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Microbial characteristics in anaerobic membrane bioreactor treating domestic sewage:Effects of HRT and process performance

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Journal of Environmental Sciences 2022年第1期34卷 392-399页

作者： jialing Ni jiayuan ji Yu-You Li Kengo Kubota Department of Civil and Environmental Engineering Graduate School of EngineeringTohoku University6-6-06 AobaAramakiAoba-ku 980-8579SendaiJapan Department of Frontier Science for Advanced Environment Graduate School of Environmental StudiesTohoku University6-6-06 AobaAramakiAoba-ku 980-8579SendaiJapan

Two anaerobic membrane bioreactors(AnMBRs)equipped with different membrane pore size(0.4 or 0.05μm)were operated at 25℃and fed with domestic *** hydraulic retention time(HRT)of the reactors was *** microbial communities of the two AnMBRs were investigated by 16S rRNA gene amplicon sequencing to see the effects of *** predominant Archaea was an aceticlastic methanogen *** composition of hydrogenotrophic methanogens changed with the HRTs:the population of Methanobacterium was higher for longer HRTs,whereas the population of unclassified Methanoregulaceae was higher for shorter *** Anaerolineae,Bacteroidia and Clostridia bacteria were dominant in both of the reactors,with a combined relative abundance of over 55%.The relative abundance of Anaerolineae was proportional to the biogas production *** change in the population of hydrogenotrophic methanogens or Anaerolineae can be used as an indicator for process *** sum of the relative abundance of Anaerolineae and Clostridia fluctuated slightly with changes in the HRT in both AnMBRs when the reactor was stably *** co-occurrence analysis revealed the relative abundance of the operational taxonomic units belonging to Anaerolineae and Clostridia was functionally equivalent during the treatment of real domestic sewage.A principal coordination analysis revealed that the changes in the microbial community in each reactor were consistent with the change of *** addition,both the HRT and the stability of the process are important factors for maintaining microbial community structures.

关键词： Anaerobic membrane bioreactor Co-occurrence analysis Hydrogenotrophic methanogen HRT Microbial community structure Principal coordinate analysis

基于UPLC-Q-TOF/MS技术的成人草酸钙尿石症血液代谢组学研究

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现代泌尿外科杂志 2024年第9期29卷 823-829页

作者：王翔宇冀家源崔腾肖荆首都医科大学附属北京友谊医院泌尿外科北京100050

目的基于超高效液相色谱-四极杆飞行时间质谱(UPLC-Q-TOF/MS)技术,通过血液代谢组学寻找成人草酸钙尿石症潜在的生物标志物和代谢机制,以指导草酸钙结石的临床诊治。方法前瞻性收集2017年10月—2018年7月北京友谊医院收治的36例双侧上... 详细信息

目的基于超高效液相色谱-四极杆飞行时间质谱(UPLC-Q-TOF/MS)技术,通过血液代谢组学寻找成人草酸钙尿石症潜在的生物标志物和代谢机制,以指导草酸钙结石的临床诊治。方法前瞻性收集2017年10月—2018年7月北京友谊医院收治的36例双侧上尿路草酸钙结石患者的血液样本并与36例健康体检者的血液样本对照。采用UPLC-Q-TOF/MS技术进行代谢指纹图谱分析。采用主成分分析(PCA)和正交偏最小二乘判别分析(OPLS-DA)对多元数据进行分析。通过对比人类代谢组数据库确定潜在的生物学标记物。最后对所鉴定的化合物行代谢通路分析并构建代谢网络图。结果PCA和OPLS-DA结果显示健康对照者与结石患者血液代谢物存在显著差异。进一步鉴定出包括亚油酸、枸橼酸、尿酸等29种与草酸钙结石患者血液相关的代谢物,以及胆汁酸合成通路、脂肪酸生物合成通路、甘油磷脂代谢通路、鞘脂代谢通路和嘌呤代谢通路等9条血液代谢通路。结论基于UPLC-Q-TOF/MS平台进行血液代谢组学分析,找到了29种成人草酸钙尿石症的潜在血液生物标志物,而嘌呤代谢与脂质代谢可能与草酸钙结石的成因相关。

关键词：生物学标记物代谢组学超高效液相色谱-四极杆飞行时间质谱草酸钙尿石症血液代谢

术前C反应蛋白与清蛋白比值在上尿路尿路上皮癌根治术后预后中的评估价值

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检验医学与临床 2024年第17期21卷 2523-2528页

作者：王翔宇冀家源崔腾肖荆首都医科大学附属北京友谊医院泌尿外科北京100050

目的探讨术前C反应蛋白与清蛋白比值(CAR)与接受根治性肾输尿管切除术(RNU)的上尿路尿路上皮癌(UTUC)患者肿瘤特征的关系及其对无进展生存期(PFS)和总生存期(OS)的影响。方法回顾性分析2017年1月至2020年12月该院因UTUC进行RNU的219例... 详细信息

目的探讨术前C反应蛋白与清蛋白比值(CAR)与接受根治性肾输尿管切除术(RNU)的上尿路尿路上皮癌(UTUC)患者肿瘤特征的关系及其对无进展生存期(PFS)和总生存期(OS)的影响。方法回顾性分析2017年1月至2020年12月该院因UTUC进行RNU的219例患者资料。采用约登指数确定CAR诊断UTUC的Cut-off值,按Cut-off值将219例患者分为高CAR组与低CAR组。比较高CAR组与低CAR组的年龄、性别、合并症、术前肾积水、局部肿瘤分期、淋巴结分期、淋巴血管浸润、病理分级、肿瘤位置,并使用Kaplan-Meier生存曲线分析高CAR组与低CAR组的PFS和OS。采用单因素和多因素COX比例风险回归分析PFS和OS的影响因素。结果高CAR组男性比例高于低CAR组,肾积水比例低于低CAR组,局部肿瘤分期为T3、T4比例高于低CAR组,病理分级为高级别比例高于低CAR组,有淋巴血管浸润比例高于低CAR组,肾盂肿瘤比例高于低CAR组,差异均有统计学意义(P<0.05)。高CAR与低CAR组平均PFS分别为35.4、51.4个月,平均OS分别为40.1、60.6个月,低CAR组PFS及OS明显长于高CAR组,差异均有统计学意义(P<0.05)。术前高CAR是较短PFS(HR=2.450,95%CI:1.579~3.756,P<0.001)和OS(HR=2.121,95%CI:1.417~3.173,P<0.001)的独立危险因素。结论接受RNU的UTUC患者术前高CAR是较短PFS和OS的独立危险因素,CAR有望作为独立的UTUC预后评估指标。

关键词：上尿路上皮癌生物学标志物根治性肾输尿管切除术 C反应蛋白清蛋白

On the effect of Fe(Ⅲ) on proliferation of Microcystis aeruginosa at high nitrate and low chlorophyll condition

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Journal of Environmental Sciences 2017年第2期29卷 105-110页

作者： Rong Chen Zhen Lei jiayuan ji Xiaochang Wang Yu-You Li Yuan Yang Lu Zhang Tao Xue Key Lab of Northwest Water Resource Environment and Ecology MOE Xi'an University of Architecture and Technology Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University

The impact of Fe concentrations on the growth of Microcystis aeruginosa in aquatic systems under high nitrate and low chlorophyll conditions was studied. The responses of cell density,total and cell chlorophyll-a intracellular Fe content and organic elemental composition of *** to different concentration gradients of Fe（Ⅲ） in the solutions were analysed. The results showed that the proliferation speeds of M. aeruginosa were：（1） decelerated when the Fe（Ⅲ） concentration was lower than 50 μg/L in the solutions,（2） promoted and positively related to the increase of Fe（Ⅲ） concentration from 100 to 500 μg/L in the solutions over the experimental period, and（3） promoted in the early stage but decelerated in later stages by excess adsorption of Fe by cells when the Fe（Ⅲ） concentration was higher than 500 μg/L in the solutions. The maximum cell density, total and cell chlorophyll-a were all observed at 500 μg Fe（Ⅲ）/L concentration. The organic elemental composition of M. aeruginosa was also affected by the concentration of Fe（Ⅲ） in the solutions, and the molecular formula of M. aeruginosa should be expressed as C7–7.5H14O0.8–1.3N3.5–5according to the functions for different Fe（Ⅲ）concentrations. Cell carbon and oxygen content appeared to increase slightly, while cell nitrogen content appeared to decrease as Fe（Ⅲ） concentrations increased from 100 to 500 μg/L in the solutions. This was attributed to the competition of photosynthesis and nitrogen adsorption under varying cell Fe content.

关键词： High nitrate Low chlorophyll Fe Microcystis aeruginosa Cell chlorophyll a Organic element composition

范德华力对Lennard-Jones体黏弹性的影响

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化工学报 2018年第8期69卷 3331-3337页

作者：季佳圆赵伶玲东南大学能源热转换及其过程测控教育部重点实验室能源与环境学院江苏南京210096

采用平衡态分子模拟方法对ρ*=0.85~1.0,T*=0.6~1.5范围内共30组的液固共存态Lennard-Jones体的黏弹性进行研究。模拟所得真实物质Ar的约化黏度与实验值误差为6.69%,验证了本模型对真实物质的可拓展性;同时,液固共存态下Lennard-Jones... 详细信息

采用平衡态分子模拟方法对ρ*=0.85~1.0,T*=0.6~1.5范围内共30组的液固共存态Lennard-Jones体的黏弹性进行研究。模拟所得真实物质Ar的约化黏度与实验值误差为6.69%,验证了本模型对真实物质的可拓展性;同时,液固共存态下Lennard-Jones体模型的黏度模拟值与文献值吻合较好,误差小于5.16%,模拟精度较高。从环境参数(T*、ρ*)和分子参数(L-J势参数ε、σ)两方面,观测了Lennard-Jones体的静态(黏度η*、无限大频率的剪切模量G∞*)及动态(储能模量G′*、损耗模量G″*)黏弹性的变化规律,并在此基础上解释范德华力对黏弹性的影响机理。结果表明,ρ*升高或T*降低将导致η*、G∞*的升高,而T*、ρ*的升高则会使得中高频区的G′*及G″*增大;L-J势参数ε、σ的增大均能促进体系固态化,增强其静态及动态黏弹性,可为工程上高效利用单原子物质的黏弹性提供理论指导。

关键词：分子模拟黏弹性黏度弹性范德华力

Thyroid-stimulating hormone-thyroid hormone signaling contributes to circadian regulation through repressing clock2/npas2 in zebrafish

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Journal of Genetics and Genomics 2024年第1期51卷 61-74页

作者： Cheng ji Yue Ou Wangjianfei Yu jiaxin Lv Fanmiao Zhang Huashan Li Zeyun Gu jiayuan Li Zhaomin Zhong Han Wang Center for Circadian Clocks Soochow UniversitySuzhouJiangsu 215123China School of Biology and Basic Medical Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

Thyroid-stimulating hormone(TSH)is important for the thyroid gland,development,growth,and *** in TSH production or the thyrotrope cells within the pituitary gland cause congenital hypothyroidism(CH),resulting in growth retardation and neurocognitive *** human TSH is known to display rhythmicity,the molecular mechanisms underlying the circadian regulation of TSH and the effects of TSH-thyroid hormone(TH)signaling on the circadian clock remain *** we show that TSH,thyroxine(T4),triiodothyronine(T3),and tshba display rhythmicity in both larval and adult zebrafish and tshba is regulated directly by the circadian clock via both E′-box and *** tshba^(−/−)mutants manifest congenital hypothyroidism,with the characteristics of low levels of T_(4)and T_(3)and growth *** or overexpression of tshba alters the rhythmicity of locomotor activities and expression of core circadian clock genes and hypothalamic-pituitary-thyroid(HPT)axis-related ***,TSH-TH signaling regulates clock2/npas2 via the thyroid response element(TRE)in its promoter,and transcriptome analysis reveals extensive functions of Tshba in ***,our results demonstrate that zebrafish tshba is a direct target of the circadian clock and in turn plays critical roles in circadian regulation along with other functions.

关键词： Thyroid-stimulating hormone subunitβa (tshba) Thyroid hormone Circadian rhythm TALEN Zebrafish

经尿道输尿管软镜下钬激光内切开引流术治疗肾盂旁囊肿疗效分析

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国际外科学杂志 2024年第6期51卷 399-403,I0013页

作者：冀家源肖荆阮极盟王翔宇陈美元杨洋黎健发崔腾首都医科大学附属北京友谊医院泌尿外科北京100050 首都医科大学宣武医院泌尿外科北京100053

目的探讨经尿道输尿管软镜下钬激光内切开引流术治疗肾盂旁囊肿的安全性和有效性。方法回顾性分析2018年1月—2022年12月首都医科大学附属北京友谊医院收治的21例肾盂旁囊肿患者的临床资料,其中男性10例,女性11例;年龄36~72岁,平均(62.8... 详细信息

目的探讨经尿道输尿管软镜下钬激光内切开引流术治疗肾盂旁囊肿的安全性和有效性。方法回顾性分析2018年1月—2022年12月首都医科大学附属北京友谊医院收治的21例肾盂旁囊肿患者的临床资料,其中男性10例,女性11例;年龄36~72岁,平均(62.86±5.38)岁,中位数63.0岁;囊肿最大径为33~71 mm,平均(53.46±9.68)mm;其中伴同侧肾积水15例,合并同侧肾盂结石6例。纳入研究患者均采用经尿道输尿管软镜下钬激光内切开引流术治疗。术后1个月复查1次泌尿系超声并去除双J管,此后每6个月复查双肾CT至满12个月。随后每年定期复查双肾彩超,记录手术时间、术后住院时间、术后下床时间、术中出血量、肾囊肿有无复发及缩小情况等预后指标。结果21例成功行经尿道输尿管软镜下钬激光内切开引流术患者中,9例(42.9%)行一期手术,12例(57.1%)行二期手术,平均手术时间为(41.57±10.86)min,平均术后住院时间为(2.90±1.06)d,平均术后下床时间为(0.53±0.30)d,平均术中出血量为(6.52±2.15)mL。术后随访6~60个月,所有患者未见明显囊肿复发,且囊肿完全消失或明显缩小。结论符合适应证的肾盂旁囊肿患者采用经尿道输尿管软镜下钬激光内切开引流术安全、可靠,且手术时间短、出血量小、术后恢复快、复发率低,是肾盂旁囊肿可选的理想治疗方式之一。

关键词：输尿管镜激光疗法治疗结果肾盂旁囊肿切开引流术

Electrospinning-derived functional carbon-based materials for energy conversion and storage

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Chinese Chemical Letters 2024年第6期35卷 3-13页

作者： Xinyu Ren Hong Liu jingang Wang jiayuan Yu Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJi’nan 250022China State Key Laboratory of Crystal Materials Shandong UniversityJi’nan 250100China

The over-exploitation of fossil fuel energy has brought about serious environmental *** would be of great significance to construct efficient energy conversion and storage system to maximize utilize renewable energy,which contributes to reducing environmental *** the past few years,in terms of electrocatalysis and energy storage,carbon fiber materials show great advantages due to its outstanding electrical conductivity,good flexibility and mechanical *** a simple and low-cost technique,electrospinning can be employed to prepare various *** is noted that the functional fiber materials with different special structure and composition can be obtained for energy conversion and storage by combining electrospinning with other *** this paper,the structural design,controllable synthesis and multifunctional applications of electrospinning-derived functional carbon-based materials(EFCMs)is ***,we briefly introduce the history,basic principle and typical equipment of *** we discuss the strategies for preparing EFCMs with different structures and composition in *** addition,we show recently the application of advanced EFCMs in energy conversion and storage,such as nitrogen species reduction reaction,CO_(2) reduction reaction,oxygen reduction reaction,water-splitting,supercapacitors and ion *** the end,we propose some perspectives on the future development direction of EFCMs.

关键词： Electrospinning Carbon materials Functional fiber Energy conversion Energy storage Electrocatalysis

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离子对CO2-盐水系统界面特性的影响

化工学报 2017年第1期68卷 223-229页

作者：季佳圆赵伶玲李偲宇东南大学能源与环境学院能源热转换及其过程测控教育部重点实验室江苏南京210096

应用分子动力学模拟的方法对不同浓度及组分比例的CO_2-NaCl、CO_2-CaCl_2和CO_2-(NaCl+CaCl_2)等CO_2-盐水系统的界面张力进行了研究,从分子层面上分析了不同种类的盐离子对界面张力的影响。结果表明,盐离子的存在会增加CO_2-纯水的界... 详细信息

应用分子动力学模拟的方法对不同浓度及组分比例的CO_2-NaCl、CO_2-CaCl_2和CO_2-(NaCl+CaCl_2)等CO_2-盐水系统的界面张力进行了研究,从分子层面上分析了不同种类的盐离子对界面张力的影响。结果表明,盐离子的存在会增加CO_2-纯水的界面张力,界面张力增量主要由阳离子电荷数导致,其余则由阳离子兰纳-琼斯势参数、原子质量等原子特性参数引起;3种系统的界面张力增量均与离子强度呈线性关系,且其曲线的斜率和盐溶液种类无关,为IFT预测提供理论指导。

关键词： CO2-盐水系统界面张力分子模拟原子特性参数离子强度