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Properly Understanding Supply–side Structural Reform in the Cultural Sector

Contemporary Social Sciences 2018年第4期3卷 82-99页

作者： Fan zh.u zh.u jie Xu Qingtong the School of Economics and Management and Dean of the Cultural Development Institute Communication University of China Culture Development Institute of CUC

The proposal of supply–side structural reform in the cultural sector is based on theoretical inspiration from the economic sector and actual issues in the cultural sector. A proper understanding of the proposal is crucial to the implementation of the reform which should be based on the backgrounds of macroscopic reform and cultural development of the country as well as the need for theoretical innovation. The reform should be carried out with a clear understanding of China's current conditions, a clarification of the reform thinking, the similarities and differences of supply–side structural reforms between the cultural and the economic sectors, as well as an analysis of issues related to the "supply–side" and "structure" in the cultural sector. Concerted efforts from the government through guidance, and market entities through operation should be made to apply appropriately to the reform principle of "unity of doubles effects." Innovations, especially those in technology and institutions, should be promoted as a new momentum to drive cultural development. Concerted efforts from the government and enterprises should underpin optimal supply and a mechanism for competition should be established to ensure effective supply in the cultural sector. In the meantime, the upgrading of demand should be used as a new guidance for effective supply and investment should be oriented to supplement the need for public cultural services. Attention should be paid to a satisfaction–oriented approach to fill the gaps in cultural consumption. For the cultural industry and undertakings, it is now the prime time which brings along great opportunities for development and challenges for reform. From now on the cultural sector should seek its development from transformation and upgrading. Supported by the central government through policy incentives and driven by technological innovations and the capital markets, the cultural industry will maintain stable growth for a relatively long period.

关键词： cultural sector supply–side structural reform unity of benefits innovation–driven cultural industry

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Honeycomb-Like Hydrogel Microspheres for 3D Bulk Construction of Tumor Models

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Research 2022年第2期2022卷 245-258页

作者： Jiachen He Chichi Chen Liang Chen Ruoyu Cheng jie Sun Xingzh. Liu Lin Wang Can zh. Sihan Hu Yuan Xue Jian Lu Huiling Yang Wenguo Cui Qin Shi Department of Orthopedics The First ffliated Hospital of Soochow UrniversilyOrthopedic Institute of Soochow University899 Pinghai RoadSuzhouJiangsu 215031China National Clinical Research Center for Hematologic Diseases The First Afliated Hospital of Soochow University899 Pinghai RoadSuzhouJiangsu 215031China Department of Orthopaedis Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijjin HospitalShanghai liao Tong University School of Medicine197 Ruijini 2nd RoadSharghai 200025China School of Nanotech and Nano-Bionics Universily of Science and Techmology of China388 Ruoshui RoadSuzhouJiangsu 215123 China Department of Orthopedics Wiuxi Ninth People's Hospital Afiliated to Soochow UniversityWiuciJiangs 214026China

A two-dimensional(2D)cell culture-based model is widely applied to study tumorigenic mechanisms and drug ***,it cannot authentically simulate the threedimensional(3D)microenvironment of solid tumors and provide reliable and predictable data in response to in vivo,thus leading to the research ilusionis and failure of drug *** this study,honeycomb-like gelatin methacryloyl(GelMA)hydrogel microspheres are developed by synchronous photocrosslinking microluidic technique to construct a 3D model of *** in vitro study shows that ostcosarcoma cells(K7M2)culured in 3D GelMA microspheres have stronger tumorous stemness。proliferation and migration abilitics,more osteoclastogenetic ability,and reistance to chemotherapeutic drugs(DOX)than that of cells in 2D *** imporantly,the 3D-cultured K7M2 cells show more tumorigenicity in immunologically sound mice,characterized by shorter tumorigenesis time,larger tumor volumc,severe bone destruction,and higher *** conclusion,honeycomb like porous microsphere scaffolds are constructed with uniform structure by micofluidic technology to massively produce tumor cells with original *** microspheres could recapitulate the physiology microenvironment of *** ell-cell and cell-extracellular matrix interactions,and thus provide an efective and convenient strategy for tumor pathogenesis and drug screening research.

关键词： drugs maintain shorter

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LncRNA MIR205HG expression predicts efficacy of neoadjuvant chemotherapy for patients with locally advanced breast cancer

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Genes & Diseases 2022年第4期9卷 837-840页

作者： Yaqian Xu Chenwei Yuan Jing Peng Liheng zh.u Yanping Lin Yaohui Wang jie zh.ng Jiayi Ma Wenjin Yin Jinsong Lu Department of Breast Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127PR China Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100050PR China

To the Editor,Recent studies reported that lncRNA MIR205HG expression is associated with sensitivity to anti-epidermal growth factor receptor(EGFR)drug in lung cancer ***,few clinical studies reported the role of this molecule in breast cancer,particularly in the neoadjuvant *** this study,we explored the clinical significance of MIR205HG expression with its predictive and prognostic value for patients with locally advanced breast cancer.

关键词： breast patients cancer

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公共政策评估的制度基础与基本范式

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管理世界 2023年第1期39卷 128-137页

作者：贠杰中国社会科学院大学政府管理学院中国社会科学院政治学研究所

在推进国家治理现代化进程中,公共政策评估的重要作用正日益凸显,进一步加强公共政策评估的科学化、制度化和专业化显得尤为必要。公共政策评估的制度基础与基本范式是当前公共政策评估领域的两大基础性问题,直接影响着公共政策的质量... 详细信息

在推进国家治理现代化进程中,公共政策评估的重要作用正日益凸显,进一步加强公共政策评估的科学化、制度化和专业化显得尤为必要。公共政策评估的制度基础与基本范式是当前公共政策评估领域的两大基础性问题,直接影响着公共政策的质量和水平。责任化政府体制是开展规范的公共政策评估的逻辑起点和制度基础。制度范式与技术范式的构建,是推进公共政策评估科学化、制度化和专业化的基本途径。制度范式包括构建专门的政策评估法律制度体系、建立完备的评估组织体系以及健全政策评估的长效运行管理机制等三大要素。技术范式包括狭义层面的政策效果评估与广义层面的系统化综合分析两个层次。加快建设全面责任化政府体制和科学有效的政策评估基本范式,是新时代推进公共政策评估发展的主导方向。

关键词：公共政策评估制度基础制度范式技术范式

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明清时期民瑶的族群互动与社会发展

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中南大学学报（社会科学版） 2020年第5期26卷 219-228页

作者：杨洁中南大学中国村落文化研究中心湖南长沙410083

从四大民瑶镇守楚南隘口开始,无论是卫所军屯设撤、田产买卖限制,还是瑶目瑶长制的常规化,莫不体现出国家治理手段下民瑶的生存状态及其与周边族群的关系模式。瑶、军、汉的体制分野,使民瑶在历史建构过程中,常与其他族群产生纠纷。通... 详细信息

从四大民瑶镇守楚南隘口开始,无论是卫所军屯设撤、田产买卖限制,还是瑶目瑶长制的常规化,莫不体现出国家治理手段下民瑶的生存状态及其与周边族群的关系模式。瑶、军、汉的体制分野,使民瑶在历史建构过程中,常与其他族群产生纠纷。通过国家政策的宏观控制以及府县的直接管理,清溪瑶、古调瑶、扶灵瑶、勾蓝瑶在与所军、汉民等官方组织和文化代表的交往过程中,逐步融合成为四大民瑶,形成了典型的多元一体的民族格局。

关键词：民瑶族群族群互动社会发展

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《寻羊冒险记》中的“羊”与隐喻脑文本的建构机制

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外国文学 2023年第2期 50-58页

作者：任洁浙江大学外国语学院浙江杭州310013

在文学伦理学批评的脑文本认知结构里,解喻、施喻的过程就是建构隐喻脑文本的过程,均表现出鲜明的伦理特点。在解喻活动中,解喻者运用能指脑概念与所指脑概念,在特定伦理语境中对喻体进行解构与重构以获得隐喻意义。隐喻意义作为解喻的... 详细信息

在文学伦理学批评的脑文本认知结构里,解喻、施喻的过程就是建构隐喻脑文本的过程,均表现出鲜明的伦理特点。在解喻活动中,解喻者运用能指脑概念与所指脑概念,在特定伦理语境中对喻体进行解构与重构以获得隐喻意义。隐喻意义作为解喻的结果在人的大脑中存储下来,形成隐喻脑文本。隐喻脑文本具有指导解喻主体实践的作用。在施喻过程中,施喻者将既有脑概念或脑文本按照隐喻伦理重新组合、编辑和加工,生成隐喻脑文本,继而借助语言或文字等方式表达出来,得到隐喻。施喻是为了向解喻者传递脑文本。在《寻羊冒险记》中,日本作家村上春树通过设置“羊”这一隐喻,从解喻和施喻的角度揭示了隐喻主体建构脑文本的基本伦理原则。

关键词：村上春树《寻羊冒险记》隐喻脑文本脑概念

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环保PVF碳氮硫硅钢结构防火涂料的研究

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非金属矿 2024年第4期47卷 45-48页

作者：邹威亮邓跃全叶刚曾洁成静李恒高川林何志强西南科技大学材料与化学学院四川绵阳621010 四川瑞特消防科技有限公司四川眉山620000

为降低防火涂料的成本,实现绿色环保,本试验制备了一种环保聚乙烯醇缩甲醛(PVF)及其钢结构防火涂料,研究了PVF加入量对防火涂料理化性能和防火性能的影响,并分析了其耐火机理。结果表明,当聚乙烯醇与甲醛质量比为5.7∶3.5时,加入2%左右... 详细信息

为降低防火涂料的成本,实现绿色环保,本试验制备了一种环保聚乙烯醇缩甲醛(PVF)及其钢结构防火涂料,研究了PVF加入量对防火涂料理化性能和防火性能的影响,并分析了其耐火机理。结果表明,当聚乙烯醇与甲醛质量比为5.7∶3.5时,加入2%左右尿素和0.2%左右过氧化氢制备环保PVF,甲醛含量符合GB 18582—2020的规定;PVF与涂层的黏结强度呈正相关,能增强涂层的黏结强度,对涂层的基本性能无影响,对涂层耐火性能有显著影响。涂层钢板平均温度随PVF加入量的增加呈先降低后增加趋势,加入7%~13%的PVF,涂层发泡厚度大于3.3cm,涂层背面温度小于300℃,PVF加入量为10%时,涂层背面温度温度最低,为220℃。PVF在297.3℃左右发生热解,相变结束时残碳量约为23.8%,两者受热均产生大量阻燃气体,在涂层中主要起气源和少量碳源作用,具有较好的黏结性和成膜性能。

关键词： PVF 钢结构防火涂料环保耐火性能成膜性能

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基于野外调查、遥感信息和CSLE模型的土壤侵蚀强度分级

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南水北调与水利科技 2014年第5期12卷 170-174页

作者：宋文龙张荣华高云飞路京选杨胜天曲伟赵东杰中国水利水电科学研究院北京100038 山东农业大学林学院山东省土壤侵蚀与生态修复重点实验室山东泰安271018 黄河水土保持生态环境监测中心西安710021 北京师范大学地理学与遥感科学学院北京100875 山东省德州市陵县国土资源局山东陵县253500

基于野外调查、遥感信息和土壤侵蚀模型等方法的土壤侵蚀强度分级计算,是开展区域土壤侵蚀长期变化监测的重要途径。选取位于西北黄土高原丘陵沟壑区的陕西省靖边县和位于西南土石山区的广西省横县为研究区,基于野外调查数据和遥感信息... 详细信息

基于野外调查、遥感信息和土壤侵蚀模型等方法的土壤侵蚀强度分级计算,是开展区域土壤侵蚀长期变化监测的重要途径。选取位于西北黄土高原丘陵沟壑区的陕西省靖边县和位于西南土石山区的广西省横县为研究区,基于野外调查数据和遥感信息,应用CSLE土壤侵蚀模型、水利部土壤侵蚀强度面蚀分级指标(三因子法),计算得到30m像元尺度土壤侵蚀模数,据此划分土壤侵蚀强度等级。对比研究结果表明:CSLE土壤侵蚀模型计算结果总体优于三因子法;与三因子法和第二次全国土壤侵蚀遥感调查结果相比,CSLE土壤侵蚀模型计算结果中极强烈侵蚀和剧烈侵蚀所占比例较大;应用土壤侵蚀模型对各因子进行监测和变化分析,有利于对区域土壤侵蚀变化开展长期监测并做出合理解释,但因子赋值对模型模拟结果影响较大。

关键词：土壤侵蚀野外调查遥感 CSLE 模型三因子法

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17β-estradiol inhibits TGF-β-induced collagen gel contraction mediated by human Tenon fibroblasts via Smads and MAPK signaling pathways

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1441-1449页

作者： Cheng-Cheng Yang Meng-jie Liu Yun-Ze-Peng Li zh.ng-Hua Xu Yang Liu Zi-Han Guo Bin-Hui Li Xiu-Xia Yang Department of Ophthalmology the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

AIM:To investigate the impact of 17β-estradiol on the collagen gels contraction(CGC)and inflammation induced by transforming growth factor(TGF)-βin human Tenon fibroblasts(HTFs).METHODS:HTFs were three-dimensionally cultivated in type I collagen-generated gels with or without TGF-β(5 ng/mL),17β-estradiol(12.5 to 100μmol/L),or progesterone(12.5 to 100μmol/L).Then,the collagen gel diameter was determined to assess the contraction,and the development of stress fibers was analyzed using immunofluorescence *** and gelatin zymography assays were used to analyze matrix metalloproteinases(MMPs)and tissue inhibitors of metalloproteinases(TIMPs)being released into culture ***-linked immunosorbent assay(ELISA)and reverse transcription-quantitative polymerase chain reaction(RT-PCR)were used to detect interleukin(IL)-6,monocyte chemoattractant proteins(MCP)-1,and vascular endothelial growth factor(VEGF)in HTFs at the translational and transcriptional *** phosphorylation levels of Sma-and Mad-related proteins(Smads),mitogen-activated protein kinases(MAPKs),and protein kinase B(AKT)were measured by *** analysis was performed using either the Tukey-Kramer test or Student’s unpaired t-test to compare the various ***:The CGC caused by TGF-βin HTFs was significantly inhibited by 17β-estradiol(25 to 100μmol/L),and a statistically significant difference was observed when comparing the normal control group with 17β-estradiol concentrations exceeding 25μmol/L(P<0.05).The suppressive impact of 17β-estradiol became evident 24h after administration and peaked at 72h(P<0.05),whereas progesterone had no ***,17β-estradiol attenuated the formation of stress fibers,and the production of MMP-3 and MMP-1 in HTFs stimulated by TGF-β.The expression of MCP-1,IL-6,and VEGF mRNA and protein in HTFs were suppressed by 100μmol/L 17β-estradiol(P<0.01).Additionally,the phosphorylation of Smad2 Smad3,p38,and extracellula

关键词： Tenon fibroblasts transforming growth factor-β 17β-estradiol fibrosis wound healing

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Peripheral monocyte count： an independent diagnostic and prognostic biomarker for prostate cancer - a large Chinese cohort study

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Asian Journal of Andrology 2017年第5期19卷 579-585页

作者： Yan-Qing Wang Yin-jie zh. Jia-Hua Pan Fan Xu Xiao-Guang Shao Jian-Jun Sha Qiang Liu Yi-Ran Huang Bai-Jun Dong Wei Xue Department of Urology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Department of Pathology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Increasing evidence indicates that inflammation may play important roles in tumorigenesis and progression, and an elevated peripheral monocyte count predicts a poor prognosis in various types of malignancies. Here, we evaluate the roles of peripheral monocyte count in the diagnosis and prognosis for prostate cancer in Chinese patients. A total of 1107 consecutive patients who had undergone prostate biopsy and 290 prostate cancer patients receiving androgen deprivation therapy as first-line therapy were retrospectively analyzed. The parameters were measured at the time of diagnosis. Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of a positive biopsy. Patients were categorized in two groups using a cutoff point of 0.425 x 109 1-1 as calculated by the receiver-operating curve analysis for prognosis. Univariate and multivariate Cox regression analyses were performed to determine the associations of monocyte count with progression-free survival, cancer-specific survival, and overall survival. Multivariate logistic regression analyses showed that monocyte count, age, prostate-specific antigen （PSA）, free/total PSA, and prostate volume were independent predictors for prostate cancer. Multivariate Cox regression analyses identified an elevated monocyte count as an independent prognostic factor for worse cancer-specific survival （hazard ratio = 2.244, P 〈 0.05） and overall survival （hazard ratio = 1.995, P 〈 0.05）, but not progression-free survival （P = 0.117）. Our results indicated that an elevated monocyte count was an independent diagnostic biomarker for prostate cancer, and pretreatment peripheral monocyte count might play a significant role in the prognosis of prostate cancer patients treated with androgen deprivation therapy.

关键词： diagnosis monocyte prognosis prostate cancer

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