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Effect of moxibustion on expression profile of miRNAs in Tripterygium glycoside-induced decreased ovarian reserve

Journal of Traditional Chinese Medicine 2024年第4期44卷 745-752页

作者： shen jie YIN Yaoli LI Hongxiao LU Ge ZHU Yaoyao QIN Yantong JIN Xun CHENG jie shen Meihong College of Acupuncture and Tuina Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the possible regulatory mechanism of microRNA(miRNA)in moxibustion treatment for decreased ovarian reserve(DOR).METHODS:The DOR model was constructed by intragastrical Tripterygium glycoside suspension administration,and moxibustion therapy was simultaneously *** morphological ovarian changes were observed by hematoxylin and eosin *** miRNA expression profile was detected by RNA sequencing,and bioinformatics analysis was *** software 3.6.1 was used to establish a regulatory network and differentially expressed miRNAs were verified by reverse transcription quantitative polymerase chain reaction(RT-qPCR).RESULTS:Decreased number of mature follicles,increased atresia follicles,and abnormal granulosa cell morphology were observed in the model group compared with the control *** moxibustion group demonstrated increased mature follicles,decreased atretic follicles,and significantly decreased abnormal morphology of granulosa cells compared with the model ***,RNA sequencing results manifested significantly up-regulated miRNA expressions(miR-92b-3p,miR-26-5p_R+1_1ss10TC,miR-206-3p,miR-9993b-3p_1ss6GA,miR-7857-3p_R-1,miR-219a-2-3p_1ss10GC,miR-3968-p5_1ss10AT,and PC-5p-6478_1795)and down-regulated miR-664-2-5p_R+1 in the model group,compared with the control group,and the moxibustion group reversed abnormal disorder levels of these ***,these differentially expressed miRNAs were mainly involved in the phosphatidylinositol-3-kinase/protein kinase B signaling pathway and nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 signaling ***,network and RT-qPCR verification revealed miR-9993b-3p_1ss6GA as the most critical ***:This experiment proved the effectiveness of moxibustion in improving the ovarian reserve of rats by regulating miRNA expression,especially miR-9993b-3p_1ss6GA.

关键词： ovarian reserve moxibustion microRNAs mechanics

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Mechanistic study on 4,4'-sulfonylbis removal with CO_(2)/Ar gas-liquid DBD plasma

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Plasma Science and Technology 2024年第10期26卷 82-92页

作者： Guangjia WANG Shidong FANG Baoguo LIN Chengzhu ZHU jie shen School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009People’s Republic of China Institute of Plasma Physics HFIPSChinese Academy of SciencesHefei 230031People’s Republic of China Anhui Kexin Environmental Protection Co.Ltd. Hefei 230031People’s Republic of China

In this study,a single dielectric barrier discharge(DBD)coaxial reactor was used to degrade 4,4'-sulfonylbis(TBBPS)in water using greenhouse gas(CO_(2))and argon as the carrier *** investigation focused on CO_(2)conversion,reactive species formation,gas-liquid mass transfer mechanism,and degradation mechanism of TBBPS during the discharge plasma *** the decrease of CO_(2)/Ar ratio in the process of plasma discharge,the emission spectrum intensity of Ar,CO_(2)and excited reactive species was *** increase promoted collision and dissociation of CO_(2),resulting in a series of chemical reactions that improved the production of reactive species such as·OH,^(1)O_(2),H_(2)O_(2)and O_(3).These reactive species initiated a sequence of reactions with *** indicated that at a gas flow rate of 240 mL/min with a CO_(2)/Ar ratio of 1:5,both the highest CO_(2)conversion rate(17.76%)and TBBPS degradation rate(94.24%)were *** degradation mechanism was elucidated by determining types and contents of reactive species present in treatment liquid along with analysis of intermediate products using liquid chromatography-mass spectrometry *** research provides novel insights into carbon dioxide utilization and water pollution control through dielectric barrier discharge plasma technology.

关键词： dielectric barrier discharge carbon dioxide conversion 4 4'-sulfonylbis wastewater treatment

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Magnetic emission intensity enhancement for amorphous alloys by constructing a multi-phase structure withα-Fe nanocrystals

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Nano Research 2024年第7期17卷 6630-6637页

作者： Ke Liu Zhi Qin jie shen Zhi Cheng Shiyue You Liang Ma Jing Zhou Wen Chen State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park Wuhan University of TechnologySanya 572024China Hubei Longzhong Laboratory Wuhan University of Technology Xiangyang Demonstration ZoneXiangyang 441000China

The perturbation in the magnetic field generated by the rotation or oscillation of magnetic domains in magnetic materials can emit low-frequency electromagnetic waves,which are expected to be used in low-frequency ***,the magnetic emission intensity,defined by the perturbation ability,of current commercially applied amorphous alloys,such as Metglas,cannot meet the application requirements for low-frequency antennas due to the domain motion energy ***,a multi-phase Metglas amorphous alloy was constructed by incorporatingα-Fe nanocrystals using rapid annealing to manipulate the domain *** was found that 3.89 times higher magnetic emission intensity is obtained compared to the pristine due to the synergism of the deformation and displacement ***,the low-frequency magnetic emission performance verification was carried out by preparing magnetoelectric composites as the antenna vibrator by assembling the alloy and macro piezoelectric fiber composites(MFC).Enhancements of magnetic emission intensity are found at 93.3%and 49.2%at the first and second harmonic frequencies compared with the unmodified alloy ***,the approach leads to the development of high-performance communication with a novel standard for evaluation.

关键词： multi-phase amorphous alloys magnetic emission intensity enhancing mechanism magnetic domain pinning theory Jiles-Atherton model analysis

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Long non-coding RNA GATA6-AS1 is mediated by N6-methyladenosine methylation and inhibits the proliferation and metastasis of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1019-1028页

作者： Jun-jie shen Min-Chang Li Shao-Qi Tian Wen-Ming Chen Department of Oncology Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Department of Hepatopancreatobiliary Surgery Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Clinical Medical School Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Oncology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

BACKGROUND Through experimental research on the biological function of GATA6-AS1,it was confirmed that GATA6-AS1 can inhibit the proliferation,invasion,and migration of gastric cancer cells,suggesting that GATA6-AS1 plays a role as an anti-oncogene in the occurrence and development of gastric *** experi-ments confirmed that the overexpression of fat mass and obesity-associated protein(FTO)inhibited the expression of GATA6-AS1,thereby promoting the occurrence and development of gastric *** To investigate the effects of GATA6-AS1 on the proliferation,invasion and migration of gastric cancer cells and its mechanism of *** We used bioinformatics methods to analyze the Cancer Genome Atlas(https://***/.The Cancer Genome Atlas)and download expression data for GATA6-AS1 in gastric cancer tissue and normal *** also constructed a GATA6-AS1 lentivirus overexpression vector which was transfected into gastric cancer cells to investigate its effects on proliferation,migration and invasion,and thereby clarify the expression of GATA6-AS1 in gastric cancer and its biological role in the genesis and development of gastric ***,we used a database(http://***/starbase2/)to analysis GATA6-AS1 whether by m6A methylation modify regulation and predict the methyltransferases that may methylate ***,RNA immunoprecipitation experiments confirmed that GATA6-AS1 was able to bind to the m6A methylation modification *** data allowed us to clarify the ability of m6A methylase to influence the action of GATA6-AS1 and its role in the occurrence and development of gastric *** Low expression levels of GATA6-AS1 were detected in gastric *** also determined the effects of GATA6-AS1 overexpression on the biological function of gastric cancer ***6-AS1 had strong binding ability with the m6A demethylase FTO,which was expressed at high levels in gastric cancer and negatively correlat

关键词： Long non-coding RNA GATA6-AS1 N6-methyladenine modification Fat mass and obesity-associated protein Gastric cancer

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Convenient folding-hot-pressing fabrication and enhanced piezoelectric properties of highβ-phasecontent poly(vinylidene fluoride)films

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Interdisciplinary Materials 2024年第5期3卷 715-725页

作者： jie shen Yicheng Zeng Qiangzhi Li Jing Zhou Wen Chen State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhanChina Sanya Science and Education Innovation Park Wuhan University of TechnologySanyaChina Hubei Longzhong Laboratory Wuhan University of Technology Xiangyang Demonstration ZoneXiangyangChina

Poly(vinylidene fluoride)(PVDF)is the most attractive piezoelectric polymer for application in flexible *** attain excellent piezoelectric properties,a substantial amount of spontaneous polarβ-phase content is highly ***,the current reported manufacturing methods to increaseβ-phase contents are inconvenient and complex,hindering progress in PVDF's *** work proposes a folding-hot-pressing method to fabricate highβ-phase-content PVDF *** characterization indicates that the films haveαandβphases and the folding-hot-pressing process transforms theαphase into theβ*** to the 97.5%β-phase content and aligned structure,a piezoelectric constant of 20 pC/N is achieved in the three-times folded ***,the process method enhances the tensile strength(126.2 MPa)of the films,with a low Young's modulus(0.87 GPa)remaining,making the films applicable for flexible piezoelectric ***,sensors based on the achieved films were assembled and applied for human physiological activity *** work offers a scalable new melt-processing strategy for developing high-performance PVDF-based piezo-electric composite films for wearable electronic devices.

关键词： flexible sensors highβ-phase content piezoelectric properties PVDF film

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Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy

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Chinese Chemical Letters 2024年第10期35卷 205-212页

作者： Ying Gao Rong Zhou Qiwen Wang Shaolong Qi Yuanyuan Lv Shuang Liu jie shen Guocan Yu Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015 China Department of Cardiology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China MOE Key Laboratoryof Bioorganic Phosphorus Chemistry & Chemical Biology Department of ChemistryTsinghua UniversityBeijing04Chin Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

Photodynamic therapy(PDT)has garnered significant attention as a promising approach to cancer therapy,harnessing the combined benefits of localized light treatment and the accompanying host immune *** this study,we engineered an immuno-enhanced PDT nanoplatform,denoted as HM@p-MOF(hybrid membrane@porphyrin-metal organic framework).The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells,resulting in enhanced *** both in vitro and in vivo experiments,our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform,leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death(ICD)induced by photodynamic ***,in conjunction with the immunomodulatory functions of the NK cell membrane,we observed an expansion of in situ immune infiltration leading to a systemic immune *** HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress *** innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic *** provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.

关键词： Biomimetic Cell membrane Metal-organic framework Phototherapy Tumor targeting

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Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 364-371页

作者： Ji-Chun Tang Jia-Wei Ma Jin-Jin Jian jie shen Liang-Liang Cao Department of Anesthesiology The Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Anesthesiology People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture 843599Xinjiang Uygur Autonomous RegionChina Department of Critical Care Medicine Jiangnan University Medical CenterWuxi 214122Jiangsu ProvinceChina Department of Critical Care Medicine People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture843599Xinjiang Uygur Autonomous RegionChina

BACKGROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative *** current approach involves intravenous self-control analgesia,often utilizing opioid analgesics such as morphine,sufentanil,and *** for colo-rectal cancer typically involves general ***,optimizing anes-thetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative *** study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients'postoperative *** To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal *** Following the inclusion criteria and exclusion criteria,a total of 126 patients with colorectal cancer admitted to our hospital from January 2020 to December 2022 were included,of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group,and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research *** data collection,the effects of postoperative analgesia,sedation,and recovery were *** Compared to the control group,the research group had shorter recovery times for orientation,extubation,eye-opening,and spontaneous respiration(P<0.05).The research group also showed lower Visual analog scale scores at 24 h and 48 h,higher Ramany scores at 6 h and 12 h,and improved cognitive function at 24 h,48 h,and 72 h(P<0.05).Additionally,interleukin-6 and interleukin-10 levels were significantly reduced at various time points in the research group compared to the control group(P<0.05).Levels of CD3+,CD4+,and CD4+/CD8+were also lower in the research group at multiple time points(P<0.05).CONCLUSION For patients with colorectal cancer,g

关键词： Multimodal analgesia Anesthesia Colorectal cancer Postoperative pain

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Absence of ultrasonic-vibration-induced plasticity in metallic glacial glasses

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Rare Metals 2024年第7期43卷 3422-3429页

作者： Zhe Chen Shuai Ren Jian Zhu jie shen Xin Li He-Ting Zhang Hong-Ji Lin Sajad Sohrabi Wen-Qing Ruan Zhen-Xuan Zhang Xiong Liang Jiang Ma Jun shen shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060China Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Mechanical Electrical and Information EngineeringShandong UniversityWeihai 264209China

Metallic glasses (MGs) have been found to exhibit unexpected ultrasonic-vibration-induced plasticity (UVIP),which provides a promising way to realize room temperature processing and molding of ***,whether all MGs poss... 详细信息

关键词： glasses metallic plasticity

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Characterization of the CpsQ Regulon Reveals Its Role in the Transcription of Type Ⅵ Secretion System 2 Genes in Vibrio parahaemolyticus

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Biomedical and Environmental Sciences 2024年第4期37卷 436-439页

作者： LUO Xi LI Xue ZHANG Miao Miao HUANG Qing Lian ZHANG Yi Quan JI shen jie LU Ren Fei Department of Clinical Laboratory Affiliated Nantong Hospital 3 of Nantong UniversityNantong Third People’s HospitalNantong 226006JiangsuChina Department of Clinical Laboratory Qidong People’s HospitalQidong 226200JiangsuChina

Vibrio parahaemolyticus,a gram-negative halophilic bacterium that naturally inhabits coastal waters,causes gastroenteritis,skin infections,and septicemia in human beings[1].This bacterium produces multiple virulence factors,including thermostable direct hemolysin(TDH),TDH-related hemolysin(TRH),type Ⅲ secretion system 1(T3SS1),T3SS2,type Ⅵ secretion system 1(T6SS1),and T6SS2[1].Furthermore,Ⅴ.parahaemolyticus forms biofilms on the surface,which help it in adapting to unfavorable conditions[2].Mature biofilm formation requires special structures,including lateral and polar flagella,exopolysaccharide(EPS),and type Ⅳ pili[2].

关键词： coastal system T3SS

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1943年新绥公司资助边疆学生赴内地升学事件研究——以国家、地方与社会互动为视角

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新疆大学学报（哲学社会科学版） 2024年第4期52卷 55-62页

作者：沈杰华中师范大学中国近代史研究所湖北武汉430079

1943年下半年,新绥公司总经理朱炳先后向国民政府提出资助新疆及西北五省学子赴内地国立大学升学的计划。教育部对此深表嘉许和支持。然而主政新疆的盛世才虽已公开投归国民党中央,但依旧心存防范,抛出朱炳阴谋破坏新疆、勾结日军、危... 详细信息

1943年下半年,新绥公司总经理朱炳先后向国民政府提出资助新疆及西北五省学子赴内地国立大学升学的计划。教育部对此深表嘉许和支持。然而主政新疆的盛世才虽已公开投归国民党中央,但依旧心存防范,抛出朱炳阴谋破坏新疆、勾结日军、危害国家等罪名,反对实施该计划,试图抵制新疆与内地日益密切的联系。最终,尚未在新疆站稳脚跟的国民政府选择向地方势力暂时妥协,资助计划被迫搁浅。此事件乃抗战时期以民族企业为代表的社会力量主动参与国家边疆教育事业的典型案例,反映了国家、地方与社会的复杂纠葛,凸显出制约战时边疆教育发展的历史困局,并提示特殊政治生态下的边疆教育史研究在中央与地方之外的社会力量尚有进一步探讨的余地。

关键词：新绥公司朱炳盛世才教育部边疆教育

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