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Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAO Kai-xin YANG Yi-hong LIANG Qi MEI Li-yan LIANG You-bang WANG Mao-jie CHEN Xiu-min HUANG Qing-chun WEN Ze-huai HUANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems

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Science China(Life Sciences) 2024年第1期67卷 188-203页

作者： Xuan Dong Cixiu Li Yiting Wang Tao Hu Fan zh.ng Fanzeng Meng Meirong Gao Xuekai Han Guohao Wang Jiahao Qin Hans Nauwynck Edward CHolmes Patrick Sorgeloos Liying Sui jie Huang Weifeng Shi State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesLaboratory for Marine Fisheries Science and Food Production ProcessesLaoshan LaboratoryKey Laboratory of Maricultural Organism Disease ControlMinistry of Agriculture and Rural AffairsQingdao Key Laboratory of Mariculture Epidemiology and BiosecurityQingdao 266071China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000China Dalian Ocean University Dalian 116023China Asian Regional Artemia Reference Center Tianjin University of Science&TechnologyTianjin 300457China Ghent University Ghent 9000Belgium Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydney 2006Australia Network of Aquaculture Centres in Asia-Pacific Bangkok 10900Thailand School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Brine shrimp(Artemia)has existed on Earth for 400 million years and has major ecological importance in hypersaline *** a crucial live food in aquaculture,brine shrimp cysts have become one of the most important aquatic products traded ***,our understanding of the biodiversity,prevalence and global connectedness of viruses in brine shrimp is still very limited.A total of 143 batches of brine shrimp(belonging to seven species)cysts were collected from six continents including 21 countries and more than 100 geographic locations worldwide during 1977–*** total,55 novel RNA viruses were identified,which could be assigned to 18 different viral families and related *** viruses were dsRNA viruses,16 were+ssRNA viruses,and 28 were−ssRNA *** analyses of the RNA-directed RNA polymerase(RdRp)showed that brine shrimp viruses were often grouped with viruses isolated from other invertebrates and ***,most brine shrimp viruses were related to those from different hosts that might feed on brine shrimp or share the same ecological niche.A notable case was the novel brine shrimp noda-like virus 3,which shared 79.25%(RdRp)and 63.88%(capsid proteins)amino acid identity with covert mortality nodavirus(CMNV)that may cause losses in *** addition,both virome composition and phylogenetic analyses revealed global connectedness in certain brine shrimp viruses,particularly among Asia and Northern *** highlights the incredible species diversity of viruses in these ancient species and provides essential data for the prevalence of RNA viruses in the global aquaculture *** broadly,these findings provide novel insights into the previously unrecognized RNA virosphere in hypersaline ecosystems worldwide and demonstrate that human activity might have driven the global connectedness of brine shrimp viruses.

关键词： brine shrimp Artemia virus diversity novel virus discovery global connectedness hypersaline ecosystem

AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

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Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han Wang Lumin Xing Yi Pan Feng Gu Junbin Fang Xiangrong Yu Chi Pui Pang Kelvin Kam-Lung Chong Carol Yim-Lui Cheung Xulin Liao Xiaoxiao Fang jie Yang Ruoyu zh.u Xiaoshu zh.u Fengling Wang Wenjian Liu zh.hai People’s Hospital(zh.hai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China zh.hai Institute of Advanced Technology Chinese Academy of Sciences Zhuhai 519000China Perspective Technology Group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzh.n Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China zh.hai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between China and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

氮添加对不同氮需求豆科植物幼苗根系形态性状和根叶养分含量的影响

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生态学杂志 2024年第5期43卷 1255-1262页

作者：董佳乐许涵解亚鑫陈洁李艳朋雷婕中国林业科学研究院热带林业研究所广州510520 南京林业大学南京210037

为揭示氮添加对不同氮需求豆科植物幼苗的影响,以海南热带雨林3种不同氮生境偏好的豆科植物——低氮需求的长脐红豆(Ormosia balansae)、中氮需求的荔枝叶红豆(Ormosia semicastrata ***)和高氮需求的猴耳环(Archidendron clypearia)幼... 详细信息

为揭示氮添加对不同氮需求豆科植物幼苗的影响,以海南热带雨林3种不同氮生境偏好的豆科植物——低氮需求的长脐红豆(Ormosia balansae)、中氮需求的荔枝叶红豆(Ormosia semicastrata ***)和高氮需求的猴耳环(Archidendron clypearia)幼苗为研究对象,设置5种氮添加水平(0、75、150、300和600 mg·kg^(-1))盆栽试验,观测它们根系形态性状与根叶器官养分含量的响应特征。结果表明:(1)氮添加水平的升高显著降低了低氮需求(长脐红豆)和中氮需求(荔枝叶红豆)豆科物种的总根长、总根表面积和根系干重,而对高氮需求(猴耳环)豆科物种的根系形态性状无影响。(2)相关性分析表明,在不同氮添加水平下,低氮需求的长脐红豆和中氮需求的荔枝叶红豆总根长、总根表面积、根系干重与根际土壤硝态氮、铵态氮浓度呈显著负相关。(3)氮添加仅对低氮和中氮需求豆科物种的根叶养分含量具有促进作用,而对高氮需求物种的根叶养分含量无显著影响。具体而言,氮添加显著增加了低氮需求的豆科物种(长脐红豆)叶片和根系的全氮含量,而对中氮需求的豆科物种(荔枝叶红豆)叶片和根系的氮、磷含量均有促进作用。综上所述,氮添加对豆科植物的影响因氮需求的不同以及氮添加水平而存在差异,一方面显著抑制低氮需求和中氮需求的豆科植物的根系形态性状的生长,促进了两者根叶氮、磷含量的增加,另一方面对高氮需求的豆科植物根系形态性状无影响,且仅促进了根系氮含量。未来关于氮沉降对豆科植物的化学计量特征以及群落动态变化的研究,有必要充分考虑豆科植物的自身不同特性。

关键词：热带雨林豆科植物土壤无机氮根系形态性状养分状态

增加类簇级对比的SCCL文本深度聚类方法研究

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数据分析与知识发现 2024年第3期8卷 98-109页

作者：李婕张智雄王宇飞中国科学院文献情报中心北京100190 中国科学院大学经济与管理学院信息资源管理系北京100190

【目的】改进SCCL模型在文本深度聚类任务上的效果,提出一种新的基于SCCL的文本深度聚类模型ISCCL。【方法】ISCCL模型基于句向量预训练语言模型对输入文本进行数据增强和编码获取两组增强表征,在SCCL模型的基础上增加两层非线性网络,... 详细信息

【目的】改进SCCL模型在文本深度聚类任务上的效果,提出一种新的基于SCCL的文本深度聚类模型ISCCL。【方法】ISCCL模型基于句向量预训练语言模型对输入文本进行数据增强和编码获取两组增强表征,在SCCL模型的基础上增加两层非线性网络,将增强表征降维到维度与聚类数量相同的类簇特征空间。从列空间的角度构造正负簇对进行对比学习,引导模型挖掘对聚类任务有用的特征,并减少假正样本产生的影响。【结果】在AgNews、Biomedical、StackOverflow、20NewsGroups和zh.0共5种基准数据集中,ISCCL模型的聚类准确率分别达到88.89%、48.74%、78.17%、56.97%和86.42%,较SCCL模型提升0.69%~2.67%。【局限】需要预先设定类簇特征空间维度(与聚类数目K值相同),然而在实际应用中往往很难明确原始数据的具体聚类数目,应当根据数据情况适当调整。【结论】ISCCL模型能够有效提取类簇特征,在SCCL模型的基础上提升了文本深度聚类效果。

关键词：对比学习深度聚类 SCCL 类簇特征学习表示学习

超广域SS-OCTA联合超广角激光扫描眼底成像对糖尿病视网膜病变的诊断价值

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眼科新进展 2024年第4期44卷 291-296页

作者：毛明珠黎梦宇韦丁杨陈丽刘逸李杰钟捷成都中医药大学眼科学院四川省成都市610032 四川省医学科学院·四川省人民医院(电子科技大学附属医院)眼科四川省成都市610072

目的超广域扫频源光学相干断层扫描血管成像(UWF SS-OCTA)联合超广角激光扫描眼底成像(UWF SLO)对糖尿病视网膜病变(DR)患者病变的检出率以及对DR分级诊断价值的研究。方法横断面研究。招募在四川省人民医院眼科就诊的糖尿病患者。所... 详细信息

目的超广域扫频源光学相干断层扫描血管成像(UWF SS-OCTA)联合超广角激光扫描眼底成像(UWF SLO)对糖尿病视网膜病变(DR)患者病变的检出率以及对DR分级诊断价值的研究。方法横断面研究。招募在四川省人民医院眼科就诊的糖尿病患者。所有参与者都接受了UWF SS-OCTA、UWF SLO和荧光素眼底血管造影(FFA)检查,用于检测DR病变,包括微动脉瘤(MA)、视网膜内出血(IRH)、视网膜无灌注区(NPAs)、视网膜内微血管异常(IRMAs)、视网膜静脉串珠(VB)、视网膜新生血管(NVE)、视盘新生血管(NVD)及玻璃体积血(VH)。联合三类影像检查(以下简称三联影像)结果作为标准对照,对比不同影像两两联合对DR病变的检出率及对DR严重度分级的一致性。结果共纳入101例175眼。与三联影像结果相比,UWF SS-OCTA联合UWF SLO对MA、IRH、NPAs、IRMAs、NVE、NVD及VH的检出率分别为91%、83%、77%、69%、27%、10%及12%,Kappa依次为0.812、1.000、1.000、1.000、0.986、0.970及1.000。与三联影像结果相比,UWF SS-OCTA联合UWF SLO对DR的严重度分级具有优异一致性(Kappa=0.943)。结论 UWF SS-OCTA联合UWF SLO能准确识别MA、IRH、NPAs、IRMAs、NVE、NVD及VH,对DR筛查及分级诊断准确性高,适用于临床上对DR的大规模筛查与管理。

关键词：超广域扫频源光学相干断层扫描血管成像超广角激光扫描眼底成像荧光素眼底血管造影糖尿病性视网膜病变

Corneal ulcer caused by nocardia brasiliensis in a patient with diabetes

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 381-383页

作者： Xian-Ning Liu Na An jie Wu Kun Xu Xiu-Ping zh.Sheng-Li Mi Department of Ophthalmology the First Hospital of Xi'an Shaanxi Provincial Key Laboratory of Ophthalmology Ophthalmological Institute of Shaanxi Province Biomanufacturing Engineering Laboratory Graduate School at Shenzhen Tsinghua University

Dear Sir,Iam ***-Li Mi,from the Biomanufacturing engineering laboratory,Graduate School at Shenzh.n,Tsinghua University,Shenzh.n,China.I write to present a case report of nocardia brasiliensis in a patient with *** is part of a group of aerobic actinomycetes,widely distributed in *** asteroids and nocardia brasiliensis are the most common human *** infected by nocardia asteroids through the respiratory tract mainly suffer from primary suppurative pulmonary *** of nocardia brasiliensis often occurs in the advanced stages of a progressive disease or immune disorder,especially Cushing syndrome,diabetes,or in patients using corticosteroids,immunosuppressive agents and broad-spectrum antibiotics for long time[1].To our knowledge,the reports of nocardia keratitis was very rare

关键词： Corneal ulcer caused by nocardia brasiliensis in a patient with diabetes

Accurate prediction of myopic progression and high myopia by machine learning

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Precision Clinical Medicine 2024年第1期7卷 14-20页

作者： Jiahui Li Simiao Zeng zh.huan Li jie Xu zh.o Sun Jing zh.o Meiyan Li Zixing Zou Taihua Guan Jin Zeng zh.ang Liu Wenchao Xiao Ran Wei Hanpei Miao Ian Ziyar Junxiong Huang Yuanxu Gao Yangfa Zeng Xing-Tao zh.u Kang zh.ng Guangzh.u Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510120China Guangzh.u National Laboratory Guangzhou 510o0oChina zh.hai International Eye Center of the First Affiliated Hospital of Faculty of Medicine Macao University of Science and TechnologyZhuhai 519000China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Myopia Ministry of HealthShanghai Key Laboratory of Visual Impairment and RestorationDepartment of OphthalmologyEye InstituteEye and EarNoseand Throat HospitalFudan UniversityShanghai 200031China DongguanPeople's Hospital The First School of Clinical MedicinelSouthern Medical UniversityDongguan 523059China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Wenzh.u Eye Hospital and Institute for Advanced Study on Eye Health and Diseases Wenzhou Medical UniversityWenzhou 32500oChina

Background Myopia is a leading cause of visual impairment in Asia and ***,accurately predicting the progression of myopia and the high risk of myopia remains a *** study aims to develop a predictive model for the development of *** We first retrospectively gathered 612530 medical records from five independent cohorts,encompassing 227543 patients ranging from infants to young ***,we developed a multivariate linear regression algorithm model to predict the progression of myopia and the risk of high *** The model to predict the progression of myopia achieved an R^(2) value of 0.964 vs a mean absolute error(MAE)of 0.119D[95%confidence interval(CI):0.119,1.146]in the internal validation *** demonstrated strong generalizability,maintaining consistent performance across external validation sets:R^(2)=0.950 vs MAE=0.119D(95%CI:0.119,1.136)in validation study 1,R^(2)=0.950 vs MAE=0.121D(95%CI:0.121,1.144)in validation study 2,and R^(2)=0.806 vs MAE=−0.066D(95%CI:−0.066,0.569)in the Shanghai Children Myopia *** the Beijing Children Eye Study,the model achieved an R^(2) of 0.749 vs a MAE of 0.178D(95%CI:0.178,1.557).The model to predict the risk of high myopia achieved an area under the curve(AUC)of 0.99 in the internal validation set and consistently high area under the curve values of 0.99,0.99,0.96 and 0.99 in the respective external validation *** Our study demonstrates accurate prediction of myopia progression and risk of high myopia providing valuable insights for tailoring strategies to personalize and optimize the clinical management of myopia in children.

关键词： myopia progression machine learning prevention precision medicine

程序化血糖管理模式对脓毒症合并糖尿病患者血糖水平控制及预后的影响

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中国基层医药 2024年第9期31卷 1352-1357页

作者：范良梅杨杰赵荣美吴芬温州医科大学附属第五医院、丽水市中心医院感染科丽水323000

目的探讨程序化血糖管理模式对脓毒症合并糖尿病患者血糖水平控制情况及预后的影响。方法收集2021年1月至2023年10月在温州医科大学附属第五医院(丽水市中心医院)就诊的脓毒症合并糖尿病患者76例的临床资料,按照程序化血糖管理模式实施... 详细信息

目的探讨程序化血糖管理模式对脓毒症合并糖尿病患者血糖水平控制情况及预后的影响。方法收集2021年1月至2023年10月在温州医科大学附属第五医院(丽水市中心医院)就诊的脓毒症合并糖尿病患者76例的临床资料,按照程序化血糖管理模式实施时间前后,将2021年1月至2022年12月实施常规护理的37例患者设为常规组,将2023年1—10月在常规护理基础上联合程序化血糖管理模式的39例患者设为试验组。比较两组患者感染科住院时间、28 d病死率、血糖控制水平(感染科住院期间糖化血红蛋白水平、血糖变异度、低血糖发生率,空腹及餐后2 h血糖)、健康状况[美国简明健康测量量表(MOS-SF36)]以及不良事件发生情况。结果试验组患者感染科住院时间(14.85±2.77)d,短于常规组的(17.42±3.24)d(t=3.72,P<0.001);试验组患者28 d病死率为7.69%(3/39),低于常规组的24.32%(9/37)(χ^(2)=3.95,P=0.047);试验组患者感染科住院期间糖化血红蛋白水平[10.4,(8.5,12.1)mmol/L]、血糖变异度[(31.54±7.16)%]均低于常规组[12.8(8.9,15.3)mmol/L、(45.63±12.19)%](Z=6.88,P<0.001;t=6.18,P<0.001);试验组患者低血糖发生率为10.81%(4/37),与常规组的5.13%(2/39)比较,差异无统计学意义(χ^(2)=0.84,P=0.358);干预后试验组患者MOS-SF36限制维度[(72.21±5.37)分、机体疼痛维度[(82.98±6.41)分]、总体健康维度[(81.32±6.23)分]、躯体功能维度[(71.43±5.22)分]均高于常规组的(68.39±6.21)分、(78.35±6.17)分、(74.50±7.57)分、(65.57±6.96)分(t=2.87,P=0.005;t=3.20,P=0.002;t=4.29,P<0.001;t=4.16,P<0.001);试验组患者不良事件发生率为10.26%(4/39),与常规组的13.51%(5/37)比较,差异无统计学意义(χ^(2)=0.19,P=0.660)。结论程序化血糖管理模式可提高脓毒症合并糖尿病患者血糖水平控制水平,并改善患者预后。

关键词：脓毒症糖尿病血糖糖蛋白类低血糖症预后死亡率