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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang jie lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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适变与应变:“十五五”时期人口发展规划的新格局、新挑战及其实践路径

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河北学刊 2025年第1期45卷 130-139页

作者：陆杰华冯雨欣北京大学中国社会与发展研究中心北京大学社会学系

“十五五”时期是中国基本实现社会主义现代化承上启下的关键时期,同时也是人口发展深度转型的重要节点。“十五五”人口发展规划的制定必须准确识别人口规模、结构、素质、分布等要素呈现的趋势性变化,及时把握当前人口发展的潜在机遇... 详细信息

“十五五”时期是中国基本实现社会主义现代化承上启下的关键时期,同时也是人口发展深度转型的重要节点。“十五五”人口发展规划的制定必须准确识别人口规模、结构、素质、分布等要素呈现的趋势性变化,及时把握当前人口发展的潜在机遇和堵点难点,根据人口发展新格局适时调整应变思路,不断推进人口自身均衡发展,以及人口与经济社会、资源环境的协调发展。从长远来看,人口发展规划的制定还需要纵向锚定人口高质量发展的战略目标,形成应对未来人口发展新变化的超前预案。

关键词： “十五五” 人口发展规划人口高质量发展适变与应变

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Studies on Thermal Stability and Fluid Property of PVC Filled with Hydrotalcite

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Chemical Research in Chinese Universities 2002年第4期18卷 424-426页

作者： ZHANG Qiang lu jie-bin College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing 100029P.R.China

Hydrotalcite can act as a co-stabilizer with other main stabilizer for poly(vinyl chloride)(PVC). The thermal stability and fluid property of PVC filled with hydrotalcite surface-treated with titanate and silane were studied in this work. Organic Sn is a main stabilizer and hydrotalcite is a stabilizing assistant. The stability of the PVC resin mixed with organic Sn and hydrotalcite is better than that of the PVC resin mixed with organic Sn alone. It is shown that the PVC resin filled with hydrotalcite possesses a better static and dynamic heat stability. Moreover, hydrotalcite can improve the fluid property of PVC, which is advantageous to the processing of PVC, and the optimum content of hydrotalcite is about 1%-2%(mass fraction).

关键词： Hydrotalcite PVC Thermal stability Fluid property

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Improvement and application of GM(1,1) model based on multivariable dynamic optimization

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Journal of Systems Engineering and Electronics 2020年第3期31卷 593-601页

作者： WANG Yuhong lu jie School of Business Jiangnan UniversityWuxi 214122China

For the classical GM(1,1)model,the prediction accuracy is not high,and the optimization of the initial and background values is *** this paper,the Lagrange mean value theorem is used to construct the background value as a variable related to *** the same time,the initial value is set as a variable,and the corresponding optimal parameter and the time response formula are determined according to the minimum value of mean relative error(MRE).Combined with the domestic natural gas annual consumption data,the classical model and the improved GM(1,1)model are applied to the calculation and error comparison *** proves that the improved model is better than any other models.

关键词： grey prediction GM(1,1)model background value grey system theory

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Functional Envelope of Cantor Spaces

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Acta Mathematica Sinica,English Series 2017年第3期33卷 327-340页

作者： Xing Fu ZHONG jie lu School of Mathematics Sun Yat-Sen University Guangzhou 510275 P. R. China School of Mathematics South China Normal University Guangzhou 510630 P. R. China

Given a topological dynamical system （X, T）, where X is a compact metric space and T a continuous selfmap of X. Denote by S（X） the space of all continuous selfmaps of X with the compactopen topology. The functional envelope of （X,T） is the system （S（X）,FT）, where FT is defined by FT（φ） = T o φ for any φ ∈ S（X）. We show that （1） If （∑, T） is respectively weakly mixing, strongly mixing, diagonally transitive, then so is its functional envelope, where ∑ is any closed subset of a Cantor set and T a selfmap of ∑ （2） If （S（∑）,Fσ） is transitive then it is Devaney chaos, where （∑, σ） is a subshift of finite type; （3） If （∑, T） has shadowing property, then （Su （∑）, FT） has shadowing property, where ∑ is any closed subset of a Cantor set and T a selfmap of ∑; （4） If （X,T） is sensitive, where X is an interval or any closed subset of a Cantor set and T： X → X is continuous, then （Su（X）,FT） is sensitive; （5） If ∑, is a closed subset of a Cantor set with infinite points and T ：∑ →∑ is positively expansive then the entropy entv（FT） of the functional envelope of （∑, T） is infinity.

关键词： Mixing topological entropy Cantor spaces functional envelopes

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End-to-end data-driven modeling framework for automated and trustworthy short-term building energy load forecasting

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Building Simulation 2024年第8期17卷 1419-1437页

作者： Chaobo Zhang jie lu Jiahua Huang Yang Zhao Department of the Built Environment Eindhoven University of TechnologyEindhovenThe Netherlands Energy Efficient Cities Initiative Department of EngineeringUniversity of CambridgeCambridgeUK Institute of Refrigeration and Cryogenics Zhejiang UniversityHangzhouChina Institute of Green Building and Engineering Design Zhejiang Province Institute of Architectural Design and Research Co.Ltd.HangzhouChina Key Laboratory of Clean Energy and Carbon Neutrality of Zhejiang Province Jiaxing Research InstituteZhejiang UniversityJiaxingChina

Conventional automated machine learning(AutoML)technologies fall short in preprocessing low-quality raw data and adapting to varying indoor and outdoor environments,leading to accuracy reduction in forecasting short-term building energy ***,their predictions are not transparent because of their black box ***,the building field currently lacks an AutoML framework capable of data quality enhancement,environment self-adaptation,and model *** address this research gap,an improved AutoML-based end-to-end data-driven modeling framework is *** optimization is applied by this framework to find an optimal data preprocessing process for quality improvement of raw *** bridges the gap where conventional AutoML technologies cannot automatically handle missing data and outliers.A sliding window-based model retraining strategy is utilized to achieve environment self-adaptation,contributing to the accuracy enhancement of AutoML ***,a local interpretable model-agnostic explanations-based approach is developed to interpret predictions made by the improved *** overcomes the poor interpretability of conventional AutoML *** performance of the improved framework in forecasting one-hour ahead cooling loads is evaluated using two-year operational data from a real *** is discovered that the accuracy of the improved framework increases by 4.24%–8.79%compared with four conventional frameworks for buildings with not only high-quality but also low-quality operational ***,it is demonstrated that the developed model interpretation approach can effectively explain the predictions of the improved *** improved framework offers a novel perspective on creating accurate and reliable AutoML frameworks tailored to building energy load prediction tasks and other similar tasks.

关键词： building energy load forecasting end-to-end data-driven modeling automated machine learning Bayesian optimization model retraining model interpretation

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Preliminary study of non-isothermal phase change phenomena in vertical Bridgman crystal growth

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Chinese Science Bulletin 2007年第5期52卷 701-710页

作者： LIU jie lu WenQiang College of Physical Sciences Graduate University of Chinese Academy of Sciences Beijing 100049 China

Axisymmetric dual reciprocity boundary element method (DRBEM) with augmented items is extended to simulate the heat and mass transfer problems in the vertical Bridgman method (VBM) crystal growth of HgCdTe and CdZnTe. Axial solute concentration redistribution of three regions numerically reap-pears, and the influence of the pulling rate of the ampoule on it is further studied. Secondly, one di-mensional transient phase change phenomena is studied, and non-isothermal phase change phe-nomena is obtained from the initial transient region through the steady growth region to the final tran-sient region. Thirdly, the two-dimensional axisymmetric phase change interface position, interfacial shape and the temperature field of the melt and the crystal are numerically captured under the condi-tion to arrive at the steady state with zero pulling rate of the ampoule. Finally, the study of transient axisymmetric non-isothermal phase change phenomena is stressed and the results are compared with those in isothermal phase change. The influence of the pulling rate on non-isothermal phase change phenomena is revealed.

关键词：法向布里奇曼法晶体生长非等温相变 HgCdTe CdZnTe 半导体材料

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Mechanical Simulation of a Diatom Frustule Structure

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Journal of Bionic Engineering 2015年第1期12卷 98-108页

作者： jie lu Cheng Sun Q. Jane Wang Department of Mechanical Engineering Northwestern University Evanston IL 60208

Diatoms possess intricately complicated nanopatterned silica outer shells, the so called frustules. Due to their excellent three-dimensional （3D） nanostructures, diatom frustules have attracted attentions from many fields to look for potential appli- cations, such as structural material design, light harvesting, photonics, molecular separation and bio-sensing. However, the mechanical property of frustule, especially the role of each single portion that structures a frustule, need to be clearly examined in order to provide a scientific support to frustule utilization. The reported work uses the Finite-Element （FE）-based simulation to investigate the relative mechanical properties of the frustule of the diatom Coscinodiscus sp. as compared with reference non-frustule structures. A three-dimensional model for the three featured layers of this frustule and a simplified model for its girdle band are built with the assistance of ABAQUS. A basic-cell concept is suggested; and the comparative results of several simulation groups are reported. The numerical results indicate that the seven-unit-cell model is able to catch the essential me- chanics of the Coscinodiscus sp. frustule under pressure and that the layered and porous structure of this frustule can effectively resist pressure.

关键词： diatom frustule FE simulation structure analysis bio-material

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Flow Characteristics of Expansion Energy Used Pneumatic Booster

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Chinese Journal of Mechanical Engineering 2012年第5期25卷 889-896页

作者： SHI Yan CAI Maolin XU Weiqing lu jie School of Automation Science and Electrical Engineering Beihang University Beijing 100191 China National Quality Supervision andInspection Center of Pneumatic Products Fenghua 315500 China

The most common booster is called input pressure reduced （IPR） booster. However, this type of booster has its own shortages, such as its small output flow, when the boosting ratio is higher, the shortage becomes more distinct. Recent research on pneumatic boosters mainly focused on the factors that influence the characteristics of the boosters, some new kinds of pneumatic booster structures were designed, but the efficiency and output flow of these boosters are still not improved sufficiently. In order to improve the output flow of the pneumatic booster, a new kind of booster, expansion energy used （EEU） booster, is proposed. Non-linear differential equations of the pneumatic booster are set up. By using the software MATLAB/Simulink for simulation, the motion characteristics of the pistons, the characteristics of the output flow of the boosters are obtained for analysis of a principle. The principle, which is used to elevate the output flow of the two kinds of boosters, is that the average pressure of the air in the driving chambers of the EEU booster is higher than that of the IPR booster. The simulation and experimental research of the output flow characteristics are done. The simulation and experimental results are in a good accordance. And the simulation and experimental results show that when the air source pressure and the output pressure are set at 0.6 MPa and 0.8 MPa, respectively, with the increase of the terminal pressure of the air in the driving chamber, the output flow of the IPR booster ascends stably. As the terminal pressure of the air in the driving chamber goes up, the output flow of the EEU booster rises, and later it almost remains constant. In addition, with the same terminal pressure, the output flow of the EEU booster is greater than that of the IPR booster, and the difference decreases when the terminal pressure grows. At last, the output pressure is set at 0.8 MPa, under the optimum work state of the EEU booster, the output flow of the two k

关键词： pneumatic system booster modeling simulation experimental study

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Reference gene validation for quantification of gene expression during final oocyte maturation induced by diethylstilbestrol and di-(2-ethylhexyl)-phthalate in common carp

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Journal of Environmental Sciences 2016年第8期28卷 47-54页

作者： Yanyan Shi jie lu Yilei Wang Shuhong Wang Fisheries College Jimei University School of Physics and Mechanical & Electrical Engineering Xiamen University

Final oocyte maturation is the key step to successful spawning and *** real-time PCR（q PCR） is the technique of election to quantify the abundance of functional genes in such study. Reference gene is essential for correct interpretation of q PCR data. However, an ideal universal reference gene that is stable under all experimental circumstances has not been described. Researchers should validate their reference genes while performing q PCR analysis. The expression of 6 candidate reference genes： 18 s r RNA,28 s r RNA, Cathepsin Z, Elongation factor 1-α, Glyceraldehyde-3-phosphate dehydrogenase andβ-actin were investigated during final oocyte maturation induced by different compounds（DES and DEHP） in common carp（Cyprinus carpio）. Four softwares（Bestkeeper, ge Norm,Norm Finder and Ref Finder） were used to screen the most stable gene in order to evaluate their expression stability. The results revealed that EF1α was highly stable expressed when final oocyte maturation was induced by DES, while gapdh was the most stable gene when final oocyte maturation was induced by DEHP. Stable expressed reference gene selection is critical for all q PCR analysis to get accurate target gene m RNA expression information.

关键词： Cyprinus carpio Reference gene Final oocyte maturation Diethylstilbestrol Di-(2-ethylhexyl)-phthalate

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