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Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

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Eye and Vision 2024年第3期10卷 1-12页

作者： Meifang Yan Junjian Li Li Yan Xue Li jie-Guang chen School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityState Key Laboratory of OptometryOphthalmology and Vision Scienceand Zhejiang Provincial Key Laboratory of Optometry and Ophthalmology270 Xueyuan RoadWenzhouZhejiang325027People’s Republic of China Joint Shantou International Eye Center(JSIEC)of Shantou University and the Chinese University of Hong Kong ShantouGuangdong515000People’s Republic of China

Background The exudative form of age-related macular degeneration(AMD)is characterized by abnormal blood vessel growth,which is stimulated by vascular endothelial growth factor(VEGF)released from retinal pigment epithelium(RPE).The angiogenic behaviors of vascular endothelial cells in vitro depend on forkhead box protein P1(Foxp1),a transcription repressor widely expressed in human and murine tissues during *** this study,we aimed to determine whether loss of Foxp1 affects laser-induced choroidal neovascularization(CNV)in *** Eye-selective deletion of Foxp1 was obtained by crossing Foxp1flox/flox with Six3-Cre *** photocoagulation was delivered to six-to eight-week-old mice to induce *** expression of Foxp1 and Cre was determined by immunofluorescence in cryostat sections of the *** fluorescein angiography(FFA),optical coherence tomography(OCT),and B4 isolectin staining were applied to analyze the leakage,bulge height,and area of CNV lesions,***-choroid tissues were isolated for the determination of VEGF and pigment epithelium derived factor(PEDF)by Western *** Foxp1 was expressed in retinal ganglion cells,RPE,and the choroidal endothelial *** photocoagulation increased the number of Foxp1+-endothelial cells and induced ***3-Cre reduced Foxp1 expression in RPE but not the endothelium,leading to a lower level of VEGF in the ***1 knockout inhibited pathological angiogenesis and vascular leakage of the laser-induced CNV *** Foxp1 regulates the expression of VEGF in the RPE,and inhibition of Foxp1 could potentially be a novel strategy for the prevention and therapy of neovascularization related to AMD.

关键词： Foxp1 Choroidal neovascularization Angiogenesis Laser photocoagulation Age-related macular degeneration

Significant effect of ordered micro-domain on cell boundary phase distribution and demagnetization curve squareness of Sm_(2)Co_(17)-type magnet

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Rare Metals 2024年第4期43卷 1724-1735页

作者： Zhuang Liu Hai-chen Wu Chao-Yue Zhang Chao-Qun Zhu Guo-Xin chen Huan-Ming Lu Ren-jie chen Aru Yan CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China Analytical Center Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China

Cu-rich cell boundary phase is difficult to precipitate evenly,resulting in a generally poor demagnetization curve squareness for Fe-rich Sm_(2)Co_(17)-type magnet,which is a key factor limiting the further improvement of magnetic energy *** this study,we report that nanoscale strip-like ordered micro-domains distributed in1:7H disordered matrix phase of the solid solution precursor is a new factor significantly affecting the precipitation and distribution of the cell boundary *** strip-like and continuous micro-twin structure with twin boundaries neatly perpendicular to the C-axis is observed after sintering *** solution treatment,sequential and long strip-like micro-twins gradually transform into disordered state along the basal plane,forming narrow disordered 1:7H(TbCu_(7)-type structure)phase between the separated strip-like ordered *** disordering transformation takes place via broken down of the long strip-like ordered micro-domains,which is accomplished by narrowing along the width direction followed by reduction of the ***,a new model revealing the effect of the ordered micro-domains on the formation of the cell boundary phase is *** boundaries enriched in Cu have already existed in the precursor with long strip-like ordered ***,the Cu-rich cell boundary phase acting as strong pinning centers cannot be precipitated homogeneously and distributed continuously after aging,resulting in a poor demagnetization curve squareness of Sm_(2)Co_(17)-type *** results indicate that significant broken down of the nanoscale ordered micro-domains in solution precursor is the key factor improving the distribution of cell boundary phase in Sm_(2)Co_(17)-type magnets.

关键词： Sm_(2)Co_(17) magnets Solution precursor Ordered micro-domains Disordering transformation Cellular structure

MgSO·7HO for thermochemical energy storage: dehydration and hydration kinetics and cyclability

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储能科学与技术 2024年

作者： chen jie Ma Hongkun Ding Yulong Birmingham Centre for Energy Storage， University of Birmingham

The use of MgSO4·7H2O （Epsomite） as a potential thermochemical based thermal energy storage material has attracted considerable attention in recent decades. This material has a high theoretical energy density with abundant availability and low costs. Despite considerable efforts， little progress has been made in achieving the high energy density， largely due to insufficient understanding of the reaction mechanisms and unfavourable dehydration/hydration kinetics. A systematic study on the hydration/dehydration kinetics and cyclability of MgSO4·7H2O has therefore been conducted in this study. The results show conclusively that the dehydration process depends on the heating rate with the 5 ℃/min being the optimal， leading to seven steps of MgSO4·7H2O dehydration with the dehydration heat very close to the theoretical value. The reaction kinetic studies show that the rate of hydration is ～50% lower than that of dehydration. The thermal cycling tests of MgSO4·7H2O under the conditions of this study （small sample size） suggest a good cyclability， with the hydration rate increasing with increasing cycling number up to ～10 cycles where level-off occurs. This is consistent with scanning electron microscopic analyses， which shows the formation of cracks and channels on the salt hydrate particles， facilitating mass transfer and the enhanced kinetics.

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Recent Advances on Networked Systems and Intelligent Control--Dedicated to a Visionary Leader:*** Xie's 60th Birthday

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Journal of Systems Science & Complexity 2024年第1期37卷 1-2页

作者： jie chen jie Huang Zongli Lin Tongji University The Chinese University of Hong Kong China University of Virginia

It is with great pleasure and admiration that we celebrate the 60th birthday of ProfessorLihua Xie, a distinguished researcher and visionary leader in the field of robust control andestimation. Prof. Xie’s remarkable journey, marked by outstanding achievements and groundbreaking contributions, has left an indelible mark on the world of engineering and academia.

关键词： estimation breaking outstanding

Construct a 3D microsphere of HMX/B/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： Jian Wang jie chen Yaofeng Mao Yongjun Deng Wei Cao Fude Nie Jun Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy ***,the low combustion efficiency and reactivity of metal fuels,especially boron(B),severely limit their practical ***,multi-component 3D microspheres of HMX/B/Al/PTFE(HBA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion *** reactivity and energy output of HBA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb *** to the increased interfacial contact and reaction area,HBA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HBA-P).Meanwhile,HBA also shows enhanced energy output and reactivity than 3D microspheres of HMX/B/PTFE(HB)resulting from the high reactivity of *** reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HBA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and B_(2)O_(3))and the initiation effect of Al to *** work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： HMX/B/Al/PTFE 3D microspheres Surface etching Reaction mechanism

Anti-abrasion collagen fiber-based membrane functionalized by UiO-66-NH_(2)with ultra-high efficiency and stability for oil-in-water emulsions separation

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Chinese Journal of Chemical Engineering 2024年第2期66卷 285-297页

作者： Xiaoxia Ye Rixin Huang Zhihong Zheng Juan Liu jie chen Yuancai Lv College of Environmental and Safety Engineering Fuzhou UniversityFuzhou 350108China College of Chemical Engineering Fuzhou UniversityFuzhou 350108China

Membrane separation strategies offer promising platform for the emulsion ***,the low mechanical strength of membrane separation layers and the trade-off between separation flux and efficiency present significant *** this study,we report a CFM@UiO-66-NH_(2)membrane with high separation flux,efficiency and stability,through utilizing a robust anti-abrasion collagen fiber membrane(CFM)as the multifunctional support and UiO-66-NH_(2)by an in-situ growth as the separation *** high mechanical strength of the CFM compensated for the weakness of the separation layer,while the charge-breaking effect of UiO-66-NH_(2),along with the size sieving of its constituent separating layers and the capillary effect of the collagen fibers,contributed to the potential for efficient ***,the CFM@UiO-66-NH_(2)membrane exhibited superhydrophilic properties,making it suitable for separating oil-in-water microemulsions and nanoemulsions stabilized by anionic *** membrane demonstrated remarkable separation efficiencies of up to 99.960%and a separation flux of370.05 L·m^(-2)·h^(-1).Moreover,it exhibits stability,durability,and abrasion resistance,maintaining excellent separation performance even when exposed to strong acids and alkalis without any damage to its structure and *** six cycles of reuse,it achieved a separation flux of 417.97 L·m^(-2)·h^(-1)and a separation efficiency of 99.747%.Furthermore,after undergoing 500 cycles of strong abrasion,the separation flux remained at 124.39 L·m^(-2)·h^(-1),with a separation efficiency of 99.992%.These properties make it suitable for the long-term use in harsh operating *** attribute these properties to the electrostatic effect resulting from the amino group on UiO-66-NH_(2)and its in-situ growth on the CFM,which forms a size-screening separation *** work highlights the potential of the CFM@UiO-66-NH_(2)membrane as an environmentally friendly size-screening

关键词： Collagen fibers Metal-organic frameworks Oil-in-water emulsion separation Size sieving

Enhancing microseismic/acoustic emission source localization accuracy with an outlier-robust kernel density estimation approach

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International Journal of Mining Science and Technology 2024年第7期34卷 943-956页

作者： jie chen Huiqiong Huang Yichao Rui Yuanyuan Pu Sheng Zhang Zheng Li Wenzhong Wang State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Central South UniversityChangsha 410083China Chongqing City Construction Investment Group Co. Ltd.Chongqing 400023China Coal Geological Exploration Institute of Gansu Lanzhou 730000China

Monitoring sensors in complex engineering environments often record abnormal data,leading to significant positioning *** reduce the influence of abnormal arrival times,we introduce an innovative,outlier-robust localization method that integrates kernel density estimation(KDE)with damping linear correction to enhance the precision of microseismic/acoustic emission(MS/AE)source *** approach systematically addresses abnormal arrival times through a three-step process:initial location by 4-arrival combinations,elimination of outliers based on three-dimensional KDE,and refinement using a linear correction with an adaptive damping *** validate our method through lead-breaking experiments,demonstrating over a 23%improvement in positioning accuracy with a maximum error of 9.12 mm(relative error of 15.80%)—outperforming 4 existing *** under various system errors,outlier scales,and ratios substantiate our method’s superior *** blasting experiments also confirm the practical applicability,with an average positioning error of 11.71 m(relative error of 7.59%),compared to 23.56,66.09,16.95,and 28.52 m for other *** research is significant as it enhances the robustness of MS/AE source localization when confronted with data *** also provides a practical solution for real-world engineering and safety monitoring applications.

关键词： Microseismic source/acoustic emission(MS/AE) Kernel density estimation(KDE) Damping linear correction Source location Abnormal arrivals

The association and underlying mechanism of the digit ratio(2D:4D)in hypospadias

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Asian Journal of Andrology 2024年第4期26卷 356-365页

作者： Yu Ding Zu-Quan chen Wen-Feng Pan Hao-jie chen Min Wu Yi-Qing Lyu Hua Xie Yi-chen Huang Zhong-Zhong chen Fang chen Department of Urology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Urogenital Development Research Center Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Clinical Research Center for Hypospadias Pediatric CollegeShanghai Jiao Tong University School of MedicineShanghai 200062China.

The second-to-fourth digit(2D:4D)ratio is thought to be associated with prenatal androgen ***,the relationship between the 2D:4D ratio and hypospadias is poorly understood,and its molecular mechanism is not *** this study,by analyzing the hand digit length of 142 boys with hypospadias(23 distal,68 middle,and 51 proximal)and 196 controls enrolled in Shanghai Children’s Hospital(Shanghai,China)from December 2020 to December 2021,we found that the 2D:4D ratio was significantly increased in boys with hypospadias(P<0.001)and it was positively correlated with the severity of the *** was further verified by the comparison of control mice and prenatal low testosterone mice model obtained by knocking out the risk gene(dynein axonemal heavy chain 8[DNAH8])associated with ***,the discrepancy was mainly caused by a shift in *** characterization of a mouse model validated that low testosterone levels during pregnancy can impair the growth and development of *** mechanistic explorations revealed that during the androgen-sensitive window,the downregulation of the androgen receptor(AR)caused by low testosterone levels,as well as the suppressed expression of chondrocyte proliferation-related genes such as Wnt family member 5a(Wnt5a),Wnt5b,Smad family member 2(Smad2),and Smad3;mitochondrial function-related genes in cartilage such as AMP-activated protein kinase(AMPK)and nuclear respiratory factor 1(Nrf-1);and vascular development-related genes such as myosin light chain(MLC),notch receptor 3(Notch3),and sphingosine kinase 1(Sphk1),are responsible for the limitation of 4D growth,which results in a higher 2D:4D ratio in boys with hypospadias via decreased endochondral *** study indicates that the ratio of 2D:4D is a risk marker of hypospadias and provides a potential molecular mechanism.

关键词： androgen receptor digit ratio(2D:4D) endochondral ossification hypospadias testosterone level

Hydrogen-rich surface of MoC catalysts for efficient CO_(2) hydrogenation induced by a coupled hydrogen donator

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Nano Research 2024年第8期17卷 7762-7767页

作者： Dong Xu Si-Yuan Xia Qi-Yuan Li jie-Sheng chen Xin-Hao Li School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Direct CO_(2) hydrogenation offers an important strategy for promoting the global carbon balance,but high thermodynamic and kinetic stability of CO_(2) has restricted its applicability to only a handful of industrial ***,we introduce a proof-of-concept application of the electron-rich Pt surface to promote hydrogen donation for electron-rich MoC particles acting as hydrogen acceptors,thereby constructing hydrogen-rich surface of MoC active ***,the formed hydrogen-rich and electronrich surface could greatly decrease reaction activation energy to boost the efficient CO_(2) hydrogenation into formic acid over the MoC *** optimized MoC@NC/Pt-0.1(NC:nitrogen-doped carbon)catalyst exhibits a high turnover frequency(TOF)value of 1.2 h^(−1) at a lower temperature of 60℃and a TOF of 24.2 h^(−1) under standard reaction conditions widely used in the literature,exceeding 7 times of MoC@NC catalyst and surpassing the benchmark classical non-noble metal active center-based heterogeneous catalyst.

关键词： electron-rich Pt nanoparticles hydrogen donation hydrogen-rich MoC nanoparticles CO_(2) hydrogenation formic acid