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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu Xiao-Yu Chen jie zhao Pin Li Zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

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Inspired by Grape Seed and Wine: Tannic Acid as a Modified Coating for Fabricating Highly Flexible, Transparent and Conductive Film

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Chemical Research in Chinese Universities 2019年第5期35卷 945-950页

作者： zhao jie School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510640P.R.China

The application of transparent conductive films in flexible electronics has shown promising prospects recently. Tannic acid(TA) was successfully applied to modifying the surface of polydimethylsiloxane(PDMS) to fhbricate highly flexible, transparent and conductive Ag nanowires(NWs) based films. TA modification transformed the PDMS surface from hydrophobicity into hydrophilicity without decreasing the transparence. A sheet resistance(Rs) of 80 Ω/cm^2 with an optical transmittance of 94% was achieved, which was superior to that of indium tin oxide(ITO) films. More importantly, the TA layer enhanced the interaction between Ag NWs and the PDMS substrate. The Ag NWs films on TA modified PDMS substrate exhibited excellent stability in Rs when subjected to a bending test.

关键词： Flexible conductive film Tannic acid Surface modification Transparence Adhesion

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Learning to Identify Footholds from Geometric Characteristics for a Six-legged Robot over Rugged Terrain

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Journal of Bionic Engineering 2020年第3期17卷 512-522页

作者： jie Chen Chong Liu Haibin zhao Yanhe Zhu jie zhao School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China

Foothold identification is a key ability for legged robots that allows generating terrain adaptive behaviors(e.g.,gait and control parameters)and thereby improving mobility in complex *** this end,this paper addresses the issue of foothold characterization and identification over rugged terrain,from the terrain geometry point of *** a terrain region that might be a potential foothold of a robotic leg,the characteristic features are extracted as two first-order partial derivatives and two curvature parameters of a quadric regression surface at this *** features are able to give an intuitive and,more importantly,accurate characterization towards the specific geometry of the ground *** this basis,a supervised learning technique,Support Vector Machine(SVM),is employed,seeking to Ieam a foothold identification policy from human expert *** a result,an SVM classifier is leamt using the extracted features and human-demonstrated labels,which is able to identify whether or not a certain ground location is suited as a safe foot support for a robotic *** is shown that over 90%identification rate can be achieved with the proposed ***,preliminary experiment is implemented with a six-legged robot to demonstrate the effectiveness of the proposed approach.

关键词： six-legged robot foothold characterization foothold identification geometric characteristics support vector machine

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Multidimensional Multiplicative Large Sets in Totally Minimal Systems

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Acta Mathematica Sinica,English Series 2023年第8期39卷 1635-1649页

作者： Jian jie zhao School of Mathematics Hangzhou Normal UniversityHangzhou 311121P.R.China

In this paper,it is shown that for a residual set of points in a totally minimal system with finitely many commuting homeomorphisms,the set of return times to any non-empty open set contains a subset with positive multidimensional multiplicative upper Banach density,extending a previous result by Glasscock,Koutsogiannis and ***,we give some combinatorial properties of the sets with positive multidimensional multiplicative upper Banach density.

关键词： Multidimensional multiplicative upper Banach density totally minimal systems

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A time integral formulation and algorithm for structural dynamics with nonlinear stiffness

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Acta Mechanica Sinica 2006年第5期22卷 479-485页

作者： Kaiping Yu jie zhao Department of Astronautical Science and Mechanics Harbin Institute of Technology Harbin 150001 China

A newly-developed numerical algorithm, which is called the new Generalized-α （G-α） method, is presented for solving structural dynamics problems with nonlinear stiffness. The traditional G-α method has undesired overshoot properties as for a class of α-method. In the present work, seven independent parameters are introduced into the single-step three-stage algorithmic formulations and the nonlinear internal force at every time interval is approximated by means of the generalized trapezoidal rule, and then the algorithm is implemented based on the finite difference theory. An analysis on the stability, accuracy, energy and overshoot properties of the proposed scheme is performed in the nonlinear regime. The values or the ranges of values of the seven independent parameters are determined in the analysis process. The computational results obtained by the new algorithm show that the displacement accuracy is of order two, and the acceleration can also be improved to a second order accuracy by a suitable choice of parameters. Obviously, the present algorithm is zero- stable, and the energy conservation or energy decay can be realized in the high-frequency range, which can be regarded as stable in an energy sense. The algorithmic overshoot can be completely avoided by using the new algorithm without any constraints with respect to the damping force and initial conditions.

关键词： Nonlinear structural dynamics Numerical algorithm Stability Overshoot

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Identifying superword level parallelism with extended directed dependence graph reachability

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Science China(Information Sciences) 2017年第1期60卷 214-216页

作者： jie zhao Rongcai zhao National Digital Switching System Engineering & Technological Research Center Computer Science Department cole Normale Supérieure

Dear editor,The increasing trend of multimedia applications’proliferation brings about multimedia extensions’wide use among existing microprocessors of mainstream manufacturers,e.g.,Intel’s MMX,AMD’s3DNow!,IBM’s VMX/Altivec,***,the implementation details behind these multimedia extensions vary from one architecture to another;hence,it generally comes in form of SIMD(single

关键词： node SIMD Identifying superword level parallelism with extended directed dependence graph reachability SLP

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Parametric Gait Online Generation of a Lower-limb Exoskeleton for Individuals with Paraplegia

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Journal of Bionic Engineering 2018年第6期15卷 941-949页

作者： Tianjiao Zheng Yanhe Zhu ZongweiZhang Sikai zhao jie Chen jie zhao State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150001 China School of Mechanical Engineering and Automation Northeastern University Shenyang 110819 China

Lower-limb exoskeletons can provide paraplegics with the ability to restore gait function. In the community ambulation, the user would frequently meet different floors, doorsills, and other obstacles. Therefore, parametric gait generation is a significant issue for this kind of exoskeletons. In this paper, a parametric gait online generation approach is proposed, which combines a parametric gait control method with a torque compensation control strategy, based on the state machine. In the torque compensation control, the reference tra- jectories of joint positions are obtained through compensating gravity, inertia, and friction, which is intent on the natural and well-directed source data. Based on the reference trajectories, the parametric gait control method is established, in which the gait can be controlled via three parameters： velocity, step-length, and step-height. Two test cases are performed on three healthy subjects. The results demonstrate that the parametric gait can be online generated smoothly and correctly, meanwhile every variable step can be triggered as users expect. The effectiveness and practicability of the gait generation approach proposed in this paper are validated. In addition, this research is the foundation of autonomous gait planning.

关键词： exoskeleton parametric gait gait online generation paraplegic bionic design

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Microstructural evolution and change in hardness during creep of NF709 austenitic stainless steel

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 220-224页

作者： Yan zhao jie zhao Xiaona LI School of Material Science and Engineering Dalian University of Technology Dalian 116085 China Key Laboratory of Materials Modification by Laser Ion and Electron Beams of Ministry of Education Dalian University of Technology Dalian 116085 China

Microstructural evolution and the change in hardness during creep deformation of NF709 austenitic stainless steel were investigated. Creep tests were carried out at 650 ℃ for 2932 h under a load of 210 MPa for comparison with aging specimen at 650 ℃ for 3000 h. The hardness results indicated that applied stress during creep process induced hardness increase. Analysis of longitudinal section microstructure showed that the creep damage caused by pores and the grain boundary hardening caused by elongated grains could be the factors leading to hardness differences. The C phase dispersedly precipitated in intragranular and interacted with dislocations during creep process, indicating strain hardening.

关键词： NFT09 Creep-introduced Hardness Microstructural evolution

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Improving Kinematic Flexibility and Walking Performance of a Six-legged Robot by Rationally Designing Leg Morphology

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Journal of Bionic Engineering 2019年第4期16卷 608-620页

作者： jie Chen Zhongchao Liang Yanhe Zhu jie zhao School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China

This paper explores the design of leg morphology in a six-legged *** by nature,where animals have different leg morphology,we examined how the difference in leg morphology influences behaviors of the *** this end,a systematic search was conducted by scanning over the parameter space consisting of default angles of leg joints of the six-legged robot,with two main objectives:to maximize the kinematic flexibility and walking performance of the *** show that(1)to have a high kinematic flexibility with both the torso and swing legs,the femur segment should tilt downwards by 5°-10°and the tibia segment should be vertically downwards or with a slight inward tilt;(2)to achieve relatively energy-efficient and steady walking,the tibia segment should be approximately vertically downwards,with the femur segment tilting upwards to lower the torso *** results of this study suggest that behaviors of legged robots can be passively enhanced by careful mechanical design choices,thereby leading to more competent legged machines.

关键词： six-legged robot leg morphology kinematic flexibility walking performance

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Essential Protein Prediction Based on Shuffled Frog-Leaping Algorithm

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Chinese Journal of Electronics 2021年第4期30卷 704-711页

作者： YANG Xiaoqin LEI Xiujuan zhao jie School of Computer Science Shaanxi Normal University

Essential proteins are integral parts of living organisms. The prediction of essential proteins facilitates to discover disease genes and drug targets. The prediction precision and robustness of most of existing identification methods are not satisfactory. In this paper,we propose a novel essential proteins prediction method(EPSFLA), which applies Shuffled frog-leaping algorithm(SFLA), and integrates several biological information with network topological structure to identify essential ***, the topological property and several biological properties(function annotation, subcellular localization,protein complex, and orthology) are integrated and utilized to weight protein-protein interaction *** the position of a frog is encoded and denotes a candidate essential protein set. The frog population continuously evolve by means of local exploration and global exploration until termination criteria for algorithm are satisfied. Finally, those proteins contained in the best frog are regarded as predicted essential proteins. The experimental results show that EPSFLA outperforms some well-known prediction methods in terms of various *** proposed method aims to provide a new perspective for essential protein prediction.

关键词： Computational biology Essential protein Protein-protein interaction(PPI) network Shuffled frog leap algorithm

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