L1高表达晚期非小细胞肺癌患者76例,按照随机数字表法分为对照组和观察组,每组38... 详细信息

目的探究免疫治疗联合化疗治疗程序性死亡受体配体1(PD-L1)高表达晚期非小细胞肺癌的疗效。方法回顾性抽取安康市中心医院2020年1月至2022年12月收治的PD-L1高表达晚期非小细胞肺癌患者76例,按照随机数字表法分为对照组和观察组,每组38例。对照组接受单纯化疗,观察组接受免疫治疗联合化疗治疗,比较两组临床疗效,血清癌胚抗原(CEA)、磷状细胞癌相关抗原(SCC-Ag)、细胞角蛋白19血清片段21-1(CYFRA21-1)水平及远期生存情况。结果观察组治疗总有效率(63.16%,24/38)高于对照组(39.47%,15/38),P<0.05。治疗后,观察组CEA、SCC-Ag、CYFRA21-1水平低于对照组(P<0.05)。观察组中位生存时间[(12.26±3.26)个月]长于对照组[(8.59±1.26)个月],P<0.05。结论免疫治疗联合化疗治疗PD-L1高表达晚期非小细胞肺癌中能获取满意成效,能进一步控制病灶进展,且降低肿瘤标志物水平,延长患者生存期。

关键词：免疫治疗化疗程序性死亡受体配体1 晚期非小细胞肺癌

High linearity U-band power amplifier design:a novel intermodulation point analysis method

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Frontiers of Information Technology & Electronic Engineering 2023年第1期24卷 176-186页

作者： jie cui Peipei LI Weixing SHENG School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China

A power amplifier’s linearity determines the emission signal’s quality and the efficiency of the *** distortion can result in system bit error,out-of-band radiation,and interference with other channels,which severely influence communication system’s quality and *** from the third-order intermodulation point of the milimeter wave(mm-Wave)power amplifiers,the circuit’s nonlinearity is compensated *** analysis,design,and implementation of linear class AB mm-Wave power amplifiers based on GlobalFoundries 45 nm CMOS silicon-on-insulator(SOI)technology are *** single-ended and differential stacked power amplifiers have been implemented based on cascode cells and triple cascode cells operating in U-band *** to nonlinear analysis and on-wafer measurements,designs based on triple cascode cells outperform those based on cascode *** single-ended measurements,the differential power amplifier achieves a measured peak power-added efficiency(PAE)of 47.2%and a saturated output power(P_(sat))of 25.2 dBm at 44 *** amplifier achieves a P_(sat)higher than 23 dBm and a maximum PAE higher than 25%in the measured bandwidth from 44 GHz to 50 GHz.

关键词： CMOS silicon-on-insulator(SOI) Linearity analysis Milimeter wave(mm-Wave) Power amplifier

通心络胶囊联合阿托伐他汀治疗颈动脉粥样硬化的系统评价

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药物评价研究 2024年第2期47卷 389-400页

作者：刘伟李星星林泉范宗静崔杰吴旸北京中医药大学东方医院北京100078 陕西中医药大学附属医院陕西咸阳712000

目的系统评价通心络胶囊联合阿托伐他汀治疗颈动脉粥样硬化的有效性和安全性。方法通过网络检索中国学术期刊全文数据库(CNKI)、万方数据库(Wanfang Data)、维普中文科技期刊数据库(VIP)、PubMed、Embase、Cochrane Library、Web of S... 详细信息

目的系统评价通心络胶囊联合阿托伐他汀治疗颈动脉粥样硬化的有效性和安全性。方法通过网络检索中国学术期刊全文数据库(CNKI)、万方数据库(Wanfang Data)、维普中文科技期刊数据库(VIP)、PubMed、Embase、Cochrane Library、Web of Science,检索时间从建库至2023年8月31日,全面筛选通心络胶囊联合阿托伐他汀治疗颈动脉粥样硬化的临床随机对照试验(RCT),使用RevMan 5.4软件进行Meta分析。结果共纳入16项RCTs,总病例数1 654例,治疗组832例、对照组822例。Meta分析结果显示:在阿托伐他汀治疗基础上加用通心络胶囊能降低总胆固醇(TC)[MD=-0.62,95%CI(-0.87,-0.37),P<0.000 01]、三酰甘油(TG)[MD=-0.28,95%CI(-0.41,-0.15),P<0.000 1]、低密度脂蛋白胆固醇(LDL-C)[MD=-0.38,95%CI(-0.56,-0.20),P<0.000 1]和提高高密度脂蛋白胆固醇(HDL-C)水平[MD=0.22,95%CI(0.06,0.38),P=0.008],降低颈动脉内膜中层厚度(IMT)[MD=-0.21,95%CI(-0.27,-0.15),P<0.000 01]和斑块Crouse积分[MD=-1.05,95%CI (-1.29,-0.80),P<0.000 01],降低超敏C反应蛋白(hs-CRP)[MD=-0.44,95%CI(-0.57,-0.31),P<0.000 01]和白细胞介素-6(IL-6)水平[MD=-3.96,95%CI(-6.25,-1.66),P=0.000 7],差异均有统计学意义。两组不良反应发生率[OR=1.48,95%CI(0.78,2.82),P=0.23]比较,差异无统计学意义。结论通心络胶囊联合阿托伐他汀治疗颈动脉粥样硬化能改善血脂水平与炎症反应、减轻动脉粥样硬化程度,疗效和安全性均较好,建议临床进一步推广使用。

关键词：通心络胶囊阿托伐他汀胆固醇超敏C反应蛋白系统评价随机对照试验

健康中国背景下我国大健康产业区域发展布局路径探析

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宿州学院学报 2024年第5期39卷 57-60页

作者：崔杰韩来国蚌埠医科大学体育艺术部安徽蚌埠233030

为优化调整大健康产业发展布局,在深入分析大健康产业特征内涵的基础上,以长三角产业集群、环渤海产业集群、大湾区产业集群、川渝产业集群为研究切入点,结合具体区域健康产业发展数据,对中国大健康产业区域发展布局情况与具体特征进行... 详细信息

为优化调整大健康产业发展布局,在深入分析大健康产业特征内涵的基础上,以长三角产业集群、环渤海产业集群、大湾区产业集群、川渝产业集群为研究切入点,结合具体区域健康产业发展数据,对中国大健康产业区域发展布局情况与具体特征进行了剖析,发现其在区域布局上存在发展不均衡、技术赋能不足、发展特色薄弱的关键问题,并在此基础上提出未来大健康产业发展要顺应当前区域经济格局与产业发展布局,提升大健康产业技术内在价值,注重产业内部均衡化发展,以及探索产业内新经济增长极等建议。

关键词：健康中国大健康产业发展布局

泽布替尼治疗老年初诊套细胞淋巴瘤的效果及不良反应分析

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中国医药 2024年第8期19卷 1189-1193页

作者：彭小娟崔杰刘鹏甘肃省肿瘤医院血液科兰州730050

目的探究泽布替尼一线治疗老年初诊套细胞淋巴瘤(MCL)的有效性及安全性。方法回顾性收集甘肃省肿瘤医院血液科自2020年8月至2022年7月收住经泽布替尼治疗的13例老年初诊MCL患者临床资料。13例患者给予泽布替尼初始剂量为160 mg/次,2次/d... 详细信息

目的探究泽布替尼一线治疗老年初诊套细胞淋巴瘤(MCL)的有效性及安全性。方法回顾性收集甘肃省肿瘤医院血液科自2020年8月至2022年7月收住经泽布替尼治疗的13例老年初诊MCL患者临床资料。13例患者给予泽布替尼初始剂量为160 mg/次,2次/d,治疗时间均大于4个周期(1个月为1个周期),记录患者疗效,计算客观缓解率(ORR)、无进展生存期(PFS)、总生存期、6及12个月无进展生存率和总生存率,分析不同因素对PFS、总生存期的影响。结果随访截至2022年11月1日,13例患者中,7例完全缓解(53.8%),2例部分缓解(15.4%),4例疾病进展(30.8%);ORR为69.2%(9/13);中位PFS为8个月(范围4~28个月),中位总生存期为10个月(范围5~28个月),6个月无进展生存率和总生存率分别为68.0%、92.0%,12个月无进展生存率和总生存率分别为23.0%、31.0%。单因素分析显示,美国东部肿瘤协作组评分、Ki-67指数、乳酸脱氢酶可能影响患者PFS,年龄、Ki-67指数、乳酸脱氢酶可能影响患者总生存期(均P0.05)。13例患者中,1例血液学毒性为轻度,4例非血液学毒性包括感染、继发恶性肿瘤、关节痛、恶心,所有不良反应经减量、停用泽布替尼及对症处理均安全可控,无治疗相关死亡发生。结论泽布替尼单药一线治疗老年初诊MCL,特别是对于体能状态差不能耐受化疗及个人意愿拒绝化疗的患者有较高的ORR、完全缓解率及较好的耐受性。

关键词：套细胞淋巴瘤泽布替尼初诊

静息与感染状态下巨噬细胞和经典树突状细胞的发育及功能研究进展

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细胞与分子免疫学杂志 2024年第6期40卷 556-560页

作者：张蕾崔洁梁尹攀张欢欢伊淑莹山东第一医科大学临床与基础医学院(基础医学研究所)生物化学与分子生物学系山东济南250062

巨噬细胞(MAC)和经典树突状细胞(cDC)是免疫防御的首要防线,在先天免疫和适应性免疫中扮演着重要角色,它们具有高度组织特异性,能够精确的适应环境变化。MAC在维持组织稳态和免疫监视方面发挥作用,而cDC作为最有效的抗原提呈细胞,在免... 详细信息

巨噬细胞(MAC)和经典树突状细胞(cDC)是免疫防御的首要防线,在先天免疫和适应性免疫中扮演着重要角色,它们具有高度组织特异性,能够精确的适应环境变化。MAC在维持组织稳态和免疫监视方面发挥作用,而cDC作为最有效的抗原提呈细胞,在免疫应答中起关键作用。这两种细胞类型之间也存在相似性和相互联系,MAC和cDC都能识别病原体和组织损伤,它们通过分泌细胞因子激活其他先天免疫细胞,并通过与T细胞的相互作用启动或调节适应性免疫。本文总结了静息与感染过程中MAC及cDC的发育及功能的研究进展,阐述了它们在免疫系统中的关系和相互作用,为疾病的深入研究提供了理论基础。

关键词：巨噬细胞树突状细胞炎症免疫训练免疫耐受综述

Thermophoresis of nanoparticles hotter/colder than the surrounding dilute gases

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Particuology 2022年第4期20卷 95-102页

作者： Junjie Su jie cui Jun Wang Guodong Xia MOE Key Laboratory of Enhanced Heat Transfer and Energy Conservation Beijing Key Laboratory of Heat Transfer and Energy ConversionBeijing University of TechnologyBeijing 100124China

Aerosol particles suspended in a diluted gas with non-uniform temperature distribution are expected to experience a thermophoretic *** theoretical treatment of thermophoresis,it is usually assumed that the particle temperature is equal to the surrounding gas ***,this might not always be the *** some particular applications,the particle temperature can significantly differ from the gas *** the present paper,we theoretically investigate the effect of the particle tempera-ture on the thermophoresis of nanoparticles in the free molecule *** formulas for the thermophoretic force and thermophoretic velocity are obtained based on the gas kinetic *** exam-ples,a spherical Ag nanoparticle suspended in a dilute He gas is considered,and the Rudyak-Krasnolutski potential is employed to model the gas-particle *** is found that the influence of the particle temperature on the thermophoresis of nanoparticles can be *** increasing particle size,the error due to the equal gas-particle temperature assumption can be neglected.

关键词： Thermophoresis Particle temperature Nanoparticles Free molecule regime

Error Analysis of A New Higher Order Boundary Element Method for A Uniform Flow Passing Cylinders

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China Ocean Engineering 2023年第3期37卷 369-377页

作者： SUN Shi-yan cui jie BAO Chao-ming School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

A higher order boundary element method(HOBEM)is presented for inviscid flow passing cylinders in bounded or unbounded *** traditional boundary integral equation is established with respect to the velocity potential and its normal *** present work,a new integral equation is derived for the tangential *** boundary is discretized into higher order elements to ensure the continuity of slope at the element *** velocity potential is also expanded with higher order shape functions,in which the unknown coefficients involve the tangential *** expansion then ensures the continuities of the velocity and the slope of the boundary at element *** extensive comparison of the results for the analytical solution of cylinders,it is shown that the present HOBEM is much more accurate than the conventional BEM.

关键词： higher order boundary element method(HOBEM) error analysis integral equations for potential and velocity cylinders

Reducing voltage hysteresis of metal oxide anodes to achieve high energy efficiency for Li-ion batteries

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能源化学:英文版 2023年第8期83卷 433-444,I0011页

作者： Xuexia Lan Xingyu Xiong jie cui Renzong Hu School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640GuangdongChina Analytical and Testing Center South China University of TechnologyGuangzhou 510640GuangdongChina

In the past two decades,a lot of high-capacity conversion-type metal oxides have been intensively studied as alternative anode materials for Li-ion batteries with higher energy ***,their large voltage hysteresis(0.8-1.2 V) within reversed conversion reactions results in huge round-trip inefficiencies and thus lower energy efficiency(50%-75%) in full cells than those with graphite *** remains a long-term open question and has been the most serious drawback toward application of metal oxide *** we clarify the origins of voltage hysteresis in the typical SnO2anode and propose a universal strategy to minimize *** the established in situ phosphating to generate metal phosphates during reversed conversion reactions in synergy with boosted reaction kinetics by the added P and Mo,the huge voltage hysteresis of 0.9 V in SnO_(2),SnO_(2)-Mo,and 0.6 V in SnO2-P anodes is minimized to 0.3 V in a ternary SnO_(2)-Mo-P(SOMP) composite,along with stable high capacity of 936 mA h g^(-1)after 800 *** small voltage hysteresis can remain stable even the SOMP anode operated at high current rate of10 A g^(-1)and wide-range temperatures from 60 to 30℃,resulting in a high energy efficiency of88.5% in full *** effective strategy to minimize voltage hysteresis has also been demonstrated in Fe2O3,Co3O4-basded conversion-type *** work provides important guidance to advance the high-capacity metal oxide anodes from laboratory to industrialization.

关键词： Conversion reaction Voltage hysteresis Energy efficiency Phosphating